Chem. Soc. Rev.
Asymmetric homogeneous hydrogenations at scale
DOI: 10.1039/C2CS15312B, Critical ReviewDavid J. Ager, Andre H. M. de Vries, Johannes G. de Vries
This critical review discusses issues that can arise when scaling up an asymmetric hydrogenation.
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Categories: Royal Society of Chemistry
Ruthenium(II) polypyridyl complexes and DNA-from structural probes to cellular imaging and therapeutics
DOI: 10.1039/C2CS15299A, Tutorial ReviewMartin R. Gill, Jim A. Thomas
The wide potential applications of metal complexes that reversibly interact with DNA are illustrated through specific examples drawn from studies on ruthenium polypyridyl complexes.
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Drug development: longer-lived proteins
DOI: 10.1039/C2CS15289D, Tutorial ReviewStephan Kontos, Jeffrey A. Hubbell
Therapeutic proteins are widely used in clinic for the treatment of various diseases. Here, we review state-of-the-art chemical- and protein engineering-based methods that aim to increase the residence time of therapeutic proteins in the body, and thus potentially increase their efficacy and potency.
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Dynamic imine chemistry
DOI: 10.1039/C2CS15305J, Tutorial ReviewMatthew E. Belowich, J. Fraser Stoddart
This review highlights the utilisation of a 19th Century reaction-imine bond formation-and its exploitation in the construction of supramolecular and mechanostereochemical systems.
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Surface functionalization of nanoparticles for nanomedicine
DOI: 10.1039/C2CS15294K, HighlightRubul Mout, Daniel F. Moyano, Subinoy Rana, Vincent M. Rotello
This research Highlight emphasizes advances in tailoring nanoparticle interfaces for implementation in nanomedicine.
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Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium: biological relevance and synthetic strategies
DOI: 10.1039/C2CS15300A, Critical ReviewNicolas P. E. Barry, Peter J. Sadler
This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine.
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Chiral-at-metal complexes and their catalytic applications in organic synthesis
DOI: 10.1039/C2CS15234G, Tutorial ReviewEike B. Bauer
This tutorial review provides an introduction to the synthesis, characterization, properties and catalytic applications of complexes with stereogenic metal centers.
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Bio-inspired variable structural color materials
DOI: 10.1039/C2CS15267C, Critical ReviewYuanjin Zhao, Zhuoying Xie, Hongcheng Gu, Cun Zhu, Zhongze Gu
This critical review provides up-to-date research concerning the natural and bio-inspired photonic materials with variable structural colors.
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The impact of plant-pathogen studies on medicinal drug discovery
DOI: 10.1039/C2CS15301G, Tutorial ReviewChristian Ottmann, Renier A. L. van der Hoorn, Markus Kaiser
This tutorial review demonstrates that the investigation of plant-pathogen interactions offers unexpected opportunities for medicinal drug discovery.
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Autophagy-regulating small molecules and their therapeutic applications
DOI: 10.1039/C2CS15328A, Critical ReviewKyung-Hwa Baek, Jihye Park, Injae Shin
This critical review discusses general aspects of autophagy, autophagy-associated diseases and autophagy regulators for biological research and therapeutic applications.
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The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy
DOI: 10.1039/C2CS15260F, Critical ReviewTennyson L. Doane, Clemens Burda
The properties of nanoparticles have generated a myriad of biomedical applications. This review critically examines their unique role and recent progress in nanomedicine.
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Investigating inclusion complexes using quantum chemical methods
DOI: 10.1039/C2CS15244D, Tutorial ReviewMark P. Waller, Holger Kruse, Christian Muck-Lichtenfeld, Stefan Grimme
Investigating weak intermolecular interactions within inclusion complexes using quantum chemical methods is the focus of this tutorial review.
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Transfer hydrogenation with Hantzsch esters and related organic hydride donors
DOI: 10.1039/C1CS15268H, Critical ReviewChao Zheng, Shu-Li You
This critical review summarizes recent development of catalytic asymmetric transfer hydrogenation (ATH) reaction mediated by Hantzsch esters and other related organic hydride donors.
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Polymeric multilayer capsules for drug delivery
DOI: 10.1039/C2CS15296G, Critical ReviewStefaan De Koker, Richard Hoogenboom, Bruno G. De Geest
Here we review the recent progress in the field of polymeric multilayer thin films to design nano- and microcapsules intended for drug delivery applications.
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Recent advances in transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions using arynes
DOI: 10.1039/C2CS15310F, Tutorial ReviewAnup Bhunia, Santhivardhana Reddy Yetra, Akkattu T. Biju
A concise account of the synthetic utility of arynes in transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions is presented.
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A practical guide to modelling enzyme-catalysed reactions
DOI: 10.1039/C2CS15297E, Tutorial ReviewRichard Lonsdale, Jeremy N. Harvey, Adrian J. Mulholland
An informative overview of how to model enzyme reaction mechanisms, with the drug-metabolising cytochrome P450 enzymes used as an example.
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Signal amplification using functional nanomaterials for biosensing
DOI: 10.1039/C1CS15274B, Tutorial ReviewJianping Lei, Huangxian Ju
We review recent significant advances in signal amplification strategies based on biofunctional nanomaterials and highlight their applications in ultrasensitive bioanalysis.
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Green Chemistry: present and future
DOI: 10.1039/C1CS90064A, EditorialChao-Jun Li, Paul T. Anastas
Guest editors Chao-Jun Li and Paul Anastas introduce the themed issue of Chemical Society Reviews covering the latest developments in green chemistry.
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Categories: Royal Society of Chemistry
Ionic liquid processing of cellulose
DOI: 10.1039/C2CS15311D, Critical ReviewHui Wang, Gabriela Gurau, Robin D. Rogers
In this critical review, the respective roles of ionic liquid cations and anions in the dissolution of cellulose are discussed, and wherever possible, the greenness of ionic liquid processing is analyzed in light of the choices of cation and anion.
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Recent advances in the isolation and reactivity of organogold complexes
DOI: 10.1039/C2CS15318A, Tutorial ReviewLe-Ping Liu, Gerald B. Hammond
The isolated or detected organogold intermediates not only serve as direct evidence for the proposed mechanisms, but also help to develop new gold-catalyzed transformations.
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