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A triple A-side meta single

Sciencebase - 4 July, 2015 - 10:24
Obviously, a good old-fashioned circular slice of polyvinyl chloride, PVC, or just vinyl to audiophiles, is a disc, two sides, A and B, sometimes labelled A and A…but what if you want three sides? Is it possible to have a hyper-disk with an extra groovy surface? In reality, maybe not. In virtuality… Life, Love and […]

A triple A-side meta single is a post from the science blog of science journalist, photographer and musician David Bradley
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Categories: Science Blogs

Copper-Catalyzed Trifluoromethylation of Alkenes: Synthesis of Trifluoromethylated Benzoxazines

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01196E, Communicationsadhan jana, Athira Ashokan, Shailesh Kumar, Ajay Verma, Sangit Kumar
A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through...
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Oligoethylene glycol-substituted aza-BODIPY dyes as red emitting ER-probes

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01104C, PaperAnyanee Kamkaew, Sopida Thavornpradit, Thamon Puangsamlee, Dongyue Xin, Nantanit Wanichacheva, Kevin Burgess
This study features aza-BODIPY (BF2-chelated azadipyrromethene) dyes with two aromatic substituents linked by oligoethylene glycol fragments to increase hydrophilicity of aza-BODIPY for applications in intracellular imaging.
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Mechanistic insight into conjugated N-N bond cleavage by Rh(III)-catalyzed redox-neutral C-H activation of pyrazolones

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00977D, PaperWeirong Wu, Yuxia Liu, Siwei Bi
DFT calculations are performed to understand the conjugated N-N bond cleavage by Rh(III)-catalyzed redox-neutral C-H activation of pyrazolones with PhC[triple bond, length as m-dash]CPh.
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Synthesis of a new class of iminosugars based on constrained azaspirocyclic scaffolds by way of catalytic C-H amination

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01254F, CommunicationPierre-Antoine Nocquet, Raphael Hensienne, Joanna Wencel-Delord, Eric Wimmer, Damien Hazelard, Philippe Compain
The synthesis of the first examples of a new class of iminosugars based on constrained spirocyclic scaffolds has been achieved via Rh-catalyzed C(sp3)-H amination. In this process, the needed electronic...
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A Theoretical Investigation of Substituent Effects on the Stability and Reactivity of N-Heterocyclic Olefin Carboxylates

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01021G, PaperLiang Dong, Jun Wen, Weiyi Li
A theoretical study of substituent effects on the stability and reactivity of novel synthesized N-heterocyclic olefin (NHO) carboxylates has been performed using a combination of density functional theory (DFT) calculations,...
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A ratiometric fluorescent probe for rapid, sensitive and selective detection of sulfur dioxide with large Stokes shifts by single wavelength excitation

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00765H, PaperXiangzhi Song, Xingjiang Liu, Qinwei Yang, Wenqiang Chen, Lingna Mo, Jiang Kang, Song Chen
4-(Benzothiazol-2-yl)-3-hydroxybenzaldehyde, Probe 1, has been developed as a ratiometric fluorescent probe for the sensitive and selective detection of sulfur dioxide with a fast response time (within seconds). This probe itself...
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Formation and Aromatization of Strained Bicyclic Pyrazolidines via Tandem Reaction of Alkyl 2-Aroyl-1-chlorocyclopropanecarboxylates with Acylhydrazones

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01199J, PaperYuefa gong, Zhimei Huang, Junhao Hu
A base-promoted reaction between alkyl 2-aroyl-1-chlorocyclopropanecarboxylates and acylhydrazones was described. In common solvents, the reaction proceed smoothly under mild conditions, providing mainly formal substitution product 3, as well as a...
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Efficient routes towards a series of 5,5'-bithiazolidinylidenes as [capital Pi]-electron acceptors

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01169H, PaperDominique Lorcy, Nathalie Bellec, Yann Le Gal, Antoine Vacher, Thierry Roisnel, Vincent DORCET, olivier Jeannin, Dorine Ameline
Different approaches have been studied in order to prepare efficiently the sulfur rich electron acceptor, DEBTTT. Among the various routes used, the one going through the synthesis of a bicyclic...
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Cu(OAc)2-Promoted Reaction [60]Fullerene with Primary Amines or Diamines

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01048A, CommunicationXin-Wei Lu, Meng-Lei Xing, Chun-Bao Miao, Jiaxing Li, Xiao-Qiang Sun, Hai-Tao Yang
The Cu(OAc)2-promoted reaction of C60 with easily available primary amines allows the concise preparation of aziridinofullerenes. Both alky and aryl amines are suitable in this reaction. Moreover, the Cu(OAc)2-promoted reaction...
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Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00465A, PaperTheodore J. Hester, Sarah R. Dennison, Matthew J. Baker, Timothy J. Snape
A light-responsive azobenzene derivative provides a membrane-interactive compound with the potential for photodynamic therapy applications.
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One-shot access to [small alpha],[small beta]-difunctionalized azepenes and dehydropiperidines by reductive cross-coupling of [small alpha]-selenonyl-[small beta]-selenyl enamides with organic bromides

