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Cycloreversion of [small beta]-Lactams via Photoinduced Electron Transfer

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01416B, PaperRaul Perez-Ruiz, Jose Antonio Saez, M. Consuelo Jimenez, Miguel Miranda
The radical anions of [small beta]-lactams, photogenerated in the presence of DABCO as electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to...
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Asymmetric total synthesis of Paecilomycin E, 10´-epi-Paecilomycin E and 6´-epi-Cochliomycin C

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01400F, PaperSamik Nanda, Nandan Jana, Pratik Pal
Asymmetric total synthesis of naturally occurring Resorcylic acid lactone paecilomycin E and two of its structural congeners have been reported in this article. The major highlight of the synthetic venture...
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The Importance of Chain Conformational Mobility During 5-Exo-Cyclizations of C-, N- and O-Centred Radicals

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01419G, PaperJ C Walton
The reaction coordinates of an archetypical set of 5-exo cyclizations of C-, N- and O-centred radicals were investigated by computational methods. G4 theory, and DFT with the um062x functional, were...
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Synthesis and SARs of Indole-based [small alpha]-Amino Acids as Potent HIV-1 Non-Nucleoside Reversed Transcriptase Inhibitors

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01333F, PaperHaibing Zhou, Xin Han, Haoming Wu, Shu Wen Wu, wei wang, Chune Dong, Po Tien
Series of non-nucleoside reverse transcriptase inhibitors derived from indole-based [small alpha]-amino acids were designed and synthesized. Their inhibitory activities have been detected by a TZM-bl cell assay on HIV virus type...
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Subtle Mitsunobu couplings in super-heating: The role of high-throughput continuous flow and microwave strategies

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01432D, Review ArticleAtul Manvar, Anamik shah
Non-conventional heating techniques, high-throughput microwave-assisted synthesis and continuous flow penetrate almost every scientific field. Mitsunobu coupling is a ubiquitous choice for the dehydrative redox condensation of primary or secondary alcohols...
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Regiodivergent and short total synthesis of calothrixins

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01309C, PaperDipak Ranjan Mal, Joyeeta Roy, Kumar Biradha
The anionic annulation of MOM-protected furoindolone with 4-bromoquinoline followed by deprotection of the N-MOM group provides calothrixin B, whereas that with 3-bromoquinoline yields isocalothrixin B. The outcomes are explained by...
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Development of Chemosensor for Sr2+ using Organic Nanoparticles: Application of Sensor in Product Analysis for Oral Care

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01234H, PaperSimanpreet Kaur, Amanpreet Kaur, Narinder Singh, Navneet Kaur
A new series of compounds has been developed for recognition of metal ions and it is found that the position of substituent in the organic compound proved to be the...
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Synthesis and spectroscopic properties of novel meso-cyano boron-pyridyl-isoindoline dyes

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01077A, PaperHui Liu, Hua Lu, Fan Wu, Zhifang Li, Nagao Kobayashi, Zhen Shen
Meso-cyano boron-pyridyl-isoindoline dyes with asymmetrical structures have been synthesized through a facile two-step reaction. Broad envelopes of intense vibrational bands are observed for the main spectral bands in the absorption...
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Stereoselective Intermolecular [2 + 2]-Photocycloaddition Reactions of Maleic Anhydride: Stereocontrolled and Regiocontrolled Access to 1,2,3-Trifunctionalized Cyclobutanes

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01383B, PaperFlorian HERNVANN, Gloria RASORE, Valerie DECLERCK, David J Aitken
Short synthetic sequences commencing with the photosensitized [2 + 2] cycloaddition reactions of maleic anhydride with either allyl alcohol or propargyl alcohol have been elaborated to provide access to 1,2,3-trisubstituted...
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Coumarin-Pterocarpan Conjugate- A Natural Product Inspired Hybrid Molecular Probe for DNA Recognition

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01360C, PaperShital K Chattopadhyay, Indranil Kundu, Ratnava Maitra
Thermally induced cascade sigmatropic rearrangement of a butynyloxycoumarin derivative has led to a quick access of coumarin-pterocarpan hybrid molecule. Biophysical studies together with molecular modeling show that this nature-inspired hybrid...
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Surface patterning with natural and synthetic polymers via an inverse electron demand Diels-Alder reaction employing microcontact chemistry

