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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8977-8996
DOI: 10.1039/C4OB00325J, PaperJ. Desire, M. Mondon, N. Fontelle, S. Nakagawa, Y. Hirokami, I. Adachi, R. Iwaki, G. W. J. Fleet, D. S. Alonzi, G. Twigg, T. D. Butters, J. Bertrand, V. Cendret, F. Becq, C. Norez, J. Marrot, A. Kato, Y. Bleriot
The synthesis and biological evaluation of a library of novel seven-membered iminosugars is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8877-8887
DOI: 10.1039/C4OB01338G, PaperM. Angeles Bonache, Alessandro Alaimo, Covadonga Malo, Oscar Millet, Alvaro Villarroel, Rosario Gonzalez-Muniz
Small bis-conjugates helix A329-350-PEG-triazole-PEG-helix B508-526 (41 residues), prepared through click chemistry of PEGylated peptide derivatives, bind to CaM with nanomolar affinity, behaving as mimics of the Kv7.2 native fragment (239 residues).
The content of this RSS Feed (c) The Royal Society of Chemistry

NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines: a facile access to 4-trifluoromethyl-5-acylisoxazoles

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8942-8946
DOI: 10.1039/C4OB01790K, PaperLi Zhang, Qin Zeng, Ao Mao, Ziang Wu, Tian Luo, Yuanjing Xiao, Junliang Zhang
A NIS mediated sequential procedure involving oxidation and electrophilic cycloisomerization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines for 4-trifluoromethyl-5-acylisoxazole synthesis is developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8866-8876
DOI: 10.1039/C4OB01525H, PaperBaobin Cai, Xiantao Yang, Lidan Sun, Xinmeng Fan, Liyu Li, Hongwei Jin, Yun Wu, Zhu Guan, Liangren Zhang, Lihe Zhang, Zhenjun Yang
D-/L-IsoT were used to modify the loop regions of TBA and greatly improved its bioactivity as well as stability.
The content of this RSS Feed (c) The Royal Society of Chemistry

Imides modified benzopicenes: synthesis, solid structure and optoelectronic properties

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8902-8910
DOI: 10.1039/C4OB01486C, PaperDi Wu, Haojie Ge, Zhao Chen, Jinhua Liang, Jie Huang, Yufeng Zhang, Xiaoqiang Chen, Xianggao Meng, Sheng Hua Liu, Jun Yin
Imide-modified polycyclic aromatic hydrocarbons can be widely applied in the field of optoelectronic materials.
The content of this RSS Feed (c) The Royal Society of Chemistry

A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans from [small alpha]-oxo ketene dithioacetals and propargyl alcohols via domino coupling/annulations

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8947-8951
DOI: 10.1039/C4OB01300J, PaperXiaobing Yang, Fangzhong Hu, Hongjing Di, Xinxin Cheng, Dan Li, Xiaoli Kan, Xiaomao Zou, Qichun Zhang
A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans 2 has been developed through the domino coupling/annulations from [small alpha]-oxo ketene dithioacetals 1 and propargyl alcohols.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anion binding of a neutral bis(cyclopeptide) in water-methanol mixtures containing up to 95% water

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8851-8860
DOI: 10.1039/C4OB01497A, PaperFabian Sommer, Stefan Kubik
Selectivity of a synthetic anion receptor reverses from strongly coordinating sulfate to weakly coordinating iodide anions upon increasing the water content of the solution.
The content of this RSS Feed (c) The Royal Society of Chemistry

Directed arene/alkyne annulation reactions via aerobic copper catalysis

Org. and Biomol. Chem. - 28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8844-8850
DOI: 10.1039/C4OB01312C, PaperYi Zhang, Qian Wang, Huidong Yu, Yong Huang
We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen.
The content of this RSS Feed (c) The Royal Society of Chemistry

Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00098F, PaperNicolas P. E. Barry, Anais Pitto-Barry, Isolda Romero-Canelon, Johanna Tran, Joan J. Soldevila-Barreda, Ian Hands-Portman, Corinne J. Smith, Nigel Kirby, Andrew P. Dove, Rachel K. O'Reilly, Peter J. Sadler
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00115J, PaperA. Lesniak, D. Kilinc, Suad A. Rashdan, A. von Kriegsheim, B. Ashall, D. Zerulla, W. Kolch, G. U. Lee
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A low cost synthesis method for functionalised iron oxide nanoparticles for magnetic hyperthermia from readily available materials

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00062E, PaperJoseph C. Bear, Bin Yu, Cristina Blanco-Andujar, Paul D. McNaughter, Paul Southern, Marc-Krystelle Mafina, Quentin A. Pankhurst, Ivan P. Parkin
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design of FeBi nanoparticles for imaging applications

Faraday Disc. - 28 October, 2014 - 07:54
Faraday Discuss., 2014, Advance Article
DOI: 10.1039/C4FD00105B, PaperM. Branca, F. Pelletier, B. Cottin, D. Ciuculescu, C.-C. Lin, R. Serra, J.-G. Mattei, M.-J. Casanove, R. Tan, M. Respaud, C. Amiens
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and Controlled Self-Assembly of UV-Responsive Gold Nanoparticles in Block Copolymer Templates

J. Phys. Chem. B - 27 October, 2014 - 21:19

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