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Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosines than tyrosine prenyltransferases

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7551-7557
DOI: 10.1039/C5OB01040C, PaperAili Fan, Xiulan Xie, Shu-Ming Li
Better conversion of L-o- and L-m-tyrosine to their C-prenylated derivatives by tryptophan prenyltransferases (Trp-PTs) than tyrosine O-prenyltransferases (Tyr-O-PT).
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalysed ring-opening trifluoromethylation of cyclopropanols

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7159-7163
DOI: 10.1039/C5OB00808E, CommunicationXia-Ping He, Yong-Jin Shu, Jian-Jun Dai, Wen-Man Zhang, Yi-Si Feng, Hua-Jian Xu
A copper catalyzed ring-opening trifluoromethylation of cyclopropanols under mild reaction conditions was developed. A wide variety of synthetically useful [small beta]-trifluoromethyl ketones were obtained.
The content of this RSS Feed (c) The Royal Society of Chemistry

Reusable ionic liquid-catalyzed oxidative coupling of azoles and benzylic compounds via sp3 C-N bond formation under metal-free conditions

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7154-7158
DOI: 10.1039/C5OB00781J, CommunicationWenbo Liu, Chenjiang Liu, Yonghong Zhang, Yadong Sun, Ablimit Abdukadera, Bin Wang, He Li, Xuecheng Ma, Zengpeng Zhang
The heterocyclic ionic liquid-catalyzed direct oxidative amination of benzylic sp3 C-H bonds via intermolecular sp3 C-N bond formation for the synthesis of N-alkylated azoles under metal-free conditions is reported for the first time.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot three-component domino protocol for the synthesis of novel pyrano[2,3-d]pyrimidines as antimicrobial and anti-biofilm agents

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7294-7306
DOI: 10.1039/C5OB00693G, PaperLingala Suresh, Y. Poornachandra, S. Kanakaraju, C. Ganesh Kumar, G. V. P. Chandramouli
A simple and facile synthesis of a series of novel pyrano[2,3-d]pyrimidines have been achieved successfully via one-pot three-component reaction of 2-amino-7-methyl-5-oxo-4-phenyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitriles, DMF-DMA and arylamines.
The content of this RSS Feed (c) The Royal Society of Chemistry

A bifunctional colorimetric fluorescent probe for Hg2+ and Cu2+ based on a carbazole-pyrimidine conjugate: chromogenic and fluorogenic recognition on TLC, silica-gel and filter paper

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7149-7153
DOI: 10.1039/C5OB00907C, CommunicationMatinder Kaur, Ye-Hee Ahn, Kihang Choi, Min Ju Cho, Dong Hoon Choi
A bifunctional fluorescent probe based on a carbazole-pyrimidine conjugate exhibited a colorimetric and ratiometric turn-on response towards Hg2+/Cu2+ in the nanomolar range.
The content of this RSS Feed (c) The Royal Society of Chemistry

Theoretical investigations of the reaction between 1,4-dithiane-2,5-diol and azomethine imines: mechanisms and diastereoselectivity

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7558-7569
DOI: 10.1039/C5OB00807G, PaperLinjie Zheng, Yan Qiao, Mengxue Lu, Junbiao Chang
The detailed mechanism of the DABCO-catalyzed reaction between 1,4-dithiane-2,5-diol and azomethine imines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fluorinated enol ethers: their synthesis and reactivity

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7351-7380
DOI: 10.1039/C5OB00855G, Review ArticleM. Decostanzi, J.-M. Campagne, E. Leclerc
This review sums up the methods for the preparation of fluorinated enol ethers as well as their numerous synthetic applications.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of a novel Rhodamine B pyrene [2]rotaxane as an intracellular delivery agent for doxorubicin

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7517-7529
DOI: 10.1039/C5OB00934K, PaperJiaxin Shi, Yuan Xu, Xinlong Wang, Luyong Zhang, Jing Zhu, Tao Pang, Xiaofeng Bao
RhBPy [2]rotaxane has been demonstrated to be an efficient transport agent for delivering the cancer drug doxorubicin (DOX) into tumor cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Evaluation of the antibacterial and antibiofilm activities of novel CRAMP-vancomycin conjugates with diverse linkers

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7477-7486
DOI: 10.1039/C5OB00830A, PaperNigam M. Mishra, Yves Briers, Chris Lamberigts, Hans Steenackers, Stijn Robijns, Bart Landuyt, Jos Vanderleyden, Liliane Schoofs, Rob Lavigne, Walter Luyten, Erik V. Van der Eycken
Conjugates of CRAMP (cathelicidin-related antimicrobial peptides) and vancomycin were synthesised using click chemistry with diverse hydrophilic and hydrophobic linkers.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7381-7383
DOI: 10.1039/C5OB00904A, CommunicationXiang Sun, Xiao-Hui Lv, Lin-Miao Ye, Yu Hu, Yan-Yan Chen, Xue-Jing Zhang, Ming Yan
Benzimidazoles were prepared in good yields via the iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Interaction of myo-inositol hexakisphosphate with biogenic and synthetic polyamines

