Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 13 hours ago

Balanced [small pi]-[small pi] interactions directing the self-assembly of indolocarbazole-based low molecular mass organogelators

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6134-6144
DOI: 10.1039/C4OB00873A, PaperPeng Gong, Pengchong Xue, Chong Qian, Zhenqi Zhang, Ran Lu
New indolocarbazole-based organogelators emitting strong blue light have been synthesized.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium catalyzed synthesis and physical properties of indolo[2,3-b]quinoxalines

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6151-6166
DOI: 10.1039/C4OB00841C, PaperTran Quang Hung, Do Huy Hoang, Ngo Ngoc Thang, Tuan Thanh Dang, Khurshid Ayub, Alexander Villinger, Aleksej Friedrich, Stefan Lochbrunner, Gerd-Uwe Flechsig, Peter Langer
A series of indolo[2,3-b]quinoxaline derivatives were efficiently synthesized from 2,3-dibromoquinoxaline by two pathways.
The content of this RSS Feed (c) The Royal Society of Chemistry

Reactivity in the nucleophilic aromatic substitution reactions of pyridinium ions

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6175-6180
DOI: 10.1039/C4OB00946K, PaperJeannette T. Bowler, Freeman M. Wong, Scott Gronert, James R. Keeffe, Weiming Wu
The nucleophilic aromatic substitution reactions of piperidine with N-methylpyridinium ions in methanol occur via rate determining preassociation of a second piperidine molecule with the addition intermediate followed by barrier-free deprotonation. Loss of leaving group is concurrent with deprotonation for Cl, Br, and I (E2), but subsequent to deprotonation, although rapid, for CN and F (E1cBIRR).
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, and the antioxidant, neuroprotective and P-glycoprotein induction activity of 4-arylquinoline-2-carboxylates

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6267-6277
DOI: 10.1039/C4OB00488D, PaperJaideep B. Bharate, Abubakar Wani, Sadhana Sharma, Shahi Imam Reja, Manoj Kumar, Ram A. Vishwakarma, Ajay Kumar, Sandip B. Bharate
An efficient synthesis of 4-arylquinoline-2-carboxylates and their antioxidant, neuroprotective and P-glycoprotein induction activity have been described.
The content of this RSS Feed (c) The Royal Society of Chemistry

6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6250-6266
DOI: 10.1039/C4OB01117A, PaperGiampiero D'Adamio, Camilla Parmeggiani, Andrea Goti, Antonio J. Moreno-Vargas, Elena Moreno-Clavijo, Inmaculada Robina, Francesca Cardona
The synthesis of the first multivalent pyrrolizidine iminosugars is reported, with up to 9 bioactive molecules on the same scaffold.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of (S)- and (R)-[small alpha]-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of [small alpha]-amino acids

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6239-6249
DOI: 10.1039/C4OB00669K, PaperRyosuke Takeda, Akie Kawamura, Aki Kawashima, Hiroki Moriwaki, Tatsunori Sato, Jose Luis Acena, Vadim A. Soloshonok
A chiral ligand reacts with racemic amino acids to produce easily separable Ni(II) complexes which can be disassembled to afford both enantiomers of target amino acids.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper(I)-induced amplification of a [2]catenane in a virtual dynamic library of macrocyclic alkenes

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6167-6174
DOI: 10.1039/C4OB01009D, PaperJose Augusto Berrocal, Marko M. L. Nieuwenhuizen, Luigi Mandolini, E. W. Meijer, Stefano Di Stefano
The interlocked virtual component 1 of a well-behaved dynamic library of cyclic olefins is resuscitated by means of the template effect.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6085-6088
DOI: 10.1039/C4OB01039F, CommunicationZhongkai Tang, Yan Shi, Haibin Mao, Xuebin Zhu, Weipeng Li, Yixiang Cheng, Wen-Hua Zheng, Chengjian Zhu
A highly efficient method provides access to the bisoxindole structure moiety with two vicinal quaternary stereogenic centers (>99 : 1 dr, >99% ee).
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and Synthesis of a Macrosphelide A-Biotin Chimera

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01028K, PaperYoung-Ger Suh, Hwayoung Yun, Jaehoon Sim, Hongchan An, Jeeyeon Lee, Hun Seok Lee, Young Kee Shin, Seung-Mann Paek
The rational design and synthesis of a biochemical probe of natural (+)-macrosphelide A, a potent cell-cell adhesion inhibitor, was completed to aid in the identification of its biological target. The...
The content of this RSS Feed (c) The Royal Society of Chemistry

