Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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NBD-based fluorescent chemosensor for the selective quantification of copper and sulfide in an aqueous solution and living cells

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02178A, PaperQingtao Meng, Yu Shi, Cuiping Wang, Hongmin Jia, Xue Gao, Run Zhang, Yongfei Wang, Zhiqiang Zhang
A fluorescent chemosensor (NL) has been developed for the selective quantification of copper and sulfide in aqueous solutions and living cells.
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Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a and its stereoselective Michael addition reaction

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02491E, CommunicationJiazhu Li, Yang Liu, Xi-Sen Xu, Yan-Long Li, Shan-Guo Zhang, Il Yoon, Young Key Shim, Jin-Jun Wang, Jun-Gang Yin
pH-Dependent regioselective condensation of methyl mesopyropheophorbide a with HCHO is studied and stereoselective Michael reaction of the 132-methylene product is also discussed.
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Tuning viscoelastic properties of supramolecular peptide gels via dynamic covalent crosslinking

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02217C, CommunicationMohammad Aref Khalily, Melis Goktas, Mustafa O. Guler
A dynamic covalent crosslinking approach is used to crosslink supramolecular peptide gels.
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Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02410A, PaperXiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu, Yangjie Wu
A new and generally practical synthesis of alkynylphosphonates through a palladium-catalyzed consecutive Sonogashira/deacetonative process using aryl bromides, 2-methyl-3-butyn-2-ol and H-phosphonates is developed.
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Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02041C, PaperMaarten Danial, Sebastien Perrier, Katrina A. Jolliffe
The effect of amino acid composition on the formation of transmembrane channels in lipid bilayers upon self-assembly of alt-(L,D)-[small alpha]-cyclic octapeptides has been investigated.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02397H, PaperAnna Junker, Artur K. Kokornaczyk, Annelien J. M. Zweemer, Bastian Frehland, Dirk Schepmann, Junichiro Yamaguchi, Kenichiro Itami, Andreas Faust, Sven Hermann, Stefan Wagner, Michael Schafers, Michael Koch, Christina Weiss, Laura H. Heitman, Klaus Kopka, Bernhard Wunsch
Late-stage diversification led to selective chemokine CCR2 receptor antagonists and dual-targeting CCR2/CCR5 receptor antagonists.
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Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02049A, PaperVariam Ullas Jeankumar, Rudraraju Srilakshmi Reshma, Renuka Janupally, Shalini Saxena, Jonnalagadda Padma Sridevi, Brahmam Medapi, Pushkar Kulkarni, Perumal Yogeeswari, Dharmarajan Sriram
Exploring the Gyrase ATPase platform to tailor novel anti-tubercular leads.
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Asymmetric Michael addition of [small alpha]-fluoro-[small alpha]-nitro esters to nitroolefins: towards synthesis of [small alpha]-fluoro-[small alpha]-substituted amino acids

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02486A, PaperJacek Kwiatkowski, Yixin Lu
[small alpha]-Fluoro-[small alpha]-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities.
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LNA units present in the (2[prime or minute]-OMe)-RNA strand stabilize parallel duplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA and parallel triplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA/RNA. An improved tool for the inhibition of reverse t

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02364A, PaperAnna Maciaszek, Agnieszka Krakowiak, Magdalena Janicka, Agnieszka Tomaszewska-Antczak, Milena Sobczak, Barbara Mikolajczyk, Piotr Guga
LNA units stabilize (RNA/LNA)/RP-PS-DNA/RNA triplexes and efficiently inhibit reverse transcription of target RNA.
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Vanadyl species-catalyzed complementary [small beta]-oxidative carbonylation of styrene derivatives with aldehydes

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02621G, PaperWen-Chieh Yang, Shiue-Shien Weng, Anandhan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao, Chien-Tien Chen
By judicious choice of the counter anions in the vanadyl catalysts, we can achieve [small beta]-hydroxylated and t-butyl peroxylated carbonylation of styrenes by aromatic 1[degree] and 2[degree] alkyl aldehydes in a complementary manner.
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Preassembly-driven ratiometric sensing of H2PO4- anions in organic and aqueous environments

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02498B, CommunicationWei-tao Gong, Duo Na, Le Fang, Hassan Mehdi, Gui-ling Ning
The preassembly phenomenon of R1 facilitates novel ratiometric fluorescence sensing of H2PO4- in organic and aqueous environments.
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Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02462A, PaperYuanzhen Xu, Jianjun Chen, Ya Li, Shoujiao Peng, Xueyan Gu, Meng Sun, Kun Gao, Jianguo Fang
Thiols-triggered anticancer prodrug 1 produces an active DNA alkylating agent mechlorethamine leading to DNA damage and finally cell death.
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A comparison of chemiluminescent acridinium dimethylphenyl ester labels with different conjugation sites

21 January, 2015 - 06:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02528H, PaperAnand Natrajan, David Wen
Chemiluminescent acridinium esters containing conjugation sites at the acridinium nitrogen show increased light yield when labeled to proteins.
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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
A novel [small pi]-extended NiII-porphyrin shows a high selectivity towards human telomeric G-quadruplexes.
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, Venkitasamy Kesavan, Kurt V. Gothelf
Homopyrimidine acyclic (L)-threoninol nucleic acid (aTNA) was synthesized and found to form highly stable (L)-aTNA-DNA-(L)-aTNA and (L)-aTNA-RNA-(L)-aTNA triple helical structures.
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Benzosulfones as photochemically activated sulfur dioxide (SO2) donors

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02466D, PaperSatish R. Malwal, Harinath Chakrapani
A series of benzosulfones were synthesized and found to undergo photolysis to generate sulfur dioxide in aqueous buffer.
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Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02311K, PaperMichael S. Perryman, Matthew W. M. Earl, Sam Greatorex, Guy J. Clarkson, David J. Fox
Enantiomerically-enriched trichloromethyl-containing alcohols are transformed regioselectively into enantiomerically-enriched 1-substituted piperazinones by modified Jocic reactions.
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Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02046D, PaperYahya E. Jad, Gerardo A. Acosta, Sherine N. Khattab, Beatriz G. de la Torre, Thavendran Govender, Hendrik G. Kruger, Ayman El-Faham, Fernando Albericio
To date, DMF has been considered as the only solvent suitable for peptide synthesis.
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Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01380H, Review ArticleRicha Goel, Vijay Luxami, Kamaldeep Paul
The synthesis, reactivity and multifarious biological activities at the different positions of imidazo[1,2-a]pyrazines are concisely discussed in this review.
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[small alpha]-Tocopherol derived lipid dimers as efficient gene transfection agents. Mechanistic insights into lipoplex internalization and therapeutic induction of apoptotic activity

19 January, 2015 - 06:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02063D, PaperKrishan Kumar, Bappa Maiti, Paturu Kondaiah, Santanu Bhattacharya
Dimeric cationic tocopheryl lipids for efficacious therapeutic pDNA delivery in cancer cell lines.
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