Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7307-7312
DOI: 10.1039/C5OB00643K, PaperM. S. Chan, D. Xu, L. Guo, D. Y. Tam, L. S. Liu, Y. Chen, M. S. Wong, P. K. Lo
A novel biocompatible and macrophage cell-membrane permeable carbazole-based cyanine probe for ROS detection and cellular protection is reported.
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The design, synthesis, and biological evaluation of novel YC-1 derivatives as potent anti-hepatic fibrosis agents

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7257-7264
DOI: 10.1039/C5OB00710K, PaperJuan Xiao, Chunmei Jin, Zhixue Liu, Shujing Guo, Xiaochuan Zhang, Xin Zhou, Xue Wu
YC-1 and its derivatives have been demonstrated for the first time with significant effects on inhibiting LX-2 cell activation and inducing apoptosis of LX-2 cells, making them potential agents for hepatic fibrosis therapy.
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Copper catalysed direct amidation of methyl groups with N-H bonds

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7289-7293
DOI: 10.1039/C5OB00685F, PaperYao Huang, Tieqiao Chen, Qiang Li, Yongbo Zhou, Shuang-Feng Yin
An efficient copper catalysed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.
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Selective photoregulation of the activity of glycogen synthase and glycogen phosphorylase, two key enzymes in glycogen metabolism

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7282-7288
DOI: 10.1039/C5OB00796H, PaperMireia Diaz-Lobo, Jaume Garcia-Amoros, Ignacio Fita, Dolores Velasco, Joan J. Guinovart, Joan C. Ferrer
An azobenzene glucoside was synthesized and was shown to be an excellent selective inhibitor of Escherichia coli glycogen synthase in its photogenerated (Z)-form, which structurally resembles the three terminal glucoses of a glycogen branch.
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Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7248-7256
DOI: 10.1039/C5OB00773A, PaperFaviola Cardoso-Martinez, Jose M. de la Rosa, Ana R. Diaz-Marrero, Jose Darias, Claudia Cerella, Marc Diederich, Mercedes Cueto
Tanzawaic acids M (1), N (2), O (3) and P (4) were isolated from an extract of a cultured marine-derived fungus (strain CF07370) identified as a member of the genus Penicillium.
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N-B dative bond-induced [3.3.0] bicyclic boronate-tethered exo-selective intramolecular Diels-Alder reaction

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7136-7139
DOI: 10.1039/C5OB00917K, CommunicationChao Feng, Hong Wang, Liang Xu, Pengfei Li
We report herein a highly exo-selective intramolecular Diels-Alder reaction of alkenyl boronates which employs an N-B dative bond-involved bicyclic rigid tether.
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A three-component reaction for rapid access to underexplored 1,3-thiazine-2-thiones

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7223-7229
DOI: 10.1039/C5OB00377F, PaperDenis Kroger, Fabian Brockmeyer, Christoph Kahrs
A newly developed multicomponent reaction opens access to a variety of (poly)heterocyclic structures containing the underexplored skeleton of 1,3-thiazine-2-thione.
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Isoxazolidine-fused meso-tetraarylchlorins as key tools for the synthesis of mono- and bis-annulated chlorins

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7131-7135
DOI: 10.1039/C5OB00800J, CommunicationAntonio Aguiar, Andreia Leite, Andre M. N. Silva, Augusto C. Tome, Luis Cunha-Silva, Baltazar de Castro, Maria Rangel, Ana M. G. Silva
An efficient synthetic approach to prepare novel annulated chlorin derivatives, a meso-tetraarylchlorin bearing an azepine ring and another bearing simultaneously an azepine and a 2H-pyran ring, is described.
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Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7265-7281
DOI: 10.1039/C5OB00731C, PaperMatthias P. Quick, Roland Frohlich, Dirk Schepmann, Bernhard Wunsch
Diastereoselective opening of a tricyclic oxazolidine with allyltrimethylsilane represents a key step in the synthesis of enantiomerically pure 3-substituted tetrahydro-2-benzazepines.
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Anatomy of gold catalysts: facts and myths

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7103-7118
DOI: 10.1039/C5OB00736D, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Beatrice Ranieri, Imma Escofet, Antonio M. Echavarren
This review article covers the main types of gold(I) complexes used as precatalysts under homogeneous conditions in organic synthesis and discusses the different ways of catalyst activation as well as ligand, silver, and anion effects.
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Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7236-7247
DOI: 10.1039/C5OB00860C, PaperMamta Kaura, Patrick J. Hrdlicka
Mixmer oligonucleotides modified with LNA and C5-pyrene-functionalized DNA monomers are shown to display interesting fluorescence properties for the discrimination of single nucleotide polymorphisms (SNPs).
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RNA nucleosides as chiral sensing agents in NMR spectroscopy

