Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Amplification by nucleic acid-templated reactions

21 April, 2014 - 12:17

Org. Biomol. Chem., 2014, 12,2821-2833
DOI: 10.1039/C4OB00096J, Review ArticleJulia Michaelis, Alexander Roloff, Oliver Seitz
Nucleic acid-templated reactions that proceed with turnover provide a means for signal amplification, which facilitates the use and detection of biologically occurring DNA/RNA molecules.
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Palladium-catalyzed air-based oxidative coupling of arylboronic acids with H-phosphine oxides leading to aryl phosphine oxides

21 April, 2014 - 12:17

Org. Biomol. Chem., 2014, 12,2895-2902
DOI: 10.1039/C3OB42470G, PaperTingting Fu, Hongwei Qiao, Zhimin Peng, Gaobo Hu, Xueji Wu, Yuxing Gao, Yufen Zhao
Various valuable aryl phosphine oxides were effectively prepared via the palladium-catalyzed coupling of arylboronic acids with H-phosphine oxides.
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Triptycene-derived macrotricyclic polyether containing an anthracene unit as a powerful host for 1,2-bis(pyridium)ethane, diquat and 2,7-diazapyrenium salt

21 April, 2014 - 12:17

Org. Biomol. Chem., 2014, 12,2850-2853
DOI: 10.1039/C4OB00310A, CommunicationYa-Kun Gu, Fei Zeng, Zheng Meng, Chuan-Feng Chen
Triptycene-derived macrotricyclic polyether containing an anthracene unit was shown to be a powerful host for 1,2-bis(pyridium)ethane, diquat and 2,7-diazapyrenium salt.
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A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish

21 April, 2014 - 12:17

Org. Biomol. Chem., 2014, 12,2864-2868
DOI: 10.1039/C4OB00140K, CommunicationBagineni Prasad, B. Yogi Sreenivas, Araka Sushma, Swapna Yellanki, Raghavender Medisetti, Pushkar Kulkarni, Manojit Pal
A Pd-based strategy afforded novel indoles as potential scaffolds for apoptosis.
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Acetal initiated Prins bicyclization for the synthesis of furo[3,4-c]furan lignans and pyrano[3,4-c]pyran derivatives

17 April, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00305E, PaperVenkata Subba Reddy Basireddy, Ramana Reddy M, Sridhar Balasubramanian, Kiran Kumar Singarapu
An acetal initiated Prins bicyclization approach has been developed for the stereoselective synthesis of furo[3,4-c]furan lignan analogues. It also provides a direct access to produce a new series of pyrano[3,4-c]pyran...
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The base discriminating potential of pyrrolidinyl PNA demonstrated by magnetic FexOy particles

17 April, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00487F, CommunicationClaudua Stubinitzky, Tirayut Vilaivan, Hans-Achim Wagenknecht
Pyrrolidinyl PNA was immobilized on FexOy magnetic particles and was able to capture and thereby discriminate single base alterations in DNA counterstrands better than DNA. The selectivities of matched vs....
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Chiral Derivatives of 1,2-Benzenedisulfonimide as efficient Bronsted acid catalysts in Strecker reaction.

17 April, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00552J, PaperStefano Dughera, Margherita Barbero, Silvano Cadamuro, Roberta Torregrossa
Two chiral derivatives of 1,2-benzenedisulfonimide, namely 4-methyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide and 4,5-dimethyl-3,6-bis(o-tolyl)-1,2-benzenedisulfonimide have been easily synthetized in good overall yields (respectively 34% and 41%) by means of an eleven steps synthetic protocol from...
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The diene-transmissive hetero-Diels-Alder reaction of 2-vinyl [small alpha],[small beta]-unsaturated aldimines: stereoselective synthesis of hexahydroquinazolin-2-ones

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00224E, CommunicationSatoru Kobayashi, Kenji Kudo, Ai Ito, Satoru Hirama, Takashi Otani, Takao Saito
The tandem Diels-Alder methodology of cross-conjugated 1-azatrienes for synthesis of crossed bis-cycloadducts with high chemo-, regio- and stereoselectivities is described.
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Cation[small pi] interaction and microhydration effects in complexes formed by pyrrolidinium cation and aromatic species in amino acid side chains

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2938-2949
DOI: 10.1039/C3OB42388C, PaperAna A. Rodriguez-Sanz, Enrique M. Cabaleiro-Lago, Jesus Rodriguez-Otero
Microhydration deeply affects the characteristics of pyrrolidinium cation complexes with aromatic units found in amino acid side chains.
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Copper-mediated trifluoromethylation of propargyl acetates leading to trifluoromethyl-allenes

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2903-2906
DOI: 10.1039/C3OB42575D, PaperYun-Long Ji, Jun-Jie Kong, Jin-Hong Lin, Ji-Chang Xiao, Yu-Cheng Gu
A copper-promoted trifluoromethylation of propargyl acetates with S-(trifluoromethyl)diphenylsulfonium triflate leading to trifluoromethyl-allenes under mild conditions is described.
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Quadrupolar, emission-tunable [small pi]-expanded 1,4-dihydropyrrolo[3,2-b]pyrroles - synthesis and optical properties

