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Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to [small beta],[small beta]-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5883-5890
DOI: 10.1039/C4OB01085J, PaperJeffrey Buter, Renee Moezelaar, Adriaan J. Minnaard
Palladium catalyzed asymmetric conjugate addition of ortho-substituted arylboronic acids to cyclic enones and its application in natural product synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper(I)-induced amplification of a [2]catenane in a virtual dynamic library of macrocyclic alkenes

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,6167-6174
DOI: 10.1039/C4OB01009D, PaperJose Augusto Berrocal, Marko M. L. Nieuwenhuizen, Luigi Mandolini, E. W. Meijer, Stefano Di Stefano
The interlocked virtual component 1 of a well-behaved dynamic library of cyclic olefins is resuscitated by means of the template effect.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5995-6004
DOI: 10.1039/C4OB00830H, PaperXiaoli Wang, Linna Wang, Xiao Sheng, Zhangjian Huang, Tingting Li, Ming Zhang, Jinyi Xu, Hui Ji, Jian Yin, Yihua Zhang
Compound 8e protected against the collagen and adrenaline induced thrombosis in mice, and exhibited greater antithrombotic activity than NBP and aspirin in rats.
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C 3-Symmetric chiral trisimidazoline-catalyzed Friedel-Crafts (FC)-type reaction

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5827-5830
DOI: 10.1039/C4OB00925H, CommunicationShinobu Takizawa, Shuichi Hirata, Kenichi Murai, Hiromichi Fujioka, Hiroaki Sasai
The first imidazoline-catalyzed enantioselective Friedel-Crafts (FC)-type reaction was established using C3-symmetric chiral trisimidazolines.
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Efficient asymmetric synthesis of N-protected-[small beta]-aryloxyamino acids via regioselective ring opening of serine sulfamidate carboxylic acid

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01047G, PaperRajesh Malhotra, Tushar K. Dey, Swarup Dutta, Sourav Basu, Saumen Hajra
First regioselective ring opening of serine derived cyclic sulfamidate with ArONa is developed to provide an easy and direct access of a variety of N-Boc- and N-PMB protected [small beta]-aryloxy-[small alpha]-amino acids with complete retention of enantiopurity in moderate to high yields.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Mercaptobenzoic acid-palladium(0) complexes as active catalysts for S-benzylation with benzylic alcohols via ([small eta]3-benzyl)palladium(II) cations in water

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5964-5972
DOI: 10.1039/C4OB00688G, PaperHidemasa Hikawa, Isao Azumaya
Mercaptobenzoic acid-palladium(0) complexes show high catalytic activity for S-benzylation with benzylic alcohols via the ([small eta]3-benzyl)palladium(II) cation in water. The catalytic system can be performed using only 2.5 mol% Pd2(dba)3 without the phosphine ligand or other additives.
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Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5835-5838
DOI: 10.1039/C4OB01103A, CommunicationJianbin Chen, Helfried Neumann, Matthias Beller, Xiao-Feng Wu
The first example of palladium-catalyzed carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates, the products were isolated in moderate to good yields with the installation of two molecules of CO.
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Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,6085-6088
DOI: 10.1039/C4OB01039F, CommunicationZhongkai Tang, Yan Shi, Haibin Mao, Xuebin Zhu, Weipeng Li, Yixiang Cheng, Wen-Hua Zheng, Chengjian Zhu
A highly efficient method provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers (>99 : 1 dr, >99% ee).
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Copper catalyzed C-O bond formation via oxidative cross-coupling reaction of aldehydes and ethers

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00862F, CommunicationQuan Wang, Hao Zheng, Wen Chai, Dianyu Chen, Xiaojun Zeng, Renzhong Fu, Rongxin Yuan
A practical and efficient construction of C-O bonds via oxidative cross-coupling reaction of aldehydes and ethers has been realized under open air. When 2 mol% copper was used as the catalyst, various [small alpha]-acyloxy ethers were obtained with up to 93% isolated yield.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5954-5963
DOI: 10.1039/C4OB01176G, PaperRanfeng Sun, Huangdong Wang, Jianfeng Hu, Jiudong Zhao, Hao Zhang
A new phosphinimine ligand was used in the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines (not active in traditional CuAAC reactions) and alkynes for the first time and a series of 1-(pyridin-2-yl)-1,2,3-triazole derivatives were prepared.
The content of this RSS Feed (c) The Royal Society of Chemistry

Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5876-5882
DOI: 10.1039/C4OB00853G, PaperHongguang Li, Chi-Fai Chan, Wai-Lun Chan, Sam Lear, Steven L. Cobb, Nai-Ki Mak, Terrence Chi-Kong Lau, Rongfeng Lan, Wai-Kwok Wong, Ka-Leung Wong
Polo-like kinase 1 (Plk1) is well-known for taking part in cell cycle progression and regulation.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5822-5826
DOI: 10.1039/C4OB01019A, CommunicationHai-Lei Cui, Fujie Tanaka
Polysubstituted 3-acylpyrroles were synthesized from readily available unsaturated ketones and N-substituted propargylated amines via an aza-Michael/alkyne carbocyclization cascade followed by oxidation in one pot.
The content of this RSS Feed (c) The Royal Society of Chemistry

An unnatural amino acid based fluorescent probe for phenylalanine ammonia lyase

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5818-5821
DOI: 10.1039/C4OB00914B, CommunicationZhenlin Tian, Weiping Zhu, Yufang Xu, Xuhong Qian
An unnatural amino acid based fluorescent probe 2a-LP was designed and synthesized. 2a-LP exhibited an excellent response to phenylalanine ammonia lyase both in Tris-HCl buffer and tomato samples, and was used as an intracellular sensor for phenylalanine ammonia lyase imaging.
The content of this RSS Feed (c) The Royal Society of Chemistry

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5936-5944
DOI: 10.1039/C4OB00998C, PaperFei Mao, Jun Yan, Jianheng Li, Xian Jia, Hui Miao, Yang Sun, Ling Huang, Xingshu Li
Compound 10c exhibited excellent MTDL properties: excellent abilities to moderate A[small beta] aggregation, potential antioxidant behaviour and biometal chelation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Rapid discovery of potent [small alpha]-fucosidase inhibitors by in situ screening of a library of (pyrrolidin-2-yl)triazoles

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5898-5904
DOI: 10.1039/C4OB00931B, PaperPilar Elias-Rodriguez, Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Inmaculada Robina
The fucosidase inhibitory activity of a library of (pyrrolidin-2-yl)triazoles generated by CuAAC can be in situ analyzed, avoiding tedious purification steps. A potent and selective inhibitor was identified.
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Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,6028-6032
DOI: 10.1039/C4OB00920G, PerspectiveZhaobin Wang, Zhilong Chen, Jianwei Sun
Important progress has been made in catalytic asymmetric ring-opening of 3-substituted oxetanes, but significant challenges and opportunities remain.
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Palladium-catalyzed ortho-functionalization of azoarenes with aryl acylperoxides

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5866-5875
DOI: 10.1039/C4OB00993B, PaperCheng Qian, Dongen Lin, Yuanfu Deng, Xiao-Qi Zhang, Huanfeng Jiang, Guang Miao, Xihao Tang, Wei Zeng
With the aid of an azo directing group, a Pd-catalyzed ortho-sp2 C-H bond activation/functionalization of azoarenes with aryl acyl peroxides has been explored. This transformation provides convenient access to regioselectively introducing acyloxyl and aryl group onto azoarenes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5928-5935
DOI: 10.1039/C4OB00874J, PaperGaofei Wei, Shuai Wang, Shanshan Cui, Jia Guo, Yongxiang Liu, Yang Liu, Maosheng Cheng
We have efficiently synthesized albiziabioside A (1) together with its six disaccharide analogues and evaluated their cytotoxicity against six different skin cancer cells. The results provide for the first time a basic mechanism for the anticancer activity of 1.
The content of this RSS Feed (c) The Royal Society of Chemistry

Electrochemical behaviour of new dimeric esters and amides derived from caffeic acid in dimethylsulfoxide

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5981-5989
DOI: 10.1039/C4OB00823E, PaperAnalilia Sanchez, Omar Martinez-Mora, Evelin Martinez-Benavidez, Javier Hernandez, Zaira Dominguez, Magali Salas-Reyes
Small differences in the connectors of four new dimeric derivatives of caffeic acid exert interesting changes on their electrochemical behaviour.
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Synthesis of 4-alkynylquinazolines: Pd-Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands

Org. and Biomol. Chem. - 25 July, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,5922-5927
DOI: 10.1039/C4OB00700J, PaperYiyuan Peng, Ping Huang, Yu Wang, Yirong Zhou, Jianjun Yuan, Qin Yang, Xin Jiang, Zhihong Deng, Jingshi Xu
A Pd-Cu-cocatalyzed coupling reaction of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes (NHC) as ligands is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

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