Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 9 hours 10 min ago

An Easy Arylation of 2-Substituted 1,2,3-Triazole

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00530A, Communicationsuping shi, Wei Liu, ping he, Chunxiang Kuang
A selective, efficient and catalytic ligand-free method for the direct arylation of 2-aryl-1,2,3-triazole by Pd-catalyzed C-H bond activation is described. The process smoothly proceeds in moderate to excellent yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and Synthesis of 3,3'-biscoumarin-based c-Met inhibitors

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00364K, PaperJimin Xu, Jing Ai, Sheng Liu, Xia Peng, Linqian Yu, Meiyu Geng, FJ Nan
A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3'-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00300D, PaperK Kashinath, Prakash Jadhav, D SRINIVASA REDDY
First total synthesis of a norsesquiterpene alkaloid (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, isolated from the mushroom-forming fungus Flammulina velutipes, in both racemic and enantiomeric pure forms, is reported. The (-)-enantiomer of the natural product...
The content of this RSS Feed (c) The Royal Society of Chemistry

Far-red and near infrared BODIPY dyes: synthesis and applications for fluorescent pH probes and bio-imaging

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42554A, Review ArticleYong Ni, Jishan Wu
Far-red and near infrared (NIR) emissive dyes have advantages in the development of fluorescent probes and labelling for bio-imaging in living systems since fluorescence in long-wavelength region would generate minimum...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of [small beta]-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00097H, PaperElizabeth V. Crabtree, R. Fernando Martinez, Shinpei Nakagawa, Isao Adachi, Terry D. Butters, Atsushi Kato, George W J Fleet, Andreas Felix Gregor Glawar
The enantiomers of XYLNAc [2-N-acetylamino-1,2,4-trideoxy-1,4-iminoxylitol] are prepared from the enantiomers of glucuronolactone; the synthesis of the enantiomers of LYXNAc [2-N-acetylamino-1,2,4-trideoxy-1,4-iminolyxitol] from an L-arabinono-[small delta]-lactone and a D-ribono-[small delta]-lactone is reported. A comparison...
The content of this RSS Feed (c) The Royal Society of Chemistry

Asymmetric Synthesis of 3,3,5,5-Tetrasubstituted 1,2-Dioxolanes: Total Synthesis of Epiplakinic Acid F

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00448E, PaperHenry N.C. Wong, Xiangyin Tian, Qiong Zhao, Jianwei Han
Herein we report the first enantioselective total synthesis of epiplakinic acid F (1) through a pivotal step involving a redical-mediated asymmetric peroxidation of vinylcyclopropanes with molecular oxygen to construct highly...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cascade nitrosation and addition-elimination of nitroacetanilides for highly efficient synthesis of 1,4,2,5-dioxadiazine derivatives

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C3OB42487A, PaperShanyan Mo, Peipei Huang, Jiaxi Xu
A domino nitrosation and addition-elimination of nitroacetanilides with NaNO2 and H2SO4 has been developed to synthesize a variety of 1,4,2,5-dioxadiazine-3,6-dicarboxamides in excellent yields. The substrates can be extended to aryl...
The content of this RSS Feed (c) The Royal Society of Chemistry

Evaluating N-benzylgalactonoamidines as putative transition state analogs for [small beta]-galactoside hydrolysis

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,2792-2800
DOI: 10.1039/C4OB00153B, PaperQiu-Hua Fan, Susanne Striegler, Rebekah G. Langston, James D. Barnett
The kinetic evaluation of several N-benzylgalactonoamidines identified p-methylbenzylgalactonoamidine as a putative transition state analog for the enzymatic hydrolysis of [small beta]-galactopyranosides by [small beta]-galactosidase (A. oryzae).
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioisomeric allene dimer formation by the reaction of tetraarylbutatrienes with tetracyanoethene

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,2784-2791
DOI: 10.1039/C3OB42574F, PaperShoko Ueta, Kazuo Hida, Masaki Nishiuchi, Yasuhiko Kawamura
Title reactions formed head-to-tail unsymmetrically substituted diarylallene dimers possessing four cyano groups in appreciably high yield at room temperature.
The content of this RSS Feed (c) The Royal Society of Chemistry

Total synthesis of monosporascone and dihydromonosporascone

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,2801-2810
DOI: 10.1039/C4OB00331D, PaperKathryn A. Punch, Matthew J. Piggott
The first synthesis of monosporascone has been achieved in five steps and 57% overall yield.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diastereoselective Ireland-Claisen rearrangements of substituted allyl [small beta]-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,2702-2728
DOI: 10.1039/C4OB00274A, PaperStephen G. Davies, Ai M. Fletcher, James A. Lee, Paul M. Roberts, Myriam Y. Souleymanou, James E. Thomson, Charlotte M. Zammit
The Ireland-Claisen rearrangements of substituted allyl [small beta]-amino esters were evaluated, and subsequently employed in syntheses of C(5)-substituted transpentacins.
The content of this RSS Feed (c) The Royal Society of Chemistry