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01003A, CommunicationTimothy K. Beng, Ann Wens V. Silaire, Amir Alwali, Daniel P. Bassler
A high-yielding synthesis of vicinally functionalized azepenes and dehydropiperidines has been achieved through cobalt-catalyzed reductive cross-coupling of novel [small alpha]-selenonyl-[small beta]-selenyl enamides with cheap organic bromides.
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Correction: Synthesis of 2-deoxy-2,2-difluoro-[small alpha]-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90111A, CorrectionOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Sandeep Thanna, Jared J. Lindenberger, Vishwanath V. Gaitonde, Donald R. Ronning, Steven J. Sucheck
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Influence of receptor flexibility on intramolecular H-bonding interactions

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00805K, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hongmei Sun, Kai Guo, Haifeng Gan, Xin Li, Christopher A. Hunter
Atropisomers of a series of zinc tetraphenyl porphyrins were synthesized and used as supramolecular receptors.
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Screening of Quinoline, 1,3-Benzoxazine, and 1,3-Oxazine-based Small Molecules Against Isolated Methionyl-tRNA Synthetase and A549 and HCT116 Cancer Cells Including an In Silico Binding Mode Analysis

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00791G, PaperBharath Kumar, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Tae-Hee Kang, Keerthy Hosadurga Kumar, Julian Fuchs, Kwon Nam Hoon, Andreas Bender, Sunghoon Kim, Salundi Basappa, Kanchugarakoppal S Rangappa
Elevated activity of methionyl-tRNA synthetase (MRS) in many cancers renders it a possible drug target in this disease area, as well as in a series of parasitic diseases. In the...
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The first proton sponge-based amino acids: synthesis, acid-base properties and some reactivity

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01065A, PaperValery A. Ozeryanskii, Anastasia Yu. Gorbacheva, Alexander F. Pozharskii, Marina P. Vlasenko, Alexander Yu. Tereznikov, Margarita Sergeevna Chernov'yants
The first hybrid base constructed of 1,8-bis(dimethylamino)naphthalene (proton sponge or DMAN) and glycine, N-methyl-N-(8-dimethylamino-1-naphthyl)aminoacetic acid, was synthesised in high yield and its hydrobromide was structurally characterised and used to determine...
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Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00563A, Review ArticleYari Cabezas, Laurent Legentil, Florence Robert-Gangneux, Franck Daligault, Sorya Belaz, Caroline Nugier-Chauvin, Sylvain Tranchimand, Charles Tellier, Jean-Pierre Gangneux, Vincent Ferrieres
The basic structure of membrane glycoconjugates in Leishmania still inspires therapeutic drugs fighting against this parasite.
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Pyrido[1,2-a]pyrimidinium ions - a novel bridgehead nitrogen heterocycles: synthesis, characterisation, and elucidation of DNA binding and cell imaging properties

Org. and Biomol. Chem. - 4 July, 2015 - 00:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01082A, PaperSusanta Kumar Manna, Arabinda Mandal, Suresh Kumar Mondal, Arup Kr Adak, Akash Jana, Somnath Das, Sourav Chattopadhyay, Somenath Roy, Shyamal Kr Ghorai, Shubhankar Samanta, Maidul Hossain, Mahiuddin Baidya
A novel class of bridgehead nitrogen heterocycles, pyrido[1,2-a]pyrimidinium ions, has been readily synthesized by a two-step one-pot reaction in high yields (up to 93%).
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Cyclic acetals as cleavable linkers for affinity capture

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01056J, PaperSiyeon Lee, Wei Wang, Younjoo Lee, Nicole Sampson
Labeling proteins with biotin is a widely used method to identify target proteins due to biotin's strong binding affinity for streptavidin. Combined with alkyne-azide cycloaddition, which enables the coupling of...
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Multicomponent Domino Reactions of Hydrazinecarbodithioates: A Concise Access to 3-Substituted 5-Thiol-1,3,4-Thiadiazolines

Org. and Biomol. Chem. - 4 July, 2015 - 00:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB01166C, CommunicationHuihui Jia, Huangdi Feng, Zhihua Sun
Two classes of addition/cycloaddition cascade reactions of hydrazinecarbodithioate (1) have been developed under mild reaction conditions. Reaction of hydrazinecarbodithioate (1) with formaldehyde solution (2) and propiolic acid (3) gives 3-propargyl-5-thiol-2,3-dihydro-1,3,4-thiadiazoles...
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