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Investigations into the binding of jadomycin DS to human topoisomerase II[small beta] by WaterLOGSY NMR spectroscopy

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01508A, PaperCamilo F. Martinez-Farina, Nicole McCormick, Andrew W. Robertson, Helen Clement, Alison Jee, Anna Ampaw, Nei-Li Chan, Ray T. Syvitski, David L. Jakeman
First evidence that jadomycins bind human topoisomerase II[small beta].
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Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01255D, PaperM. Glaffig, B. Palitzsch, N. Stergiou, C. Schull, D. Stra[German sz ligature}burger, E. Schmitt, H. Frey, H. Kunz
A fully synthetic multivalent MUC1 glycopeptide vaccine based on a hyperbranched polyglycerol core induced IgG antibodies which strongly recognise epithelial tumour cells.
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Synthesis of 2- and 6-thienylazulenes by palladium-catalyzed direct arylation of 2- and 6-haloazulenes with thiophene derivatives

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01317H, PaperTaku Shoji, Akifumi Maruyama, Takanori Araki, Shunji Ito, Tetsuo Okujima
Preparation of 2- and 6-thienylazulene derivatives was established by the palladium-catalyzed direct cross-coupling reaction of 2- and 6-haloazulenes with the corresponding thiophene derivatives in good yield.
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Palladium-catalyzed direct and regioselective C-H acyloxylation of indolizines

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01359C, PaperJinwei Sun, Fuyao Wang, Yongmiao Shen, Huizhen Zhi, Hui Wu, Yun Liu
A direct and highly regioselective C1-acyloxylation of indolizines was developed via palladium-catalyzed C-H functionalization. In this reaction, the regioselectivity was achieved in the absence of a directing group.
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Bioorthogonal phase-directed copper-catalyzed azide-alkyne cycloaddition (PDCuAAC) coupling of selectively cross-linked superoxide dismutase dimers produces a fully active bis-dimer

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01702E, PaperErika M. J. Siren, Serena Singh, Ronald Kluger
Superoxide dismutase (SOD) is a 32 kDa dimeric enzyme that actively removes a toxic oxygen species within red cells.
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An organocatalytic strategy for the stereoselective synthesis of C-galactosides with fluorine at the pseudoanomeric carbon

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01471A, PaperAhmad S. Altiti, S. Bachan, W. Alrowhani, D. R. Mootoo
The fluorination of [small alpha]- and [small beta]-C-linked-galactosyl ethanals using NFSI and Jorgensen catalyst, followed by reduction or methylenation of the derived aldehydes provided versatile precursors to flluorinated glycomimetics. The (R) and (S) catalysts gave stereochemically complementary results.
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Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of [small beta]-amyloid peptides and protects neuronal cells from [small beta]-amyloid-induced cytotoxicity

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01463H, CommunicationKyoungdo Kim, Kwang-su Park, Mi Kyoung Kim, Hyunah Choo, Youhoon Chong
AJ147 derivative 3j inhibits A[small beta]42 oligomerization and fibrillization, disassembles the preformed A[small beta]42 fibrils and prevents A[small beta]42 induced neurotoxicity.
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Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01509J, PaperYi-Min Liu, Hsueh-Yun Lee, Mei-Jung Lai, Shiow-Lin Pan, Hsiang-Ling Huang, Fei-Chiao Kuo, Mei-Chuan Chen, Jing-Ping Liou
We synthesized a series of pyrimidinedione derivatives and evaluated their activities.
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Stereoselective synthesis of octahydrocyclohepta[c]pyran-6(1H)-one scaffolds through a Prins/alkynylation/hydration sequence

