Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 12 hours ago

Palladium-catalyzed Hiyama coupling reaction of arylsulfonyl hydrazides under oxygen

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4647-4651
DOI: 10.1039/C5OB00139K, CommunicationHui Miao, Fenhua Wang, Shuangliu Zhou, Guangchao Zhang, Yang Li
Palladium-catalyzed Hiyama cross-coupling reactions of various arylsulfonyl hydrazides with a wide variety of aryl silanes have been achieved in good to excellent yields under simple aerobic conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Inhibition of a multiproduct terpene synthase from Medicago truncatula by 3-bromoprenyl diphosphates

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4776-4784
DOI: 10.1039/C5OB00506J, PaperAbith Vattekkatte, Nathalie Gatto, Eva Schulze, Wolfgang Brandt, Wilhelm Boland
3-Bromo prenyl analogues bind to the active site and act as competitive inhibitors for terpene cyclases and -synthases.
The content of this RSS Feed (c) The Royal Society of Chemistry

PhI(OAc)2 mediated decarboxylative sulfonylation of [small beta]-aryl-[small alpha],[small beta]-unsaturated carboxylic acids: a synthesis of (E)-vinyl sulfones

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4785-4794
DOI: 10.1039/C5OB00417A, PaperPraewpan Katrun, Sornsiri Hlekhlai, Jatuporn Meesin, Manat Pohmakotr, Vichai Reutrakul, Thaworn Jaipetch, Darunee Soorukram, Chutima Kuhakarn
A novel and expedient method for the decarboxylative sulfonylation of [small beta]-aryl-[small alpha],[small beta]-unsaturated carboxylic acids to their (E)-vinyl sulfones is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Participation of an additional 4[prime or minute]-hydroxymethyl group in the cleavage and isomerization of ribonucleoside 3[prime or minute]-phosphodiesters

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4737-4742
DOI: 10.1039/C5OB00400D, PaperLuigi Lain, Harri Lonnberg, Tuomas Lonnberg
The impact of an additional 4[prime or minute]-hydroxymethyl group on the cleavage and isomerization of an RNA model compound is modest.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enhancement of fluorescent properties of near-infrared dyes using clickable oligoglycerol dendrons

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4727-4732
DOI: 10.1039/C5OB00299K, PaperOrit Redy-Keisar, Katharina Huth, Uwe Vogel, Bernd Lepenies, Peter H. Seeberger, Rainer Haag, Doron Shabat
Oligoglycerol dendrons effectively enhance the fluorescence properties of a cyanine NIR dye by increasing the solubility in water and the prevention of aggregate formation.
The content of this RSS Feed (c) The Royal Society of Chemistry

A novel domino cyclization for the stereoselective synthesis of indeno[2,1-c]pyran and cyclopenta[c]pyran derivatives

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4733-4736
DOI: 10.1039/C5OB00376H, PaperB. V. Subba Reddy, N. Prudhvi Raju, B. Someswarao, B. Jagan Mohan Reddy, B. Sridhar, Kanakaraju Marumudi, A. C. Kunwar
A domino cyclization of exo-methylenediol and aldehydes with 10 mol% BF3[middle dot]OEt2 provides the indeno[2,1-c]pyran scaffolds in good yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Heterocyclic carbene-catalyzed annulation of cyclic [small beta]-enamino esters with enals: access to functionalized indolo[2,3-a]quinolizidines

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4661-4667
DOI: 10.1039/C5OB00176E, CommunicationShihe Hu, Bingyang Wang, Yu Zhang, Weifang Tang, Mengyuan Fang, Tao Lu, Ding Du
A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene-catalyzed annulation of cyclic [small beta]-enamino esters with enals.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4693-4705
DOI: 10.1039/C5OB00097A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Radek Pohl, Lenka Postova Slavetinska, Wai Soon Eng, Dianne T. Keough, Luke W. Guddat, Dominik Rejman
Novel phosphonate nucleotides were synthesized. An inhibitor of the P. falciparum HGXPRT with a Ki of 0.6 [small mu ]M was found.
The content of this RSS Feed (c) The Royal Society of Chemistry

Unusual 1,2-aryl migration in Pd(II)-catalyzed aza-Wacker-type cyclization of 2-alkenylanilines

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4652-4656
DOI: 10.1039/C5OB00361J, CommunicationSo Won Youn, So Ra Lee
The discovery of an unprecedented 1,2-aryl migratory process in Pd(II)-catalyzed aza-Wacker-type cyclization of 2-alkenylanilines that led to a novel synthesis of C3-substituted indoles is demonstrated.
The content of this RSS Feed (c) The Royal Society of Chemistry

