Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,357-360
DOI: 10.1039/C4OB02071E, CommunicationTommaso Quinto, Daniel Haussinger, Valentin Kohler, Thomas R. Ward
Stereoselectively labelled isotopomers of NAD(P)H are highly relevant for mechanistic studies of enzymes which utilize them as redox equivalents.
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L-Valine derived chiral N-sulfinamides as effective organocatalysts for the asymmetric hydrosilylation of N-alkyl and N-aryl protected ketimines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,577-582
DOI: 10.1039/C4OB01257G, PaperChao Wang, Xinjun Wu, Li Zhou, Jian Sun
L-Valine derived N-sulfinamides have been developed as efficient enantioselective Lewis basic organocatalysts for the asymmetric reduction of N-aryl and N-alkyl ketimines with trichlorosilane.
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Pd(II)-catalyzed C-H arylation of aryl and benzyl Weinreb amides

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,353-356
DOI: 10.1039/C4OB02039A, CommunicationYan Wang, Kai Zhou, Quan Lan, Xi-Sheng Wang
The first example of palladium-catalyzed ortho-C-H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter.
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Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,570-576
DOI: 10.1039/C4OB02054E, PaperFilippo Doria, Marco Folini, Vincenzo Grande, Graziella Cimino-Reale, Nadia Zaffaroni, Mauro Freccero
Water-soluble naphthalene diimides have been designed and synthesized as cell permeable pH "turned-on" fluorescent sensors for cellular applications.
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Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,549-560
DOI: 10.1039/C4OB01734J, PaperMatthijs van Haren, Linda Quarles van Ufford, Ed E. Moret, Nathaniel I. Martin
PRMT inhibitors designed to simultaneously occupy both substrate binding sites display potent activity and surprising selectivity.
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Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,539-548
DOI: 10.1039/C4OB02061H, PaperWei Li, Zhoulong Fan, Kaijun Geng, Youjun Xu, Ao Zhang
Divergent ortho-selective C-H functionalization was successfully established using a pyridazinone moiety as an internal directing group.
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Indium-catalyzed intramolecular hydroarylation of aryl propargyl ethers

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,379-387
DOI: 10.1039/C4OB02033B, PaperLorena Alonso-Maranon, M. Montserrat Martinez, Luis A. Sarandeses, Jose Perez Sestelo
Indium(III) halides are efficient and selective catalysts for the intramolecular hydroarylation of aryl propargyl ethers.
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Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,527-538
DOI: 10.1039/C4OB01465K, PaperRosa M. Suarez, Pedro Bosch, David Sucunza, Ana M. Cuadro, Alberto Domingo, Francisco Mendicuti, Juan J. Vaquero
The fluorescence, DNA binding and DNA sequence selectivity properties of a library of azonia aromatic cations have been studied.
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Developing a targeting system for bacterial membranes: measuring receptor-phosphatidylglycerol interactions with 1H NMR, ITC and fluorescence correlation spectroscopy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,502-512
DOI: 10.1039/C4OB01895H, PaperAmanda Alliband, Zifan Wang, Christopher Thacker, Douglas S. English, Dennis H. Burns
We report the development of a potential targeting system for bacterial membranes containing phosphatidylglycerol.
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Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-[small beta]-enaminonitriles

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,513-519
DOI: 10.1039/C4OB01801J, PaperYing-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang, Ying-ming Pan
In this work, a novel and highly stereoselective synthesis of Z-[small beta]-enaminonitriles from azides and [small alpha],[small beta]-unsaturated nitriles is reported.
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Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,477-486
DOI: 10.1039/C4OB01758G, PaperZhi-Cheng Dai, Yong-Fei Chen, Mao Zhang, Sheng-Kun Li, Ting-Ting Yang, Li Shen, Jian-Xin Wang, Shao-Song Qian, Hai-Liang Zhu, Yong-Hao Ye
A series of 1,2,3-triazole phenylhydrazone derivatives were designed and synthesized as antifungal agents.
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Chiral recognition with a benzofuran receptor that mimics an oxyanion hole

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,493-501
DOI: 10.1039/C4OB01954G, PaperAngel L. Fuentes de Arriba, Angel Gomez Herrero, Omayra H. Rubio, Laura M. Monleon, Luis Simon Rubio, Victoria Alcazar, Francisca Sanz, Joaquin R. Moran
Chiral resolution of a novel tripodal oxyanion-hole receptor with application in amino acid derivatives enantioselective extraction.
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Mixed non-covalent assemblies of ethynyl nile red and ethynyl pyrene along oligonucleotide templates

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,487-492
DOI: 10.1039/C4OB01860E, PaperPhilipp Ensslen, Yannic Fritz, Hans-Achim Wagenknecht
The mixture makes the difference: the assemblies of ethynyl pyrene and ethynyl nile red along oligonucleotide templates are highly ordered and yield dual fluorescence.
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A peptide topological template for the dispersion of [60]fullerene in water

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,348-352
DOI: 10.1039/C4OB02102A, CommunicationS. Bartocci, D. Mazzier, A. Moretto, M. Mba
Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL-1 have been obtained using a peptide topological template as the carrier.
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The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,465-476
DOI: 10.1039/C4OB01792G, PaperJ. M. Botubol-Ares, M. J. Duran-Pena, A. J. Macias-Sanchez, J. R. Hanson, I. G. Collado, R. Hernandez-Galan
The enantioselective synthesis of 3, (E)-8, (Z)-8, 20a and 20b is reported using RCM as key step. Based in spectroscopic differences, the structure assigned to the natural product has been revised to that of a [gamma]-butyrolactone.
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Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,452-464
DOI: 10.1039/C4OB01925C, PaperGerard Artigas, Paula Lopez-Senin, Carlos Gonzalez, Nuria Escaja, Vicente Marchan
Ligands with a preferred binding site in the bulged region of the stem-loop structure of Tau pre-mRNA have been identified by dynamic combinatorial chemistry.
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Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,447-451
DOI: 10.1039/C4OB02138J, PaperInna Perepichka, Soumen Kundu, Zoe Hearne, Chao-Jun Li
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp3 and sp C-H bonds with the assistance of a photocatalyst and visible light.
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Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,428-437
DOI: 10.1039/C4OB01869A, PaperAline Alves dos Santos Naujorks, Adriano Olimpio da Silva, Rosangela da Silva Lopes, Sergio de Albuquerque, Adilson Beatriz, Maria Rita Marques, Denis Pires de Lima
Novel naphthoquinone derivatives were synthesized and tested for trypanocidal and leishmanicidal activities. Compound 11a was the most active against T. cruzi.
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Bidirectional macrocyclization of peptides by double multicomponent reactions

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,438-446
DOI: 10.1039/C4OB01915F, PaperManuel G. Ricardo, Fidel E. Morales, Hilda Garay, Osvaldo Reyes, Dimitar Vasilev, Ludger A. Wessjohann, Daniel G. Rivera
Peptide macrocyclization by multicomponent reactions.
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Preparation of asymmetrical polyynes by a solid-supported Glaser-Hay reaction

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,424-427
DOI: 10.1039/C4OB02196G, PaperJessica S. Lampkowski, Corinn E. Durham, Marshall S. Padilla, Douglas D. Young
A novel approach to the synthesis of asymmetrical polyynes utilizing solid-supported chemistry.
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