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A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1507-1514
DOI: 10.1039/C4OB01605J, PaperGaofei Wei, Weijing Luan, Shuai Wang, Shanshan Cui, Fengran Li, Yongxiang Liu, Yang Liu, Maosheng Cheng
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction.
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Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1500-1506
DOI: 10.1039/C4OB02260B, PaperYi-Chao Huang, Chao-Jian Guan, Xiang-Long Tan, Chen-Chen Chen, Qing-Xiang Guo, Yi-Ming Li
In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection.
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Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1463-1469
DOI: 10.1039/C4OB02303J, PaperAaron Johnson, Matthew J. Saunders, Thomas G. Back
BIRT-377 was synthesized by enzymatic desymmetrization in conjunction with Curtius rearrangement, affording a key [small alpha]-quaternary amine intermediate in high ee.
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Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1470-1480
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez-Bartulos, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The combination of the cell-penetrating peptide BP16 with the enzymatic cleavable sequence Gly-Phe-Leu-Gly constitutes a drug delivery system for the effective uptake and release of chlorambucil in cancer cells.
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Cu-catalyzed arylation of the amino group in the indazole ring: regioselective synthesis of pyrazolo-carbazoles

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1481-1491
DOI: 10.1039/C4OB02044H, PaperK. Anil Kumar, Prakash Kannaboina, Devendra K. Dhaked, Ram A. Vishwakarma, Prasad V. Bharatam, Parthasarathi Das
Arylated aminoindazoles were synthesized by copper-catalyzed C-N bond cross-coupling with boronic acids. These were then transformed to pyrazolo-carbazoles by Pd-catalyzed regioselective cross-dehydrogenative coupling.
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Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1453-1462
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Systematic analyses of mutant LasR quorum-sensing receptors with its native ligand and a suite of synthetic analogues reveal the importance of specific polar interactions for native receptor activation.
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The development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1446-1452
DOI: 10.1039/C4OB02197E, PaperA. L. Hurski, Yu. V. Ermolovich, V. N. Zhabinskii, V. A. Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. It was applied for the preparation of brassinolide and related brassinosteroids.
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Tris(triazole) tripodal receptors as selective probes for citrate anion recognition and multichannel transition and heavy metal cation sensing

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1429-1438
DOI: 10.1039/C4OB02135E, PaperMaria del Carmen Gonzalez, Francisco Oton, Arturo Espinosa, Alberto Tarraga, Pedro Molina
The preparation and binding properties towards citrate anions and cations of two three-armed triazole based receptors are described.
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Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1439-1445
DOI: 10.1039/C4OB01823K, PaperAlexander O. Terent'ev, Mikhail Yu. Sharipov, Igor B. Krylov, Darya V. Gaidarenko, Gennady I. Nikishin
Bisperoxidation of styrenes with tert-butyl hydroperoxide in the presence of a catalytic amount of Mn(OAc)3.
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1347-1357
DOI: 10.1039/C4OB02277G, PaperAhmed Kamal, Abdul Rahim, Sd Riyaz, Y. Poornachandra, Moku Balakrishna, C. Ganesh Kumar, Syed Mohammed Ali Hussaini, B. Sridhar, Pavan Kumar Machiraju
2-Styryl quinolines have been synthesized regioselectively from 2-methyl-quinoline using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains.
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Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and aza-Henry reactions

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1420-1428
DOI: 10.1039/C4OB02233E, PaperV. M. Tkachuk, V. A. Sukach, K. V. Kovalchuk, M. V. Vovk, V. G. Nenajdenko
A simple control of temperature and time in the nitromethane addition to 4-trifluoromethylated pyrimidin-2-ones allowed regioselective synthesis of isomeric products.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and biological evaluation of novel pyrano[3,2-c]carbazole derivatives as anti-tumor agents inducing apoptosis via tubulin polymerization inhibition

