Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Mixed non-covalent assemblies of ethynyl nile red and ethynyl pyrene along oligonucleotide templates

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01860E, PaperPhilipp Ensslen, Yannic Fritz, Hans-Achim Wagenknecht
The mixture makes the difference: the assemblies of ethynyl pyrene and ethynyl nile red along oligonucleotide templates are highly ordered and yield dual fluorescence.
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Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01796J, Review ArticleAtsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura, Takashi Kato
Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials. Molecularly controlled mechanisms of biomineralization and application of the processes towards future material synthesis are introduced.
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Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral [small alpha]-substituted carboxylic acids from [small alpha]-substituted [small alpha],[small beta]-unsaturated aldehydes

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02282C, PaperTanja Knaus, Francesco G. Mutti, Luke D. Humphreys, Nicholas J. Turner, Nigel S. Scrutton
The development of hydrogen-borrowing biocatalytic cascades is presented and applied to the synthesis of diverse [small alpha]-chiral substituted carboxylic acids.
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A peptide topological template for the dispersion of [60]fullerene in water

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02102A, CommunicationS. Bartocci, D. Mazzier, A. Moretto, M. Mba
Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL-1 have been obtained using a peptide topological template as the carrier.
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The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02105C, PaperSteffen Glockner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley
A flow process to access oxazolines and oxazoles via a rapid and practical protocol is described.
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Preparation of asymmetrical polyynes by a solid-supported Glaser-Hay reaction

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02196G, PaperJessica S. Lampkowski, Corinn E. Durham, Marshall S. Padilla, Douglas D. Young
A novel approach to the synthesis of asymmetrical polyynes utilizing solid-supported chemistry.
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Trifluoromethanesulfonyloxy-group-directed regioselective (3 + 2) cycloadditions of benzynes for the synthesis of functionalized benzo-fused heterocycles

13 November, 2014 - 14:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01627K, PaperTakashi Ikawa, Hideki Kaneko, Shigeaki Masuda, Erika Ishitsubo, Hiroaki Tokiwa, Shuji Akai
Highly regioselective (3 + 2) cycloadditions of 3- and 4-TfO-benzynes with 1,3-dipoles followed by cross-coupling reactions provided multisubstituted benzo-fused heterocycles.
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Synthesis of (Phosphonomethyl)Phosphinate Pyrophosphate Analogues via the Phospha-Claisen Condensation

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02007C, PaperJean-Luc Montchamp, Fabien Gelat, Claire Lacomme, Olivier Berger, Laurent Gavara
Pyrophosphate analogues are of great importance especially for the design of biologically active molecules. The phospha-Claisen condensation allows for the rapid synthesis of (phosphonomethyl)phosphinate pyrophosphate analogues and building blocks that...
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Multivalent Helix Mimetics for PPI-Inhibition

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02066A, PaperAnna Barnard, Jennifer A Miles, George Burslem, Amy M Barker, Andrew Wilson
The exploitation of multivalent ligands for the inhibition of protein-protein interactions has not yet been explored as a supramolecular design strategy. This is despite the fact that protein-protein interactions typically...
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Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01856G, PaperZheng Huang, Yan-Hong Liu, Yi-Mei Zhang, Ji Zhang, Qiang Liu, Xiao-Qi Yu
Imidazole-functionalized cationic lipids with a cyclen headgroup were synthesized, and the structure-activity relationship in gene delivery mediated by these lipids was discussed.
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The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01792G, PaperJ. M. Botubol-Ares, M. J. Duran-Pena, A. J. Macias-Sanchez, J. R. Hanson, I. G. Collado, R. Hernandez-Galan
The enantioselective synthesis of 3, (E)-8, (Z)-8, 20a and 20b is reported using RCM as key step. Based in spectroscopic differences, the structure assigned to the natural product has been revised to that of a [gamma]-butyrolactone.
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Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01925C, PaperGerard Artigas, Paula Lopez-Senin, Carlos Gonzalez, Nuria Escaja, Vicente Marchan
Ligands with a preferred binding site in the bulged region of the stem-loop structure of Tau pre-mRNA have been identified by dynamic combinatorial chemistry.
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Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02138J, PaperInna Perepichka, Soumen Kundu, Zoe Hearne, Chao-Jun Li
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp3 and sp C-H bonds with the assistance of a photocatalyst and visible light.
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Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01869A, PaperAline Alves dos Santos Naujorks, Adriano Olimpio da Silva, Rosangela da Silva Lopes, Sergio de Albuquerque, Adilson Beatriz, Maria Rita Marques, Denis Pires de Lima
Novel naphthoquinone derivatives were synthesized and tested for trypanocidal and leishmanicidal activities. Compound 11a was the most active against T. cruzi.
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Bidirectional macrocyclization of peptides by double multicomponent reactions

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01915F, PaperManuel G. Ricardo, Fidel E. Morales, Hilda Garay, Osvaldo Reyes, Dimitar Vasilev, Ludger A. Wessjohann, Daniel G. Rivera
Peptide macrocyclization by multicomponent reactions.
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Irreversible covalent modification of type I dehydroquinase with a stable Schiff base

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01782J, PaperLorena Tizon, Maria Maneiro, Antonio Peon, Jose M. Otero, Emilio Lence, Sergio Poza, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepcion Gonzalez-Bello
Structural and computational studies carried out with two epoxides provide insight into the irreversible inhibition of type I dehydroquinase.
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Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01951B, PaperLaurent Le Corre, Lotfi Tak-Tak, Arthur Guillard, Guillaume Prestat, Christine Gravier-Pelletier, Patricia Busca
The obtention of 4-amino-3-cyano-N-arylpyrazoles via a [small mu ]W mediated cyclization allowed the diversity oriented syntheses of various heteroyclic scaffolds.
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Formation of steroidal C-25 chiral center via asymmetric alkylation methodology

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02123A, PaperYuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii, Vladimir Aleksandrovich Khripach
A novel approach for the preparation of steroids containing a chiral center at C-25 is reported. The key stereochemistry inducing step was asymmetric alkylation of pseudoephenamine amides of steroidal C-26...
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Cucurbituril-based supramolecularly engineered nanostructured materials

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02065K, Review ArticleDonus Tuncel, SINEM GURBUZ, MUAZZAM IDRIS
Cucurbituril (CB) is a unique macrocycle with a rigid symmetrical structure which is composed of two identical hydrophilic portals decorated with partially negatively charged carbonyl groups and a hydrophobic cavity....
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New synthetic and biological evaluation of uniflorine A derivatives: towards specific insect trehalase inhibitors

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02016B, PaperFrancesca Cardona, Giampiero D'Adamio, Antonella Sgambato, Matilde Forcella, Silvia Caccia, Camilla Parmeggiani, Morena Casartelli, Paolo Parenti, Davide Bini, Laura Cipolla, Paola Fusi
7-Deoxy-uniflorine A (6), synthesized ex novo with a straightforward and simple strategy, and analogues 4, 5 and 7 were evaluated as potential inhibitors of insect trehalase from Chironomus riparius and...
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