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Peptidomimetic Inhibitors of N-Myristoyltransferase from Human Malaria and Leishmaniasis Parasites

Org. and Biomol. Chem. - 5 hours 2 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01669F, CommunicationTayo O Olaleye, James A Brannigan, Shirley M Roberts, Anthony J Wilkinson, Robin J Leatherbarrow, Edward William Tate
N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a...
The content of this RSS Feed (c) The Royal Society of Chemistry

Performance of DFT methods and origin of stereoselectivity in bipyridine N,N[prime or minute]-dioxide catalyzed allylation and propargylation reactions

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01719F, PaperDiana Sepulveda, Tongxiang Lu, Steven E. Wheeler
It is shown that many DFT methods correctly predict the stereoselectivity of bipyridine N,N[prime or minute]-dioxide catalyzed alkylation reactions despite predicting the incorrect low-lying transition state structures. A novel explanation of the origin of stereoselectivity in these reactions is also provided.
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Multi-channel colorimetric and fluorescent probes for differentiating between cysteine and glutathione/homocysteine

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01219D, PaperLun Song, Ti Jia, Wenjia Lu, Nengqin Jia, Weibing Zhang, Junhong Qian
Three fluorescent probes were rationally designed to discriminate between Cys and GSH/Hcy. Cys and GSH can be differentiated by the naked eye.
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Asymmetric synthesis of (3S,1[prime or minute]S)-3-(1-amino-2,2,2-trifluoroethyl)-1-(alkyl)-indolin-2-one derivatives by addition of (S)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine to 1-(alkyl)-indolin-2-ones

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01453G, CommunicationPing Qian, Chen Xie, Lingmin Wu, Haibo Mei, Vadim A. Soloshonok, Jianlin Han, Yi Pan
This paper for the first time presents the addition reactions between amide-derived nucleophiles and CF3-containing N-sulfinyl-imines, with synthetically useful diastereoselectivity and chemical yields.
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Oxidative damage of aromatic dipeptides by the environmental oxidants NO2[radical dot] and O3

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01577K, PaperL. F. Gamon, J. M. White, U. Wille
Irreversible oxidative damage at both aromatic side chains and dipeptide linkage occurs in aromatic N- and C-protected dipeptides upon exposure to the environmental pollutants NO2[radical dot] and O3.
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Anion effects to deliver enhanced iridium catalysts for hydrogen isotope exchange processes

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01570C, CommunicationAlan R. Kennedy, William J. Kerr, Rory Moir, Marc Reid
Enhanced catalyst efficiency and solvent applicability has been achieved for hydrogen isotope exchange processes with Ir(I) complexes possessing larger, more weakly coordinating counterions.
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Synthesis and photophysical properties of pyrene-based green fluorescent dyes: butterfly-shaped architectures

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01509F, CommunicationDevendar Goud Vanga, Mithun Santra, Ashok Keerthi, Suresh Valiyaveettil
A few pyrene-based fluorescent compounds were synthesized using Pd/Cu-catalyzed cross-coupling reaction.
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Catalytic asymmetric synthesis of the pentacyclic core of (-)-nakadomarin A via oxazolidine as an iminium cation equivalent

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01678E, CommunicationNobuya Tsuji, Michael Stadler, Naoya Kazumi, Tsubasa Inokuma, Yusuke Kobayashi, Yoshiji Takemoto
A catalytic asymmetric synthesis of the pentacyclic core of (-)-nakadomarin A was achieved.
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Investigation of desilylation in the recognition mechanism to fluoride by a 1,8-naphthalimide derivative

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01500B, PaperJeeun Woo, Gunwoo Kim, Kevanie Quintero, Michael P. Hanrahan, Hector Palencia, Haishi Cao
Desilylation based fluorescence sensor (AF-1) gives a dual signal for quantitative detection of F- in MeCN.
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Annulated and bridged tetrahydrofurans from alkenoxyl radical cyclization

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01266F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christine Schur, Harald Kelm, Thomas Gottwald, Arne Ludwig, Rainer Kneuer, Jens Hartung
4-Pentenoxyl radicals sharing two or more carbon atoms with a cycloalkane cyclize in a predictable manner stereoselectively and regioselectively to afford in solutions of bromotrichloromethane cycloalkyl-fused or -bridged 2-bromomethyltetrahydrofurans in up to 95% yield.
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Asymmetric total synthesis of paecilomycin E, 10[prime or minute]-epi-paecilomycin E and 6[prime or minute]-epi-cochliomycin C

