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Iodine-catalyzed regioselective thiolation of imidazo[1,2-a]pyridines using sulfonyl hydrazides as a thiol surrogate

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00033E, PaperAlakananda Hajra, Avik Kumar Bagdi, Shubhanjan Mitra, Monoranjan Ghosh
Iodine-catalyzed regioselective sulfenylation of imidazo[1,2-a]pyridines via C(sp2)-H bond functionalization has been achieved using sulfonyl hydrazides as a thiol surrogate. A library of 3-sulfanylimidazopyridines with broad functionalities was synthesized under metal...
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Tuning of colour and chemical stability of model boranils: a strong effect of structural modifications

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02545H, PaperGrzegorz Jan Wesela-Bauman, Mateusz Urban, Sergiusz Lulinski, Janusz Serwatowski, Krzysztof Wozniak
A series of diarylborinic complexes with salicydeneaniline ligands bearing various functional groups at the 6-position, have been synthesized with high yields by applying a straightforward one-pot multicomponent protocol. UV-Vis measurements...
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Convergent synthesis of isomeric heterosaccharides related to the fragments of galactomannan from Aspergillus fumigatus

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02634A, PaperDmitry A. Argunov, Vadim B. Krylov, Nikolay E. Nifantiev
Aspergillus fumigatus is a very common fungus with severe pathogenic potential for immunosuppressed hospital patients. A. fumigatus galactomannan, being the part of its cell-wall, is considered as a promising candidate...
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Metal-Free TBAI-Catalyzed Arylsulfonylation of Activated Alkenes with Sulfonylhydrazides

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB01651C, PaperWu bin Yu, Peizhu Hu, Yuanyuan Fan, Congyao yu, Xinhan Yan, Xiaoqing Li, Xiangsheng xu
Efficient metal-free oxidative arylsulfonylation of [small alpha],[small beta]-unsaturated imides with sulfonylhydrazides leading to isoquinoline-1,3(2H,4H)-dione derivatives has been developed. The procedure involves the generation of sulfonyl radicals via cleavage of S-N bond of...
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Synthesis and DNA binding profile of N-mono- and N,N'-disubstituted indolo[3,2-b]carbazoles

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02566K, CommunicationThomas Minehan, Harmanpreet Panesar, Jennifer Solano
A series of N-monosubstituted and N,N'-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It...
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Correction: Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90015H, CorrectionRui Wang, Anyu He, Errabelli Ramu, John R. Falck
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Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02549K, PaperR. Hudson, N. P. Bizier, K. N. Esdale, J. L. Katz
The synthesis of 2-substituted indoles and benzofurans was achieved by nucleophilic aromatic substitution, followed by subsequent 5-endo-dig cyclization between the nucleophile and an ortho acetylene.
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Synthesis of novel azole-fused quinazolines via one-pot, sequential Ullmann-type coupling and intramolecular dehydrogenative C-N bonding

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02375G, PaperNitesh Kumar Nandwana, Kasiviswanadharaju Pericherla, Pinku Kaswan, Anil Kumar
An efficient one-pot sequential procedure is described for the synthesis of novel azole-fused quinazolines through Ullmann-type coupling followed by cross dehydrogenative coupling of various azoles with 2-(2-bromophenyl)-1H-imidazole/benzimidazoles.
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Cooperative effect of Lewis pair in Friedel-Crafts hydroxyalkylation reaction: A simple and effective route for the synthesis of (+/-)-carbinoxamine

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02597K, PaperRAMANATHAN C R, Hari Krishnan A, Sanjeevi J
An efficient C-C bond formation strategy between aromatic/heteroaromatic [small pi]-nucleophiles and Lewis acid activated aldehydes is described. This aromatic electrophilic substitution reaction of arenes or heteroarenes is facilitated by Lewis acid...
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Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02424A, PaperXin-Shan Ye, Chang-Xin Huo, Xiu-Jing Zheng, An Xiao, Chang-Cheng Liu, Shuang Sun, Zhuo Lv
It is well known that tumor cells express some aberrant glycans, termed tumor-associated carbohydrate antigens (TACAs). TACAs are good targets for the development of carbohydrate-based anticancer vaccines. However, one of...
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The first study about the relationship between the extractability of thiacalix[4]arene derivatives and the position of the coordination binding sites

