Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Total syntheses and structural validation of lincitol A, lincitol B, uvacalol I, uvacalol J, and uvacalol K

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7279-7289
DOI: 10.1039/C4OB01329H, PaperSoumik Mondal, Kana M. Sureshan
First total syntheses of lincitol A, lincitol B, uvacalol I, uvacalol J and uvacalol K were achieved in racemic form, validating their structure from a common intermediate, which was synthesized in six steps from low-cost and extensively available myo-inositol.
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The effect of LNA nucleobases as enhancers for the binding of amiloride to an abasic site in DNA/DNA and DNA/RNA duplexes

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7250-7256
DOI: 10.1039/C4OB00977K, PaperYusuke Sato, Tetsushi Sato, Takaya Sato, Seiichi Nishizawa, Norio Teramae
We report on a significant effect of locked nucleic acid (LNA) nucleobases on the binding of amiloride for abasic site (AP)-containing DNA duplexes.
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Microwave assisted synthesis and QSAR study of novel NSAID acetaminophen conjugates with amino acid linkers

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7238-7249
DOI: 10.1039/C4OB01281J, PaperAnand D. Tiwari, Siva S. Panda, Adel S. Girgis, Sandhyamayee Sahu, Riham F. George, Aladdin M. Srour, Brian La Starza, Abdullah M. Asiri, C. Dennis Hall, Alan R. Katritzky
Twelve novel conjugates of NSAID linked by amino acid units to acetaminophen synthesized under microwave irradiation as potential anti-inflammatory agents.
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Recent advances in catalytic C-N bond formation: a comparison of cascade hydroaminomethylation and reductive amination reactions with the corresponding hydroamidomethylation and reductive amidation reactions

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7179-7193
DOI: 10.1039/C4OB00620H, Review ArticleSaeed Raoufmoghaddam
This review highlights and compares selected examples of hydroaminomethylation, reductive amination, hydroamidomethylation and reductive amidation reactions, and consequently reveals their potential applications.
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Palladium-catalyzed carbonylative addition of aryl bromides to arylalkynes: a simple and efficient method for chalcone synthesis

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7233-7237
DOI: 10.1039/C4OB01263A, PaperSheng Zhang, Liangguang Wang, Xiujuan Feng, Ming Bao
Chalcones can be prepared in satisfactory to excellent yields via palladium-catalyzed carbonylative addition of aryl bromides to terminal arylalkynes under mild conditions.
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Synthesis and immunological effects of heroin vaccines

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7211-7232
DOI: 10.1039/C4OB01053A, PaperFuying Li, Kejun Cheng, Joshua F. G. Antoline, Malliga R. Iyer, Gary R. Matyas, Oscar B. Torres, Rashmi Jalah, Zoltan Beck, Carl R. Alving, Damon A. Parrish, Jeffrey R. Deschamps, Arthur E. Jacobson, Kenner C. Rice
Multi-step syntheses provided three designed haptens for vaccines that were evaluated for their ability to block the effects of heroin and its metabolites.
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Ionic liquids as porogens for molecularly imprinted polymers: propranolol, a model study

7 September, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,7201-7210
DOI: 10.1039/C4OB00547C, PaperKatherine Booker, Clovia I. Holdsworth, Cara M. Doherty, Anita J. Hill, Michael C. Bowyer, Adam McCluskey
The selectivity and rebinding capacity of molecularly imprinted polymers selective for propranolol (1) using the room temperature ionic liquids [BMIM][BF4], [BMIM][PF6], [HMIM][PF6] and [OMIM][PF6] and CHCl3 were examined.
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Cycloreversion of [small beta]-Lactams via Photoinduced Electron Transfer

3 September, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01416B, PaperRaul Perez-Ruiz, Jose Antonio Saez, M. Consuelo Jimenez, Miguel Miranda
The radical anions of [small beta]-lactams, photogenerated in the presence of DABCO as electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to...
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The transition-metal-catalyst-free oxidative homocoupling of organomanganese reagents prepared by the insertion of magnesium into organic halides in the presence of MnCl2[middle dot]2LiCl