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01400F, PaperPratik Pal, Nandan Jana, Samik Nanda
The asymmetric total syntheses of paecilomycin E and its stereoisomers have been disclosed by employing the late stage Mitsunobu macrolactonization reaction.
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Synthesis and SARs of indole-based [small alpha]-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01333F, PaperXin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu, Hai-Bing Zhou
Indole-based [small alpha]-amino acids as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 have been developed using a TZM-bl cell assay on HIV virus type HIV-1IIIB. A comprehensive SAR study of these indole [small alpha]-amino acids was also presented.
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The effects of CO2 pressure and pH on the Suzuki coupling of basic nitrogen containing substrates

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7598-7602
DOI: 10.1039/C4OB01630K, PaperC. Senter, A. Rumple, W. Medina-Ramos, D. Houle, Z. Cheng, C. Gelbaum, J. Fisk, B. Holden, P. Pollet, C. A. Eckert, Charles L. Liotta
The Suzuki coupling reaction of basic nitrogen containing substrates (2-bromo- and 2-chloro-4-aminopyridine, and 2-bromo and 2-chloropyridine) with phenylboronic acid using Pd(TPP)2Cl2/K3PO4 in acetonitrile-water biphasic solvent systems under a CO2 or a N2 atmosphere is discussed.
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Fast redox-triggered shuttling motions in a copper rotaxane based on a phenanthroline-terpyridine conjugate

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7572-7580
DOI: 10.1039/C4OB01206B, PaperEugenio Coronado, Pablo Gavina, Julia Ponce, Sergio Tatay
Fast shuttling motions in solution have been observed for a Cu-complexed [2] rotaxane, whose thread contains a bidentate 1,10-phenanthroline chelating unit directly connected through its 3-position to the 5-position of a tridentate 2,2[prime or minute]:6[prime or minute],2[prime or minute][prime or minute]-terpyridine.
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9-Amino-(9-deoxy)cinchona alkaloid-derived new chiral phase-transfer catalysts

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01648C, PaperWenwen Peng, Jingwei Wan, Bing Xie, Xuebing Ma
9-Amino-(9-deoxy)cinchona alkaloid-derived chiral phase-transfer catalysts achieved high yields (92-99%) and excellent enantioselectivities (87-96% ee) in the enantioselective [small alpha]-alkylation of glycine Schiff base.
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Enantioselective copper catalysed C-H insertion reaction of 2-sulfonyl-2-diazoacetamides to form [gamma]-lactams

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7612-7628
DOI: 10.1039/C4OB01430H, PaperLeslie Ann Clarke, Aoife Ring, Alan Ford, Abhijeet S. Sinha, Simon E. Lawrence, Anita R. Maguire
The first enantioselective copper catalysed intramolecular C-H insertion reactions of 2-sulfonyl-2-diazoacetamides is reported.
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Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7445-7468
DOI: 10.1039/C4OB01033G, Review ArticleSerena Carosso, Marvin J. Miller
This review describes the use of nitroso Diels-Alder reactions for the functionalization of complex diene-containing natural products in order to generate libraries of compounds with potential biological activity.
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Recent developments in transition metal-catalysed spiroketalisation

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7423-7432
DOI: 10.1039/C4OB01325E, PerspectiveRachelle Quach, Daniel F. Chorley, Margaret A. Brimble
This perspective updates recent developments (since 2012) in the synthesis of spiroketals using transition metal catalysis.
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Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7498-7502
DOI: 10.1039/C4OB00860J, CommunicationBin He, Jing Hu, Xiaoyu Zhang, Hening Lin
Potent mechanism-based Sirt6 inhibitors.
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AcOH-mediated dichloroimination of indoles using chloramine-B: a facile access to 2,3-functionalized indolines

Org. and Biomol. Chem. - 5 hours 2 min ago

Org. Biomol. Chem., 2014, 12,7494-7497
DOI: 10.1039/C4OB01179A, CommunicationXiaozu Liu, Qinghong Hu, Zeli Yuan, Peijun Liu
A mild method for the efficient synthesis of 3,3-dichloro-2-sulfonyliminoindolines via AcOH-mediated dichloroimination of indoles using chloramine-B is described.
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