Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 4 hours 24 min ago

E. coli cells expressing the Baeyer-Villiger Monooxygenase 'MO14' (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01441C, PaperBenjamin D Summers, Muhiadin Omar, Thomas Ronson, Jared Cartwright, Michael Lloyd, Gideon Grogan
The Baeyer-Villiger monooxygenase (BVMO) 'MO14' from Rhodococcus jostii RHA1, is an enantioselective BVMO that catalyses the resolution of the model ketone substrate bicyclo[3.2.0]hept-2-en-6-one to the (1S, 5R)-2-oxa lactone and the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02348J, PaperRobert Wodtke, Gloria Ruiz Gomez , Manuela Kuchar, Teresa Pisabarro, Pavlina Novotna, Marie Urbanova, Jorg Steinbach, Jens Pietzsch, Reik Loser
The collagen telopeptides play an important role for lysyl oxidase-mediated crosslinking, a process which is deregulated during tumour progression. The DEKS motif which is located within the N-terminal telopeptide of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02267J, CommunicationSu-Ying Xu, Xiaolong Sun, Rory L. Arrowsmith, Habo Ge, John S Fossey, Sofia I Pascu, Yun-Bao Jiang, Tony D James
A fluoride receptor has been developed where the interaction between the boronic acid and amine (NH) result in fluoride selectivity and enhanced fluorescence quenching.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly efficient stabilisation of meta-ethynylpyridine polymers with amide side chains in water by coordination of rare-earth metals

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02129K, PaperHiroki Makida, Hajime Abe, Masahiko Inouye
An amphiphilic meta-ethynylpyridine polymer with chiral amide side chains coordinated with rare-earth metal salts, especially strongly with Sc(III), to stabilise its helical structure with CD enhancement.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02303J, PaperAaron Johnson, Matthew J. Saunders, Thomas G. Back
BIRT-377 was synthesized by enzymatic desymmetrization in conjunction with Curtius rearrangement, affording a key [small alpha]-quaternary amine intermediate in high ee.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez-Bartulos, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The combination of the cell-penetrating peptide BP16 with the enzymatic cleavable sequence Gly-Phe-Leu-Gly constitutes a drug delivery system for the effective uptake and release of chlorambucil in cancer cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cu-catalyzed arylation of the amino group in the indazole ring: regioselective synthesis of pyrazolo-carbazoles

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02044H, PaperK. Anil Kumar, Prakash Kannaboina, Devendra K. Dhaked, Ram A. Vishwakarma, Prasad V. Bharatam, Parthasarathi Das
Arylated aminoindazoles were synthesized by copper-catalyzed C-N bond cross-coupling with boronic acids. These were then transformed to pyrazolo-carbazoles by Pd-catalyzed regioselective cross-dehydrogenative coupling.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01898B, PaperLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
In this work the application of Hansen solubility parameters in the study of caffeine encapsulation in metal organic frameworks (MOFs) has been initiated.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Systematic analyses of mutant LasR quorum-sensing receptors with its native ligand and a suite of synthetic analogues reveal the importance of specific polar interactions for native receptor activation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

The development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02197E, PaperA. L. Hurski, Yu. V. Ermolovich, V. N. Zhabinskii, V. A. Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. It was applied for the preparation of brassinolide and related brassinosteroids.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study

13 December, 2014 - 21:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02204A, PaperLaura Gallego-Yerga, Michela Lomazzi, Valentina Franceschi, Francesco Sansone, Carmen Ortiz Mellet, Gaetano Donofrio, Alessandro Casnati, Jose M. Garcia Fernandez
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Water-soluble aryl-extended calix[4]pyrroles with unperturbed aromatic cavities: synthesis and binding studies

