Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Rapid and scalable assembly of firefly luciferase substrates

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02529F, PaperDavid McCutcheon, William Porterfield, Jennifer Prescher
Bioluminescence imaging with luciferase-luciferin pairs is a popular method for visualizing biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain prohibitively expensive for some imaging applications....
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A BODIPY-luminol chemiluminescent resonance energy-transfer (CRET) cassette for imaging of cellular superoxide

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02413C, PaperS. Bag, J.-C. Tseng, J. Rochford
Chemiluminescent resonance energy transfer is investigated for a BODIPY-luminol dyad demonstrating in cellulo biochemiluminescence with reactive oxygen species in activated splenocytes.
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A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02169J, CommunicationMarijana Radic Stojkovic, Patryciusz Piotrowski, Carsten Schmuck, Ivo Piantanida
A DNA-targeting dye exhibited pH-dependent selectivity toward AT-DNA (pH 7) or GC-DNA (pH 5), accompanied by fluorimetric (pH 5) and ICD (pH 7) recognition.
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"AND" luminescent "reactive" molecular logic gates: a gateway to multi-analyte bioimaging and biosensing

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02076F, Review ArticleAnthony Romieu
This feature article focuses on the recent development of "AND" luminescent molecular logic gates, in which the optical output is produced in response to multiple (bio)chemical inputs and through cascades of covalent bond-modifying reactions triggered by target (bio)analytes, for biosensing and bioimaging applications in complex media.
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Synthesis, and QSAR analysis of anti-oncological active spiro-alkaloids

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02149E, PaperAdel S. Girgis, Siva S. Panda, I. S. Ahmed Farag, A. M. El-Shabiny, A. M. Moustafa, Nasser S. M. Ismail, Girinath G. Pillai, Chandramukhi S. Panda, C. Dennis Hall, Alan R. Katritzky
QSAR study describes the anti-neoplastic spiro-alkaloids with relevant molecular descriptors using CODESSA III software.
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Consecutive three-component synthesis of (hetero)arylated propargyl amides by chemoenzymatic aminolysis-Sonogashira coupling sequence

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02386B, PaperSidra Hassan, Anja Ullrich, Thomas J. J. Muller
(Hetero)arylated propargyl amides are efficiently prepared by consecutive chemoenzymatic three-component synthesis based upon lipase catalyzed aminolysis followed by Sonogashira coupling.
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Syntheses of arabinose-derived pyrrolidine catalysts and their applications in intramolecular Diels-Alder reactions

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02219J, PaperTony K. M. Shing, Kwun W. Wu, Ho T. Wu, Qicai Xiao
Six hydroxylated pyrrolidine catalysts were synthesized from D-arabinose and applied to asymmetric intramolecular Diels-Alder reactions with concomitant desymmetrization.
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[small beta]-Ketothioamides: efficient reagents in synthesis of heterocycles

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02024C, Review ArticleWei-Si Guo, Li-Rong Wen, Ming Li
[small beta]-ketothioamides (KTAs) are versatile building blocks for the rapid construction of various heterocyclic compounds. In the past decade, a number of successful reactions based on KTAs have been developed for...
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Asymmetric metal free [small beta]-boration of [small alpha],[small beta]-unsaturated imines assisted by (S)-MeBoPhoz

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02478H, CommunicationElena Fernandez, Andrew Whiting, Xavier Sanz, Carles Bo, Enrico LaCascia
The adduct [MeO[rightward arrow]Bpin-Bpin]- efficiently mediates the [small beta]-boration of [small alpha],[small beta]-unsaturated imines formed "in situ". The use of chiral phosphines as additives, and in particular the chiral phosphine (S)-MeBoPhoz, enables the catalytic...
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Synthesis and physico-chemical properties of the first water soluble Cu(II)@hemicryptophane complex

