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Strategically designed biomodel: engineering C3-C4 cleavage of D-fructose

Org. and Biomol. Chem. - 26 March, 2015 - 22:54

Org. Biomol. Chem., 2015, 13,4210-4220
DOI: 10.1039/C4OB02666G, PaperPalwinder Singh, Arun Kumar, Sukhmeet Kaur, Amrinder Singh
Amongst a library of aldolase inspired, rationally designed compounds, the acridine derivative carrying a (S)-Tyr-Gly-(S)-Lys tripeptide selectively effected C3-C4 scissoring of D-fructose and produced D-glyceraldehyde and dihydroxyacetone.
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Efficacious redox-responsive gene delivery in serum by ferrocenylated monomeric and dimeric cationic cholesterols

Org. and Biomol. Chem. - 26 March, 2015 - 22:54

Org. Biomol. Chem., 2015, 13,4310-4320
DOI: 10.1039/C4OB02513J, PaperGururaja Vulugundam, Krishan Kumar, Paturu Kondaiah, Santanu Bhattacharya
New redox-active monomeric and dimeric ferrocenylated cationic cholesterols for gene transfection.
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Design and Synthesis of Analogues of Natural Products

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00169B, Review ArticleM E Maier
In this article strategies for the design and synthesis of natural product analogues are summarized and illustrated with some selected examples. Proven strategies include diverted total synthesis (DTS), function-oriented synthesis...
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Stereoselective synthesis of the C13-C22 fragment of Callystatin A by a non-aldol approach

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00413F, PaperSadagopan Raghavan, s rajendar
An efficient synthetic route to the C13-C22 subunit of callystatin A is reported. The key features include diastereoselective alkylation, using Myers auxiliary, for the preparation of the three carbon synthon...
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Highly Enantioselective Synthesis of Naphthoquinones and Pyranonaphthoquinones Catalyzed by Bifunctional Chiral Bis-Squaramides

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00105F, PaperNagaraju Molleti, Vinod Singh
A variety of enantioenriched naphthoquinones have been synthesized in high yields and excellent enantioselectivities (up to >99% ee) using a bifunctional chiral bis-squaramide catalyzed conjugate addition of 2-hydroxy-1,4-naphthoquinone to 2-enoylpyridines....
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An Efficient Approach to 1,2,3-Trisubstituted Indole Via Rhodium Catalyzed Carbene Csp3-H Bond Insertion

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00085H, CommunicationMei-Hua Shen, Ying-Peng Pan, Zhi-Hong Jia, Xin-Tao Ren, Ping Zhang, Hua-Dong Xu
A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been made through this method. Electro donating groups on both aromatic rings...
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Au-catalyzed Ring-opening Reactions of 2-(1-Alkynyl-cyclopropyl)pyridines with Nucleophiles

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00523J, CommunicationRen-Rong Liu, Shi-Chun Ye, Chuan-Jun Lu, Bin Xiang, Jianrong Gao, Yi-Xia Jia
A novel method for the C-C bond cleavage of cyclopropanes was developed by gold-catalyzed cycloisomerization of 2-(1-alkynyl-cyclopropyl)pyridine with nucleophiles, which provides an efficient access to structural diversely indolizines under mild...
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Stereoselective synthesis of (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene

Org. and Biomol. Chem. - 26 March, 2015 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00313J, PaperLiudmila Filippova, Ida Aarum, Martine Ringdal, Martin Kirkhus Dahl, Trond Vidar Hansen, Yngve Stenstrom
EPA-EE was converted in eight steps and 15% overall yield to the natural product (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene. The synthesis confirms the all-Z-configuration of all nine double bonds.
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Binding-induced, turn-on fluorescence of the EGFR/ERBB kinase inhibitor, lapatinib

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00239G, PaperJames N. Wilson, Wenjun Liu, Adrienne S. Brown, Ralf Landgraf
We report the photophysical properties, binding-induced turn-on emission, and fluorescence imaging of the cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor. Lapatinib, a type II, i.e. inactive state, inhibitor...
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Application of the Ugi reaction with multiple amino acids-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00218D, PaperMattia Stucchi, Silvia Cairati, Rengul Cetin-Atalay, Michael S. Christodoulou, Giovanni Grazioso, Gennaro Pescitelli, alessandra Silvani, Deniz Cansen Yildirim, giordano lesma
The concurrent employment of [small alpha]-amino acid-derived chiral components such as aldehydes and [small alpha]-isocyanoacetates, in a sequential Ugi reaction/cyclization two steps strategy, opens the way to the synthesis of three structurally...
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Palladium-catalyzed [small alpha]-arylation of carbonyls in the de novo synthesis of aromatic heterocycles