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01379D, PaperOliver Roling, Artur Mardyukov, Sebastian Lamping, Benjamin Vonhoren, Stefan Rinnen, Heinrich F. Arlinghaus, Armido Studer, Bart Jan Ravoo
Bioorthogonal ligation methods are the focus of current research due to their versatile applications in biotechnology and materials science for post-functionalization and immobilization of biomolecules.
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The effects of CO2 pressure and pH on the Suzuki coupling of basic nitrogen containing substrates

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01630K, PaperC. Senter, A. Rumple, W. Medina-Ramos, D. Houle, Z. Cheng, C. Gelbaum, J. Fisk, B. Holden, P. Pollet, C. A. Eckert, Charles L. Liotta
The Suzuki coupling reaction of basic nitrogen containing substrates (2-bromo- and 2-chloro-4-aminopyridine, and 2-bromo and 2-chloropyridine) with phenylboronic acid using Pd(TPP)2Cl2/K3PO4 in acetonitrile-water biphasic solvent systems under a CO2 or a N2 atmosphere is discussed.
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Fast redox-triggered shuttling motions in a copper rotaxane based on a phenanthroline-terpyridine conjugate

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01206B, PaperEugenio Coronado, Pablo Gavina, Julia Ponce, Sergio Tatay
Fast shuttling motions in solution have been observed for a Cu-complexed [2] rotaxane, whose thread contains a bidentate 1,10-phenanthroline chelating unit directly connected through its 3-position to the 5-position of a tridentate 2,2[prime or minute]:6[prime or minute],2[prime or minute][prime or minute]-terpyridine.
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Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01611D, PaperKah-Yee Li, Jianbing Jiang, Martin D. Witte, Wouter W. Kallemeijn, Wilma E. Donker-Koopman, Rolf G. Boot, Johannes M. F. G. Aerts, Jeroen D. C. Codee, Gijsbert A. van der Marel, Herman S. Overkleeft
Of six cyclophellitol analogues, the N-pentylaziridine is the most effective retaining human beta-glucosidase inhibitor considering potency and compound stability.
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Theoretical insight into the antioxidant properties of melatonin and derivatives

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01396D, PaperJeffrey R. Johns, James A. Platts
Density functional theory calculations on melatonin, metabolites and synthetic derivatives thereof, and a range of other biological antioxidant molecules are presented, with a view to understanding the antioxidant ability of these molecules.
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The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01604A, CommunicationBit Lee, Halesha D. Basavarajappa, Rania S. Sulaiman, Xiang Fei, Seung-Yong Seo, Timothy W. Corson
The homoisoflavanone cremastranone is synthesized for the first time and shown to block human retinal endothelial cell angiogenesis in vitro.
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Correction: Identification and optimization of short helical peptides with novel reactive functionality as catalysts for acyl transfer by reactive tagging

Org. and Biomol. Chem. - 28 August, 2014 - 20:17
Org. Biomol. Chem., 2014, 12,7410-7410
DOI: 10.1039/C4OB90119C, CorrectionSilvia Bezer, Masaomi Matsumoto, Michael W. Lodewyk, Stephen J. Lee, Dean J. Tantillo, Michel R. Gagne, Marcey L. Waters
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Iron-catalyzed direct difunctionalization of alkenes with dioxygen and sulfinic acids: a highly efficient and green approach to [small beta]-ketosulfones

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01369G, CommunicationWei Wei, Jiangwei Wen, Daoshan Yang, Min Wu, Jinmao You, Hua Wang
A novel and efficient iron-catalyzed direct difunctionalization of alkenes with sulfinic acids and dioxygen for the synthesis of [small beta]-ketosulfones has been developed.
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Enantioselective copper catalysed C-H insertion reaction of 2-sulfonyl-2-diazoacetamides to form [gamma]-lactams

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01430H, PaperLeslie Ann Clarke, Aoife Ring, Alan Ford, Abhijeet S. Sinha, Simon E. Lawrence, Anita R. Maguire
The first enantioselective copper catalysed intramolecular C-H insertion reactions of 2-sulfonyl-2-diazoacetamides is reported.
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Nitroxide-labeled pyrimidines for non-covalent spin-labeling of abasic sites in DNA and RNA duplexes

Org. and Biomol. Chem. - 28 August, 2014 - 20:17

Org. Biomol. Chem., 2014, 12,7366-7374
DOI: 10.1039/C4OB01095G, PaperSandip A. Shelke, Gunnar B. Sandholt, Snorri Th. Sigurdsson
Of ten new pyrimidine-derived nitroxide spin labels, an N1-ethylamino triazole-linked uracil derivative binds fully to both DNA and RNA duplexes containing an abasic site, as determined by CW-EPR.
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