Congratulations to all of our ISACS Chemistry World poster prize winners this year. Here’s a run-down of the winners:
Katie-Louise Finney, a second year PhD student in David Parker’s group at the University of Durham, UK, was the winner at ISACS 13 (Challenges in Inorganic and Materials Chemistry), held in Dublin, Ireland. Katie’s poster was titled ‘Development of 1H PARASHIFT probes for magnetic resonance spectroscopy and imaging‘.
Katie explains her work: ‘Our 1H PARASHIFT probes possess a tert-butyl reporter group that can be shifted well away from the water and fat signals at 4.7 and 1.3ppm. We have succeeded in shifting the tert-butyl reporter group as far as +65 and –75ppm. This means that in imaging experiments, we gain two orders of magnitude of sensitivity due to 1) the lack of background signal in vivo and 2) the enhanced reporter group relaxation by the proximal lanthanide ion. As a result, our probes have been imaged in live mice within minutes, at concentrations of 0.1mmol/kg.’
We’ve actually featured Katie’s MRI work in Chemistry World before in our article Moving the goalposts for MRI.
Baihua Ye, a doctoral assistant in the laboratory of asymmetric catalysis and synthesis at the Swiss Federal Institute of Technology in Lausanne, was the winner at ISACS 14 (Challenges in Organic Chemistry), held in Shanghai, China.
Baihua’s poster was titled ‘Development of chiral cyclopentadienyl ligands for Rh(III)-catalysed asymmetric C-H functionalisations‘.
Baihua explains his poster: ‘My PhD thesis under the supervision of Nicolai Cramer was devoted to the investigation of novel cyclopentadienyl (Cp) ligand as a stepping stone for the asymmetric rhodium(III)-catalyzed C-H functionalizations. The challenge to achieve the high level of enantioselectivity basically stems from the spatial arrangement of the three coordinating components around the metal center. The Cp derivative, thus, acts as the sole source of chirality. From the year of 2012, we have pioneered on the design of chiral Cp ligands and elaborated two complementary families of the CpRh(I) complexes. Upon the facile oxidation in situ of the Rh(I) species, the resulting chiral CpRh(III) have been successfully applied in the C-H functionalizations of aryl hydroxamates coupled with olefins, allenes as well as diazo esters. The corresponding heterocyclic products are generally obtained in good yields with high levels of regio- and stereo-selectivity. In the future, we believe that our effort would provide more variant on enantioselective Cp-based metal catalysis.’
David Ordinario, a graduate research assistant in Alon Gorodetsky’s group at the University of California at Irvine, was the winner at ISACS 15 (Challenges in Nanoscience), held in San Diego, US. David’s poster was titled ‘Protonic devices from a cephalopod structural protein‘.
David explains his poster: ‘In my poster, I first introduced the reflectin protein, explained where it comes from, and described some of its unusual but interesting properties. Next, I explained our electrical characterisation work on thin films from the reflectin protein. We performed tests such as two- and three-terminal IV measurements and electrochemical impedance spectroscopy (EIS). Finally, I showed and explained the protonic transistor devices we fabricated which uses reflectin as the active material. I focused on explaining the underlying mechanisms by which the reflectin-based protonic transistors function, as well as a couple of methods we developed to optimise the performance of the transistors.’
The next ISACS, ISACS 16: Challenges in Chemical Biology, will held be in Zurich, Switzerland, from 15–18 June 2014. See the Royal Society of Chemistry’s ISACS 16 event page for details.