Feed aggregator

Rhodium-catalysed arylative annulation of 1,4-enynes with arylboronic acids

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02210F, CommunicationTakanori Matsuda, Shoichi Watanuki
The rhodium(I)-catalysed arylative annulation of 1,4-enynes with arylboronic acids was investigated. The reaction was found to proceed via an addition-1,4-rhodium migration-addition sequence, affording the corresponding 1,1-disubstituted 3-(arylmethylene)indanes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Gold-Catalyzed Spiro-N,O-Ketal Synthesis

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02050B, PaperVasiliki Sarli, Margarita Grammatikopoulou, Savvas Thysiadis
An efficient method for the synthesis of spiro-N,O-ketals with 5- and 6-membered rings was developed via a gold-catalyzed spiroamidoketalization of alkynyl amidoalcohols under mild conditions. This methodology has been successfully...
The content of this RSS Feed (c) The Royal Society of Chemistry

Preparation of polydopamine nanocapsules in miscible tetrahydrofuran/buffer mixture

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02080D, CommunicationYunzhou Ni, Wenfeng Jiang, Gangsheng Tong, Jianxin Chen, Jie Wang, Huimei Li, Chunyang Yu, Xiaohua Huang, Yongfeng Zhou
A miscible tetrahydrofuran/ tris buffer mixture has been used to fabricate polydopamine hollow capsules with a size of 200 nm and with a shell thickness of 40 nm. An unusual...
The content of this RSS Feed (c) The Royal Society of Chemistry

Direct oxidative coupling of thiols and benzylic ethers via C(sp3)-H activation and C-O cleavage to lead thioesters

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02250E, CommunicationJie Feng, Meifang Lv, Guoping Lu, Chun Cai
An unprecedented C-S formation method via the direct oxidative C(sp3)-H bond functionalization and C-O cleavage of benzylic ethers was developed. Various thioesters including thioester structure containing drug intermediate could be...
The content of this RSS Feed (c) The Royal Society of Chemistry

Ruthenium-Catalyzed Direct C3 Alkylation of Indoles with [small alpha],[small beta]-Unsaturated Ketones

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02124J, PaperLin Dong, Shuai-Shuai Li, Hui Lin, Xiao-Mei Zhang
In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various [small alpha],[small beta]-unsaturated ketones via C-H activation has been developed. This novel methodology exhibits broad substrate...
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-Catalyzed Oxidative Cross-Coupling of Azole-4-carboxylates with Indoles: An approach to the Synthesis of Pimprinine

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01844C, PaperHequan Yao, Haipin Zhou, Kuo Gai, Jinyi Xu, Xiaoming Wu, Aijun Lin
An efficient and straightforward method for the construction of 5-(3-indolyl)-azoles incorporating the privileged structures indoles and azoles via palladium-catalyzed double C-H bond cleavage under mild conditions was disclosed. As expected,...
The content of this RSS Feed (c) The Royal Society of Chemistry

Label-free fluorescence detection of kinase activity using a gold nanoparticle based indicator displacement assay

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02052A, PaperCristian Pezzato, Davide Zaramella, Massimiliano Martinelli, Gregory Pieters, Mario A Pagano, Leonard Jan Prins
A straightforward indicator-displacement assay (IDA) has been developed for the quantitative analysis of ATP[rightward arrow]ADP conversion. The IDA relies on the use of gold nanoparticles passivated with a monolayer of thiols...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and Biological Evaluation of Novel Pyrano[3,2-c]carbazole Derivatives as Anti-tumor Agents inducing apoptosis via tubulin polymerization inhibition

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02015D, Paperadisherla indrasena, pannala padmaja reddy, garikapati koteswara rao rao, basireddy subba reddy, nibedita patil, Anver Basha Shaik, narayana reddy, Dubey P.K, manika pal bhadra
A series of novel pyrano[3,2-c]carbazole derivatives have been synthesized in a simple one-pot, three component reaction of aromatic aldehydes, malononitrile/ethylcyanoacetate and 4-hydroxycarbazoles catalyzed by triethylamine. The antiproliferative activity of the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Tunneling in Tocopherol-Mediated Peroxidation of 7-Dehydrocholesterol

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02377C, PaperHubert Muchalski, Libin Xu, N A Porter
The peroxidation of 7-dehydrocholesterol (7-DHC), a biosynthetic precursor to vitamin D3 and cholesterol, has been linked to the pathophysiology of Smith-Lemli-Optiz syndrome (SLOS), a devastating human disorder. In SLOS, 7-DHC...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 3,3-dichloroindolin-2-ones from Isatin-3-hydrazones and (Dichloroiodo)benzene

