Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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"Click and go": simple and fast folic acid conjugation

1 May, 2014 - 14:54

Org. Biomol. Chem., 2014, 12,3181-3190
DOI: 10.1039/C4OB00150H, PaperAlexandre F. Trindade, Raquel F. M. Frade, Ermelinda M. S. Macoas, Catia Graca, Catarina A. B. Rodrigues, Jose M. G. Martinho, Carlos A. M. Afonso
A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne-azide cycloaddition, without the need for expensive chromatographic purifcation.
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Total synthesis of lycorine-type alkaloids by cyclopropyl ring-opening rearrangement

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3191-3200
DOI: 10.1039/C4OB00126E, PaperDandan Liu, Long Ai, Fan Li, Annan Zhao, Jingbo Chen, Hongbin Zhang, Jianping Liu
Anhydrocaranine, [gamma]-lycorane and putative amarbellisine were synthesized based on a series reactions including a novel cyclopropyl ring-opening rearrangement.
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N,N[prime or minute]-Bis[3,5-bis(trifluoromethyl)phenyl]thiourea: a privileged motif for catalyst development

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3151-3162
DOI: 10.1039/C4OB00306C, Review ArticleZhiguo Zhang, Zongbi Bao, Huabin Xing
This review summarizes the key developments of N,N[prime or minute]-bis[3,5-bis(trifluoromethyl)phenyl]thiourea (Schreiner's thiourea)-mediated reactions with the aim to further expand the applications of (thio)urea-based catalysts.
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The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,2993-3003
DOI: 10.1039/C4OB00032C, Review ArticleJie An, Ross M. Denton, Tristan H. Lambert, Eric D. Nacsa
Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis.
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Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3009-3015
DOI: 10.1039/C4OB00145A, CommunicationYu Zhang, Yingyan Lu, Weifang Tang, Tao Lu, Ding Du
A novel synthesis of spirooxindoles has been developed by cooperative NHC-Lewis acid-mediated formal [3 + 2] annulations of alkynyl aldehydes with isatins.
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Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3016-3020
DOI: 10.1039/C4OB00071D, CommunicationShigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
We synthesized the genetically predicted biosynthetic intermediates of saxitoxin (STX) (1), 2, 6 and 7, and identified 2 and 6 in microorganisms.
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Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3163-3166
DOI: 10.1039/C4OB00203B, CommunicationYulong Liu, Xie Wang, Xiaoyun Wang, Wei He
Both enantiomers of diethyl 2-(3-oxo-1,3-arylpropyl)malonate are easily prepared by a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived organocatalysts.
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Tetrathiafulvalene mono- and bis-1,2,3-triazole precursors by click chemistry: structural diversity and reactivity

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3167-3174
DOI: 10.1039/C4OB00148F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas Biet, Narcis Avarvari
The ruthenium-catalyzed alkyne-azide cycloaddition reaction allowed the synthesis of electroactive TTF-mono and -bis(1,2,3-triazoles) which were structurally characterized and investigated in protonation and alkylation reactions.
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