Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 5 hours ago

Phosphonated chelates for nuclear imaging

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9601-9620
DOI: 10.1039/C4OB01514B, PaperSabah Abada, Alexandre Lecointre, Caline Christine, Laurence Ehret-Sabatier, Falk Saupe, Gertraud Orend, David Brasse, Ali Ouadi, Thomas Hussenet, Patrice Laquerriere, Mourad Elhabiri, Loic J. Charbonniere
A series of phosphonated chelates and their coordination properties is described. SPECT/CT imaging studies with 99mTc using two ligands and a bifunctional chelate labeled to a tumor targeting antibody are shown.
The content of this RSS Feed (c) The Royal Society of Chemistry

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9592-9600
DOI: 10.1039/C4OB01911C, PaperSerena Mostarda, Paolo Filipponi, Roccaldo Sardella, Francesco Venturoni, Benedetto Natalini, Roberto Pellicciari, Antimo Gioiello
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

The protecting-group directed diastereoselective Nozaki-Hiyama-Kishi (NHK) reaction: total synthesis and biological evaluation of zeaenol, 7-epi-zeaenol and its analogues

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9683-9695
DOI: 10.1039/C4OB01811G, PaperDebendra K. Mohapatra, D. Sai Reddy, N. Arjunreddy Mallampudi, Janardhan Gaddam, Sowjanya Polepalli, Nishant Jain, J. S. Yadav
A convergent and concise total synthesis of zeaenol, 7-epi-zeaenol, and its analogues is achieved using protecting group-directed NHK reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

Metal-free, one-pot conversion of proline derivatives into 2-aryl-3-iodo pyrrolidines by a sequential scission-iodination-arylation process

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9547-9556
DOI: 10.1039/C4OB01372G, PaperVenkateswara Rao Batchu, Ivan Romero-Estudillo, Alicia Boto, Javier Miguelez
A sequential radical decarboxylation-oxidation-iodination-arylation process allows the metal-free, direct conversion of proline derivatives into 2-aryl-3-iodopyrrolidines, which are valuable precursors of a variety of heterocycles.
The content of this RSS Feed (c) The Royal Society of Chemistry

The impact of LR-HSQMBC very long-range heteronuclear correlation data on computer-assisted structure elucidation

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9505-9509
DOI: 10.1039/C4OB01418A, CommunicationK. A. Blinov, A. V. Buevich, R. T. Williamson, G. E. Martin
The impact of LR-HSQMBC very long-range nJCH heteronuclear shift correlation data as a supplement to HMBC data as input for the computer-assisted structure elucidation program, Structure Elucidator[registered sign], is assessed for the first time.
The content of this RSS Feed (c) The Royal Society of Chemistry

Chiroptical molecular propellers based on hexakis(phenylethynyl)benzene through the complexation-induced intramolecular transmission of local point chirality

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9532-9538
DOI: 10.1039/C4OB01601G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ryo Katoono, Keiichi Kusaka, Shunsuke Kawai, Yuki Tanaka, Keisuke Hanada, Tatsuo Nehira, Kenshu Fujiwara, Takanori Suzuki
We designed hexakis(phenylethynyl)benzene derivatives with a tertiary amide group on each blade to achieve a helically biased propeller arrangement.
The content of this RSS Feed (c) The Royal Society of Chemistry

Alkylene-bridged viologen dendrimers: versatile cell delivery tools with biosensing properties

17 November, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,9583-9591
DOI: 10.1039/C4OB00560K, PaperDirk Bongard, Wilhelm Bohr, Marta Swierczek, Tesfaye Hailu Degefa, Lorenz Walder, Roland Brandt
Two types of tailored viologen dendrimers with different spacer lengths between the viologen (4,4[prime or minute]-bipyridinium) units have been prepared. The condensation of dsDNA induced by the dendrimers was monitored with a new electrochemical technique. This allowed us to optimize the transfection media for high dendriplex concentration.
The content of this RSS Feed (c) The Royal Society of Chemistry

