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Inhibition of HL-60 cell growth via cell cycle arrest and apoptosis induction by a cycloartane-labdane heterodimer from Pseudolarix amabilis

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02661J, PaperXinhui Tian, Niao Yang, Bo Li, Jianping Zhang, Xike Xu, Rongcai Yue, Huiliang Li, Liping Chen, Yunheng Shen, Weidong Zhang
A cycloartane-labdane heterodimer pseudolaridimer C (1) was isolated from Pseudolarix amabilis. It exerted a cytotoxicity effect on HL-60 cells by arresting the cell cycle in the G2/M phase and inducing caspase-dependent apoptosis.
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QM/MM study on the enantioselectivity of spiroacetalization catalysed by an imidodiphosphoric acid catalyst: how confinement works

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00045B, PaperLuis Simon, Robert S. Paton
An explanation of why confined imidodiphosphoric acid catalyst succeeds where other chiral phosphoric acid catalysts fail.
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A bio-inspired synthetic route to the core ring systems of Spiraea atisine-type diterpenoid alkaloids and related diterpenes

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00053C, PaperDai-Hui Tang, Ding Ma, Hang Cheng, Yong-Li Li, Liang Xu
A bio-inspired synthetic strategy for the construction of the complex substructures of biologically active atisine-type diterpenoid alkaloids and related diterpenes was successfully developed.
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Synthesis of N-heterocyclic carbene-PdCl2-(iso)quinoline complexes and their application in arylamination at low catalyst loadings

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00013D, PaperFeng Liu, Yi-Ran Zhu, Lu-Gan Song, Jian-Mei Lu
N-Heterocyclic carbene-PdCl2-(iso)quinoline complexes were synthesized and they showed efficient catalytic activity in the C-N coupling of aryl chlorides.
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The effects of an ionic liquid on unimolecular substitution processes: the importance of the extent of transition state solvation

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02598B, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sinead T. Keaveney, Benjamin P. White, Ronald S. Haines, Jason B. Harper
An ionic liquid significantly increases benzylic carbocation formation due to favourable ionic liquid-transition state interactions. The magnitude of transition state solvation was shown to be critical, explaining the difference between this and previous cases.
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Recognition of silver cations by a cucurbit[8]uril-induced supramolecular crown ether

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02590G, PaperQing-Xia Geng, Fang Wang, Hang Cong, Zhu Tao, Gang Wei
A supramolecular crown formed with the cucurbit[8]uril-induced intramolecular charge-transfer interaction is able to recognize silver cations.
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Ru-catalyzed asymmetric hydrogenation of [small delta]-keto Weinreb amides: enantioselective synthesis of (+)-Centrolobine

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02622A, PaperMengmeng Zhao, Bin Lu, Guangni Ding, Kai Ren, Xiaomin Xie, Zhaoguo Zhang
An efficient asymmetric hydrogenation of [small delta]-keto Weinreb amides catalyzed by a Ru-Xyl-SunPhos-Daipen bifunctional catalyst has been achieved.
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Rational optimization of amber suppressor tRNAs toward efficient incorporation of a non-natural amino acid into protein in a eukaryotic wheat germ extract

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02533H, PaperAtsushi Ogawa, Yuki Namba, Mai Gakumasawa
Amber suppressor tRNAs (sup-tRNAs) were rationally optimized toward efficient incorporation of a non-natural amino acid (AcPhe) into protein in a eukaryotic wheat germ extract.
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Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02477C, PaperDuygu Ayd[i without dot]n Tekdas, Geetha Viswanathan, Sevinc Zehra Topal, Chung Yeng Looi, Won Fen Wong, Grace Min Yi Tan, Yunus Zorlu, Ayse Gul Gurek, Hong Boon Lee, Fabienne Dumoulin
A novel quaternized BODIPY derivative showed potent antimicrobial activity against Staphylococcus strains.
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Radical-mediated dehydrogenation of bile acids by means of hydrogen atom transfer to triplet carbonyls

