Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
Updated: 13 hours 53 min ago

Pyridoxine-derived bicyclic amido-, ureido-, and carbamato-pyridinols: synthesis and antiangiogenic activities

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8702-8710
DOI: 10.1039/C4OB01221F, PaperHyunji Lee, Dong-Guk Kim, Suhrid Banskota, You Kyoung Lee, Tae-gyu Nam, Jung-Ae Kim, Byeong-Seon Jeong
Preparation of a series of five- and six-membered cyclic amide-, urea-, and carbamate-fused bicyclic pyridinols and their inhibitory capacities against VEGF-induced angiogenesis are described.
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Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8689-8695
DOI: 10.1039/C4OB01377H, PaperEgon Heuson, Morten Storgaard, Tri H. V. Huynh, Franck Charmantray, Thierry Gefflaut, Lennart Bunch
The membrane bound enzyme monoamine oxidase exists in two splice variants designated A and B (MAO-A and MAO-B) and are key players in the oxidative metabolism of monoamines in mammalians.
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Effects of (5[prime or minute]S)-5[prime or minute],8-cyclo-2[prime or minute]-deoxyadenosine on the base excision repair of oxidatively generated clustered DNA damage. A biochemical and theoretical study

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8671-8682
DOI: 10.1039/C4OB01089B, PaperBoleslaw T. Karwowski, Sophie Bellon, Peter O'Neill, Martine E. Lomax, Jean Cadet
Rejoining of an AP-site in ds-DNA containing the (5[prime or minute]S)-cdA in the complementary strand. Distance betwene AP-site and (5[prime or minute]S)-cdA, lanes: (1-6) -8 bases; (7-12) no (5[prime or minute]S)-cdA (control); (13-18) +8 bases.
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Rapid assembly of heterocycle grafted macrocycles via tandem one-pot double 1,3-dipolar cycloaddition reaction

13 hours 53 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01778A, PaperR. Prasanna, S. Purushothaman, R. Raghunathan
Synthesis of triazole linked macrocycles grafted with glycospiroheterocycle was accomplished by stereo- and regioselective tandem double 1,3-dipolar cycloaddition (1,3-DC) reaction.
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Thermodynamic epimeric equilibration and crystallisation-induced dynamic resolution of lobelanine, norlobelanine and related analogues

13 hours 53 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01787K, PaperZ. Amara, G. Bernadat, P.-E. Venot, P. Retailleau, C. Troufflard, E. Drege, F. Le Bideau, D. Joseph
The step-economical synthesis of lobelanine involving a ring closing double aza-Michael (RCDAM) reaction is revisited and successfully extended to the synthesis of various configurationally more stable analogues.
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Carbohydrates as a reagent in multicomponent reactions: one-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles

13 hours 53 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01791A, PaperMaryam Nourisefat, Farhad Panahi, Ali Khalafi-Nezhad
A new multicomponent reaction containing carbohydrates is developed for one-pot synthesis of a new class of hydrophilic substituted pyrimidine-fused heterocycles.
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Trienamines derived from 5-substituted furfurals: remote [varepsilon]-functionalization of 2,4-dienals

13 hours 53 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01759E, CommunicationJaime A. S. Coelho, Alexandre F. Trindade, Vania Andre, M. Teresa Duarte, Luis F. Veiros, Carlos A. M. Afonso
The remote selective [varepsilon]-functionalization of 5-substituted furfurals by trienamine catalysis is described, resulting in a new scaffold.
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Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8683-8688
DOI: 10.1039/C4OB01798F, PaperLorenzo Piola, Jose A. Fernandez-Salas, Simone Manzini, Steven P. Nolan
An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described.
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Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8598-8602
DOI: 10.1039/C4OB01738B, CommunicationJohn C. Lukesh III, Kristen A. Andersen, Kelly K. Wallin, Ronald T. Raines
Organocatalysts derived from ethylenetriamine and containing a hydrophobic moiety effect the isomerization of non-native protein disulfide bonds to native ones.
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Relative stability of benziporphyrin and naphthiporphyrin tautomers and the emergence of macrocyclic diatropicity

