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A Concise Approach to Polysubstituted Oxazoles from N-Acyl-2-bromo Enamides via a Copper(I)/Amino Acid-catalyzed Intramolecular C-O Bond Formation

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00309H, PaperBingjie Liu, Yueteng Zhang, Gang Huang, Xinting Zhang, Pengfei Niu, Jie Wu, Wenquan Yu, Junbiao Chang
A straightforward and efficient copper(I)/amino acid-catalyzed intramolecular Ullmann-type C-O coupling reaction has been developed. This protocol affords a facile methodology for the synthesis of a series of novel 2,4,5-substituted oxazoles...
The content of this RSS Feed (c) The Royal Society of Chemistry

3,6-Substituted-1,2,4,5-Tetrazines: Tuning Reaction Rates for Staged Labeling Applications

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00280F, PaperDanzhu Wang, Weixuan Chen, Yueqin Zheng, Chaofeng Dai, Ke Wang, Bowen Ke, Binghe Wang
Cycloaddition reactions involving tetrazine have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate....
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Development and application of serine/threonine ligation for synthetic protein chemistry

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00392F, PerspectiveHan Liu, Xuechen Li
Chemical synthesis of proteins, especially those with post-translational modifications, has offered new opportunities to study protein structure-function relationship. During the past four years, we have developed the serine/threonine ligation (STL),...
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Rh(III)-Catalyzed Regioselective Hydroarylation of Alkynes via Directed C-H Functionalization of Pyridines

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00612G, CommunicationZhen-Chao Qian, Jun Zhou, Bo Li, Fang Hu, Bing-Feng Shi
Rh(III)-catalyzed C-3 selective alkenylation of pyridine derivatives via hydroarylation of alkynes has been developed. The reaction shows high regioselectivity, high yield and good functional group tolerance, providing a convenient strategy...
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An Intramolecular Cascade Cyclization of 2-Aryl Indoles: Efficient Methods for the Construction of 2,3-Functionalized Indolines and 3-Indolinones

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00511B, CommunicationAK Ghosh, Zhi-Hua Chen
Efficient intramolecular N/O-nucleophilic cyclization of 2-aryl indoles has been developed to afford the corresponding 2-aza-3-oxaindolines and 3-indolinones in 80-95% yield. The methods provided convenient access to fused imidazo[1,2-c]oxazolidinone, oxazolidine, or...
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Improved selectivity of an engineered multi-product terpene synthase

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00479E, PaperRyan Lauchli, Julia Pitzer, Rebekah Kitto, Karolina Kalbarczyk, Kersten Rabe
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication. Accepted manuscripts are published online shortly after acceptance. This version of the article will be replaced by the fully edited, formatted and proof read Advance Article as soon as this is available.
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Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000

Org. and Biomol. Chem. - 5 hours 18 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00236A, PaperRobert F. Anderson, Pooja Yadav, Deepa Patel, Johannes Reynisson, Smitha R. Tipparaju, Christopher P. Guise, Adam V. Patterson, William A. Denny, Andrej Maroz, Sujata S. Shinde, Michael P. Hay
One-electron bioreduction of SN30000, a triazine 1,4-dioxide anticancer drug, forms reactive aryl and carbon-centred radicals.
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Palladium-Catalyzed Three-Component Reaction of N-Tosylhydrazone, Norbornene and Aryl Halide

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00590B, CommunicationFangdong Hu, Ying Xia, Zhenxing Liu, chen ma, Yan Zhang, Jianbo Wang
A palladium-catalyzed three-component reaction of N-tosylhydrazone, norbornene and aryl halide has been demonstrated. In this reaction, an intermolecular Heck-type reaction occurrs, which is followed by alkyl palladium carbene migratory insertion...
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"One-Pot" Access to Dihydrofurans via Tandem Oxidative Difunctionalization and Ring Contraction of Aminopyrans

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00324A, PaperManjula Alla, Santosh Reddy Mandha, Jagadeesh Babu Nanubolu
An operationally simple and efficient protocol for the construction of dihydrofuran derivatives has been accomplished via a sequential addition of N-chlorosuccinimide and a base to 2-amino-4H-pyran derivatives in alcohol medium....
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Palladium Mediated Intramolecular Multiple C-X/C-H Cross Coupling & C-H Activation: Synthesis of Carbazole Alkaloids Calothrixin B & Murrayaquinone A

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00493K, Papersyam kumar U.K, A K Srinivasan, Shyamapada Banarjee
A straightforward palladium mediated synthesis of calothrixin B and murrayaquinone A are described. Regioselective palladium mediated intramolecular multiple C-X/C-H cross coupling reaction on N-(4-((2-bromophenyl)amino)-2,5-dimethoxybenzyl)-N-(2-iodophenyl)acetamide followed by CAN oxidation afforded calothrixin...
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Friedel-Crafts alkylation mechanism using aminoindanol derived thiourea catalyst