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02085E, PaperAlexandre Martinez, Aline schmitt, CHRISTOPHE BUCHER, Vincent MAUREL, Jean-Pierre Dutasta, Solene Collin
A hemicryptophane ligand soluble in water at neutral pH was obtained thanks to the derivatization of the cyclotribenzylene unit with three carboxylate groups. The corresponding Cu(II) complex was then synthesized...
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Bacterial Patterning Controlled by Light Exposure

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02483D, CommunicationWillem Velema, Jan Pieter Van der Berg, Wiktor C Szymanski, Arnold Driessen, Ben L Feringa
Patterning of multiple bacterial strains in one system is achieved by employing a single photo-activated antibiotic. Varying the light-exposure time results in zones with mixed and single populations.
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E- or Z-Selective synthesis of 4-fluorovinyl-1,2,3-triazoles with fluorinated second-generation Julia-Kocienski reagents

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02179G, PaperRakesh Kumar, Govindra Singh, Louis J. Todaro, Lijia Yang, Barbara Zajc
Second-generation Julia-Kocienski reagents from CuAAC reactions of [small alpha]-fluoropropargyl benzothiazole sulfone with azides, react with aldehydes and ketones to give N-substituted 4-(1-fluorovinyl)triazoles. Reactions of aldehydes can be tuned towards E or Z-alkenes selectively.
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Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01380H, Review ArticleKamal Deep Paul, Vijay Luxami, Richa Goel
Imidazo[1,2-a]pyrazine acts as a versatile scaffold in organic synthesis and drug development. This review article is an effort to compile the progress in synthetic methods and to illustrate its reactivity...
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Near-instant surface-selective fluorogenic protein quantification using sulfonated triarylmethane dyes and fluorogen activating proteins

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02309A, PaperQi Yan, Brigitte Schmidt, Lydia A Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan Andreko, Marcel Bruchez
Agonist-promoted G-protein coupled receptor (GPCR) endocytosis and recycling plays an important role in many signaling events in the cell. However, the approaches that allow fast and quantitative analysis of such...
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Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02317J, CommunicationSanne Bouwman, Romano V. A. Orru, Eelco Ruijter
We report the highly stereoselective addition of lithiated difluorophosphonates to nitroglycals, providing synthetic access to biologically relevant fluorinated aminoglycosyl phosphonates.
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Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01849D, PaperBrett D. Schwartz, Tina S. Skinner-Adams, Katherine T. Andrews, Mark J. Coster, Michael D. Edstein, Donna MacKenzie, Susan A. Charman, Maria Koltun, Scott Blundell, Anna Campbell, Rebecca H. Pouwer, Ronald J. Quinn, Karren D. Beattie, Peter C. Healy, Rohan A. Davis
A series of amide and urea analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity.
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Linear dialdehydes as promising substrates for aminocatalyzed transformations

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01805B, Review ArticleIndresh Kumar, Panduga Ramaraju, Nisar A. Mir, Anoop Singh
Linear dialdehydes: This article summarizes the recent utilization of linear dialdehydes as appropriate substrates for amine catalyzed cascade/domino transformations.
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Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02385D, PaperXiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li, Hong-Bin Zhang, Xiao-Dong Yang
A series of novel 2-substituted indoline imidazolium salt derivatives were synthesized and their antitumor structure-activity relationship studies were reported.
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Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01865F, PaperJing Ren, Min Yang, Hongchun Liu, Danyan Cao, Danqi Chen, Jian Li, Le Tang, Jianhua He, Yue-Lei Chen, Meiyu Geng, Bing Xiong, Jingkang Shen
Various 3,8-diaminoimidazo[1,2-a]pyrazines were efficiently prepared by MCR and some products showed moderate Hsp90 inhibitory activity.
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N-Phosphonyl /Phosphinyl Imines and Group-Assisted Purification (GAP) Chemistry/Technology

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02254H, Review ArticleGuanghui An, Cole Seifert, Guigen Li
The development of environmentally benign, operationally simple, and economically viable synthetic methodologies has been a great challenge in organic synthesis. Group-Assisted Purification (GAP) chemistry was established to enable the synthesis...
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