Feed aggregator

Regioselective Ruthenium catalysed H-D exchange using D2O as the deuterium source

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01798F, PaperSteve Nolan, Simone Manzini, Jose Fernandez-Salas, Lorenzo Piola
An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have...
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalyst-Free Reductive Amination of Aromatic Aldehydes with Ammonium Formate and Hantzsch Ester

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01590H, CommunicationPan-Pan Zhao, Xin-Feng Zhou, Jian-Jun Dai, Hua-Jian Xu
The protocol of the reductive amination of aromatic aldehydes using ammonium formate and Hantzsch Ester is described. It's a mild, convenient, acid- and catalyst-free system applied for the synthesis of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chemical and biological evaluation of unusual sugars, [small alpha]-aculosides, as novel Michael acceptors

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01877J, CommunicationHiromasa Ikeda, Erika Kaneko, Shunsuke Okuzawa, Daisuke Takahashi, Kazunobu Toshima
The unusual sugars [small alpha]-aculosides, which appear in certain antibiotics and have an [small alpha],[small beta]-unsaturated ketone structure, were found to be novel and selective Michael acceptors for the thiol function of cysteine...
The content of this RSS Feed (c) The Royal Society of Chemistry

A straightforward modification in the thrombin binding aptamer improving stability, affinity to thrombin and nuclease resistance

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01475H, CommunicationAldo Galeone, Veronica Esposito, maria scuotto, Antonella Capuozzo, Rita Santamaria, Michela Varra, Luciano Mayol, Antonella Virgilio
Degradation of nucleic acids in biological environments is a major drawback of the therapeutic use of aptamers. Among approaches used to circumvent this negative aspect, the introduction of 3'-3' inversion...
The content of this RSS Feed (c) The Royal Society of Chemistry

TBHP-promoted sequential carboxamidation and aromatisation of aryl isonitriles with formamides

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01850H, PaperJin-Tao Yu, Xiaomei Feng, Hui Zhu, Lei Wang, Yan Jiang, Jiang Cheng
The tert-butyl hydroperoxide (TBHP)-promoted sequential carboxamidation and aromatisation of isonitriles with formamides was developed. This procedure tolerates a series of functional groups, such as methyl, fluoro, chloro, acetyl, methoxy carbonyl...
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalytic enantioselective [small alpha]-amination of 5-substituted rhodanines: an efficient approach to chiral N,S-acetals

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01921K, CommunicationBaomin Wang, Huanrui Zhang, Longchen Cui, Ying Li, Jingping Qu, Yuming Song
We report a highly efficient approach to construct chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This [small alpha]-amination reaction has a broad...
The content of this RSS Feed (c) The Royal Society of Chemistry

The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors against pyruvate dehydrogenase multienzyme complex E1 from Escherichia coli

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01347F, Paperlingling feng, Junbo He, Haifeng He, Lulu Zhao, Lingfu Deng, Li Zhang, Lin Zhang, yanliang ren, Jian Wan, Hongwu He
Pyruvate dehydrogenase multienzyme complex E1 (PDHc E1) is a potential target enzyme for finding inhibitors to combat microbial disease. In this study, we designed and synthesized a series of novel...
The content of this RSS Feed (c) The Royal Society of Chemistry

Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-subsituted benzo[e]- or [f]isoindolones via Csp2-H functionalization

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01644K, PaperPratik A Ambasana, Dipak D Vachhani, Marzia Galli, Jeroen Jacobs, Luc Van Meervelt, Anamik shah, Erik V�lery Van der Eycken
The tuning of selective ring closure is a nontrivial challenge in synthetic organic chemistry. Herein we report a solvent switchable metal-free [4+2] cycloaddition approach via Csp2-H functionalization. The protocol is...
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalysts of oxidative protein folding inspired by protein disulphide isomerase

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01738B, CommunicationJohn C. Lukesh, Kristen A. Andersen, Kelly K. Wallin, Ronald T. Raines
Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state,...
The content of this RSS Feed (c) The Royal Society of Chemistry

Relative stability of benziporphyrin and naphthiporphyrin tautomers and the emergence of macrocyclic diatropicity