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02393E, PaperJiang-Lin Zhao, Hirotsugu Tomiyasu, Xin-Long Ni, xi zeng, Mark Robert James Elsegood, Carl Redshaw, Shofiur Rahman, Paris Elias Georghiou, Takehiko Yamato
Three organic ionophores (2 - 4) based on the p-tert-butylthiacalix[4]arene backbone, blocked in the 1,3-alternate conformation, bearing two pyridyl coordinating moieties (ortho for 2, meta for 3 and para for...
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Alkynylation of heterocyclic compounds using hypervalent iodine reagent

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02625J, CommunicationMartin Kamlar, Ivana Cisarova, Jan Vesely
Organocatalytic alkynylation of various nitrogen- and/or sulphur-containing heterocyclic comounds using hypervalent iodine TMS-EBX by catalysis of tertiary amines under mild conditions is described. Developed metal-free methodology enables to obtain corresponding...
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A modular synthesis of functionalised phenols enabled by controlled boron speciation

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00078E, PaperAllan John Bell Watson, John J Molloy, Robert P Law, James WB Fyfe, Ciaran P Seath, David J Hirst
A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic...
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A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02543A, CommunicationGary Noonan, Andrew G. Leach
Boronic acids that undergo protodeboronation as solids are stable in solution: the solid state organizes them for reaction.
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Design and Synthesis of a Multivalent Fluorescent Folate‒Calix[4]arene Conjugate: Cancer Cell Penetration and Intracellular Localization

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02333A, PaperGRAZIA MARIA LETIZIA CONSOLI, Giuseppe Granata, Giorgia Fragassi, Mauro Grossi, Michele Sallese, Corrada Geraci
A novel fluorescently labeled folate conjugate in which four folic acid units are covalently conjugated with a 7-nitro-benzofurazan fluorophore by means of a calix[4]arene platform was synthesized by using a...
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Bistren cryptands and cryptates: versatile receptors for anion inclusion and recognition in water

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02618G, Review ArticleL Fabbrizzi, Valeria Amendola, Greta Bergamaschi, Giuseppe Alibrandi, Maurizio Licchelli
Bistren cryptands can be easily synthesised through Schiff base condensation of two molecules of tren and three molecules of a dialdehyde, followed by hydrogenation of the six C=N double bonds...
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BF3-Et2O mediated skeletal rearrangements of norbornyl appended cyclopentanediols

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02423K, PaperChintada Nageswara Rao, Faiz Ahmed Khan
Synthetically useful norbornyl appended cyclopentenones and pinacolone products are reported during the BF3-Et2O mediated skeletal rearrangement of norbornyl appended cyclopentanediols.
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Synthesis of new generation triazolyl and isoxazolyl containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: In vitro, Structure-activity relationship, pharmacokinetics and in vivo evaluation

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00054H, PaperGurunadham Munagala, Kushalava Reddy Yempalla, Samsher Singh, Sumit Sharma, Nitin Pal Kalia, Vikrant Singh Rajput, sunil Kumar, Sanghapal D Sawant, Inshad A Khan, Ram A Vishwakarma, Parvinder Pal Singh
Nitroimidazole scaffold developed a great interest in the last decade which ultimately led to the discovery of successful drug Delamanid for multi-drug resistant tuberculosis (MDR-TB). Here, we report medicinal chemistry...
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Physicochemical Studies on the Copper(II) Binding by Glycated Collagen Telopeptides

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02536A, PaperMargaret A Brimble, Paul Harris, Garth Cooper, Christian Hartinger, Gordon M Miskelly, Meder Kamalov
Emerging evidence indicates that levels of advanced glycation end-products (AGEs) correlate with age- and diabetes-related organ damage and may play a causative role in such damage. Increased chelation of Cu(II)...
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Selective Oxidation of the C[small alpha]-C[small beta] Linkage in Lignin Model Compounds by Baeyer-Villiger Oxidation

Org. and Biomol. Chem. - 25 January, 2015 - 07:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB01771D, PaperNIKHIL DILIP PATIL, Soledad G. Yao, Mark Stephan Meier, Justin K Mobley, Mark Crocker
Lignin is an amorphous aromatic polymer derived from plants and is a potential source of fuels and bulk chemicals. Herein, we present a survey of reagents for selective stepwise oxidation...
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