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Fermi Resonance Effects in the Vibrational Spectroscopy of Methyl and Methoxy Groups

J. Phys. Chem. A - 17 November, 2014 - 16:04

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The Journal of Physical Chemistry ADOI: 10.1021/jp510142g

Protecting-Group-Free Total Synthesis of Aplykurodinone-1

J. Org. Chem. - 17 November, 2014 - 15:53

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The Journal of Organic ChemistryDOI: 10.1021/jo501684k

Intramolecularly C,N-Coordinated Homo- and Heteroleptic Organostannylenes

Organometallics - 17 November, 2014 - 15:24

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OrganometallicsDOI: 10.1021/om500698k

Enveloping Self-Assembly of Carbon Nanotubes at Copolymer Micelle Cores

Langmuir - 17 November, 2014 - 15:23

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LangmuirDOI: 10.1021/la502298j

Post-synthesis DNA Modifications Using a trans-Cyclooctene Click Handle

Org. and Biomol. Chem. - 17 November, 2014 - 15:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02031F, PaperKe Wang, Danzhu Wang, Kaili Ji, Weixuan Chen, Yueqin Zheng, Chaofeng Dai, Binghe Wang
Post-synthesis DNA modification is a very useful method for DNA functionalization. This is achieved by using a modified NTP, which has a handle for further modifications, replacing the corresponding natural...
The content of this RSS Feed (c) The Royal Society of Chemistry

Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1)

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9665-9673
DOI: 10.1039/C4OB01591F, PaperYiqian Xie, Ran Zhou, Fulin Lian, Yan Liu, Limin Chen, Zhe Shi, Naixia Zhang, Mingyue Zheng, Bairong Shen, Hualiang Jiang, Zhongjie Liang, Cheng Luo
Two novel inhibitors against PRMT1 were identified through virtual screening and biochemical assays. Their binding with PRMT1 was validated and they also displayed an anti-proliferation effect in three cancer cell lines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalysed intramolecular O-arylation: a simple and efficient method for benzoxazole synthesis

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9696-9701
DOI: 10.1039/C4OB02068E, PaperFengtian Wu, Jie Zhang, Qianbing Wei, Ping Liu, Jianwei Xie, Haojie Jiang, Bin Dai
An efficient protocol has been developed for the copper-catalysed intramolecular cyclization of N-(2-iodo-/bromo-/chloro-phenyl)benzamides for the synthesis of 2-substituted benzoxazoles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9707-9715
DOI: 10.1039/C4OB02021A, PaperJens Langhanki, Kristina Rudolph, Gerhard Erkel, Till Opatz
The sesquiterpene (-)-cyclonerodiol is a specific inhibitor of IL-4 induced STAT6 signaling and is readily available from (-)-linalool.
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Aryl-palladium-NHC complex: efficient phosphine-free catalyst precursors for the carbonylation of aryl iodides with amines or alkynes

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9702-9706
DOI: 10.1039/C4OB01878H, PaperChunyan Zhang, Jianhua Liu, Chungu Xia
A series of aryl-palladium-NHC compounds was prepared according to the reported methods and their catalytic activity in the carbonylation of aryl iodides to synthesize [small alpha]-keto amides and alkynones was examined.
The content of this RSS Feed (c) The Royal Society of Chemistry

An efficient reagent for covalent introduction of alkynes into proteins

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9528-9531
DOI: 10.1039/C4OB01873G, CommunicationJie Zhang, Dejun Ma, Dawei Du, Zhen Xi, Long Yi
This work reports an efficient reagent for covalent introduction of alkynes into the surface of proteins and viruses under mild conditions.
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Silver(I)-catalyzed annulation for the regioselective synthesis of N-imino-[gamma]-carbolinium ylides from hydrazones of indole-3-carbonyl derivatives and propargylic alcohols

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9514-9518
DOI: 10.1039/C4OB02020K, CommunicationYu Zhu, Xin-Rui Shen, Hai-Tao Tang, Min Lin, Zhuang-Ping Zhan
A regioselective efficient synthetic approach to N-imino-[gamma]-carbolinium ylides via AgOTf-catalyzed iminoannulation from indole derivatives and propargylic alcohols has been developed.
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Silver-mediated oxidative vinylic C-H bond sulfenylation of enamides with disulfides

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9519-9523
DOI: 10.1039/C4OB01970A, CommunicationLuo Yang, Qing Wen, Fuhong Xiao, Guo-Jun Deng
A silver-mediated oxidative vinylic C-H bond sulfenylation of enamides was developed. This method is compatible with diaryl and dialkyl disulfides to deliver the biologically precious chalcogenated olefins efficiently. A plausible non-chain radical mechanism was proposed for understanding this novel sulfenylation based on the mechanistic studies.
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Synthesis and biological evaluation of (-)-kainic acid analogues as phospholipase D-coupled metabotropic glutamate receptor ligands

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9638-9643
DOI: 10.1039/C4OB02002B, PaperChiara Zanato, Sonia Watson, Guy S. Bewick, William T. A. Harrison, Matteo Zanda
A "click" 4-(1,2,3-triazolyl)-kainate derivative and its biotinylated version potently increase stretch-induced afferent firing in muscle spindles, probably acting through a hitherto uncloned phospholipase D (PLD)-coupled mGlu receptor.
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