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Correction: Identification and optimization of short helical peptides with novel reactive functionality as catalysts for acyl transfer by reactive tagging

Org. and Biomol. Chem. - 1 September, 2014 - 21:17
Org. Biomol. Chem., 2014, 12,7410-7410
DOI: 10.1039/C4OB90119C, CorrectionSilvia Bezer, Masaomi Matsumoto, Michael W. Lodewyk, Stephen J. Lee, Dean J. Tantillo, Michel R. Gagne, Marcey L. Waters
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Iron-catalyzed direct difunctionalization of alkenes with dioxygen and sulfinic acids: a highly efficient and green approach to [small beta]-ketosulfones

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01369G, CommunicationWei Wei, Jiangwei Wen, Daoshan Yang, Min Wu, Jinmao You, Hua Wang
A novel and efficient iron-catalyzed direct difunctionalization of alkenes with sulfinic acids and dioxygen for the synthesis of [small beta]-ketosulfones has been developed.
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Enantioselective copper catalysed C-H insertion reaction of 2-sulfonyl-2-diazoacetamides to form [gamma]-lactams

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01430H, PaperLeslie Ann Clarke, Aoife Ring, Alan Ford, Abhijeet S. Sinha, Simon E. Lawrence, Anita R. Maguire
The first enantioselective copper catalysed intramolecular C-H insertion reactions of 2-sulfonyl-2-diazoacetamides is reported.
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Nitroxide-labeled pyrimidines for non-covalent spin-labeling of abasic sites in DNA and RNA duplexes

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7366-7374
DOI: 10.1039/C4OB01095G, PaperSandip A. Shelke, Gunnar B. Sandholt, Snorri Th. Sigurdsson
Of ten new pyrimidine-derived nitroxide spin labels, an N1-ethylamino triazole-linked uracil derivative binds fully to both DNA and RNA duplexes containing an abasic site, as determined by CW-EPR.
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Total synthesis and biological evaluation of atrop-O-benzyl-desmethylabyssomicin C

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01436G, CommunicationR. Matovic, F. Bihelovic, M. Gruden-Pavlovic, R. N. Saicic
The desmethyl analogue of abyssomicin C was synthesized. The synthetic analogue retained its antibacterial activity, whereas its cytotoxicity decreased for three orders of magnitude, as compared to the natural product.
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Synthesis and evaluation of a photoresponsive quencher for fluorescent hybridization probes

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01185F, PaperMarina Kovaliov, Chaim Wachtel, Eylon Yavin, Bilha Fischer
dUDAB modified probes are promising probes for gene quantification in real-time PCR detection and as photoswitchable devices.
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Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-nucleotidases

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01332H, PaperOndrej Simak, Petr Pachl, Milan Fabry, Milos Budesinsky, Tomas Jandusik, Ales Hnizda, Radka Sklenickova, Magdalena Petrova, Vaclav Veverka, Pavlina Rezacova, Jiri Brynda, Ivan Rosenberg
Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-deoxynucleotidases.
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Multiple optical properties of a naphthoquinone pigment: 2-methyl-3-(hydroxyphenylthio)-1,4-naphthalenedione

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01058B, PaperHirotaka Akiyama, Takafumi Inoue, Nobuo Tajima, Reiko Kuroda, Yoshitane Imai
Naphthoquinone pigments 2-methyl-3-(4- or 2-hydroxyphenylthio)-1,4-naphthalenedione show characteristic multiple optical properties in solution and in the solid state.
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Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2[prime or minute]-alkylated RNA monomers

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01183J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Saswata Karmakar, Andreas S. Madsen, Dale C. Guenther, Bradley C. Gibbons, Patrick J. Hrdlicka
Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA with single nucleotide fidelity.
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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00860J, CommunicationBin He, Jing Hu, Xiaoyu Zhang, Hening Lin
Potent mechanism-based Sirt6 inhibitors.
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Generalized access to fluorinated [small beta]-keto amino compounds through asymmetric additions of [small alpha],[small alpha]-difluoroenolates to CF3-sulfinylimine

