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A brief word about tomatoes and prostate cancer

Sciencebase - 4 September, 2014 - 14:16

UPDATE: To avoid confusion: eating lots of tomatoes will not stop you getting prostate cancer if other risk factors are in place!

At least 20 years ago I wrote a news story in my rookie days about how the natural red pigment in tomatoes, the antioxidant lycopene, could somehow protect men against prostate cancer. Nothing was ever proven and the latest news which hit the tabloids in the last couple of weeks doesn’t add much, at least if you read between the lines.

NHS Choices, as ever, has a good summary:

“This large study has shown an association between the consumption of more than 10 portions of tomatoes per week and an 18% reduction in risk of prostate cancer. However, as this was a case controlled study, and not a randomised controlled trial, it cannot prove that eating more tomatoes prevents prostate cancer.”

Tomatoes grown and photographed by David Bradley

The study does have some strengths: large size and accounting for confounding factors. However, limitations include: reliance on dietary questionnaires and the broad categories for self-estimate of body size. After all, do you recall how many portions of tomatoes you’ve had and can honestly tell us how fat or thin you are?

The bottom line NHS Choices says:

“This study does not provide enough evidence to change the recommendations for reducing the risk of prostate cancer. A healthy, balanced diet, regular exercise and stopping smoking are still the way to go, rather than relying on eating one exclusive food type such as tomatoes.”

Tomato-rich diet 'reduces prostate cancer risk'.

Incidentally, from this paper: “Prostate cancer (PCa) represents a major public health burden in the western world. It is a peculiar disease as more men die with it than from it. Also interestingly, PCa was virtually unknown until the 20th century.”

A brief word about tomatoes and prostate cancer is a post from the science blog of science journalist, photographer and musician David Bradley
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Categories: Science Blogs

Characterization of Two Isomers of the Vinyl Fluoride···Carbon Dioxide Dimer by Rotational Spectroscopy

J. Phys. Chem. A - 4 September, 2014 - 13:43

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The Journal of Physical Chemistry ADOI: 10.1021/jp507869y

Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions

J. Am. Chem. Soc. - 4 September, 2014 - 12:31

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Journal of the American Chemical SocietyDOI: 10.1021/ja504031d

A Mononuclear Manganese(II) Complex Demonstrates a Strategy To Simultaneously Image and Treat Oxidative Stress

J. Am. Chem. Soc. - 4 September, 2014 - 11:06

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Journal of the American Chemical SocietyDOI: 10.1021/ja507034d

Efficient halogen photoelimination from dibromo, dichloro and difluoro tellurophenes

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, Advance Article
DOI: 10.1039/C4DT01751J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Elisa I. Carrera, Dwight S. Seferos
Visible light induces photoreductive elimination of bromine, chlorine, and for the first time, fluorine from the tellurium center of 2,5-diphenyltellurophene.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A new library of arsine, stibine-stabilized N-heterocyclic carbene palladium complexes: synthesis, structures and activities in C-C and C-N coupling reactions

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, 43,14114-14122
DOI: 10.1039/C4DT01773K, PaperJin Yang, Pinhua Li, Yicheng Zhang, Lei Wang
A series of N-heterocyclic carbene palladium complexes bearing AsPh3 and SbPh3 functions was synthesized and characterized. Furthermore, the catalytic activities of the complexes in the C-C and C-N coupling reactions were also investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and structures of tris(2-pyridyl)aluminate sandwich compounds [{RAl(2-py[prime or minute])2}2M] (py[prime or minute] = 2-pyridyl, M = Ca, Mn, Fe)

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, 43,14045-14053
DOI: 10.1039/C4DT00951G, PaperRaul Garcia-Rodriguez, Thomas H. Bullock, Mary McPartlin, Dominic S. Wright
While neither the bridgehead group (R) nor remote ring Me-groups have any impact on metal coordination of tris(2-pyridyl) aluminate ligands [RAl(2-py[prime or minute])3]-, Me groups adjacent to the donor pyridyl-N atoms have a large effect on their ability to form sandwich arrangements.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and structural characterization of tris(2-mercapto-1-methylbenzimidazolyl)hydroborato cadmium halide complexes, {[TmMeBenz]Cd([small mu ]-Cl)}2 and [TmMeBenz]CdI: a rare example of cadmium in a trigonal bipyramidal sulfur-rich coordination envir

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, 43,13874-13882
DOI: 10.1039/C4DT01820F, PaperJoshua H. Palmer, Gerard Parkin
Whereas [TmMeBenz]CdI is a monomer akin to all other Group 12 [TmR]MX derivatives, the chloride complex, {[TmMeBenz]Cd([small mu ]-Cl)}2, exists as a dimer with Cl bridges.
The content of this RSS Feed (c) The Royal Society of Chemistry

Silver ion enhanced C-H activation in Pt(II) hydroxo complexes

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, 43,13858-13864
DOI: 10.1039/C4DT01934B, PaperTracy L. Lohr, Warren E. Piers, Michael J. Sgro, Masood Parvez
Addition of stoichiometric Ag(I) salt to monomeric Pt(II) hydroxo complexes supported by a bulky diimine ligand results in significantly enhanced rates of C-H activation relative to the silver free systems.
The content of this RSS Feed (c) The Royal Society of Chemistry

Assignment of the oxidation states of Zr and Co in a highly reactive heterobimetallic Zr/Co complex using X-ray absorption spectroscopy (XANES)

Dalton Transactions - 4 September, 2014 - 08:17

Dalton Trans., 2014, 43,13852-13857
DOI: 10.1039/C4DT01534G, PaperJeremy P. Krogman, James R. Gallagher, Guanghui Zhang, Adam S. Hock, Jeffrey T. Miller, Christine M. Thomas
The ambiguous oxidation states in a highly reactive heterobimetallic Zr/Co complex have been assigned using XANES Co and Zr K-edge data and confirmed using computational methods.
The content of this RSS Feed (c) The Royal Society of Chemistry

Challenge of Representing Entropy at Different Levels of Resolution in Molecular Simulation

J. Phys. Chem. B - 4 September, 2014 - 05:47

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The Journal of Physical Chemistry BDOI: 10.1021/jp505045m

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