Intramolecular direct aldol reactions of sugar 2,7-diketones: syntheses of hydroxylated cycloalka(e)nones

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4795-4802
DOI: 10.1039/C5OB00253B, PaperTony K. M. Shing, Hau M. Cheng
A regio- and stereoselective intramolecular direct aldol reaction of 2,7-diketones derived from carbohydrates has been developed to construct cycloalkanones 7, which were dehydrated to obtain heavily oxygenated cycloalkenones 8.
The content of this RSS Feed (c) The Royal Society of Chemistry

A Maitland-Japp inspired synthesis of dihydropyran-4-ones and their stereoselective conversion to functionalised tetrahydropyran-4-ones

22 April, 2015 - 06:17

Org. Biomol. Chem., 2015, 13,4743-4750
DOI: 10.1039/C5OB00292C, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Paul A. Clarke, Philip B. Sellars, Nadiah Mad Nasir
New variations of the Maitland-Japp reaction have been developed to enable the synthesis of dihydropyrans and tetrahydropyrans with tertiary and quaternary stereocentres, including the functionalised tetrahydropyrans in Civet and the A-ring of lasonolide A.
The content of this RSS Feed (c) The Royal Society of Chemistry

Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4632-4636
DOI: 10.1039/C5OB00378D, CommunicationTsumoru Morimoto, Tetsuji Fujii, Kota Miyoshi, Gouki Makado, Hiroki Tanimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
The rhodium(I)/chiral Ph-bpe-catalyzed reaction of vinylarenes with formaldehyde provides an accessible protocol for asymmetric hydroformylation to enantioenriched aldehydes in high yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

An ab initio and DFT study of the autoxidation of THF and THP

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4686-4692
DOI: 10.1039/C5OB00012B, PaperHiroshi Matsubara, Syouhei Suzuki, Shun Hirano
Ab initio and DFT calculations were carried out to investigate the difference in reactivity for the autoxidation of THP (tetrahydropyran) and THF.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp2 C-H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4657-4660
DOI: 10.1039/C5OB00329F, CommunicationQiang Zheng, Puying Luo, Yuqing Lin, Wenfan Chen, Xiuxiu Liu, Yadong Zhang, Qiuping Ding
An efficient method for the synthesis of 4-aminoquinolines via palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines and isocyanides through double sp2 C-H bonds cleavage has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]pyrimidines

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4668-4672
DOI: 10.1039/C5OB00380F, CommunicationNimmakuri Rajesh, Dipak Prajapati
A copper-catalyzed one-pot, atom/step-economical, three component method for the construction of pyrano[2,3-d]pyrimidines has been developed via a tandem conjugative alkynylation/6-endo cyclization sequence.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4714-4726
DOI: 10.1039/C5OB00007F, PaperSai Fang, Lei Chen, Miao Yu, Bao Cheng, Yongsheng Lin, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Qiong Gu, Jun Xu
The design for 6-acrylic phenethyl ester 2-pyranone derivatives against five tumor cell lines is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pyrimidine-based functional fluorescent organic nanoparticle probe for detection of Pseudomonas aeruginosa

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4673-4679
DOI: 10.1039/C5OB00206K, PaperGaganpreet Kaur, Tilak Raj, Navneet Kaur, Narinder Singh
Organic nanoparticles are developed for the sensing of Pseudomonas aeruginosa.
The content of this RSS Feed (c) The Royal Society of Chemistry

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4760-4768
DOI: 10.1039/C5OB00100E, PaperPrabhakar Cherkupally, Suhas Ramesh, Thavendran Govender, Hendrik G. Kruger, Beatriz G. de la Torre, Fernando Albericio
The first total synthesis of the naturally obtainable marine siderophores amphibactin-T and moanachelin ala-B on solid-phase using standard Fmoc-chemistry is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4706-4713
DOI: 10.1039/C5OB00301F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shiho Okazaki, Shinya Oishi, Tsukasa Mizuhara, Kazuya Shimura, Hiroto Murayama, Hiroaki Ohno, Masao Matsuoka, Nobutaka Fujii
PD 404182 and benzo[4,5]isothiazolo[2,3-a]pyrimidines are possible prodrug forms of the ring-opened thiophenols with anti-HIV activity.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4642-4646
DOI: 10.1039/C5OB00409H, CommunicationZhengwei Ding, Qitao Tan, Mingchun Gao, Bin Xu
An efficient copper-catalyzed regioselective olefinic C(sp2)-H bond cycloamination and acyloxylation was developed to give acyloxylated pyrazoles under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.