Feed aggregator

Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9789-9792
DOI: 10.1039/C4OB02146K, CommunicationBuddhadeb Mondal, Subhas Chandra Pan
A high enantioselective synthesis of 2-aryl-2,3-dihydro-4-quinolones has been developed via intramolecular Mannich reaction using primary amino acids as catalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9764-9768
DOI: 10.1039/C4OB02107J, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chou-Hsiung Chen, Sivaneswary Genapathy, Peter M. Fischer, Weng C. Chan
Utilising a chiral auxiliary-facilitated Strecker amino acid synthesis strategy, indole-substituted (S)-tryptophans have been obtained from corresponding indoles; the former in turn were used for the synthesis of a potent antibacterial agent, argyrin and its analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9760-9763
DOI: 10.1039/C4OB02079K, CommunicationMohan Pal, Stephen L. Bearne
Regioselective S-acylation of coenzyme A is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anion carrier formation by calix[4]arene-bis-hydroxymethylphosphonic acid in bilayer membranes

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9811-9821
DOI: 10.1039/C4OB01886A, PaperOleg Ya. Shatursky, Ludmila A. Kasatkina, Roman V. Rodik, Sergiy O. Cherenok, Alexander A. Shkrabak, Tatiana O. Veklich, Tatiana A. Borisova, Sergyi O. Kosterin, Vitaly I. Kalchenko
Calix[4]arene C-99-mediated ionic transport follows mobile carrier mode of facilitated diffusion (relative permeability PCl-/PK+ [similar] 3) with the passage of 20 ions per second.
The content of this RSS Feed (c) The Royal Society of Chemistry

Sulfinate derivatives: dual and versatile partners in organic synthesis

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9743-9759
DOI: 10.1039/C4OB01727G, Review ArticleJessy Aziz, Samir Messaoudi, Mouad Alami, Abdallah Hamze
Recent advances in the preparation and synthetic uses of sulfinic acids and their derivatives are highlighted in this review. They are used as versatile partners in sulfonylative and desulfitative reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9781-9785
DOI: 10.1039/C4OB01807A, CommunicationGuohua Chen, Qiang Yin, Jian Yin, Xiangying Gu, Xiao Liu, Qidong You, Yue-Lei Chen, Bing Xiong, Jingkang Shen
Tf2O mediated dehydrative glycosylation was enabled by strained olefins, including beta-(-)-pinene, and inhibited by other typical bases.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium catalyzed dual C-H functionalization of indoles with cyclic diaryliodoniums, an approach to ring fused carbazole derivatives

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9777-9780
DOI: 10.1039/C4OB02170C, CommunicationYongcheng Wu, Xiaopeng Peng, Bingling Luo, Fuhai Wu, Bo Liu, Fenyun Song, Peng Huang, Shijun Wen
As the tile reaction shows, an array of dibenzocarbazoles were obtained via dual C-H functionalization of indoles with cyclic diaryliodoniums in a single operation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9881-9886
DOI: 10.1039/C4OB02035A, PaperChuan-Li Ren, Tao Zhang, Xing-Yong Wang, Tao Wu, Jing Ma, Qing-Qing Xuan, Feng Wei, Hong-Yan Huang, Dong Wang, Li Liu
An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective [small alpha]-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9864-9880
DOI: 10.1039/C4OB01930J, PaperAhmed Kamal, A. V. Subba Rao, V. Lakshma Nayak, N. V. Subba Reddy, Konderu Swapna, G. Ramakrishna, Mallika Alvala
Imidazo[1,5-a]pyridine-benzimidazole hybrids are firstly reported herein to induce cytotoxicity by targeting microtubules.
The content of this RSS Feed (c) The Royal Society of Chemistry

New insights into the structure-spectrum relationship in S65T/H148D and E222Q/H148D green fluorescent protein mutants: a theoretical assessment

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9845-9852
DOI: 10.1039/C4OB01462F, PaperPau Armengol, Ricard Gelabert, Miquel Moreno, Jose M. Lluch
Dynamic simulations and excited state calculations track the origin of the absorption spectrum red-shift in two green fluorescent protein mutants.
The content of this RSS Feed (c) The Royal Society of Chemistry

Base-switched annuloselectivity in the reactions of ethyl malonyl chloride and imines