11 December, 2014 - 21:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02108H, PaperD. Hernandez-Alonso, S. Zankowski, L. Adriaenssens, P. Ballester
An aryl-extended calix[4]pyrrole receptor with four carboxylic groups at the lower rim binds N-oxides in water with high stability constants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02258K, PaperSamuel Furse, LokHang Mak, Edward William Tate, Richard Templer, Oscar Ces, Rudiger Woscholski, Piers R J Gaffney
In this paper evidence is presented that the fatty acid component of an inositide substrate affects the kinetic parameters of the lipid phosphatase Salmonella Outer Protein B (SopB). A succinct...
The content of this RSS Feed (c) The Royal Society of Chemistry

Fixation of sulfur dioxide into small molecules

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02139H, Review ArticleGang Liu, Congbin Fan, Jie Wu
Sulfonyl-derived functional groups can be found in a broad range of natural products, pharmaceuticals, and materials. Among the methods for the introduction of sulfonyl group into small molecules, the approach...
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Heterocyclic carbene-catalyzed [4+2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: an efficient assembly of spirocarbocyclic oxindole

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01706D, PaperYuanwei Xie, Yonglei Que, Tuanjie Li, Ling Zhu, Chenxia Yu, Changsheng Yao
A NHC-catalyzed [4+2] cyclization of 2-bromo-2-enal bearing [gamma]-H with 3-alkylenyloxindoles under mild reaction conditions gives spirocarbocyclic oxindoles containing one quaternary carbon in moderate to good yields with high diastereoselectivies. The...
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-Catalyzed O-Arylation of N-Protected 1,2-Aminoalcohols Using Functionalized Trivalent Organobismuth Reagents

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02497D, CommunicationAlexandre Gagnon, Pauline Petiot, Julien Dansereau, Hebert Martin, Khene Imene, Tabinda Ahmad, Samira Samaali, Maxime Leroy, Pinsonneault Francis, Claude Y. Legault
The O-arylation of 1,2-aminoalcohols using functionalized triarylbismuth reagents is reported. The reaction can be performed using substoichiometric amounts of copper acetate and operates under mild conditions. Good functional group tolerance...
The content of this RSS Feed (c) The Royal Society of Chemistry

Trigonal Scaffolds for Multivalent Targeting of Melanocortin Receptors

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02094D, PaperN. G. R. Dayan Elshan, Thanuja Jayasundera, Bobbi L. Anglin, Craig S. Weber, Ronald M. Lynch, Eugene A Mash
Melanocortin receptors can be used as biomarkers to detect and possibly treat melanoma. To these ends, molecules bearing one, two, or three copies of the weakly binding ligand MSH(4) were...
The content of this RSS Feed (c) The Royal Society of Chemistry

Sc(OTf)3-Catalyzed Cascade Reaction of o-Aminoacetophenone with Methanamine: Construction of Dibenzo[b,h][1,6]naphthyridine Derivatives

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02220C, PaperDan Mao, Jun Tang, Wenbo Wang, Xin Liu, Shengying Wu, Jianjun Yu, Limin Wang
An unexpected Sc(OTf)3-catalyzed and air-mediated cascade reaction of o-aminoacetophenones with methanamines was discovered as an efficient synthetic approach to a novel class of fluorescent fused-four-ring dibenzo[b,h][1,6]naphthyridine derivatives. Two possible mechanisms...
The content of this RSS Feed (c) The Royal Society of Chemistry

Transition metal catalyzed meta-C-H functionalization of aromatic compounds

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02171A, Review ArticleJiong Yang
Direct functionalization of C-H bonds represents a powerful strategy for the synthesis of complex organic compounds due to its inherent efficiency. Among various approaches, transition metal-catalyzed direct activation of unreactive...
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02321H, PaperStefano Roelens, Oscar Francesconi, Matteo Gentili, Francesco Bartoli, Andrea Bencini, Luca Conti, Claudia Giorgi
In this work we have investigated the binding properties of a new synthetic receptor for phosphate anions that combines metal ion coordination with electrostatic and H-bonding interactions. The described receptor...
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.