Org. and Biomol. Chem.
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Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex
DOI: 10.1039/C3OB00012E, PaperNorihito Arichi, Junpei Yamamoto, Chiaki Takahata, Emi Sano, Yuji Masuda, Isao Kuraoka, Shigenori Iwai
The (6-4) photoproduct in DNA is heat-labile at neutral pH, while its Dewar valence isomer is relatively stable. ERCC1-XPF removes the 3[prime or minute]-blocking end in the presence of RPA.
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A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences
DOI: 10.1039/C3OB40447A, PaperWuxiang Mao, Jianlin Hu, Tingting Hong, Xiwen Xing, Sen Wang, Xi Chen, Xiang Zhou
The 5fC and 5hmC could be detected respectively, by comparing the DNA treated with piperidine with and without oxidation.
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Symmetric and unsymmetric 3,3[prime or minute]-linked bispyrroles via ring-enlargement reactions of furan-derived donor-acceptor cyclopropanes
DOI: 10.1039/C3OB40228B, PaperJohannes Kaschel, Tobias F. Schneider, Daniel Kratzert, Dietmar Stalke, Daniel B. Werz
Highly substituted symmetric and unsymmetric 3,3[prime or minute]-linked bispyrroles were obtained by a short sequence starting from furan utilizing donor-acceptor cyclopropanes as key intermediates.
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Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization
DOI: 10.1039/C3OB40306H, PaperSusana Maza, M. Mar Kayser, Giuseppe Macchione, Javier Lopez-Prados, Jesus Angulo, Jose L. de Paz, Pedro M. Nieto
A novel strategy for the synthesis of chondroitin/dermatan sulfate-like oligosaccharides is described. The binding affinities of the synthesized compounds to FGF-2 are estimated by using a fluorescence polarization assay.
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Efficient pseudo-five-component coupling-Fiesselmann synthesis of luminescent oligothiophenes and their modification
DOI: 10.1039/C3OB40124C, PaperMarco Teiber, Sonke Giebeler, Timo Lessing, Thomas J. J. Muller
Highly luminescent symmetrical terthiophenes and quinquethiophenes are accessible in a consecutive pseudo-five-component reaction in good to excellent yield.
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Synthesis of tetrasubstituted benzenes via rhodium(I)-catalysed ring-opening benzannulation of cyclobutenols with alkynes
DOI: 10.1039/C3OB40436F, CommunicationTakanori Matsuda, Norio Miura
A simple and efficient method has been developed for the synthesis of 1,2,3,5-tetrasubstituted benzenes via rhodium(I)-catalysed ring-opening benzannulation of 1,3-disubstituted cyclobutenols with internal alkynes.
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Towards a dynamic covalent molecular switch: substituent effects in chalcone/flavanone isomerism
DOI: 10.1039/C3OB40467F, CommunicationJesse Mai, Ermal Hoxha, Caitlin E. Morton, Brian M. Muller, Marc J. Adler
Chalcone/flavanone interconversion occurs facilely under aqueous alkaline conditions making it a promising scaffold for the development of a covalent molecular switch.
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Total synthesis and biological evaluation of (-)-exiguolide analogues: importance of the macrocyclic backbone
DOI: 10.1039/C3OB40131F, PaperHaruhiko Fuwa, Kana Mizunuma, Makoto Sasaki, Takaya Suzuki, Hiroshi Kubo
Synthesis and biological evaluation of (-)-exiguolide analogues elucidated the importance of the macrocyclic backbone for antiproliferative activity and the tolerance of the side chain to structural modifications.
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Synthetically amenable amide derivatives of tosylated-amino acids as organocatalysts for enantioselective allylation of aldehydes: computational rationale for enantioselectivity
DOI: 10.1039/C3OB27513B, PaperDebashis Ghosh, Debashis Sahu, S. Saravanan, Sayed H. R. Abdi, Bishwajit Ganguly, Noor-ul H. Khan, Rukhsana I. Kureshy, Hari C. Bajaj
Chirally enriched homoallyl alcohols were effectively synthesized by using synthetically amenable organocatalyst derived from L-phenylalanine.
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AApeptides as a new class of antimicrobial agents
Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40444G, PerspectiveJianfeng Cai
Antibiotic resistance is an increasing public health concern around the world, and is recognized as one of the greatest threats facing humankind in 21st century. Natural antimicrobial peptides (AMPs) are...