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1404-1414
DOI: 10.1039/C4OB02015D, PaperPannala Padmaja, Garikapati Koteswara Rao, Adisherla Indrasena, Basireddy V. Subba Reddy, Nibedita Patel, Anver Basha Shaik, Narayana Reddy, Pramod K. Dubey, Manika Pal Bhadra
A series of novel pyrano[3,2-c]carbazole derivatives have been synthesized and antiproliferative activity of the derivatives were investigated on various cancer cell lines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Improved synthesis of the super antioxidant, ergothioneine, and its biosynthetic pathway intermediates

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1415-1419
DOI: 10.1039/C4OB02023E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Peguy Lutete Khonde, Anwar Jardine
Ergothioneine and mycothiol are low molecular mass redox protective thiols present in actinomycetes, in particular mycobacteria.
The content of this RSS Feed (c) The Royal Society of Chemistry

Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1395-1403
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony C. Bishop, Artur Krezel
A library of biarsenical probes was developed, characterized and used to probe structure-activity relationships for inhibition of sensitized protein tyrosine phosphatases (PTPs), revealing the superior inhibitory properties of 2[prime or minute],7[prime or minute]-substituted biarsenicals.
The content of this RSS Feed (c) The Royal Society of Chemistry

Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1367-1374
DOI: 10.1039/C4OB02383H, PaperDikhi Firmansyah, Marzena Banasiewicz, Daniel T. Gryko
The intramolecular dehydrogenative coupling mediated by potassium constitutes the general methodology leading to weakly emitting [small pi]-expanded heterocycles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of the Passerini and Ugi reactions in [small beta]-lactam aldehydes. Synthetic applications

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1387-1394
DOI: 10.1039/C4OB02289K, PaperBenito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, M. Pilar Ruiz, M. Rosario Torres
Ugi and Passerini multicomponent reactions on 4-oxoazetidine-2-carboxaldehydes allow the straightforward synthesis of highly functionalized [small beta]-lactams.
The content of this RSS Feed (c) The Royal Society of Chemistry

Efficient synthesis of [small alpha]- and [small delta]-carbolines by sequential Pd-catalyzed site-selective C-C and twofold C-N coupling reactions

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1375-1386
DOI: 10.1039/C4OB02226B, PaperTran Quang Hung, Tuan Thanh Dang, Julia Janke, Alexander Villinger, Peter Langer
Two concise and efficient approaches were developed for the synthesis of [small alpha]- and [small delta]-carboline derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry

Gd(OTf)3-catalyzed synthesis of geranyl esters for the intramolecular radical cyclization of their epoxides mediated by titanocene(III)

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1358-1366
DOI: 10.1039/C4OB02312A, PaperWilliam H. Garcia Santos, Carlos E. Puerto Galvis, Vladimir V. Kouznetsov
The catalytic activity of Gd(OTf)3 for the direct esterification of geraniol and the regio- and stereo-controlled radical cyclization of their epoxides mediated by titanocene(III) is described.
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A case of oxoanion recognition based on combined cationic and neutral C-H hydrogen bond interactions

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1339-1346
DOI: 10.1039/C4OB02288B, PaperFabiola Zapata, Paula Sabater, Antonio Caballero, Pedro Molina
A bidentate bis-(benzimidazolium) receptor containing pyrene as fluorescent signaling units recognizes sulphate and hydrogenpyrophosphate in a competitive water-DMSO medium through combinations of cationic and neutral C-H hydrogen bonding.
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Copper(I)-promoted cycloalkylation-peroxidation of unactivated alkenes via sp3 C-H functionalisation

Org. and Biomol. Chem. - 14 hours 41 min ago

Org. Biomol. Chem., 2015, 13,1307-1312
DOI: 10.1039/C4OB01962H, CommunicationArghya Banerjee, Sourav Kumar Santra, Aniket Mishra, Nilufa Khatun, Bhisma K. Patel
A copper-promoted cycloalkylation-peroxidation strategy has been developed via a three-component reaction involving cycloalkanes, tert-butyl hydroperoxide and internal conjugated alkene.
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