Feed aggregator

Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7682-7685
DOI: 10.1039/C4OB01436G, CommunicationR. Matovic, F. Bihelovic, M. Gruden-Pavlovic, R. N. Saicic
The desmethyl analogue of abyssomicin C was synthesized. The synthetic analogue retained its antibacterial activity, whereas its cytotoxicity decreased for three orders of magnitude, as compared to the natural product.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of a photoresponsive quencher for fluorescent hybridization probes

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7844-7858
DOI: 10.1039/C4OB01185F, PaperMarina Kovaliov, Chaim Wachtel, Eylon Yavin, Bilha Fischer
dUDAB modified probes are promising probes for gene quantification in real-time PCR detection and as photoswitchable devices.
The content of this RSS Feed (c) The Royal Society of Chemistry

Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2[prime or minute]-alkylated RNA monomers

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7758-7773
DOI: 10.1039/C4OB01183J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Saswata Karmakar, Andreas S. Madsen, Dale C. Guenther, Bradley C. Gibbons, Patrick J. Hrdlicka
Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA with single nucleotide fidelity.
The content of this RSS Feed (c) The Royal Society of Chemistry

1,3-Halogen migration as an entry to aryl coppers from an unintuitive starting material

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7655-7658
DOI: 10.1039/C4OB01294A, PerspectiveR. J. Van Hoveln, S. C. Schmid, J. M. Schomaker
Cu-catalyzed 1,3-halogen migration provides a unique way to generate reactive aryl copper species for arene functionalizations.
The content of this RSS Feed (c) The Royal Society of Chemistry

Generalized access to fluorinated [small beta]-keto amino compounds through asymmetric additions of [small alpha],[small alpha]-difluoroenolates to CF3-sulfinylimine

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7836-7843
DOI: 10.1039/C4OB01575D, PaperChen Xie, Lingmin Wu, Haibo Mei, Vadim A. Soloshonok, Jianlin Han, Yi Pan
Asymmetric reactions between CF3-containing N-imines and [small alpha],[small alpha]-difluoroenolates giving [small beta]-keto-amino compounds featuring the R-CO-CF2-CH(NH2)-CF3 moiety with high yields and diastereoselectivities were developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7810-7819
DOI: 10.1039/C4OB01417K, PaperJordan Froese, Jason Reed Hudlicky, Tomas Hudlicky
Compounds of high synthetic value were produced in a much more efficient manner than was previously possible through fermentation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic amide allylation of [small alpha]-ketoesters: extremely high enantioselective synthesis of ester functionalised [small alpha]-methylene-[gamma]-butyrolactones

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7686-7689
DOI: 10.1039/C4OB01508H, CommunicationMasaki Takahashi, Yusuke Murata, Masahiro Ishida, Fumitoshi Yagishita, Masami Sakamoto, Tetsuya Sengoku, Hidemi Yoda
A significant breakthrough on the novel amide allylation on the acyclic [small alpha]-ketoester systems, achieving extremely high enantioselective synthesis of ester functionalised [small alpha]-methylene-[gamma]-butyrolactones, is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

The transition-metal-catalyst-free oxidative homocoupling of organomanganese reagents prepared by the insertion of magnesium into organic halides in the presence of MnCl2[middle dot]2LiCl

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7800-7809
DOI: 10.1039/C4OB01235F, PaperZhihua Peng, Na Li, Xinyang Sun, Fang Wang, Lanjian Xu, Cuiyu Jiang, Linhua Song, Zi-Feng Yan
An oxidative homocoupling of organomanganese reagents was performed in one pot without an additional transition-metal catalyst.
The content of this RSS Feed (c) The Royal Society of Chemistry

An economical and environmentally friendly oxidative biaryl coupling promoted by activated MnO2

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7774-7779
DOI: 10.1039/C4OB01409J, PaperJingjing Yang, Shutao Sun, Ziyu Zeng, Hongbo Zheng, Wei Li, Hongxiang Lou, Lei Liu
A mild, economical, and environmentally friendly oxidative biaryl coupling by MnO2 was developed to deliver five- to eight-membered tricyclic products.
The content of this RSS Feed (c) The Royal Society of Chemistry

Ultrasound-assisted 1,3-dipolar cycloaddition and cyclopropanation reactions for the synthesis of bis-indolizine and bis-cyclopropane derivatives

