Feed aggregator

Combining an Hsp70 inhibitor with either an N- or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00147A, PaperYao Wang, Shelli Renee McAlpine
Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones' cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90's...
The content of this RSS Feed (c) The Royal Society of Chemistry

A modular synthesis of functionalised phenols enabled by controlled boron speciation

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00078E, PaperJohn J. Molloy, Robert P. Law, James W. B. Fyfe, Ciaran P. Seath, David J. Hirst, Allan J. B. Watson
Functionalised biaryl phenols can be rapidly accessed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation, and oxidation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Physicochemical studies on the copper(II) binding by glycated collagen telopeptides

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02536A, PaperMeder Kamalov, Paul W. R. Harris, Christian G. Hartinger, Gordon M. Miskelly, Garth J. S. Cooper, Margaret A. Brimble
The strong interaction between advanced glycation end-products and Cu(II) ions has been revealed using site-specifically glycated collagenous peptides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02574A, PaperZheng-Le Zhao, Qing-Long Xu, Qing Gu, Xin-Yan Wu, Shu-Li You
Pd-catalyzed asymmetric intramolecular allylic alkylation reaction of phenols was developed, affording C4 substituted tetrahydroisoquinolines in moderate to excellent yields, enantioselectivity and regioselectivity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Acid-promoted direct electrophilic trifluoromethylthiolation of phenols

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02633K, PaperMarjan Jereb, Kaja Gosak
A highly selective and effective, acid-promoted, electrophilic trifluoromethylthiolation of phenols is described.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02438A, PaperKuruppanthara N. Vijayadas, Amol S. Kotmale, Shridhar H. Thorat, Rajesh G. Gonnade, Roshna V. Nair, Pattuparambil R. Rajamohanan, Gangadhar J. Sanjayan
This manuscript depicts an intriguing example of H-bonding reversal upon introduction of a sulfonamide linkage at the N-terminus of a synthetic reverse-turn peptide.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Recognition of bio-relevant dicarboxylate anions by an azacalix[2]arene[2]triazine derivative decorated with urea moieties

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02283A, PaperMiguel M. Santos, Igor Marques, Silvia Carvalho, Cristina Moiteiro, Vitor Felix
The binding affinity of a dichlorocalix[2]arene[2]triazine based bis-urea azamacrocycle was investigated towards a wide range of bio-relevant dicarboxylate anions by a combination of 1H NMR titrations in CDCl3 and molecular dynamics simulations.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Construction of the tricyclic core of steenkrotin-type diterpenoids via intramolecular [3 + 2] cycloaddition

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1643-1646
DOI: 10.1039/C4OB02439G, CommunicationJun Xuan, Saiyong Pan, Yuanbao Zhang, Bin Ye, Hanfeng Ding
A concise and diastereoselective route to the [5-6-7] tricyclic skeleton of steenkrotins was developed based on an intramolecular [3 + 2] cycloaddition.
The content of this RSS Feed (c) The Royal Society of Chemistry

Bacterial patterning controlled by light exposure

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1639-1642
DOI: 10.1039/C4OB02483D, CommunicationWillem A. Velema, Jan Pieter van der Berg, Wiktor Szymanski, Arnold J. M. Driessen, Ben L. Feringa
Patterning of multiple bacterial strains in one system is achieved by employing a single photo-activated antibiotic.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Phosphonyl/phosphinyl imines and group-assisted purification (GAP) chemistry/technology

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1600-1617
DOI: 10.1039/C4OB02254H, Review ArticleGuanghui An, Cole Seifert, Guigen Li
Group-assisted purification (GAP) chemistry, which can provide various chiral amines and other functionalities without the use of column chromatography or recrystallization; products are consistently obtained with excellent stereocontrol.
The content of this RSS Feed (c) The Royal Society of Chemistry

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1634-1638
DOI: 10.1039/C4OB02128B, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marielle M. E. Delville, Kaspar Koch, Jan C. M. van Hest, Floris P. J. T. Rutjes
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studies on the diastereoselective oxidation of 1-thio-[small beta]-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1904-1914
DOI: 10.1039/C4OB02030H, PaperJuan Francisco Moya-Lopez, Eleonora Elhalem, Rocio Recio, Eleuterio Alvarez, Inmaculada Fernandez, Noureddine Khiar
The exo-anomeric effect paves the way for the synthesis of the usually less favored RS-[small beta]-sulfinyl glycoside as a single diastereoisomer.
The content of this RSS Feed (c) The Royal Society of Chemistry

