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Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00164H, Review ArticleChung Yen Ang, Si Yu Tan, Yanli Zhao
This review highlights recent advances in multifunctional nanocarriers for controlled and targeted drug delivery in cancer therapy.
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The content of this RSS Feed (c) The Royal Society of Chemistry

A cyclization-carbonylation-cyclization coupling reaction of (ortho-alkynyl phenyl) (methoxymethyl) sulfides with the palladium(II)-bisoxazoline catalyst

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00299G, PaperYiyun Jiang, Taichi Kusakabe, Keisuke Takahashi, Keisuke Kato
A CCC-coupling reaction of (o-alkynylphenyl) (methoxymethyl) sulfides, catalyzed by (box)PdII complexes, afforded symmetrical ketones bearing two benzo[b]thiophene groups in good to excellent yields.
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The content of this RSS Feed (c) The Royal Society of Chemistry

Asymmetric synthesis of chloroisothreonine derivatives via syn-stereoselective Mannich-type additions across N-sulfinyl-[small alpha]-chloroimines

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00243A, PaperGert Callebaut, Filip Colpaert, Melinda Nonn, Lorand Kiss, Reijo Sillanpaa, Karl W. Tornroos, Ferenc Fulop, Norbert De Kimpe, Sven Mangelinckx
Mannich-type reactions across N-sulfinyl-[small alpha]-chloroaldimines resulted in syn-stereoselective synthesis of chloroisothreonine derivatives as excellent building blocks.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3009-3015
DOI: 10.1039/C4OB00145A, CommunicationYu Zhang, Yingyan Lu, Weifang Tang, Tao Lu, Ding Du
A novel synthesis of spirooxindoles has been developed by cooperative NHC-Lewis acid-mediated formal [3 + 2] annulations of alkynyl aldehydes with isatins.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3016-3020
DOI: 10.1039/C4OB00071D, CommunicationShigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
We synthesized the genetically predicted biosynthetic intermediates of saxitoxin (STX) (1), 2, 6 and 7, and identified 2 and 6 in microorganisms.
The content of this RSS Feed (c) The Royal Society of Chemistry

A selenium-contained aggregation-induced "turn-on" fluorescent probe for hydrogen peroxide

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3004-3008
DOI: 10.1039/C4OB00206G, CommunicationYe-Xin Liao, Kun Li, Ming-Yu Wu, Tong Wu, Xiao-Qi Yu
A novel selenium-contained aggregation-induced "turn-on" fluorescent probe was presented, which could selectively respond to hydrogen peroxide over other ROS in aqueous solution.
The content of this RSS Feed (c) The Royal Society of Chemistry

Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3026-3036
DOI: 10.1039/C4OB00115J, PaperOleg V. Larionov, David Stephens, Adelphe M. Mfuh, Hadi D. Arman, Anastasia S. Naumova, Gabriel Chavez, Behije Skenderi
Mechanistic and synthetic studies of the Mo/P-catalyzed N-oxidation of N-heterocycles with hydrogen peroxide shed light on the role and nature of the catalytically active species.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic amounts of triarylaminium salt initiated aerobic oxidative coupling of N-aryl tetrahydroisoquinolines

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3123-3128
DOI: 10.1039/C3OB42454E, PaperCongde Huo, Cheng Wang, Mingxia Wu, Xiaodong Jia, Xicun Wang, Yong Yuan, Haisheng Xie
A novel, efficient in catalytic amounts, stable radical cation triarylaminium salt induced aerobic oxidative [small alpha]-C-H functionalization of tertiary amines has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3114-3122
DOI: 10.1039/C4OB00231H, PaperChen Xu, Hong-Mei Li, Xiao-Er Yuan, Zhi-Qiang Xiao, Zhi-Qiang Wang, Wei-Jun Fu, Bao-Ming Ji, Xin-Qi Hao, Mao-Ping Song
An efficient NHC-modulated Pd/Cu cocatalyzed three-component coupling reaction for the synthesis of 2,6-diarylquinolines via oxidation, cyclization and Suzuki reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A versatile approach for site-directed spin labeling and structural EPR studies of RNAs

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3129-3136
DOI: 10.1039/C3OB42154F, PaperElena S. Babaylova, Anton V. Ivanov, Alexey A. Malygin, Maria A. Vorobjeva, Alia G. Venyaminova, Yuliya F. Polienko, Igor A. Kirilyuk, Olesya A. Krumkacheva, Matvey V. Fedin, Galina G. Karpova, Elena G. Bagryanskaya
We propose and validate a new site-directed spin labeling approach affording EPR distance measurements in long RNAs.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Bromosuccinimide as an oxidant for the transition-metal-free synthesis of 2-aminobenzoxazoles from benzoxazoles and secondary amines