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DOI: 10.1039/C3OB40444G, PerspectiveJianfeng Cai
Antibiotic resistance is an increasing public health concern around the world, and is recognized as one of the greatest threats facing humankind in 21st century. Natural antimicrobial peptides (AMPs) are...
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Stereoselective Direct Reductive Amination of Ketones with Electron-Withdrawing Amines using Re2O7/NaPF6 Catalyst
Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40918J, PaperBraja Gopal Das, Prasanta Ghorai
The first example of direct reductive amination (DRA) of ketones with electron-withdrawing amines (EWA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic...
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DOI: 10.1039/C3OB40918J, PaperBraja Gopal Das, Prasanta Ghorai
The first example of direct reductive amination (DRA) of ketones with electron-withdrawing amines (EWA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic...
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Highly Specific, Multi-branched Fluorescent Reporters for Analysis of Human Neutrophil Elastase
Org. Biomol. Chem., 2013, Accepted Manuscript
DOI: 10.1039/C3OB40212F, PaperNicolaos Avlonitis, Manuelle Debunne, Tashfeen Aslam, Neil McDonald, Chris Haslett, Kev Dhaliwal, Mark Bradley
Human Neutrophil Elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised...
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DOI: 10.1039/C3OB40212F, PaperNicolaos Avlonitis, Manuelle Debunne, Tashfeen Aslam, Neil McDonald, Chris Haslett, Kev Dhaliwal, Mark Bradley
Human Neutrophil Elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised...
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Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands
DOI: 10.1039/C3OB40360B, PaperMichael P. Carroll, Patrick J. Guiry, John M. Brown
Analysis of X-ray crystal structures for families of PN ligands reveal conformational variations that can be linked to trends in catalytic asymmetric synthesis.
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Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation
DOI: 10.1039/C3OB40578H, PaperCalum W. Muir, Alan R. Kennedy, Joanna M. Redmond, Allan J. B. Watson
4H-Quinolizin-4-ones are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to functionalised 4H-quinolizin-4-ones.
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A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones
DOI: 10.1039/C3OB40395E, PaperKristyna M. Elbel, Gianni Guizzunti, Maria A. Theodoraki, Jing Xu, Ayse Batova, Marianna Dakanali, Emmanuel A. Theodorakis
Functionalization at the A-ring regulates the selective formation of the C-ring cage and the electrophilicity of the C10 enone.
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NMR characterisation of a highly conserved secondary structural RNA motif of Halobacterium halobium 23S rRNA
DOI: 10.1039/C3OB40295A, PaperJohn King, Christos Shammas, Misbah Nareen, Moreno Lelli, Vasudevan Ramesh
The highly conserved 29-mer RNA motif corresponding to the peptidyl transferase central circle region of the domain V of Halobacterium halobium 23S rRNA has been characterised by multidimensional NMR spectroscopy.
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Copper-catalyzed aerobic oxidative synthesis of aryl nitriles from benzylic alcohols and aqueous ammonia
DOI: 10.1039/C3OB00002H, PaperChuanzhou Tao, Feng Liu, Youmin Zhu, Weiwei Liu, Zhiling Cao
Copper-catalyzed aerobic oxidative synthesis of aryl nitriles.
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A convenient solid-phase strategy for the synthesis of antimicrobial cyclic lipopeptides
DOI: 10.1039/C3OB40319J, PaperSilvia Vila, Esther Badosa, Emilio Montesinos, Lidia Feliu, Marta Planas
Cyclolipopeptides were synthesized on solid-phase through acylation of a cyclic peptidyl resin and the best sequence displayed high antimicrobial activity and low hemolysis.
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Photoresponsive two-component organogelators based on trisphenylisoxazolylbenzene
DOI: 10.1039/C3OB00041A, PaperTakeharu Haino, Yuko Hirai, Toshiaki Ikeda, Hiroshi Saito
New photoresponsive two-component organogels were developed by photochromic tris(phenylisoxazolyl)benzene and bispyridine derivatives.
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Acridine-based macrocyclic fluorescent sensors: self-assembly behavior characterized by crystal structures and a tunable bathochromic-shift in emission induced by H2PO4-via adjusting the ring size and rigidity
DOI: 10.1039/C3OB27500K, PaperDawei Zhang, Xiaozhi Jiang, Haiqiang Yang, Alexandre Martinez, Meiyuan Feng, Zhiyun Dong, Guohua Gao
Acridine-based macrocyclic sensors exhibited a tunable H2PO4--induced bathochromic shift in emission.
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