Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 14 hours 32 min ago

Gorlos-Phos for Palladium-Catalyzed Borylation of Aryl Chlorides

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00293H, PaperPengbin Li, Chunling Fu, Shengming Ma
Using readily available form of mono-phosphine ligand, Gorlos-Phos[round bullet, filled]HBF4, Pd-catalyzed borylation of aryl chlorides afforded aryl boronates in high yields. A variety of functional groups are well compatible in this palladium...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00598H, PaperAntonio Luiz Braga, Romulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Ines M. C. Brighente
In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors,...
The content of this RSS Feed (c) The Royal Society of Chemistry

Self-Assembly of Peptides to Nanostructures

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00447G, Review ArticleDindyal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang
The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry. Among all organic...
The content of this RSS Feed (c) The Royal Society of Chemistry

Benzo[a]acridinyl methyl esters as pH Sensitive Fluorescent Photoactive precursors: Synthesis, Photophysical, Photochemical and Biological Applications

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42600A, PaperMohammed Ikbal, Biswajit Saha, Sharabani Barman, Sanghamitra sangha.chem@gmail.com Atta, Debranjan Banerjee, Sudip Ghosh, Pradeep N.D. Singh
Newsworthy class of carboxylate esters based on (benzo[a]acridin-12-yl)methyl (BAM) chromophore has been shown to perform dual functions such as "pH sensitive fluorescent probe" and "phototrigger" for acids. Photophysical properties of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, Synthesis, and Biological Evaluation of Novel Trifluoromethyl Indole Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42186D, PaperHaixia Jiang, Dao-Min Zhuang, Ying Huang, Xingxin Cao, Jianhua Yao, Jingyun Li, Jian-Yong Wang, Chen Zhang, Biao Jiang
A novel series of trifluoromethyl indole derivatives have been designed, synthesized and evaluated for anti-HIV-1 activities in MT-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were predicted. Trifluoromethyl...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and Synthesis of Paracaseolide A Analogues as Selective Protein Tyrosine Phosphatase 1B Inhibitors

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00214H, PaperJianpeng Yin, Chunlan Tang, Lixin Gao, Weiping Ma, jingya Li, Ying Li, J. Li, FJ Nan
A series of structurally related analogues of the natural product paracaseolide A were synthesized and identified as potent PTP1B inhibitors. Among these analogues, compound 10 in particular showed improved PTP1B...
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydro-pyrimidine-2(1H)-thiones via non-Biginelli-type approach and evaluation of their in vitro anticancer activity

7 April, 2014 - 08:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00094C, PaperJacek G. Sosnicki, Lukasz Struk, Mateusz Kurzawski, Magdalena Peruzyska, Gabriela Maciejewska, Marek Drozdzik
An easy and novel approach to 4,5-diaryl functionalized 3,4 dihydropyrimidine-2(1H)-thiones via addition of aryllithiums to 5-aryl substituted pyrimidine-2(1H)-thiones, which could be regarded as a method complementary to the most widely...
The content of this RSS Feed (c) The Royal Society of Chemistry

Efficient synthesis of biscarbazoles by palladium-catalyzed twofold C-N coupling and C-H activation reactions

7 April, 2014 - 08:54

Org. Biomol. Chem., 2014, 12,2596-2605
DOI: 10.1039/C3OB41746H, PaperTran Quang Hung, Ngo Ngoc Thang, Do Huy Hoang, Tuan Thanh Dang, Alexander Villinger, Peter Langer
Biscarbazoles were efficiently prepared by palladium catalyzed C-N coupling and C-H activation reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Biomimetic total synthesis of (+/-)-yezo'otogirin A

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2519-2522
DOI: 10.1039/C4OB00186A, CommunicationHiu C. Lam, Kevin K. W. Kuan, Jonathan H. George
A concise total synthesis of (+/-)-yezo'otogirin A has been achieved via its presumed biosynthetic precursor using a late-stage biomimetic oxidative radical cyclization.
The content of this RSS Feed (c) The Royal Society of Chemistry