A divergent approach to the synthesis of iGb3 sugar and lipid analogues via a lactosyl 2-azido-sphingosine intermediate

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,2729-2736
DOI: 10.1039/C4OB00241E, PaperJanice M. H. Cheng, Emma M. Dangerfield, Mattie S. M. Timmer, Bridget L. Stocker
Isoglobotrihexosylceramide (iGb3, 1) is an immunomodulatory glycolipid that binds to CD1d and is presented to the T-cell receptor (TCR) of invariant natural killer T (iNKT) cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Symmetry as a new element to control molecular switches

15 April, 2014 - 10:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00230J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Luca Schweighauser, Daniel Haussinger, Markus Neuburger, Hermann A. Wegner
The switching of a tetraazocarbazole macrocycle was investigated and an interdependence of individual azo units was observed depending on their special relationship.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed highly efficient ester formation from carboxylic acids/esters and formates

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2637-2640
DOI: 10.1039/C4OB00193A, CommunicationJun Liu, Changdong Shao, Yanghui Zhang, Guangfa Shi, Shulei Pan
Copper-catalyzed ester formation from carboxylic acids/esters and formates has been developed with high efficiency and broad substrate scopes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2675-2685
DOI: 10.1039/C3OB42325E, PaperSamuel Baer, Julie Nigro, Mariusz P. Madej, Rebecca M. Nisbet, Randy Suryadinata, Gregory Coia, Lisa P. T. Hong, Timothy E. Adams, Charlotte C. Williams, Stewart D. Nuttall
Sortase A-mediated conjugation reactions were performed with a number of different nucleophiles. A peptide-Im7-labelled conjugate was used to image neuronal cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Helical folding of [small alpha]/[small beta]-peptides containing [small beta]-amino acids with an eight-membered ring constraint

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2641-2644
DOI: 10.1039/C4OB00266K, CommunicationWoohyung Lee, Sunmi Kwon, Philjae Kang, Ilia A. Guzei, Soo Hyuk Choi
Cyclic [small beta]-amino acid that contains a cyclooctane or a cyclooctene ring promotes 11/9-helical folding of [small alpha]/[small beta]-peptides.
The content of this RSS Feed (c) The Royal Society of Chemistry

An efficient ruthenium-catalyzed dehydrogenative synthesis of 2,4,6-triaryl-1,3,5-triazines from aryl methanols and amidines

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2761-2768
DOI: 10.1039/C3OB42589D, PaperFeng Xie, Mengmeng Chen, Xiaoting Wang, Huanfeng Jiang, Min Zhang
An efficient ruthenium-catalyzed dehydrogenative synthesis of 2,4,6-triaryl-1,3,5-triazines from aryl methanols and amidines has been demonstrated.
The content of this RSS Feed (c) The Royal Society of Chemistry

An induced-fit process through mechanical pivoting of aromatic walls in host-guest chemistry of calix[6]arene aza-cryptands

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2754-2760
DOI: 10.1039/C4OB00304G, PaperAndrea Brugnara, Luca Fusaro, Michel Luhmer, Thierry Prange, Benoit Colasson, Olivia Reinaud
A rigid calix[6]arene-based receptor can be fully ipso-nitrated. The nitrated receptor exhibits a new adaptive behavior upon cation and/or guest encapsulation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of [small alpha]-tribromomethylamines via Mg-mediated addition of bromoform to imines

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2769-2777
DOI: 10.1039/C4OB00259H, PaperElumalai Gopi, Irishi N. N. Namboothiri
N-Sulfonyl- and N-Boc-imines undergo facile addition of bromoform in the presence of Mg to afford [small alpha]-tribromomethyl N-sulfonyl- and N-Boc-amines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of a multibranched porphyrin-oligonucleotide scaffold for the construction of DNA-based nano-architectures

13 April, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,2778-2783
DOI: 10.1039/C4OB00202D, PaperGuillaume Clave, Gregory Chatelain, Arianna Filoramo, Didier Gasparutto, Christine Saint-Pierre, Eric Le Cam, Olivier Pietrement, Vincent Guerineau, Stephane Campidelli
A multiclick-based approach was used to build DNA-porphyrin hybrid platforms.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.