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7859-7863
DOI: 10.1039/C4OB01305K, PaperMehdi Abaszadeh, Mohammad Seifi
We report a new method for the synthesis of bis-indolizine and bis-cyclopropane derivatives under ultrasound irradiation, using a 1,3-dipolar cycloaddition reaction or a cyclopropanation reaction, respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7792-7799
DOI: 10.1039/C4OB01296H, PaperHuamin Wang, Hui Chen, Ya Chen, Guo-Jun Deng
2-Arylquinazolines were prepared from nitroarenes and benzyl alcohols or benzyl amines via a hydrogen transfer strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of isoquinoline-1,3(2H,4H)-dione derivatives via cascade reactions of N-alkyl-N-methacryloyl benzamide with aryl aldehydes

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7690-7693
DOI: 10.1039/C4OB01442A, CommunicationWannian Zhao, Ping Xie, Min Zhang, Ben Niu, Zhaogang Bian, Charles Pittman, Aihua Zhou
A cascade reaction between N-alkyl-N-methacryloylbenzamide and aryl aldehydes was developed to generate isoquinoline-1,3(2H,4H)-dione derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7728-7749
DOI: 10.1039/C4OB01200C, PaperJason M. Hargreaves, Yann Le Guen, Catherine Guerreiro, Karine Descroix, Laurence A. Mulard
Shigella flexneri serotypes 1b and 1a are Gram-negative enteroinvasive bacteria causing shigellosis in humans.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of a chiral building block for highly functionalized polycyclic ethers

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7750-7757
DOI: 10.1039/C4OB01439A, PaperG. Pazos, M. Perez, Z. Gandara, G. Gomez, Y. Fall
An efficient procedure for preparing enantiopure polycyclic ethers based on the furan singlet oxygen oxidation approach is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

A versatile strategy for appending a single functional group to a multifunctional host through host-guest covalent-capture

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7780-7785
DOI: 10.1039/C4OB01429D, PaperJean-Noel Rebilly, Assia Hessani, Benoit Colasson, Olivia Reinaud
A novel two-step strategy allowed us to selectively monofunctionalize a molecular host (calix[6]arene) with various groups of interest (redox tag, fluorophore, chelating ligand).
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01339E, PaperIsabella Tavernaro, Sebastian Hartmann, Laura Sommer, Heike Hausmann, Christian Rohner, Martin Ruehl, Anja Hoffmann-Roeder, Sabine Schlecht
The authors present the synthesis of novel MUC1-glycopeptide antigens and their multivalent presentation by gold colloids. Their biological activity was tested in a dot-blot immunoassay experiment.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed direct alkylation of 1,3-azoles with N-tosylhydrazones bearing a ferrocenyl group: a novel method for the synthesis of ferrocenyl-based ligands

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7721-7727
DOI: 10.1039/C4OB01093K, PaperQiang Teng, Jianfeng Hu, Li Ling, Ranfeng Sun, Junyang Dong, Shufeng Chen, Hao Zhang
A new type of 1,1[prime or minute]-disubstituted ferrocenyl (N,N) bidentate ligand was synthesised via CuBr-catalyzed coupling of 1,3-azoles with ferrocenyl ketone-derived N-tosylhydrazones.
The content of this RSS Feed (c) The Royal Society of Chemistry

Dithienylethene-based rotaxanes: synthesis, characterization and properties

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7712-7720
DOI: 10.1039/C4OB01213E, PaperFang Hu, Juanyun Huang, Meijiao Cao, Zhao Chen, Ying-Wei Yang, Sheng Hua Liu, Jun Yin
The photochromic materials have been widely applied in many fields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Photo-responsive [2]catenanes: synthesis and properties

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7702-7711
DOI: 10.1039/C4OB01120A, PaperZiyong Li, Fang Hu, Guoxing Liu, Wen Xue, Xiaoqiang Chen, Sheng Hua Liu, Jun Yin
A series of novel dithienylethene-based macrocycles containing ammonium moieties has been synthesized.
The content of this RSS Feed (c) The Royal Society of Chemistry

A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones

Org. and Biomol. Chem. - 22 September, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,7694-7701
DOI: 10.1039/C4OB00562G, PaperAdan B. Gonzalez-Perez, Alexander Grechkin, Angel R. de Lera
Z-Vinyl allene oxides are predicted to rearrange with high fidelity to stereodefined cyclopentenones through intermediate cyclopropanones.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.