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7230-7235
DOI: 10.1039/C5OB00513B, PaperN. Lokesh, S. L. Sachin, L. V. Narendra, K. Arun, N. Suryaprakash
The study reports chiral sensing properties of RNA nucleosides. A three component derivitazation protocol has been adopted to differentiate chiral amines. All RNA nucleosides exhibit chiral sensing property.
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Current complexity: a tool for assessing the complexity of organic molecules

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7164-7176
DOI: 10.1039/C5OB00709G, PaperJun Li, Martin D. Eastgate
A new complexity index is described, leveraging crowd-sourced knowledge to assess a molecules complexity in the context of current technology.
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5[prime or minute]-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7193-7222
DOI: 10.1039/C5OB00707K, PaperMickael J. Fer, Ahmed Bouhss, Mariana Patrao, Laurent Le Corre, Nicolas Pietrancosta, Ana Amoroso, Bernard Joris, Dominique Mengin-Lecreulx, Sandrine Calvet-Vitale, Christine Gravier-Pelletier
The synthesis of 5[prime or minute]-methylene-[1,4]-triazole-substituted aminoribosyl uridines is described. Their biological evaluation was performed and rationalized by molecular modeling.
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Synergism between genome sequencing, tandem mass spectrometry and bio-inspired synthesis reveals insights into nocardioazine B biogenesis

1 July, 2015 - 23:54

Org. Biomol. Chem., 2015, 13,7177-7192
DOI: 10.1039/C5OB00537J, PaperNorah Alqahtani, Suheel K. Porwal, Elle D. James, Dana M. Bis, Jonathan A. Karty, Amy L. Lane, Rajesh Viswanathan
A noz gene cluster encoded by Nocardiopsis sp. CMB M0232 is presented, revealing the actinomycetes' unique indole methylating and prenylating patterns, leading to anticancer nocardioazine alkaloids.
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Ring closing metathesis reactions of [small alpha]-methylene-[small beta]-lactams: application to the synthesis of a simplified phyllostictine analogue with herbicidal activity

29 June, 2015 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00890E, PaperSamuel Coe, Nicole Pereira, Joanna V. Geden, Guy J. Clarkson, David J. Fox, Richard M. Napier, Paul Neve, Michael Shipman
The first RCM reactions of [small alpha]-methylene-[small beta]-lactams are used to construct strained macrocycles that mimic elements of phyllostictine A.
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Rhodium(III)-catalyzed cascade oxidative annulation reactions of aryl imidazolium salts with alkynes involving multiple C-H bond activation

29 June, 2015 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00823A, PaperQingmei Ge, Bin Li, Haibin Song, Baiquan Wang
The cascade oxidative annulation reactions of aryl imidazolium salts with alkynes proceed efficiently in the presence of [Cp*RhCl2]2 and Cu(OAc)2[middle dot]H2O to give substituted imidazo[1,2-a]-quinolinium salts and benzo[ij]imidazo[2,1,5-de]quinolizinium salts.
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Highly water-soluble and tumor-targeted photosensitizers for photodynamic therapy

29 June, 2015 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01035G, PaperYuxi Li, Jin Wang, Xiaoxiao Zhang, Wenjun Guo, Fu Li, Min Yu, Xiuqi Kong, Wenjie Wu, Zhangyong Hong
Biological uses of photosensitizers in photodynamic therapy (PDT) often suffer from a lack of tumor selectivity; a strategy based on molecule-targeted cancer therapies could provide a promising solution.
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Organotellurium scaffolds for mass cytometry reagent development

29 June, 2015 - 23:17

Org. Biomol. Chem., 2015, 13,7027-7033
DOI: 10.1039/C5OB00593K, PaperHanuel Park, Landon J. Edgar, Matthew A. Lumba, Lisa M. Willis, Mark Nitz
Tellurophenes are promising biocompatible mass tags.
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Synthetic applications of hypophosphite derivatives in reduction

29 June, 2015 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB01032B, Review ArticleCarole Guyon, Estelle Metay, Florence Popowycz, Marc Lemaire
The purpose of this review is to collect the applications in fine synthesis of hypophosphite derivatives as reducing agents.
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