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00348A, PaperRaquel P. Herrera, David Roca-Lopez, Eugenia Marques-Lopez, Ana Alcaine, Pedro Merino
Computational calculations based on experimental results shed light on the mechanistic proposal made for the Friedel-Crafts alkylation reaction between indole and nitroalkenes catalysed by chiral aminoindanol-derived thiourea. In our hypothesis...
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Synthesis, Physicochemical Properties and Antimicrobial Activity of Mono-/Dinitroxyl Amides

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00302K, PaperMiroslav Kavala, Vlasta Brezova, Lubomir Svorc, Zuzana Vihonska, Petra Olejnikova, Jan Moncol, Jozef Kozisek, Peter Herich, Peter Szolcsanyi
A two comparative sets of mono-/dinitroxyl amides were designed and prepared. The novel TEMPO and/or PROXYL derivatives were fully characterised and their spin, redox and antimicrobial properties were determined. Cyclic...
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Proline N-oxides: Modulators of the 3D Conformation of Linear Peptides through "NO-turns"

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00433G, PaperThavendran Govender, Gert Kruger, Per I Arvidsson, Fernando Albericio, Glenn E.M. Maguire, Bahareh Honarparvar, Majid Darestani Farahani
Small peptides are essential mediators of numerous physiological processes. Consequently, there is a huge interest in the de-novo design of peptides with a predictable folding and related biological activity. In...
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Cyclodextrin Ion Channels

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00480A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jonathan Ka Wang Chui, T M Fyles
Seventeen derivatives of alpha- and beta-cyclodextrins were prepared from the cyclodextrin per-6-azide by "click" cyclization with terminal alkynes. Sixteen of these "half-channel" compounds showed significant activity as ion channels in...
The content of this RSS Feed (c) The Royal Society of Chemistry

Acetal initiated Prins bicyclization for the synthesis of furo[3,4-c]furan lignans and pyrano[3,4-c]pyran derivatives

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00305E, PaperVenkata Subba Reddy Basireddy, Ramana Reddy M, Sridhar Balasubramanian, Kiran Kumar Singarapu
An acetal initiated Prins bicyclization approach has been developed for the stereoselective synthesis of furo[3,4-c]furan lignan analogues. It also provides a direct access to produce a new series of pyrano[3,4-c]pyran...
The content of this RSS Feed (c) The Royal Society of Chemistry

The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00487F, CommunicationClaudua Stubinitzky, Tirayut Vilaivan, Hans-Achim Wagenknecht
Pyrrolidinyl PNA was immobilized on FexOy magnetic particles and was able to capture and thereby discriminate single base alterations in DNA counterstrands better than DNA. The selectivities of matched vs....
The content of this RSS Feed (c) The Royal Society of Chemistry

Chiral Derivatives of 1,2-Benzenedisulfonimide as efficient Bronsted acid catalysts in Strecker reaction.

Org. and Biomol. Chem. - 5 hours 18 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00552J, PaperStefano Dughera, Margherita Barbero, Silvano Cadamuro, Roberta Torregrossa
Two chiral derivatives of 1,2-benzenedisulfonimide, namely 4-methyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide and 4,5-dimethyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide have been easily synthetized in good overall yields (respectively 34% and 41%) by means of an eleven steps synthetic protocol from...
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Studies on the stereochemical assignment of 3-acylidene 2-oxindoles

Org. and Biomol. Chem. - 5 hours 18 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00496E, PaperSteven J. Edeson, Julong Jiang, Stephen Swanson, Panayiotis A. Procopiou, Harry Adams, Anthony J. H. M. Meijer, Joseph P. A. Harrity
UV-Vis spectroscopy offers a convenient and reliable method for alkene stereochemical assignment of 3-acylidene 2-oxindoles.
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Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes

Org. and Biomol. Chem. - 5 hours 18 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00411F, PaperFrank D. King, Abil Aliev, Stephen Caddick, Derek Tocher
N-Cinnamoyl-9-aminoanthracenes cyclise with PPA or triflic acid to form novel 2-azahexacyclo[10.6.6.01,5.06,11.013,18.019,24]tetracosa-6(11),7,9,13,15,17,19(24),20,22-nonaen-3-ones.
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The nature of persistent conformational chirality, racemization mechanisms, and predictions in diarylether heptanoid cyclophane natural products

Org. and Biomol. Chem. - 5 hours 18 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42550A, PaperOmmidala Pattawong, M. Quamar Salih, Nicholas T. Rosson, Christopher M. Beaudry, Paul Ha-Yeon Cheong
Restricted rotations of chemical bonds can lead to the presence of persistent conformational chirality in molecules lacking stereocenters.
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