Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Combinatorial Synthesis of Nicotine Analogs Using an Ugi 4-CR/Cyclization-Reduction Strategy

23 July, 2014 - 09:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00767K, PaperLuis Angel Polindara-Garcia, Alfredo Vazquez
A practical one-pot synthesis of nicotine analogs from Ugi 4-CR/propargyl adducts is reported. This methodology allows the rapid construction of the pyrrolidine moiety present in nicotine through an intramolecular base-promoted...
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Catalytic control over the formation of supramolecular materials

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01108B, PerspectiveRienk Eelkema, Jan H. van Esch
Catalytic formation of self-assembling building blocks provides control over the morphology, mechanical properties and spatial distribution of soft supramolecular materials.
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Access to novel functionalized trifluoromethyl [small beta]-lactams by ring expansion of aziridines

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01262C, CommunicationS. Decamps, L. Sevaille, S. Ongeri, B. Crousse
A wide variety of CF3-[small beta]-lactams functionalized at position C-3 were obtained stereoselectively by ring expansion of aziridines.
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Total synthesis of the cyclic monoterpenoid pyrano[3,2-a]carbazole alkaloids derived from 2-hydroxy-6-methylcarbazole

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01151A, PaperCemena Gassner, Ronny Hesse, Arndt W. Schmidt, Hans-Joachim Knolker
The synthesis of seven pyrano[3,2-a]carbazole alkaloids has been achieved using their putative biogenetic precursor 2-hydroxy-6-methylcarbazole as key intermediate.
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Synthesis of 3,3-disubstituted-2,3-dihydroazanaphthoquinones via simultaneous alkyne oxidation and nitrile hydration of ortho-alkynylarenenitriles

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00852A, PaperKaruppusamy Sakthivel, Kannupal Srinivasan
Simultaneous activation of alkynes and nitriles in o-alkynylarenenitriles in the presence of Pd(OAc)2/H2O/(+/-)-CSA afforded 3,3-disubstituted-2,3-dihydroazanaphthoquinones in moderate to excellent yields.
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Tandem metal relay catalysis: from cyclopropene to polysubstituted furan

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5802-5806
DOI: 10.1039/C4OB00987H, PerspectiveChuanling Song, Jianwu Wang, Zhenghu Xu
Transmetalation is a key step in traditional coupling reactions. An efficient synthetic methodology of tetrasubstituted furans from cyclopropenes with Cu-Pd transmetalation relay catalysis was presented.
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Synthesis of 4-methyl-N[prime or minute]-(3-alkyl-2r,6c-diarylpiperidin-4-ylidene)-1,2,3-thiadiazole-5-carbohydrazides with antioxidant, antitumor and antimicrobial activities

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5911-5921
DOI: 10.1039/C4OB00739E, PaperKodisundaram Paulrasu, Arul Duraikannu, Manikandan Palrasu, Amirthaganesan Shanmugasundaram, Murugavel Kuppusamy, Balasankar Thirunavukkarasu
The structures of the newly synthesized 4-methyl-N[prime or minute]-(3-alkyl-2r,6c-diarylpiperidin-4-ylidene)-1,2,3-thiadiazole-5-carbohydrazide (5a-5l) were confirmed by spectral and elemental analysis.
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A facile route to 5-methyl-5H-indeno[1,2-c]quinolones via palladium-catalyzed cyclization of 2-alkynylbromobenzenes with N,N-dimethyl-2-alkynylanilines

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5861-5865
DOI: 10.1039/C4OB00706A, PaperXiaolin Pan, Yong Luo, Yunyan Kuang, Guangming Li
A tandem reaction catalyzed by palladium is developed to provide a facile and simple route for the synthesis of 5-methyl-5H-indeno[1,2-c]quinolones.
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Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and a copper mediated tandem cyanation-lactonization approach

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5973-5980
DOI: 10.1039/C4OB00965G, PaperU. Nookaraju, Eeshwaraiah Begari, Pradeep Kumar
A simple and novel synthesis of (+)-monocerin was achieved from 3-buten-1-ol employing HKR, Julia olefination, intramolecular tandem Sharpless asymmetric dihydroxylation-SN2 cyclization and a novel copper mediated tandem cyanation-cyclization as the key steps.
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Theoretical study of the reaction of hydroxyl radicals with uridine: the influence of ribose and solvent

