Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 23 hours 44 min ago

Two-channel Dansyl/Tryptophan Emitters with a Cholic Acid Bridge as Reporters for Local Hydrophobicity within Supramolecular Systems Based on Bile Salts

14 September, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01394H, PaperMiguel Gomez-Mendoza, Maria Luisa Marin, Miguel Miranda
The aim of the present work is to develop two-channel emitters to probe local hydrophobicity by means of fluorescence quenching within different biomimetic supramolecular environments. To achieve this goal, the...
The content of this RSS Feed (c) The Royal Society of Chemistry

ent-Kaurane-Based Regio- and Stereoselective Inverse Electron Demand Hetero-Diels-Alder Reactions: Synthesis of Dihydropyran-Fused Diterpenoids

14 September, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01040J, PaperChunyong Ding, Lili Wang, Haijun Chen, Christopher Wild, Na Ye, Ye Ding, Tianzhi Wang, Mark A White, Qiang Shen, Jia Zhou
A mild and concise approach for the construction of 3,4-dihydro-2H-pyran ring integrated into the A-ring of the natural product oridonin using an optimized inverse electron demand hetero-Diels-Alder (IED HDA) reaction...
The content of this RSS Feed (c) The Royal Society of Chemistry

A small synthetic molecule forms selective potassium channels to regulate cell membrane potential and blood vessel tone

14 September, 2014 - 00:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01420K, PaperHui-Yan Zha, Bing Shen, Kwok-Hei Yau, Shing-To Li, Xiao-Qiang Yao, Dan Yang
A molecule forms a K+-selective channel in the cell membrane to regulate vascular muscle cell membrane potential and blood vessel tone.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Adaptable synthesis of C-lactosyl glycoclusters and their binding properties with galectin-3

14 September, 2014 - 00:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01374C, PaperWang Yao, Meng-jie Xia, Xiang-bao Meng, Qing Li, Zhong-jun Li
The synthesis of mono- to tetravalent C-[small beta]-lactosyl glycoclusters has been achieved in good yield. The KD values of glycoclusters against galectin-3 were tested by SPR assay, and the structure-activity relationship has been summarized in detail.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Discovery and SAR study of piperidine-based derivatives as novel influenza virus inhibitors

14 September, 2014 - 00:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01079E, PaperGuoxin Wang, Longjian Chen, Tongmei Xian, Yujie Liang, Xintao Zhang, Zhen Yang, Ming Luo
A series of 4-(quinolin-4-yloxy)piperidine-1-carboxylate derivatives were identified as novel and potent inhibitors of the influenza virus through structural modification of a compound from a high-throughput screen.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

An experimental and theoretical study of reaction mechanisms between nitriles and hydroxylamine

14 September, 2014 - 00:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00854E, PaperAttila Voros, Zoltan Mucsi, Zoltan Baan, Geza Timari, Istvan Hermecz, Peter Mizsey, Zoltan Finta
The industrially relevant reaction between nitriles and hydroxylamine yielding amidoximes was studied in different molecular solvents and in ionic liquids.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A General Pd/Cu-Catalyzed C-H Heteroarylation of 3-Bromoquinolin-2(1H)-ones

11 September, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01610F, PaperAlexandre BRUNEAU, Jean Daniel BRION, SAMIR MESSAOUDI, Mouad Alami
3-(heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanism and Regioselectivity of Gold (I) or Platinum (II) Catalyzed Intramolecular Hydroarylation to Pyrrolopyridinones and Pyrroloazepinones

11 September, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00894D, PaperRan Fang, Xiaoxiao Wei, Lizi Yang
We report here the theoretical analysis of the mechanism and regioselectivity of gold (I) or platinum (II) catalyzed intramolecular hydroarylation to pyrrolopyridinones and pyrroloazepinones. AuPH3+ and PtCl2 have been considered...
The content of this RSS Feed (c) The Royal Society of Chemistry

Direct Synthesis of Polysubstituted 2-Aminothiophenes through Cu(II)-Catalyzed Addition/Oxidative Cyclization of Alkynoates with Thioamides

11 September, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01534G, PaperLi-Shi Ge, Zheng-Lin Wang, Xing-Lan An, Xiaoyan Luo, Wei-Ping Deng
A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available...
The content of this RSS Feed (c) The Royal Society of Chemistry

