Org. and Biomol. Chem.

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Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00708A, CommunicationZhushuang Bai, Ling Ji, Zemei Ge, Xin Wang, Runtao Li
The first bifunctional thiourea catalyzed asymmetric Michael addition reactions of nitroalkanes to 2-furanones are described.
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Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00617A, CommunicationYa-Min Li, Shi-Sheng Wang, Fuchao Yu, Yuehai Shen, Kwen-Jen Chang
A novel Cu-catalyzed addition/cyclization cascade of o-cyanoarylacrylamide has been developed for the synthesis of various phosphonylated quinoline-2,4(1H,3H)-diones.
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Synthesis of naked amino-pyrroloindoline via direct aminocyclization of tryptamine

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00546A, CommunicationZhigao Shen, Zilei Xia, Huijun Zhao, Jiadong Hu, Xiaolong Wan, Yisheng Lai, Chen Zhu, Weiqing Xie
Direct access to unprotected amino-pyrroloindoline via aminocyclization of tryptamine and tryptophan catalyzed by Rh2(esp)2 has been described using O-(2,4-dinitrophenyl)hydroxylamine (DPH) as the nitrogen source.
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Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of [small beta]-galactosidases

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00532A, PaperAnna Alcaide, Ana Trapero, Yolanda Perez, Amadeu Llebaria
N-Aminoaziridines are potent irreversible inhibitors of galactosidases.
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Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00651A, CommunicationLenka Vachova, Miloslav Machacek, Radim Kucera, Jiri Demuth, Pavel Cermak, Kamil Kopecky, Miroslav Miletin, Adela Jedlickova, Tomas Simunek, Veronika Novakova, Petr Zimcik
Synthesis and photophysical properties are reported for substituted tetra(3,4-pyrido)porphyrazines that absorb light as far as at 800 nm.
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Enantioselective synthesis of chiral heterocycles containing both chroman and pyrazolone derivatives catalysed by a chiral squaramide

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02653E, PaperJun-Hua Li, Da-Ming Du
An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to 3-nitro-2H-chromenes afforded chiral heterocycles containing both chroman and pyrazolone derivatives in high to excellent yields (up to 98%) with high enantioselectivities (up to 96%) under very low catalyst loading (0.2 mol%).
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Kinetic resolution of primary allylic amines via palladium-catalyzed asymmetric allylic alkylation of malononitriles

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00671F, CommunicationYong Wang, Ya-Nan Xu, Guo-Sheng Fang, Hong-Jian Kang, Yonghong Gu, Shi-Kai Tian
A new strategy has been developed for the catalytic kinetic resolution of primary allylic amines via enantioselective C-N bond cleavage.
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Cu(I)/TF-BiphamPhos-catalyzed asymmetric Michael addition of cyclic ketimino esters to alkylidene malonates

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00591D, PaperZhi-Yong Xue, Zhi-Min Song, Chun-Jiang Wang
Cu(I)-catalyzed asymmetric Michael addition of cyclic ketimino esters with alkylidene malonates has been developed for efficient construction of [small beta]-branched [small alpha]-amino acids containing adjacent quaternary and tertiary stereogenic centers in good yields with excellent diastereo-/enantioselectivities.
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Rhodium-catalyzed annulation between 2-arylimidazo[1,2-a]pyridines and alkynes leading to pyrido[1,2-a]benzimidazole derivatives

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00450K, CommunicationHaibo Peng, Jin-Tao Yu, Yan Jiang, Lei Wang, Jiang Cheng
A rhodium-catalyzed annulation between 2-arylimidazo[1,2-a]pyridines and alkynes was developed, leading to pyrido[1,2-a]benzimidazole derivatives in moderate to excellent yields.
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Alkynylation of steroids via Pd-free Sonogashira coupling

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00559K, PaperYury N. Kotovshchikov, Gennadij V. Latyshev, Nikolay V. Lukashev, Irina P. Beletskaya
A new biligand catalytic system was applied for the Pd-free Sonogashira syntheses of valuable steroidal enynes.
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The effect of terminal groups of viologens on their binding behaviors and thermodynamics upon complexation with sulfonated calixarenes

