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Synthesis of New Asymmetric Xanthene Dyes via Catalyst-free SNAr with Sulfur Nucleophiles

Org. and Biomol. Chem. - 23 April, 2014 - 12:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00533C, CommunicationMichaela Kotaskova, Okan Osman Oglou, Mark Helm
Addition of a single functional handle to the tricyclic moiety of fluorescein results in asymmetric xanthene dyes. Our synthesis of a new class of asymmetric xanthenes proceeds via an unusual...
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An easy route to synthetic Analogues of Radicamine B, Codonopsine and Codonopsinine from D-Mannitol

Org. and Biomol. Chem. - 23 April, 2014 - 12:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00503A, PaperYashwant D Vankar, Suresh Dharuman, Ashok Kumar Palanivel
A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine...
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Practically convenient and industrially-aligned methods for iridium-catalysed hydrogen isotope exchange processes

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00465E, PaperA. R. Cochrane, C. Idziak, W. J. Kerr, B. Mondal, L. C. Paterson, T. Tuttle, S. Andersson, G. N. Nilsson
The use of alternative solvents in the iridium-catalysed hydrogen isotope exchange reaction with developing phosphine/NHC Ir(I) complexes has identified reaction media which are more widely applicable than the commonly employed chlorinated solvent, dichloromethane.
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Cyclodextrin ion channels

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00480A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonathan K. W. Chui, T. M. Fyles
Cyclodextrin ion channels, assembled by click chemistry, exhibit mechanistically diverse behaviors including transient blockage by hydrophobic guests.
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Studies on the stereochemical assignment of 3-acylidene 2-oxindoles

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, 12,3201-3210
DOI: 10.1039/C4OB00496E, PaperSteven J. Edeson, Julong Jiang, Stephen Swanson, Panayiotis A. Procopiou, Harry Adams, Anthony J. H. M. Meijer, Joseph P. A. Harrity
UV-Vis spectroscopy offers a convenient and reliable method for alkene stereochemical assignment of 3-acylidene 2-oxindoles.
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Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, 12,3211-3221
DOI: 10.1039/C4OB00411F, PaperFrank D. King, Abil Aliev, Stephen Caddick, Derek Tocher
N-Cinnamoyl-9-aminoanthracenes cyclise with PPA or triflic acid to form novel 2-azahexacyclo[10.6.6.01,5.06,11.013,18.019,24]tetracosa-6(11),7,9,13,15,17,19(24),20,22-nonaen-3-ones.
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The nature of persistent conformational chirality, racemization mechanisms, and predictions in diarylether heptanoid cyclophane natural products

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, 12,3303-3309
DOI: 10.1039/C3OB42550A, PaperOmmidala Pattawong, M. Quamar Salih, Nicholas T. Rosson, Christopher M. Beaudry, Paul Ha-Yeon Cheong
Restricted rotations of chemical bonds can lead to the presence of persistent conformational chirality in molecules lacking stereocenters.
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Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, 12,3271-3281
DOI: 10.1039/C4OB00176A, PaperSimon J. Mountford, Mengjie Liu, Lei Zhang, Marleen Groenen, Herbert Herzog, Nicholas D. Holliday, Philip E. Thompson
The potent Y1 receptor antagonist, 1229U91 has an unusual cyclic dimer structure. We have developed three new routes to the synthesis of analogues. Such variants, including fluorescent conjugates, show potent Y1 antagonism.
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Fluorescent push-pull pH-responsive probes for ratiometric detection of intracellular pH

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00147H, PaperMartin Ipuy, Cyrielle Billon, Guillaume Micouin, Jacques Samarut, Chantal Andraud, Yann Bretonniere
Fluorophores displaying a sensitive response to pH are reported. Structural variations allow fine tuning of pKa and ratiometric intracellular pH imaging.
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Silyl alkynylphosphine-boranes: key precursors of triazolylphosphines via tandem desilylation-Click chemistry

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00397G, PaperRomain Veillard, Elise Bernoud, Ibrahim Abdellah, Jean-Francois Lohier, Carole Alayrac, Annie-Claude Gaumont
A versatile synthesis of P-stereogenic 1,2,3-triazolyl-4-phosphines from the borane complexes of phosphino-alkynes has been developed.
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Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00155A, PaperYaping Zhao, Lu Sun, Tieqiang Zeng, Jiayi Wang, Yanqing Peng, Gonghua Song
Copper-catalyzed direct olefination of benzaldehydes into unsymmetrical 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp3-H activation sequence using simpler substrates like benzaldehydes.
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An enantioselective strategy for the total synthesis of (S)-tylophorine via catalytic asymmetric allylation and a one-pot DMAP-promoted isocyanate formation/Lewis acid catalyzed cyclization sequence

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00200H, PaperBo Su, Hui Zhang, Meng Deng, Qingmin Wang
A novel total synthesis of (S)-tylophorine is reported, featuring asymmetric allylation and cascade isocyanate formation and cyclization.
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Diastereoselective formation of aziridines from diazocarbonyl compounds and N-(O-pivaloylated D-galactosyl)benzylideneamines and ring-opening reactions with p-toluenethiol

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00443D, CommunicationYizhou Zhao, Gang Wang, Shanshan Zhou, Zhongjun Li, Xiangbao Meng
N-Galactosyl aziridines were synthesized, and the ring-opening reactions provided enantiometrically pure [small beta]-S-substituted phenylalanine derivatives with high regioselectivity.
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Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00384E, PaperBao-Quan Liu, Wen-Jing Yi, Ji Zhang, Qiang Liu, Yan-Hong Liu, Sheng-Di Fan, Xiao-Qi Yu
Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.
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Carbohydrate-based first stereoselective total synthesis of bioactive cytospolide P

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00323C, CommunicationPathi Suman, Bhimapaka China Raju
A facile stereoselective approach has been developed for the total synthesis of cytospolide P via Yamaguchi macrolactonization.
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A simple structural hydrazide-based gelator as a fluoride ion colorimetric sensor

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00056K, PaperBinglian Bai, Jie Ma, Jue Wei, Jianxi Song, Haitao Wang, Min Li
The C8 organogel could show reversible gel-sol transition and color changes by the use of F- stimuli and proton control.
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Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00598H, PaperRomulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Ines M. C. Brighente, Antonio Luiz Braga
We report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
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Self-assembly of peptides to nanostructures

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00447G, Review ArticleDindyal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang
The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry.
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Benzo[a]acridinylmethyl esters as pH sensitive fluorescent photoactive precursors: synthesis, photophysical, photochemical and biological applications

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42600A, PaperMohammed Ikbal, Biswajit Saha, Shrabani Barman, Sanghamitra Atta, Deb Ranjan Banerjee, Sudip Kumar Ghosh, N. D. Pradeep Singh
(Benzo[a]acridin-12-yl)methyl (BAM) chromophore has been shown to perform dual functions as a "pH sensitive fluorescent probe" and a "phototrigger" for acids.
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Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

Org. and Biomol. Chem. - 23 April, 2014 - 12:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42186D, PaperHai-Xia Jiang, Dao-Min Zhuang, Ying Huang, Xing-Xin Cao, Jian-Hua Yao, Jing-Yun Li, Jian-Yong Wang, Chen Zhang, Biao Jiang
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
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