Org. and Biomol. Chem.

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Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers

26 August, 2014 - 19:54

Org. Biomol. Chem., 2014, 12,6994-7003
DOI: 10.1039/C4OB00517A, PaperHazit Zayas, Clovia I. Holdsworth, Michael C. Bowyer, Adam McCluskey
Six novel functional monomers (M1-M6) were examined for their ability to imprint theophylline (1). The best selectivity was observed with M2.
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Molecular Iodine-Mediated Reaction of 2-(2-phenylethynyl)-Morita-Baylis-Hillman Adducts: An Easy Access to Naphthyl ketones and Iodo-Substituted Isochromenes

26 August, 2014 - 19:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00938J, PaperChing-Fa Yao, Janreddy Donala, Veerababurao Kavala, Trimurtulu Kotipalli, Rajawinslin. R. R, Chun-Wei Kuo, Wen-Chang Huang
The molecular iodine-promoted reaction of 2-(2-phenylethynyl)-Morita-Baylis-Hillman adducts is reported. In the presence of I2, naphthyl ketone derivatives are produced, whereas, in the presence of I2/K3PO4, iodo-substituted isochromenes derivatives are produced.
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Approaches to the total synthesis of chaetochalasin A

26 August, 2014 - 19:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01308E, PaperEric J. Thomas, Mark Willis
Chaetochalasin A is a complex natural product whose biosynthesis may involve two domino Diels-Alder reactions.
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Synthesis of Fluorescent 2,3,5,6-Tetraalkynylpyridines by Site-Selective Sonogashira-Reactions of 2,3,5,6-Tetrachloropyridines

24 August, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01292E, PaperPeter Ehlers, Andranik Petrosyan, Antje Neubauer, Timo Broese, Stefan Lochbrunner, Tariel Ghochikyan, Ashot Saghyan, Peter Langer
4-Substituted 2,3,5,6-tetraalkynylpyridines were prepared by tetra-fold Sonogashira reactions of the corresponding 2,3,5,6-tetrachloropyridines. 2,6-Dialkynyl-3,5-dichloropyridines were prepared by site-selective Sonogashira reactions from various 4-unsubstituted and 4-substituted tetrachloropyridines. Subsequent two-fold Sonogashira reactions of...
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Asymmetric Michael addition of ketones to nitroolefins: Pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

24 August, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01223B, PaperAhmed Kamal, Sathish Manda, vunnam srinivasulu, Chetna Jadala, Chandra Shekar Kunta, Shalini Nekkanti, Yellaiah Tangella, Nagula Shankaraiah
Chiral pyrrolidinyl-oxazole-carboxamides were synthesized and used as efficient new organocatalysts for the asymmetric Michael addition of ketones with nitroalkenes under solvent-free conditions. Gratifyingly, the corresponding Michael adducts were obtained in...
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Pyrazole-oxadiazole Conjugates: Synthesis, Antiproliferative Activity and Inhibition of Tubulin Polymerization

24 August, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01152J, PaperAhmed Kamal, Anver Basha Shaik, Sowjanya Polepalli, Santhosh Reddy Vangala, Bharath Kumar G, Soma Gupta, Nagabhushana Ananthamurthy, Rakesh K Mishra, Nishant Jainb, Venkata Siva Ramakrishna Kallaganti
A number of pyrazole-oxadiazole conjugates were synthesized and evaluated for their ability to function as antiproliferative agents on various human cancer cell lines. These conjugates comprise of pyrazole and oxadiazole...
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Rhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation

20 August, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01440E, CommunicationLiang Wang, Wen Wu, Qun Chen, Ming-Yang He
Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group. This reaction provides a straightforward way for the synthesis of ortho-alkenyl aryl tetrazoles....
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Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6812-6815
DOI: 10.1039/C4OB01164C, CommunicationHiroki Iwasaki, Kenji Suzuki, Mitsunari Yamane, Shohei Yoshida, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita
A novel method for indole skeleton synthesis under mild conditions mediated by samarium(II) diiodide has been developed.
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Directed arene/alkyne annulation reactions via aerobic copper catalysis

