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Catalytic amounts of triarylaminium salt initiated aerobic oxidative coupling of N-aryl tetrahydroisoquinolines

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3123-3128
DOI: 10.1039/C3OB42454E, PaperCongde Huo, Cheng Wang, Mingxia Wu, Xiaodong Jia, Xicun Wang, Yong Yuan, Haisheng Xie
A novel, efficient in catalytic amounts, stable radical cation triarylaminium salt induced aerobic oxidative [small alpha]-C-H functionalization of tertiary amines has been developed.
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N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3114-3122
DOI: 10.1039/C4OB00231H, PaperChen Xu, Hong-Mei Li, Xiao-Er Yuan, Zhi-Qiang Xiao, Zhi-Qiang Wang, Wei-Jun Fu, Bao-Ming Ji, Xin-Qi Hao, Mao-Ping Song
An efficient NHC-modulated Pd/Cu cocatalyzed three-component coupling reaction for the synthesis of 2,6-diarylquinolines via oxidation, cyclization and Suzuki reactions.
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A versatile approach for site-directed spin labeling and structural EPR studies of RNAs

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3129-3136
DOI: 10.1039/C3OB42154F, PaperElena S. Babaylova, Anton V. Ivanov, Alexey A. Malygin, Maria A. Vorobjeva, Alia G. Venyaminova, Yuliya F. Polienko, Igor A. Kirilyuk, Olesya A. Krumkacheva, Matvey V. Fedin, Galina G. Karpova, Elena G. Bagryanskaya
We propose and validate a new site-directed spin labeling approach affording EPR distance measurements in long RNAs.
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Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00390J, PaperZhifang Zhou, Mohabul Mondal, Guochao Liao, Zhongwu Guo
Monophosphoryl lipid A derivatives were used as both carrier molecules and built-in adjuvants to create fully synthetic self-adjuvanting glycoconjugate cancer vaccines.
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"Click and go": simple and fast folic acid conjugation

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00150H, PaperAlexandre F. Trindade, Raquel F. M. Frade, Ermelinda M. S. Macoas, Catia Graca, Catarina A. B. Rodrigues, Jose M. G. Martinho, Carlos A. M. Afonso
A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne-azide cycloaddition, without the need for expensive chromatographic purifcation.
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Total synthesis of lycorine-type alkaloids by cyclopropyl ring-opening rearrangement

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00126E, PaperDandan Liu, Long Ai, Fan Li, Annan Zhao, Jingbo Chen, Hongbin Zhang, Jianping Liu
Anhydrocaranine, [gamma]-lycorane and putative amarbellisine were synthesized based on a series reactions including a novel cyclopropyl ring-opening rearrangement.
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The diene-transmissive hetero-Diels-Alder reaction of 2-vinyl [small alpha],[small beta]-unsaturated aldimines: stereoselective synthesis of hexahydroquinazolin-2-ones

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00224E, CommunicationSatoru Kobayashi, Kenji Kudo, Ai Ito, Satoru Hirama, Takashi Otani, Takao Saito
The tandem Diels-Alder methodology of cross-conjugated 1-azatrienes for synthesis of crossed bis-cycloadducts with high chemo-, regio- and stereoselectivities is described.
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N,N[prime or minute]-Bis[3,5-bis(trifluoromethyl)phenyl]thiourea: a privileged motif for catalyst development

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00306C, Review ArticleZhiguo Zhang, Zongbi Bao, Huabin Xing
This review summarizes the key developments of N,N[prime or minute]-bis[3,5-bis(trifluoromethyl)phenyl]thiourea (Schreiner's thiourea)-mediated reactions with the aim to further expand the applications of (thio)urea-based catalysts.
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N-Bromosuccinimide as an oxidant for the transition-metal-free synthesis of 2-aminobenzoxazoles from benzoxazoles and secondary amines

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3108-3113
DOI: 10.1039/C4OB00386A, PaperXiaoe Wang, Daqian Xu, Chengxia Miao, Qiaohong Zhang, Wei Sun
A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles.
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Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3100-3107
DOI: 10.1039/C4OB00228H, PaperHui-Jing Li, Ying-Ying Wu, Qin-Xi Wu, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie, Yan-Chao Wu
Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system generates salicyl alcohols in excellent yields.
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Regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to enals, enones and enoates. The remarkable [small alpha]-effect of silicon

