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Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9572-9582
DOI: 10.1039/C4OB01658K, PaperMarco Franceschin, Daniele Nocioni, Annamaria Biroccio, Emanuela Micheli, Stefano Cacchione, Chiara Cingolani, Alessandro Venditti, Pasquale Zizza, Armandodoriano Bianco, Alessandro Altieri
Dimerization of the xanthone core greatly enhances G-quadruplex binding and biological activity.
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphonated chelates for nuclear imaging

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9601-9620
DOI: 10.1039/C4OB01514B, PaperSabah Abada, Alexandre Lecointre, Caline Christine, Laurence Ehret-Sabatier, Falk Saupe, Gertraud Orend, David Brasse, Ali Ouadi, Thomas Hussenet, Patrice Laquerriere, Mourad Elhabiri, Loic J. Charbonniere
A series of phosphonated chelates and their coordination properties is described. SPECT/CT imaging studies with 99mTc using two ligands and a bifunctional chelate labeled to a tumor targeting antibody are shown.
The content of this RSS Feed (c) The Royal Society of Chemistry

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9592-9600
DOI: 10.1039/C4OB01911C, PaperSerena Mostarda, Paolo Filipponi, Roccaldo Sardella, Francesco Venturoni, Benedetto Natalini, Roberto Pellicciari, Antimo Gioiello
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

The protecting-group directed diastereoselective Nozaki-Hiyama-Kishi (NHK) reaction: total synthesis and biological evaluation of zeaenol, 7-epi-zeaenol and its analogues

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9683-9695
DOI: 10.1039/C4OB01811G, PaperDebendra K. Mohapatra, D. Sai Reddy, N. Arjunreddy Mallampudi, Janardhan Gaddam, Sowjanya Polepalli, Nishant Jain, J. S. Yadav
A convergent and concise total synthesis of zeaenol, 7-epi-zeaenol, and its analogues is achieved using protecting group-directed NHK reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

Metal-free, one-pot conversion of proline derivatives into 2-aryl-3-iodo pyrrolidines by a sequential scission-iodination-arylation process

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9547-9556
DOI: 10.1039/C4OB01372G, PaperVenkateswara Rao Batchu, Ivan Romero-Estudillo, Alicia Boto, Javier Miguelez
A sequential radical decarboxylation-oxidation-iodination-arylation process allows the metal-free, direct conversion of proline derivatives into 2-aryl-3-iodopyrrolidines, which are valuable precursors of a variety of heterocycles.
The content of this RSS Feed (c) The Royal Society of Chemistry

The impact of LR-HSQMBC very long-range heteronuclear correlation data on computer-assisted structure elucidation

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9505-9509
DOI: 10.1039/C4OB01418A, CommunicationK. A. Blinov, A. V. Buevich, R. T. Williamson, G. E. Martin
The impact of LR-HSQMBC very long-range nJCH heteronuclear shift correlation data as a supplement to HMBC data as input for the computer-assisted structure elucidation program, Structure Elucidator[registered sign], is assessed for the first time.
The content of this RSS Feed (c) The Royal Society of Chemistry

Chiroptical molecular propellers based on hexakis(phenylethynyl)benzene through the complexation-induced intramolecular transmission of local point chirality

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9532-9538
DOI: 10.1039/C4OB01601G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryo Katoono, Keiichi Kusaka, Shunsuke Kawai, Yuki Tanaka, Keisuke Hanada, Tatsuo Nehira, Kenshu Fujiwara, Takanori Suzuki
We designed hexakis(phenylethynyl)benzene derivatives with a tertiary amide group on each blade to achieve a helically biased propeller arrangement.
The content of this RSS Feed (c) The Royal Society of Chemistry

Alkylene-bridged viologen dendrimers: versatile cell delivery tools with biosensing properties

Org. and Biomol. Chem. - 17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9583-9591
DOI: 10.1039/C4OB00560K, PaperDirk Bongard, Wilhelm Bohr, Marta Swierczek, Tesfaye Hailu Degefa, Lorenz Walder, Roland Brandt
Two types of tailored viologen dendrimers with different spacer lengths between the viologen (4,4[prime or minute]-bipyridinium) units have been prepared. The condensation of dsDNA induced by the dendrimers was monitored with a new electrochemical technique. This allowed us to optimize the transfection media for high dendriplex concentration.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pyrene Schiff Base: Photophysics, Aggregation Induced Emission, and Antimicrobial Properties

J. Phys. Chem. B - 17 November, 2014 - 14:59

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The Journal of Physical Chemistry BDOI: 10.1021/jp509697n

Master and Slave Relationship Between Two Types of Self-Propagating Insulin Amyloid Fibrils

J. Phys. Chem. B - 17 November, 2014 - 14:58

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The Journal of Physical Chemistry BDOI: 10.1021/jp510980b

Interactions of Urea with Native and Unfolded Proteins: A Volumetric Study

J. Phys. Chem. B - 17 November, 2014 - 14:58

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The Journal of Physical Chemistry BDOI: 10.1021/jp509356k

Pyrrolidinium-Based Ionic Liquids Doped with Lithium Salts: How Does Li+ Coordination Affect Its Diffusivity?

J. Phys. Chem. B - 17 November, 2014 - 14:57

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The Journal of Physical Chemistry BDOI: 10.1021/jp509387r

Role of Zwitterions in Kindling Fluorescent Protein Photochemistry

J. Phys. Chem. B - 17 November, 2014 - 14:48

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The Journal of Physical Chemistry BDOI: 10.1021/jp5075219

Interaction between Antimalarial 2-Aryl-3H-indol-3-one Derivatives and Human Serum Albumin

J. Phys. Chem. B - 17 November, 2014 - 14:48

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The Journal of Physical Chemistry BDOI: 10.1021/jp507569e

Excitonic Splitting, Delocalization, and Vibronic Quenching in the Benzonitrile Dimer

J. Phys. Chem. A - 17 November, 2014 - 14:42

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The Journal of Physical Chemistry ADOI: 10.1021/jp509626b

Secondary Structures in Phe-Containing Isolated Dipeptide Chains: Laser Spectroscopy vs Quantum Chemistry

J. Phys. Chem. A - 17 November, 2014 - 14:42

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The Journal of Physical Chemistry ADOI: 10.1021/jp509494c

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