Large dipole moment to promote gelation for 4-nitrophenylacrylonitrile derivatives with gelation-induced emission enhancement property

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00768A, Paperpeng chong Xue, Boqi Yao, Yuan Zhang, Peng Chen, kechang li, Baijun Liu, Ran Lu, Qiux xu
A series of 4-nitrophenylacrylonitrile and phenylacrylonitrile derivatives consisting of carbazole moiety was synthesized. Some of these derivatives with longer alkyl chains and nitro group could gelatinize some organic solvents, such...
The content of this RSS Feed (c) The Royal Society of Chemistry

Effect of Conformational Rigidity on the Stereoselectivity of Nucleophilic Additions to Five-membered Ring Bicyclic Oxocarbenium Ion Intermediates

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01251H, PaperOlga Lavinda, Vi Tran, Keith Woerpel
Nucleophilic substitution reactions of five-membered ring acetals bearing fused rings reveal that subtle changes in structure of the fused ring can exert dramatic influences on selectivity. If the fused ring...
The content of this RSS Feed (c) The Royal Society of Chemistry

Expedient Synthesis of [small alpha]-S-(1[rightward arrow]6)-Linked Pentaglucosyl Thiol

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01094A, PaperHuali Wang, Xiangming Zhu
An [small alpha]-S-(1[rightward arrow]6)-linked pentaglucosyl thiol has been synthesized in a convenient and stereoselective way. Key steps of the synthesis involved thioglycosylation of 6-iodinated sugars with [small alpha]-glycosyl thiols under phase transfer conditions....
The content of this RSS Feed (c) The Royal Society of Chemistry

Recent Advances in Catalytic C-N bond Formation: A Comparison of Cascade Hydroaminomethylation and Reductive Amination Reactions with the Corresponding Hydroamidomethylation and Reductive Amidation Reactions

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00620H, Review Articlesaeed raoufmoghaddam
The design and catalytic implementation of tandem reactions to selectively create nitrogen-containing products under mild conditions has encountered numerous challenges in synthetic chemistry. Several known classes of the homogeneously catalyzed...
The content of this RSS Feed (c) The Royal Society of Chemistry

Ratiometric fluorescent chemosensor based on Tyrosine derivatives for monitoring mercury ions in aqueous solutions

29 July, 2014 - 11:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01044B, PaperPoonaboina Thirupathi, Ponnaboina Saritha, Keun-Hyeung Lee
Ratiometric fluorescent chemosensors, 1 and 2 were synthesized based on Tyrosine amino acid derivatives with a pyrene fluorophore. 1 and 2 displayed high selectivity for Hg(II) ions among 13 metal...
The content of this RSS Feed (c) The Royal Society of Chemistry

Iridium(I) hydroxides in catalysis: rearrangement of allylic alcohols to ketones

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01428F, PaperDavid J. Nelson, Jose A. Fernandez-Salas, Byron J. Truscott, Steven P. Nolan
The iridium(I) hydroxide complex [Ir(OH)(COD)(IiPr)] has been shown to be a competent catalyst for the rearrangement of allylic alcohols to ketones.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diaporine, a novel endophyte-derived regulator of macrophage differentiation

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01123F, CommunicationHao Chen Wu, Hui Ming Ge, Le Yun Zang, Yun Cheng Bei, Zhi Yuan Niu, Wei Wei, Xiu Jing Feng, Sen Ding, Seik Weng Ng, Ping Ping Shen, Ren Xiang Tan
Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus Diaporthe sp. Diaporine was demonstrated to inhibit significantly the differentiation of macrophages.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A study on the chiral inversion of mandelic acid in humans

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42515K, PaperMaksims Yevglevskis, Catherine R. Bowskill, Chloe C. Y. Chan, Justin H.-J. Heng, Michael D. Threadgill, Timothy J. Woodman, Matthew D. Lloyd
Mandelic acid 1 undergoes uni-directional chiral inversion in mammalian cells by a separate pathway to that of Ibuprofen 3.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01208A, PaperRenata Kowalczyk, Margaret A. Brimble, Yusuke Tomabechi, Antony J. Fairbanks, Madeleine Fletcher, Debbie L. Hay
The synthesis of a library of N-glycosylated pramlintide analogues to establish the SAR of amylin receptor agonism has been undertaken.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01025F, CommunicationLiang Gong, Li-Juan Xing, Tong Xu, Xue-Ping Zhu, Wen Zhou, Ning Kang, Bin Wang
An oxidative olefination reaction between aliphatic primary amines and benzylic sp3 C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.