Differentiation of small alkane and alkyl halide constitutional isomers via encapsulation

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1869-1877
DOI: 10.1039/C4OB02357A, PaperMatthew R. Sullivan, Bruce C. Gibb
Previously we have demonstrated that host 1 is capable of hydrocarbon gas separation by selective sequestration of butane from a mixture with propane in the headspace above a solution of the host (C. L. D. Gibb, B. C. Gibb, J. Am. Chem. Soc., 2006, 128, 16498-16499).
The content of this RSS Feed (c) The Royal Society of Chemistry

E. coli cells expressing the Baeyer-Villiger monooxygenase 'MO14' (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1897-1903
DOI: 10.1039/C4OB01441C, PaperBenjamin D. Summers, Muhiadin Omar, Thomas O. Ronson, Jared Cartwright, Michael Lloyd, Gideon Grogan
(1S,5R)-2-Oxalactone of >99% ee and (1S,5R)-ketone of 96% ee are produced after approximately 14 h at a temperature of 16 [degree]C.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1878-1896
DOI: 10.1039/C4OB02348J, PaperRobert Wodtke, Gloria Ruiz-Gomez, Manuela Kuchar, M. Teresa Pisabarro, Pavlina Novotna, Marie Urbanova, Jorg Steinbach, Jens Pietzsch, Reik Loser
The conformational stabilisation of the DEKS motif at the [small alpha]1(I) collagen N-telopeptide within a cyclic hexapeptide together with its conformational analysis is described. This sequence is critical for lysyl oxidase-mediated collagen crosslinking, a process which is deregulated during tumour progression.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fixation of sulfur dioxide into small molecules

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1592-1599
DOI: 10.1039/C4OB02139H, Review ArticleGang Liu, Congbin Fan, Jie Wu
Recent advances in the insertion of sulfur dioxide under transition metal catalysis or metal-free conditions via a radical process are presented.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-heterocyclic carbene-catalyzed [4 + 2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: efficient assembly of spirocarbocyclic oxindole

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1829-1835
DOI: 10.1039/C4OB01706D, PaperYuanwei Xie, Yonglei Que, Tuanjie Li, Ling Zhu, Chenxia Yu, Changsheng Yao
A NHC-catalyzed [4 + 2] cyclization of 2-bromo-2-enal bearing [gamma]-H with 3-alkylenyloxindoles under mild reaction conditions gives spirocarbocyclic oxindoles containing one quaternary carbon with high diastereoselectivies.
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1860-1868
DOI: 10.1039/C4OB02321H, PaperOscar Francesconi, Matteo Gentili, Francesco Bartoli, Andrea Bencini, Luca Conti, Claudia Giorgi, Stefano Roelens
Excellent affinities and selectivities toward triphosphates are achieved through an adaptive ditopic receptor featuring a metal ion and a macrocyclic polyammonium cation binding sites, concertedly bridging phosphate anions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Amphiphilic benzothiadiazole-triphenylamine-based aggregates that emit red light in water

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1818-1828
DOI: 10.1039/C4OB02181A, PaperTsutomu Ishi-i, Ikumi Kitahara, Shimpei Yamada, Yusuke Sanada, Kazuo Sakurai, Asami Tanaka, Naoya Hasebe, Toshitada Yoshihara, Seiji Tobita
An amphiphilic donor-acceptor dye can provide red light emission in water in an aggregate state.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studies towards the synthesis of bielschowskysin. Construction of the highly functionalized bicyclo[3.2.0]heptane segment

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,1846-1859
DOI: 10.1039/C4OB02182G, PaperAnupam Jana, Sujit Mondal, Subrata Ghosh
A stereocontrolled approach for the construction of a highly functionalized bicyclo[3.2.0]heptane derivative embodying the bridged lactone present in the diterpene bielschowskysin is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.