The importance of chain conformational mobility during 5-exo-cyclizations of C-, N- and O-centred radicals

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01419G, PaperJohn C. Walton
The access angle of a radical centre to an alkene acceptor was found to be a key parameter that pinpointed difficult chain reorganizations as responsible for the slow 5-exo cyclizations of N-centred radicals.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01063A, Review ArticleAlexander C. Drohat, Atanu Maiti
We review advances in understanding the mechanism of DNA glycosylases, emphasizing the role of the nucleobase leaving-group.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and evaluation of a photoresponsive quencher for fluorescent hybridization probes

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01185F, PaperMarina Kovaliov, Chaim Wachtel, Eylon Yavin, Bilha Fischer
dUDAB modified probes are promising probes for gene quantification in real-time PCR detection and as photoswitchable devices.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-nucleotidases

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01332H, PaperOndrej Simak, Petr Pachl, Milan Fabry, Milos Budesinsky, Tomas Jandusik, Ales Hnizda, Radka Sklenickova, Magdalena Petrova, Vaclav Veverka, Pavlina Rezacova, Jiri Brynda, Ivan Rosenberg
Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5[prime or minute](3[prime or minute])-deoxynucleotidases.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01223B, PaperAhmed Kamal, Manda Sathish, Vunnam Srinivasulu, Jadala Chetna, Kunta Chandra Shekar, Shalini Nekkanti, Yellaiah Tangella, Nagula Shankaraiah
New pyrrolidinyl-oxazole-carboxamides were synthesized and utilized as efficient organocatalysts for asymmetric Michael addition reaction. In addition, computational mechanistic studies were performed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Multiple optical properties of a naphthoquinone pigment: 2-methyl-3-(hydroxyphenylthio)-1,4-naphthalenedione

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01058B, PaperHirotaka Akiyama, Takafumi Inoue, Nobuo Tajima, Reiko Kuroda, Yoshitane Imai
Naphthoquinone pigments 2-methyl-3-(4- or 2-hydroxyphenylthio)-1,4-naphthalenedione show characteristic multiple optical properties in solution and in the solid state.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01152J, PaperAhmed Kamal, Anver Basha Shaik, Sowjanya Polepalli, Vangala Santosh Reddy, G. Bharath Kumar, Soma Gupta, K. V. S. Rama Krishna, Ananthamurthy Nagabhushana, Rakesh K. Mishra, Nishant Jain
A library of pyrazole-oxadiazole conjugates were synthesized and investigated for their antiproliferative activity in human cancer cell lines.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of L-rhamnose derived chiral bicyclic triazoles as novel sodium-glucose transporter (SGLT) inhibitors

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01319K, PaperSiddamal Reddy Putapatri, Abhinav Kanwal, Balasubramanian Sridhar, Sanjay K. Banerjee, Srinivas Kantevari
Fused chiral bicyclic 1,2,3-triazoles synthesized from commercially available natural L-rhamnose exhibited excellent SGLT inhibition activity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Friedel-Crafts alkylations of electron-rich aromatics with 3-hydroxy-2-oxindoles: scope and limitations

11 September, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01264J, PaperLakshmana K. Kinthada, Santanu Ghosh, K. Naresh Babu, Mohd. Sharique, Soumava Biswas, Alakesh Bisai
Lewis acid-catalyzed activation of 3-hydroxy-2-oxindoles +/-5 followed by reactions with various electron-rich aromatics was investigated. A variety of products were synthesized in high yields.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Short, Efficient Synthesis of Fluorinated [small delta]-Lactams.

9 September, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01547A, PaperRodolfo Marquez, Tom Cogswell, Craig Donald, Deliang Long
The diastereoselective synthesis of fluorinated [small delta]-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionality, and provides a quick route for the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chiroptical molecular propeller based on hexakis(phenylethynyl)benzene through the complexation-induced intramolecular transmission of local point chirality

9 September, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01601G, PaperRyo Katoono, Keiichi Kusaka, Shunsuke Kawai, Yuki Tanaka, Keisuke Hanada, Tatsuo Nehira, Kenshu Fujiwara, Takanori Suzuki
We designed hexakis(phenylethynyl)benzene derivatives with a tertiary amide group on each blade to achieve a helically-biased propeller arrangement through the complexation-induced intramolecular transmission of point chirality. A hydrogen-bonding ditopic guest...
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.