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01408E, PaperA. Venkateswarlu, M. Kanakaraju, Ajit C. Kunwar, B. V. Subba Reddy
Aldehydes undergo a smooth coupling with (E/Z)-non-3-en-8-yn-1-ol in the presence of 10 mol% of CuX and BF3[middle dot]OEt2 under mild conditions to produce a novel class of octahydrocyclohepta[c]pyran-6(1H)-one derivatives in good yields with excellent diastereoselectivity.
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Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01474C, PaperKatarzyna Jastrzebska, Anna Maciaszek, Rafal Dolot, Grzegorz Bujacz, Piotr Guga
Oxathiaphospholane derivatives of four LNA-nucleosides were separated into P-diastereomers, and further used in the synthesis of P-stereodefined PS-(DNA/LNA) 11-mers containing 2-3 LNAs.
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Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01257K, PaperAhmed Kamal, Anver Basha Shaik, Bala Bhaskara Rao, Irfan Khan, G. Bharath Kumar, Nishant Jain
A series of pyrazole/isoxazole linked arylcinnamide conjugates were synthesized and investigated for their cytotoxic activity against a panel of four human cancer cell lines. Most of them have shown significant cytotoxicity apart from potential tubulin depolymerization activity.
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Dual-mode chemodosimetric response of dibromo-BODIPY with anions

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01386K, PaperAdiki Raja Sekhar, Masood Ayoub Kaloo, Jeyaraman Sankar
Fluorometric response of dibromo-BODIPY to various anions.
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Synthesis and electronic properties of [small pi]-extended flavins

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01418B, PaperL. N. Mataranga-Popa, I. Torje, T. Ghosh, M. J. Leitl, A. Spath, M. L. Novianti, R. D. Webster, B. Konig
Three flavins with extended aromatic systems were synthesized in moderate to good yields by condensation of the corresponding amines with violuric acid. The compounds are highly fluorescent, show quantum yields of up to 80% and redox mechanisms similar to riboflavin.
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Copper-catalyzed cyanation of aryl iodides with [small alpha]-cyanoacetates via C-CN bond activation

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01675D, PaperSong-Lin Zhang, Lu Huang
A mild copper-catalyzed cyanation of aryl iodides using readily available and friendly [small alpha]-cyanoacetates as the CN source is reported.
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Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01636C, PaperHaibo Tan, Hongxin Liu, Xinzheng Chen, Huiyu Chen, Shengxiang Qiu
An efficient approach towards the first racemic total synthesis of dactyloidin (2) and demethyldactyloidin (3) is described.
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Synthesis of trifluoromethyl [gamma]-aminophosphonates by nucleophilic aziridine ring opening

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01411E, PaperT. Cytlak, M. Saweliew, M. Kubicki, H. Koroniak
The synthesis of phosphonated derivatives of trifluoromethyl aziridines by two methods and their application in ring opening reactions have been demonstrated.
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Synthesis of bicyclic tetrahydrofurans from linear precursors using manganese(III) acetate

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,9190-9193
DOI: 10.1039/C5OB01091H, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anne-Caroline Chany, Leo B. Marx, Jonathan W. Burton
Cyclisation of a range of alkoxy-malonates in the presence of manganese(III) acetate gives rise to bicyclic lactone/THFs and lactone/lactones in synthetically useful yields and diastereoselectivities.
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A computational study of the phosphoryl transfer reaction between ATP and Dha in aqueous solution

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01079A, PaperI. Bordes, J. J. Ruiz-Pernia, R. Castillo, V. Moliner
Phosphoryl transfer reactions are ubiquitous in biology. The reaction mechanism of the phosphorylation of dihydroxyacetone by ATP in aqueous solution has been studied by means of QM/MM simulations in the present paper.
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A novel protocol for the facile construction of tetrahydroquinoline fused tricyclic frameworks via an intramolecular 1,3-dipolar nitrile oxide cycloaddition reaction

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01060H, PaperManickam Bakthadoss, Varathan Vinayagam
An efficient method towards the synthesis of quinoline fused tricyclic compounds involving an intramolecular 1,3-dipolar nitrile oxide cycloaddition reaction utilizing Baylis-Hillman derivatives in good yields has been described for the first time.
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Activation of aqueous hydrogen peroxide for non-catalyzed dihydroperoxidation of ketones by azeotropic removal of water

Org. and Biomol. Chem. - 27 August, 2015 - 12:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01503K, CommunicationK. Starkl Renar, S. Pecar, J. Iskra
Cyclic and acyclic ketones were selectively converted to gem-dihydroperoxides in 72-99% yield with 30% aq. hydrogen peroxide by azeotropic distillation of water from the reaction mixture without any catalyst.
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