Chem. Soc. Rev.

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Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6859-6869
DOI: 10.1039/C4CS00047A, Review ArticleRebecca A. Kohnz, Daniel K. Nomura
This review describes the development of inhibitors for endocannabinoid metabolism and their potential therapeutic benefit.
The content of this RSS Feed (c) The Royal Society of Chemistry

PET/SPECT imaging agents for neurodegenerative diseases

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6683-6691
DOI: 10.1039/C3CS60430F, Tutorial ReviewLin Zhu, Karl Ploessl, Hank F. Kung
Amyvid/PET imaging of a living brain detects [small beta]-amyloid plaque deposition, a risk factor for developing Alzheimer's disease.
The content of this RSS Feed (c) The Royal Society of Chemistry

Metal complexes designed to bind to amyloid-[small beta] for the diagnosis and treatment of Alzheimer's disease

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6701-6715
DOI: 10.1039/C4CS00026A, Review ArticleDavid J. Hayne, SinChun Lim, Paul S. Donnelly
The use radioactive copper and technetium complexes as amyloid imaging agents, the use of luminescent metal complexes as non-conventional probes of amyloid formation and the potential of metal complexes to be inhibitors of amyloid toxicity are discussed.
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Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6750-6764
DOI: 10.1039/C3CS60459D, Review ArticleHyunbum Jang, Fernando Teran Arce, Srinivasan Ramachandran, Bruce L. Kagan, Ratnesh Lal, Ruth Nussinov
Aggregation of small A[small beta] oligomers into common [small beta]-sheet rich annular structural motifs is responsible for Alzheimer's disease.
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Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6814-6838
DOI: 10.1039/C3CS60467E, Review ArticleParamita Mukherjee, Maris A. Cinelli, Soosung Kang, Richard B. Silverman
Overproduction of nitric oxide by neuronal nitric oxide synthase is implicated in neurodegenerative diseases and neuropathic pain; inhibition is therapeutically desirable.
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P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6716-6726
DOI: 10.1039/C3CS60448A, Review ArticleAndrew A. Pieper, Steven L. McKnight, Joseph M. Ready
The P7C3 compounds emerged from an in vivo screen and were found to protect neurons in models of neurodegenerative disease.
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Differences between amyloid-[small beta] aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6692-6700
DOI: 10.1039/C3CS60431D, Tutorial ReviewSamuel A. Kotler, Patrick Walsh, Jeffrey R. Brender, Ayyalusamy Ramamoorthy
The association of the amyloid-[small beta] (A[small beta]) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease.
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Molecular medicine and neurodegenerative diseases

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6668-6671
DOI: 10.1039/C4CS90065K, EditorialChristopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson, Mi Hee Lim
Guest editors Christopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson and Mi Hee Lim introduce the Molecular medicine and neurodegenerative diseases themed issue of Chemical Society Reviews.
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Biological metals and metal-targeting compounds in major neurodegenerative diseases

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6727-6749
DOI: 10.1039/C4CS00138A, Review ArticleKevin J. Barnham, Ashley I. Bush
Metals are functionally essential, but redistribute in neurodegenerative disease where they induce protein aggregates, catalyze radical formation, and lose bioavailability.
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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

6 October, 2014 - 03:17

Chem. Soc. Rev., 2014, 43,6839-6858
DOI: 10.1039/C4CS00038B, Review ArticleScott A. Yuzwa, David J. Vocadlo
Increasing levels of glucose responsive O-GlcNAcylation of proteins in Alzheimer disease mouse models decreases the toxicity of tau and A[small beta].
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