Dalton Transactions

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Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3563-3572
DOI: 10.1039/C4DT03237C, PaperY. Qu, R. G. Kipping, N. P. Farrell
NMR studies confirmed phosphate clamp-DNA binding in solution and the sequence dictates minor-groove spanning or backbone tracking.
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Characterisation of the interactions between substrate, copper(II) complex and DNA and their role in rate acceleration in DNA-based asymmetric catalysis

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3656-3663
DOI: 10.1039/C4DT02734E, PaperApparao Draksharapu, Arnold J. Boersma, Wesley R. Browne, Gerard Roelfes
High effective molarity is responsible for the significant increase of binding of substrates to copper(II) complexes in DNA-based catalysis.
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Unprecedented dinuclear silver(I)-mediated base pair involving the DNA lesion 1,N6-ethenoadenine

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3540-3543
DOI: 10.1039/C4DT02663B, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Soham Mandal, Alexander Hepp, Jens Muller
For the first time, a dinuclear purine-based metal-mediated homo base pair has been incorporated into a B-DNA duplex.
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Binding of copper(II) polypyridyl complexes to DNA and consequences for DNA-based asymmetric catalysis

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3647-3655
DOI: 10.1039/C4DT02733G, PaperApparao Draksharapu, Arnold J. Boersma, Miriam Leising, Auke Meetsma, Wesley R. Browne, Gerard Roelfes
Insight into the structure of DNA-based catalysts is obtained by elucidation of the DNA-binding mode of catalytically active copper complexes.
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Interactions of selected gold(III) complexes with DNA G quadruplexes

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3633-3639
DOI: 10.1039/C4DT02698E, PaperP. Gratteri, L. Massai, E. Michelucci, R. Rigo, L. Messori, M. A. Cinellu, C. Musetti, C. Sissi, C. Bazzicalupi
The interactions of three Au(III) complexes with human telomeric DNA sequences: Auoxo6 turned out to be very effective in inducing and binding the G-quadruplex DNA conformation.
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Metal complex interactions with DNA

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3505-3526
DOI: 10.1039/C4DT02700K, PerspectiveBenjamin J. Pages, Dale L. Ang, Elise P. Wright, Janice R. Aldrich-Wright
Increasing numbers of DNA structures are being revealed using a diverse range of transition metal complexes and biophysical spectroscopic techniques. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.
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Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3583-3593
DOI: 10.1039/C4DT02942A, PaperJoseph J. Moniodis, Donald S. Thomas, Murray S. Davies, Susan J. Berners-Price, Nicholas P. Farrell
The trinuclear platinum drug BB3464 pre-associates in the minor groove at two different sites on a 14-mer duplex and this dictates the nature of the adducts formed in both 5[prime or minute]-5[prime or minute] and 3[prime or minute]-3[prime or minute] directions.
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Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3614-3623
DOI: 10.1039/C4DT02764G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexey A. Nazarov, Samuel M. Meier, Olivier Zava, Yulia N. Nosova, Elena R. Milaeva, Christian G. Hartinger, Paul J. Dyson
The conjugation of chlorambucil to the RAPTA scaffold results in an anticancer active agent capable of cross-linking DNA and proteins.
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The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3573-3582
DOI: 10.1039/C4DT02603A, PaperViktor Brabec, Jitka Pracharova, Olga Novakova, Dan Gibson, Jana Kasparkova
DNA is the cellular target for antitumor derivatives of transplatin including those containing small aliphatic amino ligands.
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Binding of Ru(terpyridine)(pyridine)dipyridophenazine to DNA studied with polarized spectroscopy and calorimetry

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3604-3613
DOI: 10.1039/C4DT02642J, PaperAnna K. F. Martensson, Per Lincoln
Achiral Ru(tpy)(py)dppz2+ intercalated into DNA has similar intermolecular interactions as opposite enantiomers of its structural isomer, the "light-switch" complex Ru(bpy)2dppz2+.
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Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a "boring" element

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3527-3535
DOI: 10.1039/C4DT02881C, PerspectiveAlessio Terenzi, Antonino Lauria, Anna Maria Almerico, Giampaolo Barone
Recent applications of zinc(II) complexes as fluorescent probes for nucleic acids are described highlighting their potential as diagnostic tools.
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Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3686-3700
DOI: 10.1039/C4DT02910K, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Verity S. Stafford, Kogularamanan Suntharalingam, Arun Shivalingam, Andrew J. P. White, David J. Mann, Ramon Vilar
A series of metal complexes with substituted terpyridines show high affinity towards quadruplex DNA, particularly bimetallic (trpy)Pt/M(cyclen) complexes.
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Convenient detection of metal-DNA, metal-RNA, and metal-protein adducts with a click-modified Pt(II) complex

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3536-3539
DOI: 10.1039/C4DT02649G, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Alan D. Moghaddam, Jonathan D. White, Rachael M. Cunningham, Andrea N. Loes, Michael M. Haley, Victoria J. DeRose
cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA.
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RNA and DNA binding of inert oligonuclear ruthenium(II) complexes in live eukaryotic cells

13 February, 2015 - 02:54

Dalton Trans., 2015, 44,3594-3603
DOI: 10.1039/C4DT02575J, PaperXin Li, Anil K. Gorle, Tracy D. Ainsworth, Kirsten Heimann, Clifford E. Woodward, J. Grant Collins, F. Richard Keene
Oligonuclear polypyridylruthenium(II) complexes show selectivity for the nucleus of eukaryotic cells with a considerable preference for the RNA-rich nucleolus.
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DNA fragment conformations in adducts with Kiteplatin

11 February, 2015 - 02:17

Dalton Trans., 2015, 44,3544-3556
DOI: 10.1039/C4DT01796J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nicola Margiotta, Emanuele Petruzzella, James A. Platts, Shaun T. Mutter, Robert J. Deeth, Rosa Ranaldo, Paride Papadia, Patricia A. Marzilli, Luigi G. Marzilli, James D. Hoeschele, Giovanni Natile
The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.
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