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3108-3113
DOI: 10.1039/C4OB00386A, PaperXiaoe Wang, Daqian Xu, Chengxia Miao, Qiaohong Zhang, Wei Sun
A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3100-3107
DOI: 10.1039/C4OB00228H, PaperHui-Jing Li, Ying-Ying Wu, Qin-Xi Wu, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie, Yan-Chao Wu
Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system generates salicyl alcohols in excellent yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to enals, enones and enoates. The remarkable [small alpha]-effect of silicon

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3021-3025
DOI: 10.1039/C4OB00139G, CommunicationXincui Ye, Xianwei Sun, Zhenggang Huang, Na Yang, Zhishan Su, Changwei Hu, Zhenlei Song
The remarkable [small alpha]-effect of silicon leads to a regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to [small alpha],[small beta]-unsaturated carbonyl compounds.
The content of this RSS Feed (c) The Royal Society of Chemistry

A unique dithiocarbamate chemistry during design & synthesis of novel sperm-immobilizing agents

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3090-3099
DOI: 10.1039/C4OB00005F, PaperSantosh Jangir, Veenu Bala, Nand Lal, Lalit Kumar, Amit Sarswat, Lokesh Kumar, Bhavana Kushwaha, Pratiksha Singh, Praveen Kumar Shukla, Jagdamba Prasad Maikhuri, Gopal Gupta, Vishnu Lal Sharma
Unusual loss of CS2 observed in benzyl substituted dithiocarbamates during synthesis of double edged spermicides which acted through sulfhydryl binding.
The content of this RSS Feed (c) The Royal Society of Chemistry

Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3045-3061
DOI: 10.1039/C4OB00031E, PaperS. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, K. V. Radhakrishnan
Lewis acid catalyzed ring-opening of pentafulvene derived diazabicyclic olefins with various ortho-functionalized aryl iodides is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

A fluorescent probe for estimation of adenosine diphosphate and monitoring of glucose metabolism

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3071-3079
DOI: 10.1039/C3OB42505C, PaperArun Kumar, Parteek Prasher, Palwinder Singh
An ADP selective fluorescent probe working in aqueous medium was identified and the change in fluorescence as a function of ADP concentration was standardized.
The content of this RSS Feed (c) The Royal Society of Chemistry

Discovery of 2[prime or minute]-hydroxychalcones as autophagy inducer in A549 lung cancer cells

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3062-3070
DOI: 10.1039/C3OB42429D, PaperFang-Wu Wang, Sheng-Qing Wang, Bao-Xiang Zhao, Jun-Ying Miao
A series of 2[prime or minute]-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,2989-2992
DOI: 10.1039/C3OB42205D, Review ArticleDaniela Gamenara, Pablo Dominguez de Maria
Adding value to organic synthesis. Novel imine reductases enable the enantioselective reduction of imines to afford chiral amines. Likewise, novel bioinspired artificial metalloenzymes can perform the same reaction as well. Remarkable recent examples are herein discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry

The versatile enzyme Araf51 allowed efficient synthesis of rare pathogen-related [small beta]-D-galactofuranosyl-pyranoside disaccharides

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3080-3089
DOI: 10.1039/C3OB42519C, PaperIlona Chlubnova, Blanka Kralova, Hana Dvorakova, Petr Hosek, Vojtech Spiwok, Dominik Filipp, Caroline Nugier-Chauvin, Richard Daniellou, Vincent Ferrieres
A chemo-enzymatic approach was developed for the synthesis of galactofuranosyl-containing disaccharides. The biocatalyst Araf51 was efficient in producing various rare pathogen-related [small beta]-D-galactofuranosyl-pyranosides.
The content of this RSS Feed (c) The Royal Society of Chemistry

A new pyrene based highly sensitive fluorescence probe for copper(II) and fluoride with living cell application

Org. and Biomol. Chem. - 10 hours 39 min ago

Org. Biomol. Chem., 2014, 12,3037-3044
DOI: 10.1039/C4OB00067F, PaperShyamaprosad Goswami, Shampa Chakraborty, Sima Paul, Sandipan Halder, Sukanya Panja, Subhra Kanti Mukhopadhyay
A new pyrene based fluorescence probe has been synthesized for fluorogenic detection of Cu2+ in acetonitrile-aqueous media (7:3 CH3CN-HEPES buffer v/v, pH 7.5) with the bioimaging in both prokaryotic and eukaryotic living cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

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