Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
Updated: 17 hours 19 min ago

Self-immolative base-mediated conjugate release from triazolylmethylcarbamates

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8703-8707
DOI: 10.1039/C5OB00984G, PaperChristopher A. Blencowe, David W. Thornthwaite, Wayne Hayes, Andrew T. Russell
A range of carbamate functionalized 1,4-disubstituted triazoles featuring a model aromatic amine reporter group (R) have been prepared via copper(I) catalysed azide-alkyne cycloaddition and revealed self-immolative characteristics under basic conditions.
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A simple fluorescent probe based on a pyrene derivative for rapid detection of protamine and monitoring of trypsin activity

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8708-8712
DOI: 10.1039/C5OB01034A, PaperBaiyang Tang, Yan Yang, Gefu Wang, Zhiyi Yao, Li Zhang, Hai-Chen Wu
Detection of protamine and trypsin with a simple fluorescent probe based on a pyrene derivative.
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Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8734-8739
DOI: 10.1039/C5OB00891C, PaperWataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi, Hirokazu Tamamura
The trivalent ligand with rigid linkers designed for exploration of GPCR multimerization shows specific recognition for overexpressed CXCR4.
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Regioselective synthesis of nitrosoimidazoheterocycles using tert-butyl nitrite

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8717-8722
DOI: 10.1039/C5OB01345C, PaperKamarul Monir, Monoranjan Ghosh, Sourav Jana, Pallab Mondal, Adinath Majee, Alakananda Hajra
A simple and practical method has been developed for the regioselective nitrosylation of imidazopyridines via C(sp2)-H bond functionalization using tert-butyl nitrite under mild reaction conditions.
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Silver-catalyzed cascade reaction of tosylmethyl isocyanide (TosMIC) with propargylic alcohols to (E)-vinyl sulfones: dual roles of TosMIC

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8723-8728
DOI: 10.1039/C5OB01129A, PaperHaniya Bounar, Zhenhua Liu, Lin Zhang, Xiaoxue Guan, Zonglian Yang, Peiqiu Liao, Xihe Bi, Xingqi Li
An silver-catalyzed cascade reaction of tosylmethyl isocyanide (TosMIC) with propargylic alcohols for the synthesis of (E)-vinyl sulfones has been developed where TosMIC plays a dual role as both the reactant in the allenylation of propargylic alcohols and the sulfonyl source.
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A Sn atom-economical approach toward arylstannanes: Ni-catalysed stannylation of aryl halides using Bu3SnOMe

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8713-8716
DOI: 10.1039/C5OB01096A, PaperKimihiro Komeyama, Ryota Asakura, Ken Takaki
This article describes a Ni-catalysed stannylation of aryl halides using Bu3SnOMe without a liberation of wasteful and toxic stannyl residue.
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Investigation of glycofullerene dynamics by NMR spectroscopy

17 August, 2015 - 10:17

Org. Biomol. Chem., 2015, 13,8750-8755
DOI: 10.1039/C5OB00929D, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Olof Engstrom, Antonio Munoz, Beatriz M. Illescas, Nazario Martin, Renato Ribeiro-Viana, Javier Rojo, Goran Widmalm
Mannose residues linked to flexible spacers on slowly diffusing glycofullerenes may facilitate efficient rebinding to receptors.
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Regioselective functionalisation of dibenzothiophenes through gold-catalysed intermolecular alkyne oxyarylation

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8676-8686
DOI: 10.1039/C5OB01241D, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew J. Barrett, Paul W. Davies, Richard S. Grainger
Site-selective and direct C-H functionalisation of dibenzothiophenes is achieved using a gold-catalysed oxyarylation approach.
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An efficient one pot regioselective synthesis of a 3,3[prime or minute]-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8669-8675
DOI: 10.1039/C5OB01020A, PaperAnil M. Shelke, Gurunath Suryavanshi
A one pot, highly regioselective synthesis of 3,3[prime or minute]-spiro-phosphonylpyrazole-oxindole by 1,3-dipolar cycloaddition of the Bestmann-Ohira reagent (BOR) & methyleneindolinones has been developed.
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A ratiometric fluorescent probe for rapid, sensitive and selective detection of sulfur dioxide with large Stokes shifts by single wavelength excitation