3 September, 2014 - 21:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01235F, PaperZhihua Peng, Na Li, Xinyang Sun, Fang Wang, Lanjian Xu, Cuiyu Jiang, Linhua Song, Zi-Feng Yan
An oxidative homocoupling of organomanganese reagents was performed in one pot without an additional transition-metal catalyst.
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Palladium-catalyzed one pot 2-arylquinazoline formation via hydrogen-transfer strategy

3 September, 2014 - 21:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01296H, PaperHuamin Wang, Hui Chen, Ya Chen, Guo-Jun Deng
2-Arylquinazolines were prepared from nitroarenes and benzyl alcohols or benzyl amines via a hydrogen transfer strategy.
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A versatile strategy for appending a single functional group to a multifunctional host through host-guest covalent-capture

3 September, 2014 - 21:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01429D, PaperJean-Noel Rebilly, Assia Hessani, Benoit Colasson, Olivia Reinaud
A novel two-step strategy allowed us to selectively monofunctionalize a molecular host (calix[6]arene) with various groups of interest (redox tag, fluorophore, chelating ligand).
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Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2[prime or minute]-alkylated RNA monomers

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01183J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Saswata Karmakar, Andreas S. Madsen, Dale C. Guenther, Bradley C. Gibbons, Patrick J. Hrdlicka
Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA with single nucleotide fidelity.
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MIDA as a simple and highly efficient ligand for palladium-catalyzed Hiyama cross-coupling of aryl halides

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7136-7139
DOI: 10.1039/C4OB01056F, PaperMengping Guo, Liang Qi, Qiaochu Zhang, Zhiyong Zhu, Wei Li, Xiaogang Li
N-Methyliminodiacetic acid (MIDA) as a simple, air stable and water-soluble ligand shows high catalytic activity in Hiyama reaction.
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Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,7159-7166
DOI: 10.1039/C4OB01201A, PaperHassen Bel Abed, Oscar Mammoliti, Omprakash Bande, Guy Van Lommen, Piet Herdewijn
The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported.
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An economical and environmentally friendly oxidative biaryl coupling promoted by activated MnO2

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01409J, PaperJingjing Yang, Shutao Sun, Ziyu Zeng, Hongbo Zheng, Wei Li, Hongxiang Lou, Lei Liu
A mild, economical, and environmentally friendly oxidative biaryl coupling by MnO2 was developed to deliver five- to eight-membered tricyclic products.
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Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi-Huisgen tandem reaction

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, 12,6986-6989
DOI: 10.1039/C4OB01381F, CommunicationT. M. A. Barlow, M. Jida, D. Tourwe, S. Ballet
Herein we describe a catalyst-free procedure employing an Ugi-4CR followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library with up to four points of diversification and high atom economy.
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Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01200C, PaperJason M. Hargreaves, Yann Le Guen, Catherine Guerreiro, Karine Descroix, Laurence A. Mulard
Shigella flexneri serotypes 1b and 1a are Gram-negative enteroinvasive bacteria causing shigellosis in humans.
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Synthesis of a chiral building block for highly functionalized polycyclic ethers

1 September, 2014 - 21:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01439A, PaperG. Pazos, M. Perez, Z. Gandara, G. Gomez, Y. Fall
An efficient procedure for preparing enantiopure polycyclic ethers based on the furan singlet oxygen oxidation approach is reported.
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Development and mechanistic studies of an optimized receptor for trimethyllysine using iterative redesign by dynamic combinatorial chemistry

30 August, 2014 - 20:54

Org. Biomol. Chem., 2014, 12,7059-7067
DOI: 10.1039/C4OB01249F, PaperNicholas K. Pinkin, Marcey L. Waters
Iterative monomer redesign leads to a Kme3-peptide receptor with 10-fold tighter affinity and 5-fold improved selectivity over Kme2 than the original receptor. Thermodynamic analysis provides insight into this improvement.
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Novel ruthenium-catalyst for hydroesterification of olefins with formates

30 August, 2014 - 20:54

Org. Biomol. Chem., 2014, 12,6972-6976
DOI: 10.1039/C4OB01246A, CommunicationIrina Profir, Matthias Beller, Ivana Fleischer
A new catalyst based on a bidentate P,N-ligand and ruthenium dodecacarbonyl for the hydroesterification of olefins with formates is reported.
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