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02561C, PaperP. Miro, M. L. Marin, M. A. Miranda
The aim of the present paper is to explore the potential of radical-mediated dehydrogenation of bile salts (BSs), which is reminiscent of the enzymatic action of hydroxysteroid dehydrogenase enzymes (HSDH).
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Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C6OB00031B, CommunicationP. Shaul, R. I. Benhamou, I. M. Herzog, S. Louzoun Zada, Y. Ebenstein, M. Fridman
Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi.
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Multivalency in the recognition and antagonism of a HIV TAR RNA-TAT assembly using an aminoglycoside benzimidazole scaffold

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,2052-2056
DOI: 10.1039/C5OB02016F, PaperSunil Kumar, Nihar Ranjan, Patrick Kellish, Changjun Gong, Derrick Watkins, Dev P. Arya
Recognition of RNA by high-affinity binding small molecules is crucial for expanding existing approaches in RNA recognition, and for the development of novel RNA binding drugs.
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Catalyst and solvent-free alkylation of quinoline N-oxides with olefins: A direct access to quinoline-substituted [small alpha]-hydroxy carboxylic derivatives

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB02600H, CommunicationRakesh Kumar, Inder Kumar, Ritika Sharma, Upendra Sharma
A catalyst/solvent-free, one-pot and operationally simple method for the synthesis of quinoline-substituted [small alpha]-hydroxy carboxylic derivatives by the hydroxyheteroarylation of olefins with quinoline N-oxides is reported.
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Synthesis and evaluation of a desymmetrised synthetic lectin: an approach to carbohydrate receptors with improved versatility

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,1930-1933
DOI: 10.1039/C6OB00023A, CommunicationTiddo J. Mooibroek, Matthew P. Crump, Anthony P. Davis
A new design for carbohydrate receptors features unmatched apolar surfaces, and could lead to selectivities for a broader range of substrates.
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Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,2034-2040
DOI: 10.1039/C5OB02576A, PaperRobert D. Giacometti, Juan C. Salinas, Michael E. Ostergaard, Eric E. Swayze, Punit P. Seth, Stephen Hanessian
The design, synthesis and biophysical evaluation of two highly-constrained tricyclic analogues of locked nucleic acid (LNA), which restrict rotation around torsion angle [gamma] are reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,2121-2126
DOI: 10.1039/C5OB02459E, PaperHolisoa Rajerison, Djibril Faye, Aurelia Roumesy, Nicolas Louaisil, Fabien Boeda, Alain Faivre-Chauvet, Jean-Francois Gestin, Stephanie Legoupy
Efficiency of ionic liquid supported organotin reagents in halodemetalation reaction has been investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry

Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-L-fucose biosynthetic enzymes

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,1988-2006
DOI: 10.1039/C5OB02292D, PaperHsien-Tai Chiu, Chien-Pao Weng, Yu-Chin Lin, Kuan-Hung Chen
From Nocardia was cloned and functionally characterized a giant gene cluster for biosyntheses of brasilinolides as potent immunosuppressive and anticancer agents.
The content of this RSS Feed (c) The Royal Society of Chemistry

A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,2127-2133
DOI: 10.1039/C5OB02558C, PaperA. Ikeda, M. Omote, K. Kusumoto, M. Komori, A. Tarui, K. Sato, A. Ando
A dramatic enhancing effect of InBr3 was observed towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane.
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Quantitative chirality sensing of amines and amino alcohols via Schiff base formation with a stereodynamic UV/CD probe

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,1934-1939
DOI: 10.1039/C5OB02529J, CommunicationZeus A. De los Santos, Ransheng Ding, Christian Wolf
A readily available probe is used for quantitative sensing of the concentration and ee of chiral amines and amino alcohols.
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Development of a stable phosphoarginine analog for producing phosphoarginine antibodies

Org. and Biomol. Chem. - 7 February, 2016 - 03:17

Org. Biomol. Chem., 2016, 14,1925-1929
DOI: 10.1039/C5OB02603B, CommunicationHan Ouyang, Chuan Fu, Songsen Fu, Zhe Ji, Ying Sun, Peiran Deng, Yufen Zhao
pAIE is designed and synthesized as a stable analog and bioisostere of acid-labile pArg, to produce pArg specific antibodies, facilitating the detection of protein arginine phosphorylation.
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