Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Pd-Catalyzed Benzylic C-H Oxidation of Cyclotriveratrylene - Product Diversity

19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02469A, PaperBeeran Senthilkumar, Rajesh Gonnade, Chepuri Ramana
The inner-rim functionalization of CTV has been examined by employing Pd-catalyzed benzylic oxidation. The outcome of the oxidation depends upon the solvent and co-oxidants employed. An interesting array of CTV...
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Diastereoselective desymmetrization of diarylphosphinous acid-borane amides under Birch reduction

19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02440K, PaperMarek Stankevic
Treatment of diarylphosphinous acid-borane amides possessing a chiral amido functionality with a solution of an alkali metal in liquid ammonia induced a preferential dearomatization of one aryl substituent at phosphorus...
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E. coli cells expressing the Baeyer-Villiger monooxygenase 'MO14' (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01441C, PaperBenjamin D. Summers, Muhiadin Omar, Thomas O. Ronson, Jared Cartwright, Michael Lloyd, Gideon Grogan
(1S,5R)-2-Oxalactone of >99% ee and (1S,5R)-ketone of 96% ee are produced after approximately 14 h at a temperature of 16 [degree]C.
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Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02348J, PaperRobert Wodtke, Gloria Ruiz-Gomez, Manuela Kuchar, M. Teresa Pisabarro, Pavlina Novotna, Marie Urbanova, Jorg Steinbach, Jens Pietzsch, Reik Loser
The conformational stabilisation of the DEKS motif at the [small alpha]1(I) collagen N-telopeptide within a cyclic hexapeptide together with its conformational analysis is described. This sequence is critical for lysyl oxidase-mediated collagen crosslinking, a process which is deregulated during tumour progression.
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Fixation of sulfur dioxide into small molecules

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02139H, Review ArticleGang Liu, Congbin Fan, Jie Wu
Recent advances in the insertion of sulfur dioxide under transition metal catalysis or metal-free conditions via a radical process are presented.
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N-heterocyclic carbene-catalyzed [4 + 2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: efficient assembly of spirocarbocyclic oxindole

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01706D, PaperYuanwei Xie, Yonglei Que, Tuanjie Li, Ling Zhu, Chenxia Yu, Changsheng Yao
A NHC-catalyzed [4 + 2] cyclization of 2-bromo-2-enal bearing [gamma]-H with 3-alkylenyloxindoles under mild reaction conditions gives spirocarbocyclic oxindoles containing one quaternary carbon with high diastereoselectivies.
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Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02321H, PaperOscar Francesconi, Matteo Gentili, Francesco Bartoli, Andrea Bencini, Luca Conti, Claudia Giorgi, Stefano Roelens
Excellent affinities and selectivities toward triphosphates are achieved through an adaptive ditopic receptor featuring a metal ion and a macrocyclic polyammonium cation binding sites, concertedly bridging phosphate anions.
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Amphiphilic benzothiadiazole-triphenylamine-based aggregates that emit red light in water

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02181A, PaperTsutomu Ishi-i, Ikumi Kitahara, Shimpei Yamada, Yusuke Sanada, Kazuo Sakurai, Asami Tanaka, Naoya Hasebe, Toshitada Yoshihara, Seiji Tobita
An amphiphilic donor-acceptor dye can provide red light emission in water in an aggregate state.
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Studies towards the synthesis of bielschowskysin. Construction of the highly functionalized bicyclo[3.2.0]heptane segment

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02182G, PaperAnupam Jana, Sujit Mondal, Subrata Ghosh
A stereocontrolled approach for the construction of a highly functionalized bicyclo[3.2.0]heptane derivative embodying the bridged lactone present in the diterpene bielschowskysin is reported.
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Ambient temperature synthesis of [small beta],[small beta][prime or minute]-fused nickel(II) pyrrolo[1,2-a]pyrazinoporphyrins via a DBSA-catalyzed Pictet-Spengler approach

