Org. and Biomol. Chem.

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Molecular binding behavior of a bispyridinium-containing bis([small beta]-cyclodextrin) and its corresponding [2]rotaxane towards bile salts

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2559-2567
DOI: 10.1039/C3OB42103A, PaperYing-Ming Zhang, Ze Wang, Yong Chen, Hong-Zhong Chen, Fei Ding, Yu Liu
The molecular binding behavior of a bispyridinium-bridged bis([small beta]-cyclodextrin) and its corresponding [2]rotaxane with a series of bile salts was systematically studied, revealing a significant conformational change upon host-guest complexation.
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Isovanillin derived N-(un)substituted hydroxylamines possessing an ortho-allylic group: valuable precursors to bioactive N-heterocycles

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2552-2558
DOI: 10.1039/C3OB42460J, PaperBalakrishna Dulla, Neelima D. Tangellamudi, Sridhar Balasubramanian, Swapna Yellanki, Raghavender Medishetti, Rakesh Kumar Banote, Girish Hari Chaudhari, Pushkar Kulkarni, Javed Iqbal, Oliver Reiser, Manojit Pal
Isovannillin based N-heterocycles are synthesized and evaluated for their potential anxiogenic properties.
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Recent progress on asymmetric organocatalytic construction of chiral cyclohexenone skeletons

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2499-2513
DOI: 10.1039/C3OB42293C, Review ArticleXin Yang, Jun Wang, Pengfei Li
Chiral cyclohex-2-enones are important intermediates in synthetic chemistry as well as in the life science industries. In this focus review, recent advances in the organocatalytic asymmetric synthesis of chiral cyclohex-2-enone skeletons are summarized. The reaction mechanisms are also briefly discussed.
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A direct access to bioactive fused N-heterocyclic acetic acid derivatives

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2514-2518
DOI: 10.1039/C3OB42535E, CommunicationRaju Adepu, A. Rajitha, Dipali Ahuja, Atul Kumar Sharma, B. Ramudu, Ravikumar Kapavarapu, Kishore V. L. Parsa, Manojit Pal
A Cu-catalyzed domino reaction afforded novel fused N-heterocycles as potential PDE4 inhibitors.
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Mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2523-2527
DOI: 10.1039/C3OB42431F, CommunicationJian Li, Hongni Wang, Jiangtao Sun, Yang Yang, Li Liu
A mild gold-catalyzed three-component dehydrogenative coupling of terminal alkynes to amines and indole-2-carboxaldehyde has been developed, which provides a practical synthetic strategy for the synthesis of indole derivatives.
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Organocatalytic Asymmetric Decarboxylative Cyanomethylation of Isatins using L-Proline Derived Bifunctional Thiourea

1 April, 2014 - 07:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00271G, Paperpratap reddy gajulapali, Vinayagam vkesavan@iitm.ac.in Poopathy, KESAVAN Venkitasamy
First asymmetric decarboxylative cyanomethylation of isatins is reported herewith using bifunctional thiourea derived from L-proline in good yields and enantioselectivities. This strategy enables the construction of various 3-cyanomethylene substituted-3-hydroxy oxindoles...
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Microwave-Assisted One-Pot Synthesis and Anti-Biofilm Activity of 2-Amino-1H-imidazole/Triazole Conjugates

1 April, 2014 - 07:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42282H, PaperHans Steenackers, Denis S. Ermolat'ev, Tran T. Trang, Bharat Savaliya, Upendra K Sharma, Ami De Weerdt, Anamik shah, Jos Vanderleyden, Erik V�lery Van der Eycken
A microwave-assisted protocol was developed for the construction of 2-amino-1H-imidazole/triazole conjugates starting from the previously described 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts. The process involves a one-pot hydrazinolysis/Dimroth-rearrangement of these salts followed by a...
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Development of a New rhodamine-based FRET Platform and the Applications for Cu2+ probe

1 April, 2014 - 07:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00131A, PaperXiaoyu Guan, Weiying Lin, Weimin Huang
We have constructed a new rhodamine-based FRET platform and the application for ratiometric fluorescent Cu2+ probe. The novel Cu2+ probe exhibits several favorable features including a larger variation in the...
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Selective aliphatic carbon-hydrogen bond activation of protected alcohol substrates by cytochrome P450 enzymes

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2479-2488
DOI: 10.1039/C3OB42417K, PaperStephen G. Bell, Justin T. J. Spence, Shenglan Liu, Jonathan H. George, Luet-Lok Wong
Protected cyclohexanol and cyclohex-2-enol substrates were efficiently and selectively oxidised by different P450cam mutants providing a general methodology for generating substituted diols using biocatalysts.
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Acyclic CB[n]-type molecular containers: effect of solubilizing group on their function as solubilizing excipients

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2413-2422
DOI: 10.1039/C3OB42603C, PaperBen Zhang, Peter Y. Zavalij, Lyle Isaacs
Acyclic CB[n]-type receptors with sulfonate solubilizing groups function best as hosts for soluble guests and solubilizing agents for insoluble drugs.
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Tandem halogenation/Michael-initiated ring-closing reaction of [small alpha],[small beta]-unsaturated nitriles and activated methylene compounds: one-pot diastereoselective synthesis of functionalized cyclopropanes