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9822-9830
DOI: 10.1039/C4OB01454E, PaperZhanhui Yang, Siqi Li, Zhong Zhang, Jiaxi Xu
The [2 + 2] and [2 + 2 + 2] annuloselectivity in the reactions of ethyl malonyl chloride with imines was controlled by different bases, providing a simple synthesis of [small beta]-lactam-3-carboxylates and 2,3-dihydro-1,3-oxazin-4-ones.
The content of this RSS Feed (c) The Royal Society of Chemistry

An efficient synthetic route to 1,3-bis(arylethynyl)isobenzofuran using alkoxybenzocyclobutenone as a reactive platform

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9773-9776
DOI: 10.1039/C4OB02012J, CommunicationKenta Asahina, Suguru Matsuoka, Ryosuke Nakayama, Toshiyuki Hamura
An efficient synthetic method of 1,3-bis(arylethynyl)isobenzofurans is developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

1-Trifluoromethylated isoquinolines via radical trifluoromethylation of isonitriles

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9895-9898
DOI: 10.1039/C4OB02145B, PaperBo Zhang, Armido Studer
A simple and efficient approach to biologically important 1-trifluoroalkylated isoquinolines starting with readily prepared [small beta]-aryl-[small alpha]-isocyano-acrylates and Rf-I(III)-reagents (Rf = CF3, C2F5, C3F7) is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Conformational equilibria in selected A-type trimeric procyanidins

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9837-9844
DOI: 10.1039/C4OB02086C, PaperMarta K. Dudek (Jamroz), Slawomir Kazmierski, Kamil Stefaniak, Vitold B. Glinski, Jan. A. Glinski
There are two favored conformations of A-type procyanidin trimers: the (+[small phi])-rotamer and the (-[small phi]) one. Their ratio depends on the procyanidin structure and solvent - different solvents favor different conformers.
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective oxygenation of alkynes: a direct approach to diketones and vinyl acetate

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9909-9913
DOI: 10.1039/C4OB01404A, PaperXiao-Feng Xia, Zhen Gu, Wentao Liu, Ningning Wang, Haijun Wang, Yongmei Xia, Haiyan Gao, Xiang Liu
Convenient and expedient methods for the synthesis of [small alpha]-diketones and [small beta]-haloenol acetates from arylalkynes using PhI(OAc)2 as an oxidant are developed at room temperature.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9887-9894
DOI: 10.1039/C4OB01438C, PaperYuko Murakami, Rina Suzuki, Hiroto Yanuma, Jiangtao He, Shuren Ma, Gerard M. Turino, Yong Y. Lin, Toyonobu Usuki
Chemical synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine, are achieved.
The content of this RSS Feed (c) The Royal Society of Chemistry

Gold-catalyzed carboalkoxylations of 2-ethynylbenzyl ethers to form 1- and 3-substituted 2-methoxy-1-H-indenes: Bronsted acids versus gold catalysis

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9831-9836
DOI: 10.1039/C4OB01794C, PaperChun-Hao Chen, Chiou-Dong Wang, Yi-Feng Hsieh, Rai-Shung Liu
Selective synthesis of 1- and 3-substituted 2-methoxyindenes from the carboalkoxylations of 2-ethynylbenzyl ethers is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Efficient synthesis of oligosaccharyl 1,2-O-orthoesters from n-pentenyl glycosides and application to the pentaarabinofuranoside of the mycobacterial cell surface

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9914-9920
DOI: 10.1039/C4OB01395F, PaperShivaji A. Thadke, Srinivas Hotha
Conversion of n-pentenyl glycosides to glycosyl 1,2-orthoesters that is mild, high yielding, and importantly suitable for oligosaccharide synthesis is identified.
The content of this RSS Feed (c) The Royal Society of Chemistry

Radical reactions of borohydrides

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9733-9742
DOI: 10.1039/C4OB01784F, Review ArticleTakuji Kawamoto, Ilhyong Ryu
This review article focuses on state-of-the-art borohydride based radical reactions, also covering earlier work, kinetics and some DFT calculations with respect to the hydrogen transfer mechanism.
The content of this RSS Feed (c) The Royal Society of Chemistry

Thermodynamic epimeric equilibration and crystallisation-induced dynamic resolution of lobelanine, norlobelanine and related analogues

Org. and Biomol. Chem. - 23 November, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,9797-9810
DOI: 10.1039/C4OB01787K, PaperZ. Amara, G. Bernadat, P.-E. Venot, P. Retailleau, C. Troufflard, E. Drege, F. Le Bideau, D. Joseph
The step-economical synthesis of lobelanine involving a ring closing double aza-Michael (RCDAM) reaction is revisited and successfully extended to the synthesis of various configurationally more stable analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.