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02370F, PaperDileep Kumar Singh, Mahendra Nath
Synthesis of novel [small beta],[small beta][prime or minute]-fused nickel(II) pyrrolo[1,2-a]pyrazinoporphyrins is accomplished for the first time at ambient temperature via a DBSA-catalyzed Pictet-Spengler approach.
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An asymmetric pericyclic cascade approach to 3-alkyl-3-aryloxindoles: generality, applications and mechanistic investigations

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02526A, PaperEdward Richmond, Kenneth B. Ling, Nicolas Duguet, Lois B. Manton, Nihan Celebi-Olcum, Yu-Hong Lam, Sezen Alsancak, Alexandra M. Z. Slawin, K. N. Houk, Andrew D. Smith
The reaction of L-serine derived N-arylnitrones with alkylarylketenes generates 3-alkyl-3-aryloxindoles in good yields and excellent enantioselectivities.
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A supramolecular topical gel derived from a non steroidal anti-inflammatory drug-fenoprofen capable of treating skin inflammation in mice

19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02344G, PaperP. Dastidar, Joydeb Majumder, Pavni Yedoti
A new series of bioconjugates derived from a non-steroidal-anti-inflammatory drug (NSAID) namely fenoprofen has been synthesised by amidation with various biogenic molecules such as -alanine, aminocaproic acid and tyramine with...
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Multicomponent one-pot synthesis of highly-functionalized pyrrole-3-carbonitriles in aqueous medium and their computational study

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02229G, PaperRamakanth Pagadala, Devendar Reddy Kommidi, Shravankumar Kankala, Suresh Maddila, Parvesh Singh, Brenda Moodley, N. A. Koorbanally, Sreekantha B. Jonnalagadda
A one-pot protocol involving four-components in water is developed to synthesize functionalized pyrroles.
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Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Bing Chen, Ting Pan, Qianwen Li, Hui Zhang, Chuan Bai
A benzenesulfonamide quinoline compound with potent anti-HIV-1 replication activity and low toxicity by targeting HIV-1 Rev protein was identified with high-throughput screening and SAR studies.
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Fluoride binding in water with the use of micellar nanodevices based on salophen complexes

19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02298J, PaperFlore Keymeulen, Paolo De Bernardin, ilaria Giannicchi, Luciano Galantini, Kristin Bartik, Antonella Dalla Cort
The use of micelles to transpose lipophilic receptors, such as uranyl-salophen complexes, into an aqueous environment is a valuable and versatile tool. Receptor 1 incorporated in CTABr micelles forms a...
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In situ intramolecular catalytic 1,2-addition of allenoates to cyclic ketones towards polycyclic allenoates

19 December, 2014 - 23:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02451F, PaperClement F. HEINRICH, Michel Miesch, Laurence Miesch
Sequential deprotonation, isomerization of 3-alkynoates and subsequent 1,2-addition led to bicyclic allenoate in the presence of a catalytic amount of Cs2CO3. Cyclization proceeds in a stereoselective manner in the case...
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Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02497D, CommunicationPauline Petiot, Julien Dansereau, Martin Hebert, Imene Khene, Tabinda Ahmad, Samira Samaali, Maxime Leroy, Francis Pinsonneault, Claude Y. Legault, Alexandre Gagnon
The O-arylation of 1,2-aminoalcohols using functionalized triarylbismuth reagents is reported.
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Trigonal scaffolds for multivalent targeting of melanocortin receptors

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02094D, PaperN. G. R. Dayan Elshan, Thanuja Jayasundera, Bobbi L. Anglin, Craig S. Weber, Ronald M. Lynch, Eugene A. Mash
Short, efficient syntheses of multivalent molecules targeted to the human melanocortin 4 receptor based on phloroglucinol, tripropargylamine, and 1,4,7-triazacyclononane are described.
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A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

19 December, 2014 - 23:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02376E, PaperMaria Victoria Rojo, Lucie Guetzoyan, Ian. R. Baxendale
An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor.
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Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

19 December, 2014 - 23:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02452D, PaperClara Brieke, Veronika Kratzig, Kristina Haslinger, Andreas Winkler, Max J. Cryle
One Cytochrome P450 enzyme performs the phenolic crosslinking of a range of chemically synthesized, carrier-protein loaded glycopeptide antibiotic precursor peptides.
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