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Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8598-8602
DOI: 10.1039/C4OB01738B, CommunicationJohn C. Lukesh III, Kristen A. Andersen, Kelly K. Wallin, Ronald T. Raines
Organocatalysts derived from ethylenetriamine and containing a hydrophobic moiety effect the isomerization of non-native protein disulfide bonds to native ones.
The content of this RSS Feed (c) The Royal Society of Chemistry

Relative stability of benziporphyrin and naphthiporphyrin tautomers and the emergence of macrocyclic diatropicity

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8719-8736
DOI: 10.1039/C4OB01659A, PaperDeyaa I. AbuSalim, Timothy D. Lash
The conformations and relative stabilities of a series of benziporphyrin and naphthiporphyrin tautomers were calculated and the diatropic properties of each of these species were assessed. The results were in good agreement with experimental observations and allow favorable delocalization pathways to be identified.
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8745-8751
DOI: 10.1039/C4OB01299B, PaperAndrea Barba-Bon, Ana M. Costero, Salvador Gil, Ramon Martinez-Manez, Felix Sancenon
A new naked eye colorimetric BODIPY probe able to discriminate DCNP and DFP nerve agent mimics with good LODs.
The content of this RSS Feed (c) The Royal Society of Chemistry

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained [small alpha]-helix peptides

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8775-8782
DOI: 10.1039/C4OB01832J, PaperBoris Aillard, Naomi S. Robertson, Adam R. Baldwin, Siobhan Robins, Andrew G. Jamieson
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified NiII Schiff base complex as the key step.
The content of this RSS Feed (c) The Royal Society of Chemistry

Rhodium-catalyzed ortho-cyanation of symmetrical azobenzenes with N-cyano-N-phenyl-p-toluenesulfonamide

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8603-8606
DOI: 10.1039/C4OB01736F, CommunicationJie Han, Changduo Pan, Xuefeng Jia, Chengjian Zhu
A rhodium(III)-catalyzed ortho-cyanation of symmetrical azobenzenes with NCTS via azo-group-directed C(sp2)-H bond activation is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8607-8610
DOI: 10.1039/C4OB01646G, CommunicationShuanghua Cheng, Shouyun Yu
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er).
The content of this RSS Feed (c) The Royal Society of Chemistry

Preparation of indium nitronates and their Henry reactions

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8593-8597
DOI: 10.1039/C4OB01468E, CommunicationRaquel G. Soengas, Rita Acurcio, Artur M. S. Silva
Indium nitronates were readily prepared from commercially available nitroalkanes by transmetallation of the corresponding lithium nitronates with indium salts. The Henry reaction of this nitronates with aldehydes afforded [small beta]-nitroalkanols in moderate to high yields and excellent stereoselectivity (when using chiral aldehydes).
The content of this RSS Feed (c) The Royal Society of Chemistry

Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8764-8774
DOI: 10.1039/C4OB01196A, PaperJun-Jiang Lv, Ya-Feng Wang, Jing-Min Zhang, Shan Yu, Dong Wang, Hong-Tao Zhu, Rong-Rong Cheng, Chong-Ren Yang, Min Xu, Ying-Jun Zhang
The sesquiterpenoid glycoside dimers isolated from Phyllanthus emblica have anti-HBV activities towards HBsAg and HBeAg secretions inhibition.
The content of this RSS Feed (c) The Royal Society of Chemistry

A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8588-8592
DOI: 10.1039/C4OB01829J, CommunicationChandrasekhar Challa, Jamsheena Vellekkatt, Jaice Ravindran, Ravi S. Lankalapalli
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cross-strand histidine-aromatic interactions enhance acyl-transfer rates in beta-hairpin peptide catalysts

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8711-8718
DOI: 10.1039/C4OB01754D, PaperM. Matsumoto, S. J. Lee, M. R. Gagne, M. L. Waters
A His-aryl interaction in a beta-hairpin catalyst provides rate enhancements of up to 18 000 for acyl transfer catalysis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective phosphination and hydrophosphonylation of azomethine imines: using chiral squaramide as a hydrogen bonding organocatalyst

Org. and Biomol. Chem. - 22 October, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,8656-8670
DOI: 10.1039/C4OB01472C, PaperLing-Pei Kong, Nai-Kai Li, Shao-Yun Zhang, Xiang Chen, Min Zhao, Ya-Fei Zhang, Xing-Wang Wang
Highly enantioselective phosphination and hydrophosphonylation reactions of azomethine imines are respectively reported in this paper.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studying Regioisomer Formation in the Pd-Catalyzed Fluorination of Aryl Triflates by Deuterium Labeling

J. Am. Chem. Soc. - 21 October, 2014 - 21:35

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Journal of the American Chemical SocietyDOI: 10.1021/ja509144r

Interactions of Lipids and Detergents with a Viral Ion Channel Protein: Molecular Dynamics Simulation Studies

J. Phys. Chem. B - 21 October, 2014 - 21:32

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The Journal of Physical Chemistry BDOI: 10.1021/jp505127y

The Formation of Highly Oxidized Multifunctional Products in the Ozonolysis of Cyclohexene

J. Am. Chem. Soc. - 21 October, 2014 - 21:03

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Journal of the American Chemical SocietyDOI: 10.1021/ja507146s

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