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A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02417F, PaperMarc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant, Luke R. Odell
A series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a novel cascade imine/cyclization/aza-Henry reaction in moderate to excellent yields.
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Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02340D, PaperLuis R. Domingo, Jose A. Saez, Saeed R. Emamian
The elimination of HCl and CO2 in the corresponding cycloadducts makes the unfavourable polar Diels-Alder reaction of 3-chloroindole irreversible.
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A coumarin based gold(I)-alkynyl complex: a new class of supramolecular hydrogelators

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02077D, PaperArtur J. Moro, Bertrand Rome, Elisabet Aguilo, Julia Arcau, Rakesh Puttreddy, Kari Rissanen, Joao Carlos Lima, Laura Rodriguez
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via fluorescence microscopy and dynamic light scattering.
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Conformational modulation of peptides using [small beta]-amino benzenesulfonic acid (SAnt)

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02421D, PaperGowri Priya, Amol S. Kotmale, Debamitra Chakravarty, Vedavati G. Puranik, Pattuparambil R. Rajamohanan, Gangadhar J. Sanjayan
This communication describes the utility of the conformationally restricted aromatic [small beta]-amino acid (2-aminobenzenesulfonic acid, SAnt) for inducing various folding interactions in short peptides.
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Asymmetric syntheses of three-membered heterocycles using chiral amide-based ammonium ylides

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02318H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mathias Pichler, Johanna Novacek, Raphael Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Muller, Mario Waser
Phenylglycinol serves as a powerful chiral auxiliary in ammonium ylide-mediated reactions to obtain chiral epoxides/aziridines with excellent stereoselectivities.
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Studies on the diastereoselective oxidation of 1-thio-[small beta]-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02030H, PaperJuan Francisco Moya-Lopez, Eleonora Elhalem, Rocio Recio, Eleuterio Alvarez, Inmaculada Fernandez, Noureddine Khiar
The exo-anomeric effect paves the way for the synthesis of the usually less favored RS-[small beta]-sulfinyl glycoside as a single diastereoisomer.
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Binding modes of a core-extended metalloporphyrin to Human Telomeric DNA G-quadruplexes

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
The molecular recognition of Human telomeric G-quadruplexes by a novel cationic [small pi]-extended NiII-porphyrin (NiII-TImidP4, Chart 1) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting...
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Styryl ether formation from benzyl alcohols under transition-metal-free basic DMSO conditions

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02358G, PaperKai Yang, Qiuling Song
A phenol-catalyzed aerobic oxidative styryl ether formation method was developed with benzyl alcohol under basic DMSO.
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Mixed Alkyl Aryl Phosphonate Esters as Quenched Fluorescent Activity-Based Probes for Serine Proteases

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02444C, PaperSevnur Serim, Philipp Baer, Steven H.L. Verhelst
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging,...
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, KESAVAN Venkitasamy, Kurt Vesterager Gothelf
Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The...
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Stereoelectronic effects: A simple yet powerful tool to manipulate anion affinity

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02470B, PaperMasoud Samet, S R Kass, Alireza Fattahi
Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found...
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Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02267J, CommunicationSu-Ying Xu, Xiaolong Sun, Haobo Ge, Rory L. Arrowsmith, John S. Fossey, Sofia I. Pascu, Yun-Bao Jiang, Tony D. James
A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching.
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Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02258K, PaperSamuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rudiger Woscholski, Piers R. J. Gaffney
Single enantiomers of PI-4-P, with a range of sn-2-fatty acid esters, were prepared efficiently. The effects of the degree of sn-2-unsaturation on the kinetic parameters of SopB were determined.
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Short and efficient synthesis of fluorinated [small delta]-lactams

Org. and Biomol. Chem. - 19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, 13,717-728
DOI: 10.1039/C4OB01547A, PaperThomas J. Cogswell, Craig S. Donald, De-Liang Long, Rodolfo Marquez
The diastereoselective synthesis of fluorinated [small delta]-lactams.
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Benzosulfones as Photochemically Activated Sulfur Dioxide (SO2) Donors

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02466D, PaperSatish Malwal, Harinath Chakrapani
Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic...
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Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: kinetic and thermodynamic control

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02329C, PaperDaniele Castagnolo, Leonardo Degennaro, RENZO LUISI, Jonathan Clayden
The addition of n-butyllithium to alkenylthiocarbamates in the presence of (-)-sparteine or the (+)-sparteine surrogate leads to asymmetric carbolithiation, and returns enantiomerically enriched thiocarbamate derivatives of secondary thiols. In THF,...
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Energy Transfer Between Amphiphilic Porphyrin Polymer Shells and Upconverting Nanoparticle Cores in Water-Dispersible Nano-assemblies

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02401J, PaperTuoqi Wu, Sandeep Kaur, Neil R. Branda
The synthesis of water-dispersible nano-assemblies containing upconverting nanoparticles (UCNPs) and porphyrin molecules using a one-pot method is described. When the nano-assemblies are excited by 980 nm near-infrared light, the intensity...
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Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02311K, PaperDavid Fox, Michael S. Perryman, Matthew Earl, Sam Greatorex, Guy James Clarkson
Enantiomerically-enriched trichloromethyl-containing alcohols, obtained by asymmetric reduction, can be transformed regioselectively into 1-substituted piperazinones by modified Jocic reactions with little or no loss of stereochemical integrity. This methodology can be...
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Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02041C, PaperMaarten Danial, Sebastien Perrier, Katrina A Jolliffe
The effect of amino acid composition on the formation of transmembrane channels in lipid bilayers upon self-assembly of alt-(L,D)-[small alpha]-cyclic octapeptides has been investigated. Cyclic peptides comprising D-leucine, alternating with different...
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microRNA detection methods

Org. and Biomol. Chem. - 19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02104E, Review ArticleXiang Zhou, Tian Tian, Jiaqi Wang
MicroRNA (miRNA) detection is of considerable significance in both disease diagnosis and the study of miRNA function. The importance of miRNA itself is due to the complicated regulatory functions it...
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