Feed aggregator

Synthesis, structure and reactivity of [15]-macrodilactones

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00809C, CommunicationDebjani Si, Mark W. Peczuh
Synthesis and characterization of some new [15]-macrodilactones revealed that the interplay between three planar units, a stereogenic center and a hinge atom generated a planar chirality that governs their molecular topology.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I-XIV

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00715A, CommunicationFabrizio Carta, Sameh M. Osman, Daniela Vullo, Zeid AlOthman, Claudiu T. Supuran
As extension of our previous study herein we report a comprehensive investigation of poly(amidoamine) (PAMAM) dendrimers as modulators of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms I-XIV.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00410A, PaperAdel S. Girgis, Siva S. Panda, Aladdin M. Srour, Hanaa Farag, Nasser S. M. Ismail, Mohamed Elgendy, Amal K. Abdel-Aziz, Alan R. Katritzky
Anti-oncological active spiro-alkaloids were synthesized exhibiting promising antitumor properties against melanoma cell lines. Molecular modeling studies describe the observed properties.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanisms and stereoselectivities of the Rh(I)-catalyzed carbenoid carbon insertion reaction of benzocyclobutenol with diazoester

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00608B, PaperYanyan Wang, Yang Wang, Wenjing Zhang, Yanyan Zhu, Donghui Wei, Mingsheng Tang
Mechanisms and stereoselectivities of a Rh(I)-catalyzed carbenoid carbon insertion reaction of benzocyclobutenol with diazoester have been investigated using the DFT method.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanistic insights into the synergistic catalysis by Au(I), Ga(III), and counterions in the Nakamura reaction

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00626K, PaperRameswar Bhattacharjee, A. Nijamudheen, Ayan Datta
DFT calculations explain the origin of Au/Ga dual catalyzed regioselectivity of Nakamura reactions. The role of the counterions and the triazole ligand is shown to be significant.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tandem rhodium catalysis: exploiting sulfoxides for asymmetric transition-metal catalysis

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,5844-5847
DOI: 10.1039/C5OB00083A, PerspectiveK. G. M. Kou, V. M. Dong
Sulfoxides are uncommon substrates for transition-metal catalysis due to their propensity to inhibit catalyst turnover. We have developed the first DKR of racemic allylic sulfoxides where rhodium catalyzed both sulfoxide epimerization and alkene hydrogenation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of pretubulysin-derivatives via the TubUgi-approach

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,6010-6020
DOI: 10.1039/C5OB00587F, PaperJudith Hoffmann, Jan Gorges, Lukas Junk, Uli Kazmaier
The Ugi reaction is a powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of functionalized side chains.
The content of this RSS Feed (c) The Royal Society of Chemistry

Corrole and nucleophilic aromatic substitution are not incompatible: a novel route to 2,3-difunctionalized copper corrolates

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00659G, PaperM. Stefanelli, F. Mandoj, S. Nardis, M. Raggio, F. R. Fronczek, G. T. McCandless, K. M. Smith, R. Paolesse
Although corrole is an electron rich macrocycle, nucleophilic aromatic substitution reactions can be used to peripherally elaborate this contracted porphyrinoid.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Molecular design and synthesis of a pH independent and cell permeant fluorescent dye and its applications

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00448A, PaperXiaojie Jiao, Chang Liu, Kun Huang, Siwen Zhang, Song He, Liancheng Zhao, Xianshun Zeng
A novel xanthene fluorescent dye with a combination of the desirable characters for fluorescent chemosensors and biomarkers including low molecular weight, water solubility, cell permeability, good biocompatibility, and strong tolerance to pH has been designed and synthesized.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Uncatalysed diaryldiazo cyclopropanations on bicyclic lactams: access to annulated prolines

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00648A, PaperLawrence Harris, Martin Gilpin, Amber L. Thompson, Andrew R. Cowley, Mark G. Moloney
The uncatalysed cycloaddition of substituted diaryldiazo compounds onto bicyclic unsaturated lactams derived from pyroglutamic acid efficiently leads to highly functionalised azatricyclononanes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00405E, PaperXiu-Jing Zheng, Fan Yang, Mingwei Zheng, Chang-Xin Huo, Ye Zhang, Xin-Shan Ye
N-modified GM3 glycoconjugates improved the efficiency of the vaccination without the combination of metabolic oligosaccharide engineering technology.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00668F, PaperKishor S. Gavale, Shrawan R. Chavan, Ayesha Khan, Rakesh Joshi, Dilip D. Dhavale
Azetidine and an unprecedented N-carboxylic azetidine iminosugars were synthesized from D-glucose, which showed prominent amyloglucosidase inhibitory activity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of new fluconazole analogues

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00590F, PaperVandana S. Pore, Sandip G. Agalave, Pratiksha Singh, Praveen K. Shukla, Vikash Kumar, Mohammad I. Siddiqi
The synthesis of new fluconazole analogues containing two different 1,2,3-triazole units and an amide group is described. All the compounds showed very high antifungal activity and no toxicity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00755K, PaperTing-Jun Wang, Wen-Wen Chen, Yi Li, Ming-Hua Xu
A facile and efficient approach for the synthesis of a variety of acridines via the tandem coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and properties of unsymmetrical azatrioxa[8]circulenes

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,5937-5943
DOI: 10.1039/C5OB00676G, PaperMalene Plesner, Thomas Hensel, Bjarne E. Nielsen, Fadhil S. Kamounah, Theis Brock-Nannestad, Christian B. Nielsen, Christian G. Tortzen, Ole Hammerich, Michael Pittelkow
Synthesis and properties are reported for a series of unsymmetrical antiaromatic azatrioxa[8]circulenes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective chemical modification of DNA with alkoxy- and benzyloxyamines

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,6059-6065
DOI: 10.1039/C5OB00595G, PaperLorina Gjonaj, Gerard Roelfes
DNA is modified selectively at cytosine with benzyloxyamine and -derivatives carrying handles for click reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Substrate geometry controls the cyclization cascade in multiproduct terpene synthases from Zea mays

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,6021-6030
DOI: 10.1039/C5OB00711A, PaperAbith Vattekkatte, Nathalie Gatto, Tobias G. Kollner, Jorg Degenhardt, Jonathan Gershenzon, Wilhelm Boland
Multiproduct terpene synthases on incubation with (2Z) substrates showed enhanced enzymatic turnover with distinct preference for cyclic products than corresponding (2E) substrates.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fluorinated hydroxypiperidines as selective [small beta]-glucosidase inhibitors

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,5983-5996
DOI: 10.1039/C5OB00721F, PaperClothilde Le Guen, Teresa Mena-Barragan, Carmen Ortiz Mellet, David Gueyrard, Emmanuel Pfund, Thierry Lequeux
Synthesis and glucosidase inhibitory activity of piperidines revealed a reverse selectivity between F- and H-alkenes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,6066-6072
DOI: 10.1039/C5OB00564G, PaperValeria Solari, Timothy R. Rudd, Scott E. Guimond, Andrew K. Powell, Jeremy E. Turnbull, Edwin A. Yates
Sugar sequence and M+ binding defines HS phage display Ab recognition.
The content of this RSS Feed (c) The Royal Society of Chemistry

HIV-1 drug discovery: targeting folded RNA structures with branched peptides

Org. and Biomol. Chem. - 26 May, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,5848-5858
DOI: 10.1039/C5OB00589B, Review ArticleJessica E. Wynn, Webster L. Santos
Branched peptides utilize multivalent binding to selectively recognize HIV RNA.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.