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2874-2881
DOI: 10.1039/C4OB00143E, PaperAnita Janiga, Dominika Bednarska, Bjarne Thorsted, Jonathan Brewer, Daniel T. Gryko
A-D-A chromophores containing pyrrolo[3,2-b]pyrrole, as a central donor moiety, display blue, turquoise, yellow and orange fluorescence, depending on the strength of the electron-withdrawing substituent.
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A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2926-2937
DOI: 10.1039/C3OB42503G, PaperShaheen K. Mulani, Jih-Hwa Guh, Kwok-Kong Tony Mong
The total synthesis of natural glycosides for the anti-proliferation of cancer cell lines.
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Complexity generation by chemical synthesis: a five-step synthesis of (-)-chaetominine from L-tryptophan and its biosynthetic implications

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2859-2863
DOI: 10.1039/C4OB00314D, CommunicationChu-Pei Xu, Shi-Peng Luo, Ai-E Wang, Pei-Qiang Huang
We demonstrated, for the first time, that the hexacyclic peptidyl alkaloid (-)-chaetominine (1) can be synthesized in a straightforward manner from L-Trp, which could be helpful in understanding the biosynthetic pathway of (-)-chaetominine (1).
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Gold-catalysed cyclisation of N-propargylic [small beta]-enaminones to form 3-methylene-1-pyrroline derivatives

17 April, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,2869-2873
DOI: 10.1039/C3OB42513D, CommunicationKommuru Goutham, N. S. V. M. Rao Mangina, Surisetti Suresh, Pallepogu Raghavaiah, Galla V. Karunakar
A gold(I) catalysed reaction between N-propargylic [small beta]-enaminones and arynes was developed to access 3-methylene-1-pyrrolines. The title compounds were obtained in 57-78% yields.
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Palladium(II)-catalysed total synthesis of naturally occurring pyrano[3,2-a]carbazole and pyrano[2,3-b]carbazole alkaloids

17 April, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00367E, PaperHans-Joachim Knolker, Ronny Hesse, Anne Jager, Arndt W. Schmidt
Seven naturally occurring pyranocarbazole alkaloids (pyrayafoline A-E, O-methylmurrayamine A and O-methylmahanine) have been obtained by total synthesis using a palladium(II)-catalysed oxidative cyclisation of a diarylamine to an orthogonally diprotected 2,7-dihydroxycarbazole...
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The Asymmetric Cu(II)-Indolinylmethanol Complex Catalyzed Diels-Alder Reaction of 2-Vinylindoles with [small beta],[gamma]-Unsaturated [small alpha]-Ketoesters: An Efficient Route to Functionalized Tetrahydrocarbazoles

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00196F, PaperBanlai Ouyang, Tingting Yu, Renshi Luo, Gui Lu
An efficient asymmetric Diels-Alder reaction of 2-vinylindoles with [small beta],[gamma]-unsaturated [small alpha]-ketoesters has been developed for the construction of functionalized tetrahydrocarbazoles. The products were obtained in high yields (up to 96%) with...
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Aryl Ethynyl Anthraquinones: a Useful Platform for Targeting Telomeric G-quadruplex Structures

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00220B, PaperClaudia Percivalle, Claudia Sissi, Maria Laura Greco, Caterina Musetti, Angelica Mariani, Anna Artese, Giosue Costa, Maria Lucia Perrone, Stefano Alcaro, Mauro Freccero
Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by FRET melting assay, circular dichroism, DNA synthesis arrest assay and molecular docking. Both the...
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sp3 C-H Oxidation by Remote H-Radical Shift with Oxygen- and Nitrogen-Radicals: A Recent Update

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00469H, Review ArticleShunsuke Chiba, Hui Chen
This review updates recent advances in aliphatic sp3 C-H bond oxidation by remote H-radical abstraction with oxygen- and nitrogen-radicals classifying by types of the radical precursors.
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Phosphate Esters and Anhydrides - Recent Strategies Targeting Nature's Favoured Modifications

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00478G, PerspectiveHenning Jacob Jessen, Nisar Ahmed, Alexandre Hofer
Esters and anhydrides of phosphoric acid are essential in biology. It is very difficult to identify processes in life that do not involve these modifications and their transformation at some...
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Synthesis of novel 1,2,3-triazolyl derivatives of pregnane, androstane and D-homoandrostane. Tandem "Click" reaction/Cu-catalyzed D-homo rearrangement

15 April, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00404C, PaperNikolai Lukashev, Yury Kotovshchikov, Irina P Beletskaya, Gennadij Latyshev
Copper-catalyzed 1,3-dipolar cycloaddition has been employed in the reaction of steroidal azides with various terminal alkynes. A number of novel 1,2,3-triazolyl derivatives of pregnane, androstane and D-homoandrostane was obtained in...
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