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00053J, PaperKui Wang, Si-Yang Xing, Xiu-Guang Wang, Hong-Xi Dou
The effect of terminal groups of viologens on their binding behaviors with sulfonated calixarenes was systematically studied in this study.
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Gold(I)-catalyzed hydroindolylation of allenyl ethers

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00635J, CommunicationChandrababu Naidu Kona, Mahesh H. Shinde, Chepuri V. Ramana
Nucleophilicity game: the gold(I)-catalyzed reaction/rearrangement of allenyl ethers has been investigated in the presence of indoles. The reaction outcome seems to be decided mainly by the nature of the pendant group of allenyl ether. Control experiments are indicative of an inner sphere mechanism for the hydroindolylation reaction.
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Tandem Prins/Wagner/Ritter process for the stereoselective synthesis of (3-oxabicyclo[4.2.0]octanyl)amide and (1-(5-aryltetrahydrofuran-3-yl)cyclobutyl)amide derivatives

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00031A, PaperB. V. Subba Reddy, K. Muralikrishna, J. S. Yadav, N. Jagdeesh Babu, K. Sirisha, A. V. S. Sarma
A novel synthesis of 4-aryl-(3-oxabicyclo[4.2.0]octan-1-yl)amide and (1-(5-aryltetrahydrofuran-3-yl)cyclobutyl)amide derivatives was achieved through a sequential Prins/Wagner/Ritter process.
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Stereoselective reaction of 2-carboxythioesters-1,3-dithiane with nitroalkenes: an organocatalytic strategy for the asymmetric addition of a glyoxylate anion equivalent

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00492F, CommunicationElisabetta Massolo, Maurizio Benaglia, Andrea Genoni, Rita Annunziata, Giuseppe Celentano, Nicoletta Gaggero
Under mild reaction conditions [gamma]-nitro-[small beta]-aryl-[small alpha]-keto esters with up to 92% ee were obtained, realizing a formal catalytic stereoselective conjugate addition of the glyoxylate anion synthon.
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Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00406C, PaperBaljinder Singh, Ashok Kumar, Prashant Joshi, Santosh K. Guru, Suresh Kumar, Zahoor A. Wani, Girish Mahajan, Aashiq Hussain, Asif Khurshid Qazi, Ajay Kumar, Sonali S. Bharate, Bishan D. Gupta, Parduman R. Sharma, Abid Hamid, Ajit K. Saxena, Dilip M. Mondhe, Shashi Bhushan, Sandip B. Bharate, Ram A. Vishwakarma
Colchicine derivatives with reduced P-gp induction liability have been identified.
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Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00354G, PaperSandy Desrat, Camille Remeur, Fanny Roussi
The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer.
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Cu-catalysed direct C-H (hetero)arylation of [1,2,4]triazolo[4,3-a]pyridine to construct deep-blue-emitting luminophores

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00552C, CommunicationJie Wu, Qiulin You, Jingbo Lan, Qiang Guo, Xiaoyu Li, Ying Xue, Jingsong You
An efficient protocol for the synthesis of 3-aryl-[1,2,4]triazolo[4,3-a]pyridines has been developed via Cu-catalysed direct C-H (hetero)arylation. The resulting compounds exhibit deep-blue emission with high quantum yields, photostability, and thermal stability.
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An interactive database to explore herbicide physicochemical properties

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00469A, CommunicationMichael N. Gandy, Maxime G. Corral, Joshua S. Mylne, Keith A. Stubbs
An interactive database containing the physicochemical properties of successful herbicidal compounds that allows rapid comparison to potential, new herbicidal compounds is presented.
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Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective [small kappa] opioid receptor agonists

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00350D, PaperZong-Jie Gan, Yu-Hua Wang, Yun-Gen Xu, Ting Guo, Jun Wang, Qiao Song, Xue-Jun Xu, Shi-Yuan Hu, Yu-Jun Wang, De-Chuan Wang, De-Zhu Sun, Di Zhang, Tao Xi, Hao-Dong Li, Hai-Bo Zhang, Tai-Jun Hang, Hong-Guo Lu, Jing-Gen Liu
11a produces potent peripheral antinociception.
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The tale of RNA G-quadruplex

28 April, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02681K, Review ArticlePrachi Agarwala, Satyaprakash Pandey, Souvik Maiti
The RNA secondary structure G-quadruplex with its malleable nature can execute diverse biological functions and can be manipulated and used for various applications.
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