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C–H···π Interactions and the Nature of the Donor Carbon Atom

J. Org. Chem. - 10 September, 2014 - 04:55

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The Journal of Organic ChemistryDOI: 10.1021/jo501251s

Correction: Identification and optimization of short helical peptides with novel reactive functionality as catalysts for acyl transfer by reactive tagging

Org. and Biomol. Chem. - 9 September, 2014 - 22:17
Org. Biomol. Chem., 2014, 12,7410-7410
DOI: 10.1039/C4OB90119C, CorrectionSilvia Bezer, Masaomi Matsumoto, Michael W. Lodewyk, Stephen J. Lee, Dean J. Tantillo, Michel R. Gagne, Marcey L. Waters
The content of this RSS Feed (c) The Royal Society of Chemistry

Nitroxide-labeled pyrimidines for non-covalent spin-labeling of abasic sites in DNA and RNA duplexes

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7366-7374
DOI: 10.1039/C4OB01095G, PaperSandip A. Shelke, Gunnar B. Sandholt, Snorri Th. Sigurdsson
Of ten new pyrimidine-derived nitroxide spin labels, an N1-ethylamino triazole-linked uracil derivative binds fully to both DNA and RNA duplexes containing an abasic site, as determined by CW-EPR.
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7197-7200
DOI: 10.1039/C4OB01156B, CommunicationMichael A. Bertucci, Stephen J. Lee, Michel R. Gagne
Hydrazine derivatives are employed for selective amide cleavage of 3-oxo-N-acyl homoserine lactones under physiologically relevant conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A computational study of the activation of allenoates by Lewis bases and the reactivity of intermediate adducts

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7297-7309
DOI: 10.1039/C4OB01177E, PaperGou-Tao Huang, Timm Lankau, Chin-Hui Yu
Several chemical properties of Lewis base-allenoate adducts (LB[middle dot]allenoate), such as solvent effect, basicity, nucleophilicity and cycloaddition, are studied to provide a detailed foundation for the analysis of LB-catalyzed reactions of allenoates.
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Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7261-7269
DOI: 10.1039/C4OB01550A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Felix F. Schumacher, Joao P. M. Nunes, Antoine Maruani, Vijay Chudasama, Mark E. B. Smith, Kerry A. Chester, James R. Baker, Stephen Caddick
Highly homogeneous ADCs are generated by the efficient bridging of interchain disulfide bonds in trastuzumab, using next generation maleimides.
The content of this RSS Feed (c) The Royal Society of Chemistry

A hydrazide-anchored dendron scaffold for chemoselective ligation strategies

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7290-7296
DOI: 10.1039/C4OB00870G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Liz O'Donovan, Paul A. De Bank
We report the design and synthesis of a dendron scaffold, enabling the chemoselective decoration of target molecules with multiple copies of functional species, such as peptides, via a hydrazone bond.
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Iridium-catalyzed C-H borylation of pyridines

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7318-7327
DOI: 10.1039/C4OB01565G, PaperScott A. Sadler, Hazmi Tajuddin, Ibraheem A. I. Mkhalid, Andrei S. Batsanov, David Albesa-Jove, Man Sing Cheung, Aoife C. Maxwell, Lena Shukla, Bryan Roberts, David C. Blakemore, Zhenyang Lin, Todd B. Marder, Patrick G. Steel
Iridium-catalysed C-H borylation is an efficient method for the preparation of pyridyl and related azinyl boronate esters.
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of transannular cycloaddition reactions involving furanoxonium ions using DFT calculations. Implications for the origin of plumarellide and rameswaralide and related polycyclic metabolites isolated from corals

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7270-7278
DOI: 10.1039/C4OB00734D, PaperB. Lygo, M. J. Palframan, G. Pattenden
DFT calculations probing potential cycloaddition pathways leading to the polycyclic ring systems found in the coral secondary metabolites plumarellide, mandapamate and rameswaralide are described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Divergent total synthesis of 1,6,8a-tri-epi-castanospermine and 1-deoxy-6,8a-di-epi-castanospermine from substituted azetidin-2-one ([small beta]-lactam), involving a cascade sequence of reactions as a key step

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7389-7396
DOI: 10.1039/C4OB00948G, PaperDipak Kumar Tiwari, Kishor Chandra Bharadwaj, Vedavati G. Puranik, Dharmendra Kumar Tiwari
A divergent, short, and novel total synthesis of 1,6,8a-tri-epi-castanospermine (7) and 1-deoxy-6,8a-di-epi-castanospermine (8) has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Stereoselective synthesis of C-fused pyranoindoles, pyranobenzofurans and pyranobenzothiophene scaffolds using oxa-Pictet-Spengler type reaction of vinylogous carbonates

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7397-7409
DOI: 10.1039/C4OB01387E, PaperSantosh J. Gharpure, V. Prasath
C-fused pyranoheterocycles can be assembled in a highly diastereoselective manner using an intramolecular oxa-Pictet-Spengler type reaction of vinylogous carbonates.
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Linear versus branched poly-lysine/arginine as polarity enhancer tags

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7194-7196
DOI: 10.1039/C4OB01354A, CommunicationMarta Paradis-Bas, Maria Albert-Soriano, Judit Tulla-Puche, Fernando Albericio
The design and synthesis of Lys- and Arg-containing peptides as solubilizing tags were studied to evaluate their influence on polarity.
The content of this RSS Feed (c) The Royal Society of Chemistry

A neighboring group participation strategy: direct and highly diastereoselective synthesis of 2-substituted and 2,2-bisubstituted perhydrofuro[2,3-b]pyran derivatives

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7381-7388
DOI: 10.1039/C4OB00642A, PaperXiaofeng Ma, Qin Tang, Jun Ke, Jichao Zhang, Xinglong Yang, Xudong Shen, Huawu Shao
A highly diastereoselective synthesis method for 2-substituted and 2,2-bisubstituted perhydrofuro[2,3-b]pyran derivatives from 2-C-branched sugars via a neighboring group participation strategy was developed.
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Cooperative hybridization of [gamma]PNA miniprobes to a repeating sequence motif and application to telomere analysis

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7345-7354
DOI: 10.1039/C4OB00953C, PaperHa H. Pham, Connor T. Murphy, Gopalsamy Sureshkumar, Danith H. Ly, Patricia L. Opresko, Bruce A. Armitage
High affinity [gamma]PNA oligomers hybridize cooperatively on telomeric DNA and provide bright fluorescent signals.
The content of this RSS Feed (c) The Royal Society of Chemistry

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP

Org. and Biomol. Chem. - 9 September, 2014 - 22:17

Org. Biomol. Chem., 2014, 12,7338-7344
DOI: 10.1039/C4OB01470G, PaperChaolei Wang, Guoxiang Wei, Xue Yang, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu, Jinyi Xu
The first total synthesis of S-(+)-XJP and R-(-)-XJP has been achieved via intramolecular Heck reaction. A latent functionality strategy was implemented to circumvent the racemization in this endeavor.
The content of this RSS Feed (c) The Royal Society of Chemistry

The biosafety of lanthanide upconversion nanomaterials

Chem. Soc. Rev. - 9 September, 2014 - 22:17

Chem. Soc. Rev., 2015, Advance Article
DOI: 10.1039/C4CS00175C, Review ArticleYun Sun, Wei Feng, Pengyuan Yang, Chunhui Huang, Fuyou Li
The association between the chemo-physical properties of UCNPs and their biodistribution, excretion, and toxic effects is presented in this review.
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