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8663-8668
DOI: 10.1039/C5OB00765H, PaperXingjiang Liu, Qinwei Yang, Wenqiang Chen, Lingna Mo, Song Chen, Jiang Kang, Xiangzhi Song
A ratiometric fluorescent probe was developed for rapid, sensitive and selective detection of SO32- with large Stokes shifts. Imaging intracellular SO32- was successfully demonstrated in living HNE-2 cells.
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1,3-Dipolar cycloadditions of azomethine imines

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8596-8636
DOI: 10.1039/C5OB01086A, Review ArticleCarmen Najera, Jose M. Sansano, Miguel Yus
Azomethine imines react with alkenes and alkynes to give pyrazolines, pyrazolidines, pyrazolopyridines, indazoloisoquinolines, pyrazolo[1,5-a]isoquinolines and pyrazolopyrazolones through regio-, stereo- and enantioselective 1,3-dipolar cycloadditions.
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Morita-Baylis-Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8578-8595
DOI: 10.1039/C5OB00865D, Review ArticlePeizhong Xie, You Huang
MBHADs, which exert diverse and amazing reactivity and emerged as novel "multi-role synthons", can participate in diverse annulation.
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PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-[small beta]-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I

13 August, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,8652-8662
DOI: 10.1039/C5OB00871A, PaperAhmed Kamal, Yellaiah Tangella, Kesari Lakshmi Manasa, Manda Sathish, Vunnam Srinivasulu, Jadala Chetna, Abdullah Alarifi
A new strategy for synthesis of [small beta]-carbolines via one-pot oxidative decarboxylation at room temperature is developed for the first time.
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Synthesis and antimicrobial potential of nitrofuran-triazole congeners

11 August, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01353D, PaperAhmed Kamal, S. M. Ali Hussaini, M. Lakshmi Sucharitha, Y. Poornachandra, Faria Sultana, C. Ganesh Kumar
A series of nitrofuran-triazole congeners were synthesized that displayed excellent to appreciable antimicrobial and antibiofilm activities. Compound 9f inhibited CYP51, an enzyme involved in ergosterol biosynthesis in fungi.
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Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles

11 August, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,8545-8549
DOI: 10.1039/C5OB00856E, PaperAnatol P. Spork, Timothy J. Donohoe
We describe herein the synthesis of aziridine-containing amino acids embedded within tripeptide structures.
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A facile approach to [small beta]-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid

11 August, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,8429-8432
DOI: 10.1039/C5OB01304F, CommunicationJie Dai, Wenlong Ren, Haining Wang, Yian Shi
An effective Pd(0)-catalyzed hydrocarboxylation of enimides with formic acid in the presence of a catalytic amount of HCOOPh is described.
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Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors

11 August, 2015 - 08:54

Org. Biomol. Chem., 2015, 13,8500-8504
DOI: 10.1039/C5OB01177A, PaperS. Roe, M. Gunaratnam, C. Spiteri, P. Sharma, R. D. Alharthy, S. Neidle, J. E. Moses
The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described.
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Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

9 August, 2015 - 08:17

Org. Biomol. Chem., 2015, 13,8495-8499
DOI: 10.1039/C5OB01134E, PaperBrian Leon, F. P. Jake Haeckl, Roger G. Linington
The biofilm state is an integral part of the lifecycle of many bacterial pathogens, but no treatments currently exist that directly impact biofilm formation or persistence. Here we report the development of a quinoline amino alcohol scaffold with both biofilm inhibitory and biofilm dispersal activities against the human pathogen Vibrio cholerae.
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Iridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines

9 August, 2015 - 08:17

Org. Biomol. Chem., 2015, 13,8425-8428
DOI: 10.1039/C5OB01243K, CommunicationChaoyuan Zeng, Fan Yang, Jingchao Chen, Jun Wang, Baomin Fan
Chiral trans-vicinal diamines were synthesized via an asymmetric ring opening reaction of azabenzonorbornadienes with amines.
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Synthesis and evaluation of 2-ethynyl-adenosine-5[prime or minute]-triphosphate as a chemical reporter for protein AMPylation

9 August, 2015 - 08:17

Org. Biomol. Chem., 2015, 13,8550-8555
DOI: 10.1039/C5OB01081K, PaperChrista Creech, Mukul Kanaujia, Corey P. Causey
2-Ethynyl-adenosine-5[prime or minute]-triphosphate is a chemical reporter for AMPylation that enables visualization of modified protein substrates.
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