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02213K, CommunicationGraham Murphy, Keith E Coffey, Ryan Moreira, Farhana Z Abbas
Aryl- and N-substituted isatins were converted to isa-tin-3-hydrazones and subjected to a dichlorination re-action with PhICl2. Lewis base-catalysis was key to the reaction occurring rapidly and chemoselectively, providing 3,3-dichloroindolin-2-ones in...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of Isoxazolidine-containing Uridine Derivatives as Caprazamycin Analogues

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02142H, PaperMayumi Yamaguchi, Akira Matsuda, Satoshi Ichikawa
Simplification of caprazamycins, which are promising antibacterial nucleoside natural products, was conducted by scaffold-hopping of the structurally complex diazepanone moiety to the isoxazolidine scaffold. The designed isoxazolidine-containing uridine derivatives were...
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of benzoindolizidine derivatives using chiral phase-transfer catalytic intramolecular domino aza-Michael addition/ alkylation

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02227K, PaperJiajia Guo, Shouyun Yu
An efficient and enantioselective strategy to synthesize benzoindolizidines from [small alpha], [small beta]-unsaturated amino ketones via domino intramolecular aza-Michael addition/alkylation was developed. These reactions were enabled by cinchona alkaloid-derived quaternary ammonium salts...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of new unnatural N[small alpha]-Fmoc pyrimidin-4-one amino acids: use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group

Org. and Biomol. Chem. - 21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02235A, PaperAbdellatif ElMarrouni, Montserrat Heras
The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A thermodynamic insight into the recognition of hydrophilic and hydrophobic amino acids in pure water by aza-scorpiand type receptors

Org. and Biomol. Chem. - 21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02092H, PaperSalvador Blasco, Begona Verdejo, Carla Bazzicalupi, Antonio Bianchi, Claudia Giorgi, Concepcion Soriano, Enrique Garcia-Espana
Thermodynamic studies about the interaction of scorpiand aza-macrocycles with amino acids in water show entropy driven stabilisations often associated with solvation/desolvation processes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products

Org. and Biomol. Chem. - 21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02143F, PerspectiveK. Kashinath, D. Srinivasa Reddy
Multiple reactions in one pot has always been a useful technique for synthetic organic chemists, as it can minimizes solvent usage, time and the number of purification steps when compared to individual multi-step syntheses.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Carbocycles from Donor-Acceptor Cyclopropanes

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02117G, Review ArticleHuck K. Grover, Michael R. Emmett, Michael A Kerr
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions both inter- and intramolecularly mediated...
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper(I) Promoted Cycloalkylation-Peroxidation of Unactivated Alkenes via sp3 C-H Functionalisation

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01962H, CommunicationBhisma K Patel, Arghya Banerjee, Sourav Santra, Aniket Mishra, Nilufa Khatun
A copper (I) promoted cycloalkylation-peroxidation strategy has been developed via a three-component reaction involving cycloalkanes, tert-butyl hydroperoxide (TBHP) and internal conjugated alkene possessing electron-withdrawing groups (EWGs). This process installs C-O...
The content of this RSS Feed (c) The Royal Society of Chemistry

Efficient Synthesis of [small alpha]- and [small delta]-Carbolines by Sequential Pd-Catalyzed Site-Selective C-C and Twofold C-N Coupling Reactions

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02226B, PaperTran Quang Hung, Tuan T Dang, Julia Janke, Alexander Villinger, Peter Langer
Two concise and efficient approaches were developed for the synthesis of [small alpha]- and [small delta]-carboline derivatives. The success of the synthesis relies on site-selective Suzuki-Miyaura reaction of 1-chloro-2-bromopyridine or 2,3-dibromopyridine with...
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalyst-free synthesis of 2 aryl 1,2 dihydro-quinazolin-4(1H)-thiones from 2 aminobenzothio-amides and aldehydes in water

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02207F, PaperXiao-Feng Wu, Stefan Oschatz, Tom Brunzel, Peter Langer
2-Dihydroquinazolin-4(1H)-thiones were prepared in up to excellent yields from 2-aminobenzothioamides and aldehydes. The reaction is carried out in water without the use of any catalyst or promoter. The sulfur-containing substrate...
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium Catalyzed unactivated [small beta]-methylene C(sp3)-H Bond Alkenylation of Aliphatic Amides and Application in A sequential C(sp3)-H/C(sp2)-H Bond Alkenylation

Org. and Biomol. Chem. - 21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02389G, Communicationyu rao, gang shan, guiyi huang
A palladium(II) catalyzed [small beta]-methylene C(sp3)-H bond alkenylation of acyclic aliphatic amides with alkenyl halides has been developed. Both (E)-olefin and (Z)-olefin can be readily accessed by this method and a...
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.