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01659A, PaperTimothy D Lash, Deyaa I AbuSalim
The conformations of a series of benziporphyrins, naphthiporphyrins, oxybenziporphyrins, and related structures were minimized using DFT-B3LYP/6-311++G(d,p). The relative stabilities of the tautomers for each series were also calculated using M06-2X...
The content of this RSS Feed (c) The Royal Society of Chemistry

Structures, chemotaxonomic significance, cytotoxic and Na+,K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01545B, PaperRong-Rong Zhang, Hai-Yan Tian, Ya-Fang Tan, Tse-Yu Chung, Xiao-Hui Sun, Xue Xia, Wen-Cai Ye, David Middleton, Natalya Fedosova, Mikael Esmann, Jason T.C. Tzen, Renwang Jiang
Five new cardenolide lactates (1-5) and one new dioxane double linked cardenolide glycoside (17) along with 15 known compounds (6-16 and 18-21) were isolated from the ornamental milkweed Asclepias curassavica....
The content of this RSS Feed (c) The Royal Society of Chemistry

2-Alkynylbenzaldoxime: A versatile building block for the generation of N-heterocycles

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01618A, Review ArticleLinman He, Guanyinsheng Qiu, Yueqiu Gao, Jie Wu
2-Alkynylbenzaldoxime as a versatile building block has been applied widely for the construction of N-heterocycles in organic synthesis. Since it could be easily transferred to isoquinoline N-oxide via intramolecular 6-endo...
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye

Org. and Biomol. Chem. - 20 September, 2014 - 01:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01299B, PaperAna M. Costero, Andrea Barba Bon, Salvador Gil, Ramon Martinez-Manez, Felix Sancenon
A novel colorimetric probe (P4) for the selective differential detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) was prepared. Probe P4 contains three reactive sites;...
The content of this RSS Feed (c) The Royal Society of Chemistry

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01669F, CommunicationTayo O. Olaleye, James A. Brannigan, Shirley M. Roberts, Robin J. Leatherbarrow, Anthony J. Wilkinson, Edward W. Tate
Peptidomimetic inhibitors of N-myristoyltransferase from malaria and leishmaniasis parasites have been designed with nanomolar potency, and reveal the first direct structural evidence for a ternary NMT/CoA/myristoyl peptide product complex.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

5-Nitroindole oligonucleotides with alkynyl side chains: universal base pairing, triple bond hydration and properties of pyrene "click" adducts

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01478B, PaperSachin A. Ingale, Peter Leonard, Haozhe Yang, Frank Seela
Universal base pairing of 5-nitroindole oligonucleotides with alkynyl and pyrene functionalized side chains was demonstrated.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01564A, PaperVenkatachalam Rajeshkumar, Selvaraj Chandrasekar, Govindasamy Sekar
A novel molecular I2-catalyzed synthesis of isatins through C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Base-promoted annulation of [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01858C, CommunicationHaitao He, Chaorong Qi, Yanglu Ou, Wenfang Xiong, Xiaohan Hu, Yanwei Ren, Huanfeng Jiang
A novel direct synthesis of pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones from [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate via a base-promoted cascade annulation has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Reversible deactivation radical polymerization mediated by cobalt complexes: recent progress and perspectives

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01427H, Review ArticleChi-How Peng, Tsung-Yao Yang, Yaguang Zhao, Xuefeng Fu
The current status and future perspective of cobalt mediated radical polymerization that showed efficient control of vinyl acetate and acrylate polymerization are described.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to [small beta]-ketosulfones

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00776J, PaperAtul K. Singh, Ruchi Chawla, Twinkle Keshari, Vinod K. Yadav, Lal Dhar S. Yadav
A direct and efficient one-pot synthetic route to [small beta]-ketosulfones via aerobic oxysulfonylation of alkenes using thiophenols at an ambient temperature is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes

Org. and Biomol. Chem. - 20 September, 2014 - 01:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01583E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Monica Dell'Acqua, Valentina Pirovano, Giorgio Confalonieri, Antonio Arcadi, Elisabetta Rossi, Giorgio Abbiati
A modular entry to 2-propargylbenzaldehydes and their use in [small mu ]W-promoted cascade reaction with ammonium acetate for the synthesis of 3-benzylisoquinolines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.