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2584-2591
DOI: 10.1039/C3OB42512F, PaperThomas James, Paul MacLellan, George M. Burslem, Iain Simpson, J. Andrew Grant, Stuart Warriner, Visuvanathar Sridharan, Adam Nelson
A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazine, 1,4-diazepine and 1,5-diazocane scaffolds.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2568-2575
DOI: 10.1039/C3OB42428F, PaperMu Cheng, Zyta M. Ziora, Karl A. Hansford, Mark A. Blaskovich, Mark S. Butler, Matthew A. Cooper
Dalbavancin, a semi-synthetic glycopeptide with enhanced antibiotic activity compared to vancomycin and teicoplanin, dimerises strongly in an anti-cooperative manner with ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphodiesters serve as potentially tunable aglycones for fluoro sugar inactivators of retaining [small beta]-glycosidases

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2592-2595
DOI: 10.1039/C4OB00235K, PaperB. P. Rempel, S. G. Withers
2-Deoxy-2-fluoroglycosides were synthesised and tested as covalent glycosidase inactivators. [small beta]-D-Gluco-, -manno- and -galacto-configured benzyl-benzylphosphonate derivatives efficiently inactivate [small beta]-gluco-, [small beta]-manno- and [small beta]-galactosidases, while [small alpha]-gluco- and [small alpha]-manno-configured phosphate and phosphonate derivatives instead served as slow substrates for their cognate [small alpha]-glycosidases.
The content of this RSS Feed (c) The Royal Society of Chemistry

The ferrocene-pyrylium dyad as a selective colorimetric chemodosimeter for the toxic cyanide and hydrogen sulfide anions in water

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2547-2551
DOI: 10.1039/C4OB00157E, CommunicationAntonia Sola, Alberto Tarraga, Pedro Molina
A pyrylium derivative showing a remarkable ability to recognize cyanide and hydrogen sulfide anions in aqueous media through two different channels, electrochemical and chromogenic, is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fructose controlled ionophoric activity of a cholate-boronic acid

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2576-2583
DOI: 10.1039/C4OB00165F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.James R. D. Brown, Inmaculada C. Pintre, Simon J. Webb
The transport of Na+ through phospholipid bilayers by Wulff-type boronic acids at pH 8.2 is reported. Concentrations of fructose greater than 5 mM strongly inhibited ionophoric activity.
The content of this RSS Feed (c) The Royal Society of Chemistry

A nanomotor involves a metastable, left-handed DNA duplex

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2543-2546
DOI: 10.1039/C4OB00317A, CommunicationYingmei Li, Chuan Zhang, Cheng Tian, Chengde Mao
A metastable left-handed DNA is used to power a DNA nanomotor by non-toehold-mediated strand displacement.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium catalyzed N-H bond insertion and intramolecular cyclization cascade: the divergent synthesis of heterocyclics

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2533-2537
DOI: 10.1039/C4OB00001C, CommunicationDong Ding, Gang Liu, Guangyang Xu, Jian Li, Guoping Wang, Jiangtao Sun
A palladium-catalyzed one-pot procedure of N-H insertion and Heck cyclization/base promoted cyclization has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pd(II)-catalyzed oxidative alkoxycarbonylation of 2-phenoxypyridine derivatives with CO and alcohols

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2538-2542
DOI: 10.1039/C4OB00084F, CommunicationBin Liu, Huai-Zhi Jiang, Bing-Feng Shi
A Pd(II)-catalyzed oxidative alkoxycarbonylation of phenol derivatives with atmospheric pressure of CO-O2 and alcohols has been achieved.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed benzylic C(sp3)-H alkoxylation of heterocyclic compounds

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2528-2532
DOI: 10.1039/C4OB00215F, CommunicationNoriaki Takemura, Yoichiro Kuninobu, Motomu Kanai
Intra- and intermolecular C(sp3)-H alkoxylation on a gram scale.
The content of this RSS Feed (c) The Royal Society of Chemistry

Versatile C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2606-2614
DOI: 10.1039/C3OB42251H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Arne Berthelmann, Johannes Lach, Melissa A. Grawert, Michael Groll, Jutta Eichler
Attachment of foldon monomers to a trimesic acid scaffold enhances thermal stability of the trimer, while maintaining the correct fold.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins

3 April, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,2615-2625
DOI: 10.1039/C3OB42308E, PaperLaxminarayan Sahoo, Anadi Singhamahapatra, Duraikkannu Loganathan
5-Halo triazole linked glycolipids, potentially useful for extraction and crystallization of integral membrane proteins synthesized by Cu(I) catalyzed click reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.