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01575D, PaperChen Xie, Lingmin Wu, Haibo Mei, Vadim A. Soloshonok, Jianlin Han, Yi Pan
Asymmetric reactions between CF3-containing N-imines and [small alpha],[small alpha]-difluoroenolates giving [small beta]-keto-amino compounds featuring the R-CO-CF2-CH(NH2)-CF3 moiety with high yields and diastereoselectivities were developed.
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AcOH-mediated dichloroimination of indoles using chloramine-B: a facile access to 2,3-functionalized indolines

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01179A, CommunicationXiaozu Liu, Qinghong Hu, Zeli Yuan, Peijun Liu
A mild method for the efficient synthesis of 3,3-dichloro-2-sulfonyliminoindolines via AcOH-mediated dichloroimination of indoles using chloramine-B is described.
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Palladium-catalyzed ortho-acylation of 2-benzyl-1,2,3-triazoles with aldehydes

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01406E, CommunicationQingshan Tian, Ping He, Chunxiang Kuang
A palladium-catalyzed ortho-acylation of 2-benzyl-1,2,3-triazoles with aldehydes as an acyl source was developed. A wide variety of ketones containing 1,2,3-triazoles were obtained in good to excellent yields. This methodology provides a convenient access to the acylation of 2-substituted-1,2,3-triazoles.
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Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01417K, PaperJordan Froese, Jason Reed Hudlicky, Tomas Hudlicky
Compounds of high synthetic value were produced in a much more efficient manner than was previously possible through fermentation.
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Catalytic amide allylation of [small alpha]-ketoesters: extremely high enantioselective synthesis of ester functionalised [small alpha]-methylene-[gamma]-butyrolactones

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01508H, CommunicationMasaki Takahashi, Yusuke Murata, Masahiro Ishida, Fumitoshi Yagishita, Masami Sakamoto, Tetsuya Sengoku, Hidemi Yoda
A significant breakthrough on the novel amide allylation on the acyclic [small alpha]-ketoester systems, achieving extremely high enantioselective synthesis of ester functionalised [small alpha]-methylene-[gamma]-butyrolactones, is reported.
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Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7197-7200
DOI: 10.1039/C4OB01156B, CommunicationMichael A. Bertucci, Stephen J. Lee, Michel R. Gagne
Hydrazine derivatives are employed for selective amide cleavage of 3-oxo-N-acyl homoserine lactones under physiologically relevant conditions.
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Oxidative cleavage of benzylic C-N bonds under metal-free conditions

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01633E, CommunicationJin-Long Gong, Xinxin Qi, Duo Wei, Jian-Bo Feng, Xiao-Feng Wu
An interesting and practical metal-free strategy has been developed for the synthesis of aromatic aldehydes using various N,N-dimethylbenzylamines as starting materials.
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A computational study of the activation of allenoates by Lewis bases and the reactivity of intermediate adducts

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7297-7309
DOI: 10.1039/C4OB01177E, PaperGou-Tao Huang, Timm Lankau, Chin-Hui Yu
Several chemical properties of Lewis base-allenoate adducts (LB[middle dot]allenoate), such as solvent effect, basicity, nucleophilicity and cycloaddition, are studied to provide a detailed foundation for the analysis of LB-catalyzed reactions of allenoates.
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MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7136-7139
DOI: 10.1039/C4OB01056F, PaperMengping Guo, Liang Qi, Qiaochu Zhang, Zhiyong Zhu, Wei Li, Xiaogang Li
N-Methyliminodiacetic acid (MIDA) as a simple, air stable and water-soluble ligand shows high catalytic activity in Hiyama reaction.
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Efficient cobalt-catalyzed C-N cross-coupling reaction between benzamide and aryl iodide in water

Org. and Biomol. Chem. - 1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01483A, CommunicationBryan Yong-Hao Tan, Yong-Chua Teo
A practical and efficient strategy for the N-arylation of benzamide catalysed by a Co(C2O4)[middle dot]2H2O/dmeda system in water is reported. Under the optimized conditions, a wide variety of N-arylated products were obtained in good yields (up to 92%) using substituted aryl iodides.
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