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3021-3025
DOI: 10.1039/C4OB00139G, CommunicationXincui Ye, Xianwei Sun, Zhenggang Huang, Na Yang, Zhishan Su, Changwei Hu, Zhenlei Song
The remarkable [small alpha]-effect of silicon leads to a regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to [small alpha],[small beta]-unsaturated carbonyl compounds.
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A unique dithiocarbamate chemistry during design & synthesis of novel sperm-immobilizing agents

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3090-3099
DOI: 10.1039/C4OB00005F, PaperSantosh Jangir, Veenu Bala, Nand Lal, Lalit Kumar, Amit Sarswat, Lokesh Kumar, Bhavana Kushwaha, Pratiksha Singh, Praveen Kumar Shukla, Jagdamba Prasad Maikhuri, Gopal Gupta, Vishnu Lal Sharma
Unusual loss of CS2 observed in benzyl substituted dithiocarbamates during synthesis of double edged spermicides which acted through sulfhydryl binding.
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Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3045-3061
DOI: 10.1039/C4OB00031E, PaperS. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, K. V. Radhakrishnan
Lewis acid catalyzed ring-opening of pentafulvene derived diazabicyclic olefins with various ortho-functionalized aryl iodides is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

KOAc-promoted alkynylation of [small alpha]-C-H bonds of ethers with alkynyl bromides under transition-metal-free conditions

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2969-2978
DOI: 10.1039/C4OB00002A, PaperJiajun Zhang, Pinhua Li, Lei Wang
KOAc-promoted [small alpha]-position C-H activation and alkynylation of ethers with alkynyl bromides to 2-alkynyl ethers was developed under transition-metal-free conditions.
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A fluorescent probe for estimation of adenosine diphosphate and monitoring of glucose metabolism

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3071-3079
DOI: 10.1039/C3OB42505C, PaperArun Kumar, Parteek Prasher, Palwinder Singh
An ADP selective fluorescent probe working in aqueous medium was identified and the change in fluorescence as a function of ADP concentration was standardized.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tailoring fluorescent strigolactones for in vivo investigations: a computational and experimental study

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2960-2968
DOI: 10.1039/C3OB42592D, PaperCristina Prandi, Giovanni Ghigo, Ernesto G. Occhiato, Dina Scarpi, Stefano Begliomini, Beatrice Lace, Gabriele Alberto, Emma Artuso, Marco Blangetti
Fluorescent strigolactones have been designed and synthesized to fit bioimaging requirements.
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A unified strategy for the synthesis of the C1-C14 fragment of marinolic acids, mupirocins, pseudomonic acids and thiomarinols: total synthesis of pseudomonic acid methyl monate C

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2950-2959
DOI: 10.1039/C4OB00025K, PaperY. Sridhar, P. Srihari
A flexible stereoselective approach to the common C1-C14 skeleton present in natural products of the pseudomonic acid family is described.
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Amplification by nucleic acid-templated reactions

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2821-2833
DOI: 10.1039/C4OB00096J, Review ArticleJulia Michaelis, Alexander Roloff, Oliver Seitz
Nucleic acid-templated reactions that proceed with turnover provide a means for signal amplification, which facilitates the use and detection of biologically occurring DNA/RNA molecules.
The content of this RSS Feed (c) The Royal Society of Chemistry

Discovery of 2[prime or minute]-hydroxychalcones as autophagy inducer in A549 lung cancer cells

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,3062-3070
DOI: 10.1039/C3OB42429D, PaperFang-Wu Wang, Sheng-Qing Wang, Bao-Xiang Zhao, Jun-Ying Miao
A series of 2[prime or minute]-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated.
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Palladium-catalyzed air-based oxidative coupling of arylboronic acids with H-phosphine oxides leading to aryl phosphine oxides

Org. and Biomol. Chem. - 17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2895-2902
DOI: 10.1039/C3OB42470G, PaperTingting Fu, Hongwei Qiao, Zhimin Peng, Gaobo Hu, Xueji Wu, Yuxing Gao, Yufen Zhao
Various valuable aryl phosphine oxides were effectively prepared via the palladium-catalyzed coupling of arylboronic acids with H-phosphine oxides.
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