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7500-7512
DOI: 10.1039/C5OB00900F, PaperJulia Torres, Claudia Giorgi, Nicolas Veiga, Carlos Kremer, Antonio Bianchi
myo-Inositol hexakisphosphate (phytate) forms very stable adducts with biogenic and synthetic polyamines in aqueous solution.
The content of this RSS Feed (c) The Royal Society of Chemistry

Visual detection of formaldehyde by highly selective fluorophore labeling via gold(III) complex-mediated three-component coupling reaction

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7408-7411
DOI: 10.1039/C5OB00966A, CommunicationKong-Fan Wong, Jie-Ren Deng, Xiao-Qun Wei, Shi-Ping Shao, Da-Peng Xiang, Man-Kin Wong
Visual fluorescence detection of formaldehyde by a highly selective gold(III) complex-mediated three component coupling reaction has been described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphonate derivatives of tetraazamacrocycles as new inhibitors of protein tyrosine phosphatases

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7437-7444
DOI: 10.1039/C5OB00713E, PaperOleksandr L. Kobzar, Michael V. Shevchuk, Alesya N. Lyashenko, Vsevolod Yu. Tanchuk, Vadim D. Romanenko, Sergei M. Kobelev, Alexei D. Averin, Irina P. Beletskaya, Andriy I. Vovk, Valery P. Kukhar
[small alpha],[small alpha]-Difluoro-[small beta]-ketophosphonate derivatives of tetraazamacrocycles were synthesized and found to be potential inhibitors of protein tyrosine phosphatases.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anti-inflammatory diterpene dimers from the root barks of Aphanamixis grandifolia

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7452-7458
DOI: 10.1039/C5OB00674K, PaperHong-Jian Zhang, Yang-Mei Zhang, Jian-Guang Luo, Jun Luo, Ling-Yi Kong
14 new diterpene dimers, aphanamenes C-P (1-14), were isolated from the root barks of A. grandifolia Bl. Their structures were elucidated by spectroscopic analyses and CD exciton chirality method. In addition, all the compounds exhibited significant inhibition of nitric oxide production (IC50 7.75-38.23 [small mu ]M).
The content of this RSS Feed (c) The Royal Society of Chemistry

Hydrogen sulfide mediated cascade reaction forming an iminocoumarin: applications in fluorescent probe development and live-cell imaging

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7430-7436
DOI: 10.1039/C5OB00785B, PaperPratryush Kumar Mishra, Tanmoy Saha, Pinaki Talukdar
The study on a fluorescent probe that undergoes a H2S mediated cascade reaction to form an iminocoumarin fluorophore is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 8-aza-3,7-dideaza-2[prime or minute]-deoxyadenosines possessing a new adenosine skeleton as an environmentally sensitive fluorescent nucleoside for monitoring the DNA minor groove

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7459-7468
DOI: 10.1039/C5OB00862J, PaperAzusa Suzuki, Mio Saito, Ryuzi Katoh, Yoshio Saito
Fluorescent ODN probes containing 3n7zA (2) acted as effective reporter probes for homogeneous single nucleotide polymorphism (SNP) typing.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7487-7499
DOI: 10.1039/C5OB00847F, PaperDawei Hu, Namiki Miyagi, Yuki Arai, Hiroaki Oguri, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Hiroaki Gouda, Ossama El-Kabbani, Shuang Xia, Naoki Toyooka, Akira Hara, Toshiyuki Matsunaga, Akira Ikari, Satoshi Endo
Human carbonyl reductase 1 (CBR1), a member of the short-chain dehydrogenase/reductase superfamily, reduces anthracycline anticancer drugs to their less potent anticancer C-13 hydroxy metabolites, which are linked with pathogenesis of cardiotoxicity, a side effect of the drugs.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective asymmetric transfer hydrogenation (ATH) of [small alpha]-phthalimide ketones

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7513-7516
DOI: 10.1039/C5OB00568J, PaperZhou Xu, Yong Li, Jing Liu, Nan Wu, Ke Li, Songlei Zhu, Rongli Zhang, Yi Liu
Optically active amino alcohols are obtained in good yield and excellent ee via an efficient asymmetric transfer hydrogenation (ATH) of [small alpha]-phthalimide ketones.
The content of this RSS Feed (c) The Royal Society of Chemistry

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2[prime or minute]-deoxyuridine on telomeric G-quadruplex structures

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7421-7429
DOI: 10.1039/C5OB00748H, PaperAntonella Virgilio, Veronica Esposito, Luciano Mayol, Concetta Giancola, Luigi Petraccone, Aldo Galeone
The effects of 5-hydroxymethyl-2[prime or minute]-deoxyuridine on two human telomeric G-quadruplexes have been investigated. Reported results suggest a possible protecting effect of the loop residues on the other parts of the structure.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanistic insights into the synergistic catalysis by Au(I), Ga(III), and counterions in the Nakamura reaction

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, 13,7412-7420
DOI: 10.1039/C5OB00626K, PaperRameswar Bhattacharjee, A. Nijamudheen, Ayan Datta
DFT calculations explain the origin of Au/Ga dual catalyzed regioselectivity of Nakamura reactions. The role of the counterions and the triazole ligand is shown to be significant.
The content of this RSS Feed (c) The Royal Society of Chemistry

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