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5891-5897
DOI: 10.1039/C4OB00168K, PaperYa Gao, Xiayu Chen, Li Zhong, Wei Yao, Shujin Li
The reaction of [radical dot]OH with uridine has been investigated. The influence of ribose and the solvent effect are presented.
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Organocatalytic synthesis of optically active [small beta]-branched [small alpha]-amino esters via asymmetric biomimetic transamination

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5856-5860
DOI: 10.1039/C4OB00684D, PaperCunxiang Su, Ying Xie, Hongjie Pan, Mao Liu, Hua Tian, Yian Shi
This paper describes an efficient asymmetric biomimetic transamination of [small alpha]-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of [small beta]-branched [small alpha]-amino esters in 50-96% yield and 87-95% ee.
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Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5847-5855
DOI: 10.1039/C4OB00733F, PaperNaomu Miyamae, Naruhisa Watanabe, Maya Moritaka, Keiji Nakano, Yoshiyasu Ichikawa, Hiyoshizo Kotsuki
A highly diastereoselective and enantioselective method for the asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure was developed.
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A powerful combination: recent achievements on using TBAI and TBHP as oxidation system

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5807-5817
DOI: 10.1039/C4OB00276H, Review ArticleXiao-Feng Wu, Jin-Long Gong, Xinxin Qi
Recent achievements in the use of TBAI and TBHP as an oxidation system have been summarized and discussed.
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Recent advances in trifluoromethylation of organic compounds using Umemoto's reagents

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00671B, Review ArticleCai Zhang
This review highlights recent developments in the direct introduction of a trifluoromethyl group into organic compounds with Umemoto's reagents.
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Novel EDTA-Ligands Containing an Integral Perylene Bisimide (PBI) Core as Optical Reporter Unit

23 July, 2014 - 09:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01007H, PaperMario Marcia, Prabhpreet Singh, Frank Hauke, Michele Maggini, Andreas Hirsch
The synthesis, characterization and metal complexation of a new class of perylene bisimides (PBIs) being an integral part of ethylenediaminetetraacetic acid (EDTA) - is reported. The simplest representative, namely derivative...
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Enhanced catalysis and enantioselective resolution of racemic naproxen methyl ester by lipase encapsulated within iron oxide nanoparticles coated with calix[8]arene valeric acid complexes

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01048E, PaperSerkan Sayin, Enise Akoz, Mustafa Yilmaz
In this study, two types of nanoparticles have been used as additives for the encapsulation of Candida rugosa lipase via the sol-gel method.
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C-H arylation of azaheterocycles: a direct ligand-free and Cu-catalyzed approach using diaryliodonium salts

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01061B, CommunicationDalip Kumar, Meenakshi Pilania, V. Arun, Savita Pooniya
An efficient and high yielding Cu-catalyzed direct C-H arylation of oxadiazoles, thiadiazoles, benzoxazoles and benzothiazoles has been achieved by employing easily accessible diaryliodonium salts.
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P,N,N-Pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01041H, PaperDan Wu, Zhong-Xia Wang
P,N,N-Pincer nickel was demonstrated to effectively catalyze cross-coupling of aryl fluorides and chlorides with aryl magnesium or zinc reagents.
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A "click" chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01005A, PaperYang Wang, Zeinab Assaf, Xinjun Liu, Fabio Ziarelli, Amel Latifi, Otmane Lamrabet, Gilles Quelever, Fanqi Qu, Cheng-Cai Zhang, Ling Peng
An ingenious and robust affinity resin to capture the 2-oxoglutaric acid binding proteins was constructed via "click" chemistry and validated using a known 2-OG receptor in cell lysate.
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Facile access to amides and hydroxamic acids directly from nitroarenes

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01155D, PaperShreyans K. Jain, K. A. Aravinda Kumar, Sandip B. Bharate, Ram A. Vishwakarma
Herein, we report a new method for synthesis of amides and hydroxamic acids directly from nitroarenes and aldehydes.
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