Indium-catalyzed intramolecular hydroarylation of aryl propargyl ethers

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02033B, PaperLorena Alonso-Maranon, M. Montserrat Martinez, Luis A. Sarandeses, Jose Perez Sestelo
Indium(III) halides are efficient and selective catalysts for the intramolecular hydroarylation of aryl propargyl ethers.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01465K, PaperRosa M. Suarez, Pedro Bosch, David Sucunza, Ana M. Cuadro, Alberto Domingo, Francisco Mendicuti, Juan J. Vaquero
The fluorescence, DNA binding and DNA sequence selectivity properties of a library of azonia aromatic cations have been studied.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of new unnatural N[small alpha]-Fmoc pyrimidin-4-one amino acids: use of p-benzyloxybenzyloxy group as a pyrimidinone masking group

13 November, 2014 - 14:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02235A, PaperMontserrat Heras, Abdellatif ElMarrouni
p-Benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02060J, CommunicationNicolas Chuard, Giulio Gasparini, Aurelien Roux, Naomi Sakai, Stefan Matile
We report that, with the increasing length, cell-penetrating poly(disulfide)s preferably accumulate in the endosomes, cytosol and then the nucleoli.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mild Ti-mediated transformation of t-butyl thio-ethers into thioacetates

13 November, 2014 - 14:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02120G, PaperThomas C Pijper, Jort Robertus, Wesley Browne, Ben L Feringa
We report a straightforward method for the rapid conversion of thio-ethers to thio-acetates using TiCl4, in good to excellent yields. The reaction conditions tolerate a variety of functional groups, including...
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanisms of Imine Exchange Reactions in Organic Solvents

13 November, 2014 - 14:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02110J, Review ArticleStefano Di Stefano, Maria Ciaccia
The state of the art in the mechanisms operating in imine chemistry in organic solvents is critically discussed in the present review. In particular, the reaction pathways involved in imine...
The content of this RSS Feed (c) The Royal Society of Chemistry

Niosomes based on synthetic cationic lipids for gene delivery: The influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells.

13 November, 2014 - 14:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02087A, PaperEdilberto Ojeda, Gustavo Puras, Mireia Agirre, Jon Zarate, Santiago Grijalvo, Ramon Pons, Ramon Eritja, Gemma Martinez-Navarrete, Cristina Soto, EDUARDO FERNANDEZ, Jose Luiz Pedras
We designed niosomes based on three lipids that differed only on the polar-head group to analyze the influence on the transfection efficiency. These lipids were characterized in terms of small-angle...
The content of this RSS Feed (c) The Royal Society of Chemistry

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

13 November, 2014 - 14:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01602E, PaperMaria Vetro, Barabara Costa, Giulia Donvito, Noemi Arrighetti, Laura Cipolla, Paola Perego, Federica Compostella, Fiamma Ronchetti, Diego Colombo
New glucuronosyldiacylglycerol (GlcADG) analogues based on a 2-O-[small beta]-D-glucopyranosyl-sn-glycerol scaffold and carrying one or two acyl chains of different lengths have been synthesized as phosphatidylinositol 3-phosphate (PI3P) mimics targeting the protein...
The content of this RSS Feed (c) The Royal Society of Chemistry

Developing a targeting system for bacterial membranes: measuring receptor-phosphatidylglycerol interactions with 1H NMR, ITC and fluorescence correlation spectroscopy

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01895H, PaperAmanda Alliband, Zifan Wang, Christopher Thacker, Douglas S. English, Dennis H. Burns
We report the development of a potential targeting system for bacterial membranes containing phosphatidylglycerol.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02155J, CommunicationMuhammet Tanc, Fabrizio Carta, Andrea Scozzafava, Claudiu T. Supuran
A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01810A, CommunicationHyeon Seok Kim, Woon Young Song, Hak Joong Kim
A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-[small beta]-enaminonitriles

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01801J, PaperYing-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang, Ying-ming Pan
In this work, a novel and highly stereoselective synthesis of Z-[small beta]-enaminonitriles from azides and [small alpha],[small beta]-unsaturated nitriles is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

13 November, 2014 - 14:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01758G, PaperZhi-Cheng Dai, Yong-Fei Chen, Mao Zhang, Sheng-Kun Li, Ting-Ting Yang, Li Shen, Jian-Xin Wang, Shao-Song Qian, Hai-Liang Zhu, Yong-Hao Ye
A series of 1,2,3-triazole phenylhydrazone derivatives were designed and synthesized as antifungal agents.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.