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8719-8736
DOI: 10.1039/C4OB01659A, PaperDeyaa I. AbuSalim, Timothy D. Lash
The conformations and relative stabilities of a series of benziporphyrin and naphthiporphyrin tautomers were calculated and the diatropic properties of each of these species were assessed. The results were in good agreement with experimental observations and allow favorable delocalization pathways to be identified.
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Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8745-8751
DOI: 10.1039/C4OB01299B, PaperAndrea Barba-Bon, Ana M. Costero, Salvador Gil, Ramon Martinez-Manez, Felix Sancenon
A new naked eye colorimetric BODIPY probe able to discriminate DCNP and DFP nerve agent mimics with good LODs.
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Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained [small alpha]-helix peptides

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8775-8782
DOI: 10.1039/C4OB01832J, PaperBoris Aillard, Naomi S. Robertson, Adam R. Baldwin, Siobhan Robins, Andrew G. Jamieson
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified NiII Schiff base complex as the key step.
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Rhodium-catalyzed ortho-cyanation of symmetrical azobenzenes with N-cyano-N-phenyl-p-toluenesulfonamide

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8603-8606
DOI: 10.1039/C4OB01736F, CommunicationJie Han, Changduo Pan, Xuefeng Jia, Chengjian Zhu
A rhodium(III)-catalyzed ortho-cyanation of symmetrical azobenzenes with NCTS via azo-group-directed C(sp2)-H bond activation is described.
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Antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from Pseudallescheria boydii, a beetle (coleoptera)-associated fungus

13 hours 53 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01494D, PaperQi Wu, Nan Jiang, Wen Bo Han, Ya Ning Mei, Hui Ming Ge, Zhi Kai Guo, Ng Seik Weng, Ren Xiang Tan
Pseudallescheria boydii produces four new epipolythiodioxopiperazine (ETP) boydines A-D and two novel sesquiterpene boydenes A and B.
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Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8607-8610
DOI: 10.1039/C4OB01646G, CommunicationShuanghua Cheng, Shouyun Yu
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er).
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Preparation of indium nitronates and their Henry reactions

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8593-8597
DOI: 10.1039/C4OB01468E, CommunicationRaquel G. Soengas, Rita Acurcio, Artur M. S. Silva
Indium nitronates were readily prepared from commercially available nitroalkanes by transmetallation of the corresponding lithium nitronates with indium salts. The Henry reaction of this nitronates with aldehydes afforded [small beta]-nitroalkanols in moderate to high yields and excellent stereoselectivity (when using chiral aldehydes).
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Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8764-8774
DOI: 10.1039/C4OB01196A, PaperJun-Jiang Lv, Ya-Feng Wang, Jing-Min Zhang, Shan Yu, Dong Wang, Hong-Tao Zhu, Rong-Rong Cheng, Chong-Ren Yang, Min Xu, Ying-Jun Zhang
The sesquiterpenoid glycoside dimers isolated from Phyllanthus emblica have anti-HBV activities towards HBsAg and HBeAg secretions inhibition.
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A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8588-8592
DOI: 10.1039/C4OB01829J, CommunicationChandrasekhar Challa, Jamsheena Vellekkatt, Jaice Ravindran, Ravi S. Lankalapalli
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes.
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Cross-strand histidine-aromatic interactions enhance acyl-transfer rates in beta-hairpin peptide catalysts

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8711-8718
DOI: 10.1039/C4OB01754D, PaperM. Matsumoto, S. J. Lee, M. R. Gagne, M. L. Waters
A His-aryl interaction in a beta-hairpin catalyst provides rate enhancements of up to 18 000 for acyl transfer catalysis.
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Highly enantioselective phosphination and hydrophosphonylation of azomethine imines: using chiral squaramide as a hydrogen bonding organocatalyst

13 hours 53 min ago

Org. Biomol. Chem., 2014, 12,8656-8670
DOI: 10.1039/C4OB01472C, PaperLing-Pei Kong, Nai-Kai Li, Shao-Yun Zhang, Xiang Chen, Min Zhao, Ya-Fei Zhang, Xing-Wang Wang
Highly enantioselective phosphination and hydrophosphonylation reactions of azomethine imines are respectively reported in this paper.
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