Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2664-2668
DOI: 10.1039/C4OB02427C, PaperChristopher A. P. Whittaker, Simon G. Patching, Mikael Esmann, David A. Middleton
Paramagnetic relaxation-enhanced solid-state NMR reveals a ouabain analogue with an inverted orientation in the Na,K-ATPase inhibitory site.
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Direct construction of 2-alkylbenzo-1,3-azoles via C-H activation of alkanes for C-C and C-X (X = O, S) bond formation

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2606-2611
DOI: 10.1039/C4OB02488E, PaperArvind K. Yadav, Lal Dhar S. Yadav
2-Alkylated benzo(oxa)thiazoles were prepared directly from simple alkanes and aryl isocyanates/isothiocyanates in a one-pot procedure.
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Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein-protein binding

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2612-2621
DOI: 10.1039/C4OB01926A, PaperChristoffer Karlsson, Magnus Blom, Miranda Johansson (nee Varedian), Anna M. Jansson, Enzo Scifo, Anders Karlen, Thavendran Govender, Adolf Gogoll
Peptidomimetic inhibitors with photomodulable affinity for the R1-R2 subunit association site were designed based on the R2-subunit C-terminal.
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Contrasting anion recognition behaviour exhibited by halogen and hydrogen bonding rotaxane hosts

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2582-2587
DOI: 10.1039/C4OB02547D, PaperStuart P. Cornes, Charles H. Davies, David Blyghton, Mark R. Sambrook, Paul D. Beer
A [2]rotaxane anion host that switches selectivity from dihydrogen phosphate to the halides upon substituting a hydrogen bond donor group for a halogen bond donor group within the axle component is described.
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Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at the C-4 position of oxazoles

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2600-2605
DOI: 10.1039/C4OB02224F, PaperMahesh Akula, Yadagiri Thigulla, Connor Davis, Mukund Jha, Anupam Bhattacharya
Cu(TFA)2 catalysed synthesis of 4-arylsubstituted oxazolo[4,5-c]quinolines/[1,8] naphthyridines has been described via a modified Pictet-Spengler method, without prefunctionalization of the unreactive 4th position of oxazoles.
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Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2588-2599
DOI: 10.1039/C4OB02441A, PaperYeming Ju, Di Miao, Ruiyang Yu, Sangho Koo
Coupling of ethyl acetoacetate with MVK and with 2-nitrobenzyl bromides, Mn(III)/Co(II)-catalyzed deacetylation, and heterocyclizations provide pyrroles and indoles, respectively.
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A novel Prins cascade process for the stereoselective synthesis of oxa-bicycles

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2669-2672
DOI: 10.1039/C4OB02347A, PaperB. V. Subba Reddy, A. Venkateswarlu, B. Sridevi, Kanakaraju Marumudi, A. C. Kunwar, G. Gayatri
E- and Z-9-Methyldeca-3,8-dien-1-ols undergo smooth cyclization with aldehydes in the presence of 20 mol% AgSbF6 under extremely mild conditions to generate the corresponding oxa-bicycles in good yields with excellent selectivity.
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A comparison of chemiluminescent acridinium dimethylphenyl ester labels with different conjugation sites

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2622-2633
DOI: 10.1039/C4OB02528H, PaperAnand Natrajan, David Wen
Chemiluminescent acridinium esters containing conjugation sites at the acridinium nitrogen show increased light yield when labeled to proteins.
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A facile and high-yield formation of dipyrrin-boronic acid dyads and triads: a light-harvesting system in the visible region based on the efficient energy transfer

22 February, 2015 - 14:54

Org. Biomol. Chem., 2015, 13,2574-2581
DOI: 10.1039/C4OB02351J, PaperMasaki Yamamura, Shinya Yazaki, Motofumi Seki, Yasunori Matsui, Hiroshi Ikeda, Tatsuya Nabeshima
Artificial light-harvesting systems, Ar,O-BODIPY dyads and triads conjugated with a light harvester, were synthesized in high yield by the reaction of an N2O2-type dipyrrin with boronic acids.
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Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation

20 February, 2015 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00054H, PaperGurunadham Munagala, Kushalava Reddy Yempalla, Samsher Singh, Sumit Sharma, Nitin Pal Kalia, Vikrant Singh Rajput, Sunil Kumar, Sanghapal D. Sawant, Inshad Ali Khan, Ram A. Vishwakarma, Parvinder Pal Singh
Promising nitroimidazoloxazole scaffold gives another novel triazolyl-containing 6-nitro-2,3-dihydroimidazooxazole as anti-TB lead.
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Copper(II) bromide-catalyzed intramolecular decarboxylative functionalization to form a C(sp3)-O bond for the synthesis of furo[3,2-c]coumarins

20 February, 2015 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02490G, PaperW. L. Zhang, S. N. Yue, Y. M. Shen, H. Y. Hu, Q.-H. Meng, H. Wu, Y. Liu
Copper(II) bromide-catalyzed intramolecular decarboxylative functionalization to form a C(sp3)-O bond has been developed.
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Homocoupling versus reduction of radicals: an experimental and theoretical study of Ti(III)-mediated deoxygenation of activated alcohols

18 February, 2015 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02290D, PaperConsuelo Prieto, Jose A. Gonzalez Delgado, Jesus F. Arteaga, Martin Jaraiz, Jose L. Lopez-Perez, Alejandro F. Barrero
A detailed study corroborates that the Ti(III)-mediated reductive deoxygenation of activated -OH proceeds via an allyl(benzyl)-radical and allyl(benzyl)-Ti, which is protonated, regioselectively in the case of allylic derivatives.
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PhI(OAc)2-mediated functionalisation of unactivated alkenes for the synthesis of pyrazoline and isoxazoline derivatives

18 February, 2015 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00029G, PaperXiao-Qiang Hu, Guoqiang Feng, Jia-Rong Chen, Dong-Mei Yan, Quan-Qing Zhao, Qiang Wei, Wen-Jing Xiao
A PhI(OAc)2-promoted radical cyclization of [small beta],[gamma]-unsaturated hydrazones and oximes has been developed for an efficient synthesis of pyrazolines and isoxazolines.
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A prominent bathochromic shift effect of indole-containing diarylethene derivatives

18 February, 2015 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02619E, PaperHong-Bo Cheng, Yao-Dong Huang, Lina Zhao, Xu Li, Hai-Chen Wu
Bisindole diarylethene derivatives exhibit a strong bathochromic shift effect in photochromism compared with bisbenzothiophene diarylethene.
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[gamma]-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP

18 February, 2015 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00050E, PaperY. Jagadeesh, A. T. Tran, B. Luo, N. Auberger, J. Desire, S. Nakagawa, A. Kato, Y. Zhang, M. Sollogoub, Y. Bleriot
Exploiting a [gamma]-aminoalcohol rearrangement, pentahydroxylated azepanes are converted to pyrrolidines that are epimeric to homoDMDP, a potent glycosidase inhibitor.
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Correction: A novel enantioselective synthesis of 6H-dibenzopyran derivatives by combined palladium/norbornene and cinchona alkaloid catalysis

18 February, 2015 - 13:54
Org. Biomol. Chem., 2015, 13,2481-2481
DOI: 10.1039/C5OB90021B, CorrectionDi Xu, Li Dai, Marta Catellani, Elena Motti, Nicola Della Ca', Zhiming Zhou
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Correction: Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

18 February, 2015 - 13:54
Org. Biomol. Chem., 2015, 13,2480-2480
DOI: 10.1039/C5OB90016F, CorrectionLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
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Hemisynthesis of deuteriated adenosylhopane and conversion into bacteriohopanetetrol by a cell-free system from Methylobacterium organophilum

16 February, 2015 - 13:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02560A, PaperWenjun Liu, Anne Bodlenner, Michel Rohmer
(2H2)Adenosylhopane was synthesised via a reaction sequence including a cross metathesis followed by N22H2 reduction of the resulting olefin.
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One-step protecting-group-free synthesis of azepinomycin in water

16 February, 2015 - 13:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00210A, PaperAdam J. Coggins, Derek A. Tocher, Matthew W. Powner
pH-dependent one-step multi-gram synthesis of azepinomycin in water.
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Exploring a cascade Heck-Suzuki reaction based route to kinase inhibitors using design of experiments

16 February, 2015 - 13:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02694B, PaperAndreas Ekebergh, Christine Lingblom, Peter Sandin, Christine Wenneras, Jerker Martensson
A fused tricyclic system with kinase inhibiting properties was assembled via a palladium catalyzed tandem reaction. The reaction was optimized using statistical experimental design.
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