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01312C, PaperYi Zhang, Qian Wang, Huidong Yu, Yong Huang
We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen.
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CoPc-catalyzed selective radical arylation of anilines with arylhydrazines for synthesis of 2-aminobiaryls

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6922-6926
DOI: 10.1039/C4OB00798K, PaperTao Jiang, Sheng-Yan Chen, Guo-Yu Zhang, Run-Sheng Zeng, Jian-Ping Zou
CoPc-catalyzed selective radical arylation of anilines with arylhydrazines to afford 2-aminobiaryls in moderate to good yields is described.
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Orthogonal functionalisation of [small alpha]-helix mimetics

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6794-6799
DOI: 10.1039/C4OB00915K, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Barnard, Kerya Long, David J. Yeo, Jennifer A. Miles, Valeria Azzarito, George M. Burslem, Panchami Prabhakaran, Thomas A. Edwards, Andrew J. Wilson
We present methodology to modify N-alkylated aromatic oligoamide [small alpha]-helix mimetics using 'click' chemistry.
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Direct intermolecular C-H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6820-6823
DOI: 10.1039/C4OB01211A, CommunicationYinuo Wu, Pui Ying Choy, Fuk Yee Kwong
A general C-H arylation of unactivated arenes by aryl/heteroaryl bromides in the presence of 2-pyridyl carbinol and potassium tert-butoxide is described.
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L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6816-6819
DOI: 10.1039/C4OB01362J, CommunicationFan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll, Bing Xu
The nanofibrils of an L-rhamnose-based hydrogelator illustrate the first example of the supramolecular assemblies of a saccharide to suppress immunity.
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New reagents for detecting free radicals and oxidative stress

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6757-6766
DOI: 10.1039/C4OB01172D, Review ArticleMina Barzegar Amiri Olia, Carl H. Schiesser, Michelle K. Taylor
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6842-6854
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
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Total synthesis of putative montamine and a proposed structural reassignment

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6878-6884
DOI: 10.1039/C4OB01304B, PaperLachlan M. Blair, Elizabeth A. Colby Davie, Jonathan Sperry
The spectroscopic data for synthetic montamine does not match the proposed N,N[prime or minute]-linked structure and closely resembles a known 4,4[prime or minute]-bismoschamine natural product.
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6901-6907
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E. Nielsen
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
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A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6944-6952
DOI: 10.1039/C4OB00846D, PaperHui Peng, Ya-Qin Chen, Shu-Lan Mao, Yun-Xiao Pi, You Chen, Ze-Yu Lian, Tong Meng, Sheng-Hua Liu, Guang-Ao Yu
An air-stable sulfonated indenyl phosphine/Pd-catalyst system was used in Suzuki-Miyaura and Sonogashira coupling reactions in water.
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Highly efficient synthesis of a tristable molecular shuttle and its controlled motion under chemical stimuli

18 August, 2014 - 17:54

Org. Biomol. Chem., 2014, 12,6937-6943
DOI: 10.1039/C4OB01283F, PaperZheng Meng, Chuan-Feng Chen
A tristable molecular shuttle could be efficiently synthesized in 76% yield by exploiting a K+ ion template and a bulky isocyanate stopper.
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Monopyrrolotetrathiafulvalene-succinamide conjugates and their TCNQ charge transfer complex based supramolecular gels with multiple stimulus responsiveness

18 August, 2014 - 17:54

Org. Biomol. Chem., 2014, 12,6927-6936
DOI: 10.1039/C4OB01397B, PaperYucun Liu, Ningjuan Zheng, Tie Chen, Longyi Jin, Bingzhu Yin
Monopyrrolotetrathiafulvalene-succinamide conjugates and their TCNQ charge transfer (CT) complexes have been developed as LMOGs. The native gels and CT complex gels exhibit smart multiple stimulus responsiveness.
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