Org. and Biomol. Chem. - 26 March, 2015 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00055F, PerspectiveHarish K. Potukuchi, Anatol P. Spork, Timothy J. Donohoe
The enolate cross coupling reaction is a highly efficient method for the de novo synthesis of aromatic rings.
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Chemo-, Regio-, and Stereoselective Heck-Matsuda Arylation of Allylic Alcohols under Mild Conditions

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00235D, CommunicationRanjan Jana, Tohasib Yusub Chaudhari, Asik Hossian, Manash Kumar Manna
Heck arylation with allylic alcohol is extremely challenging due to chemo-, regio-, and stereoselective scrambling. Here we report a mild protocol for the alcohol selective [small beta]- and [small alpha]-arylation of allylic...
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Correction: Tuning temperature responsive poly(2-alkyl-2-oxazoline)s by supramolecular host-guest interactions

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90053K, CorrectionVictor R. de la Rosa, Werner M. Nau, Richard Hoogenboom
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Correction: Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90054A, CorrectionXiwen Xing, Xiaolin Wang, Liang Xu, Yang Tai, Luyang Dai, Xiaolong Zheng, Wuxiang Mao, Xiaowei Xu, Xiang Zhou
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Facile Synthesis of Benzoindoles and Naphthofurans through Carbonaceous Material Catalyzed Cyclization of Naphthylamines/Naphthols with Nitroolefins in Water

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00129C, PaperFuren Zhang, Chunmei Li, Chen Wang, Chenze Qi
A facial and efficient approach for the synthesis of benzoindole and naphthofuran derivatives via metal-free cyclization reaction of nitroolefins with naphthylamines/naphthols has been established. Various substituted benzoindoles and naphthofurans are...
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Copper-Catalysed Cross-Coupling: An Untapped Potential

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00200A, Review ArticleSurendra Thapa, Bijay Shrestha, Santosh K. Gurung, ramesh giri
Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon-carbon (C‒C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety...
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Hot Water-Promoted Cyclopropylcarbinyl Rearrangement Facilitates Construction of Homoallylic Alcohols

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00305A, PaperJin Qu, Pei-Fang Li, Cheng-Bo Yi
In the refluxing 9:1 (v/v) H2O/1,4-dioxane and without additional catalyst, the rearrangements of various types of cyclopropyl carbinols were attempted. It was found that the reactions generally gave homoallylic alcohols...
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Synthesis and Antifungal Activities of Novel Polyheterocyclic Spirooxindole Derivatives

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00256G, PaperJiashou Wu, Xue Zhang, Ying-Lao Zhang, Jian-Wu Xie
A series of spirooxindole tetrahydrofuran derivatives 3 were obtained in moderate to good yields via oxindole derivatives 1 and [small beta]-arylacrylonitrile derivatives 2 via base-mediated cascade [3+2] double Michael reactions under...
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Palladium-catalyzed Hiyama coupling reaction of arylsulfonyl hydrazides under oxygen

Org. and Biomol. Chem. - 26 March, 2015 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00139K, CommunicationHui Miao, Fenhua Wang, Shuangliu Zhou, Guangchao Zhang, Yang Li
Palladium-catalyzed Hiyama cross-coupling reactions of various arylsulfonyl hydrazides with a wide variety of aryl silanes have been achieved in good to excellent yields under simple aerobic conditions.
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Dendrimer-encapsulated Pd nanoparticles as catalysts for C-C cross-couplings in flow microreactors

Org. and Biomol. Chem. - 26 March, 2015 - 22:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00289C, PaperW Verboom, Jurriaan Huskens, Roberto Ricciardi
The inner walls of glass microreactors were functionalized with dendrimer-encapsulated Pd nanoparticles. The catalysts were efficient for the copper-free Sonogashira and Suzuki-Miyaura (SMC) cross-coupling reactions. For the Sonogashira reaction between...
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