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2427-2435
DOI: 10.1039/C4OB00087K, PaperXiaoqing Xin, Qian Zhang, Yongjiu Liang, Rui Zhang, Dewen Dong
One-pot diastereoselective synthesis of cyclopropanes is developed from [small alpha],[small beta]-unsaturated nitriles and doubly activated methylene compounds under very mild conditions.
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Bi(OTf)3-catalyzed three-component synthesis of [small alpha]-amino acid derivatives

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2356-2359
DOI: 10.1039/C4OB00265B, CommunicationAngelika E. Schneider, Tamara Beisel, Andrej Shemet, Georg Manolikakes
A highly efficient Bi(OTf)3-catalyzed three-component synthesis of arylglycines from a (sulfon)amide, glyoxalate and arene is described.
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Co(III)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: its application in the synthesis of ICI-118,551, an anti-hypertensive agent

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2349-2355
DOI: 10.1039/C3OB42501K, CommunicationPratibha U. Karabal, Dayanand A. Kamble, Arumugam Sudalai
The salen Co(III)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti- or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols.
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The issue of 'molecular radiators' in microwave-assisted reactions. Computational calculations on ring closing metathesis (RCM)

1 April, 2014 - 07:17

Org. Biomol. Chem., 2014, 12,2436-2445
DOI: 10.1039/C3OB42536C, PaperA. M. Rodriguez, P. Prieto, A. de la Hoz, A. Diaz-Ortiz, J. I. Garcia
Computational calculations on ring closing metathesis clarify the influence of molecular radiators in Microwave Assisted Organic Synthesis (MAOS).
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The effect of heteroatom conformation on optoelectronic properties of cyclopentadithiophene derivatives

30 March, 2014 - 06:54

Org. Biomol. Chem., 2014, 12,2474-2478
DOI: 10.1039/C3OB41648H, PaperSompit Wanwong, Ambata Poe, Ganapathy Balaji, S. Thayumanavan
Cyclopentadithiophene (CPDT) derivatives with different heteroatom conformations have been synthesized.
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Photoinduced changes in hydrogen bonding patterns of 8-thiopurine nucleobase analogues in a DNA strand

30 March, 2014 - 06:54

Org. Biomol. Chem., 2014, 12,2468-2473
DOI: 10.1039/C3OB42427H, PaperKunihiko Morihiro, Tetsuya Kodama, Shohei Mori, Satoshi Obika
Photoinduced changes in hydrogen bonding patterns have a strong effect on base recognition by nucleobase analogues.
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Synthesis of a carborane-containing cholesterol derivative and evaluation as a potential dual agent for MRI/BNCT applications

30 March, 2014 - 06:54

Org. Biomol. Chem., 2014, 12,2457-2467
DOI: 10.1039/C3OB42414F, PaperDiego Alberti, Antonio Toppino, Simonetta Geninatti Crich, Chiara Meraldi, Cristina Prandi, Nicoletta Protti, Silva Bortolussi, Saverio Altieri, Silvio Aime, Annamaria Deagostino
A new dual imaging and therapeutic agent is proposed to improve the efficacy of boron neutron capture therapy in cancer treatment.
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Recent advances in asymmetric intra- and intermolecular halofunctionalizations of alkenes

30 March, 2014 - 06:54

Org. Biomol. Chem., 2014, 12,2333-2343
DOI: 10.1039/C3OB42335B, Review ArticleYi An Cheng, Wesley Zongrong Yu, Ying-Yeung Yeung
Recent examples of catalytic and asymmetric intramolecular and intermolecular halofunctionalization reactions are reviewed.
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Synthesis of [small beta]-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation

28 March, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,2370-2387
DOI: 10.1039/C3OB42236D, PaperAhmed Kamal, M. P. Narasimha Rao, P. Swapna, Vunnam Srinivasulu, Chandrakant Bagul, Anver Basha Shaik, Kishore Mullagiri, Jeshma Kovvuri, Vangala Santhosh Reddy, K. Vidyasagar, Narayana Nagesh
A series of [small beta]-carboline-benzimidazole conjugates were synthesized using lanthanum nitrate as a novel catalyst and evaluated for their anticancer activity.
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Synthesis of functionalized 2-vinyl-2,3-dihydropyrroles and 3-methylene-1,2,3,4-tetrahydropyridines by palladium-catalyzed cyclization of [small beta]-enaminocarbonyl compounds with allylic bisacetates

28 March, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,2394-2403
DOI: 10.1039/C3OB42510J, PaperMasahiro Yoshida, Kouki Kinoshita, Kosuke Namba
Palladium-catalyzed reactions of [small beta]-enaminocarbonyl compounds with 1,4-diacetoxybut-2-ene and 2-methylene-1,3-propanediol diacetate are described.
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