Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 12 hours 16 min ago

Molecular recognition of upper rim functionalized cavitand and its unique dimeric capsule in the solid state

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02251C, PaperTakeharu HAINO, Ryo Sekiya, Mutsumi Kobayashi, Mei Takatsuka
Cavitand 1 possesses four 2,2'-bipirydyl pillars on its upper rim that encapsulate small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form...
The content of this RSS Feed (c) The Royal Society of Chemistry

Development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02197E, PaperAlaksiej L. Hurski, Yuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii, Vladimir Aleksandrovich Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. An efficient one-pot procedure for the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Identification of Benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Ting Pan, Bing Chen, Qianwen Li, Hui Zhang, Chuan Bai
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclodextrin- and Calixarene-based Polycationic Amphiphiles as Gene Delivery Systems: A Structure-Activity Relationship Study

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02204A, PaperLaura Gallego-Yerga, Michela Lomazzi, Valentina Franceschi, Francesco Sansone, Carmen Ortiz Mellet, Gaetano Donofrio, Alessandro Casnati, Jose Manuel Garcia Fernandez
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular...
The content of this RSS Feed (c) The Royal Society of Chemistry

Quinoline-derived two-photon sensitive quadrupolar probes

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9899-9908
DOI: 10.1039/C4OB01551G, PaperPetra Dunkel, Christine Tran, Thibault Gallavardin, Hamid Dhimane, David Ogden, Peter I. Dalko
Quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile approach to spirocyclic 2-azido indolines via azidation of indoles with ceric ammonium nitrate

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9769-9772
DOI: 10.1039/C4OB01549E, CommunicationJing Li, Mao Liu, Qi Li, Hua Tian, Yian Shi
This paper describes azidation of indoles with NaN3 and ceric ammonium nitrate (CAN), giving a variety of spirocyclic 2-azido indolines in good yields and moderate diastereoselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of [small alpha]-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9853-9863
DOI: 10.1039/C4OB01476F, PaperThibaut Denoel, Astrid Zervosen, Christian Lemaire, Bernard Joris, Mireille Herve, Didier Blanot, Guillermo Zaragoza, Andre Luxen
The synthesis of modified tripeptides (S)-Ala-[gamma]-(R)-Glu-X, where X = (R,S) or (R,R) diastereomers of [small alpha]-benzyl or [small alpha]-(4-azidobenzyl)lanthionine, was carried out.
The content of this RSS Feed (c) The Royal Society of Chemistry

Contributions of pocket depth and electrostatic interactions to affinity and selectivity of receptors for methylated lysine in water

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02231A, PaperJoshua Beaver, Brendan Peacor, Julianne Bain, Lindsey Ingerman, Marcey Waters
Dynamic combinatorial chemistry was used to generate a set of receptors for peptides containing methylated lysine (KMen, n = 0=3) and study the contribution of electrostatic effects and pocket depth...
The content of this RSS Feed (c) The Royal Society of Chemistry

An expedient approach to 1, 2-dihydroisoquinoline derivatives via Cobalt catalysed 6-endo dig cyclization followed by Mannich condensation of o-alkynylarylaldimines

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02036G, CommunicationUrvashi ., Gaurav Kumar Rastogi, Sandeep K Ginotra, Alka Agarwal, Vibha Tandon
A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1, 2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9793-9796
DOI: 10.1039/C4OB01981D, CommunicationJunyan Han, Tae Hoon Lee, Ching-Hsuan Tung, Daniel Y. Lee
A novel mitochondria-targeting carrier QCy7HA was developed, which transported the covalently attached doxorubicin (DOX) to mitochondria specifically, resulting in the limitation of the effects of P-glycoprotein efflux pumps of multidrug-resistant cells on DOX.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly efficient modular metal-free synthesis of 3-substituted 2-quinolones

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9786-9788
DOI: 10.1039/C4OB02131B, CommunicationAlexander V. Aksenov, Alexander N. Smirnov, Nicolai A. Aksenov, Inna V. Aksenova, Asiyat S. Bijieva, Michael Rubin
A modular approach to 3-substituted 2-quinolones via a cascade annulation reaction between 4-nitroketones and hydrazines has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9789-9792
DOI: 10.1039/C4OB02146K, CommunicationBuddhadeb Mondal, Subhas Chandra Pan
A high enantioselective synthesis of 2-aryl-2,3-dihydro-4-quinolones has been developed via intramolecular Mannich reaction using primary amino acids as catalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9764-9768
DOI: 10.1039/C4OB02107J, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chou-Hsiung Chen, Sivaneswary Genapathy, Peter M. Fischer, Weng C. Chan
Utilising a chiral auxiliary-facilitated Strecker amino acid synthesis strategy, indole-substituted (S)-tryptophans have been obtained from corresponding indoles; the former in turn were used for the synthesis of a potent antibacterial agent, argyrin and its analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of coenzyme A thioesters using methyl acyl phosphates in an aqueous medium

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9760-9763
DOI: 10.1039/C4OB02079K, CommunicationMohan Pal, Stephen L. Bearne
Regioselective S-acylation of coenzyme A is achieved under aqueous conditions using various aliphatic and aromatic carboxylic acids activated as their methyl acyl phosphate monoesters.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anion carrier formation by calix[4]arene-bis-hydroxymethylphosphonic acid in bilayer membranes

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9811-9821
DOI: 10.1039/C4OB01886A, PaperOleg Ya. Shatursky, Ludmila A. Kasatkina, Roman V. Rodik, Sergiy O. Cherenok, Alexander A. Shkrabak, Tatiana O. Veklich, Tatiana A. Borisova, Sergyi O. Kosterin, Vitaly I. Kalchenko
Calix[4]arene C-99-mediated ionic transport follows mobile carrier mode of facilitated diffusion (relative permeability PCl-/PK+ [similar] 3) with the passage of 20 ions per second.
The content of this RSS Feed (c) The Royal Society of Chemistry

Sulfinate derivatives: dual and versatile partners in organic synthesis

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9743-9759
DOI: 10.1039/C4OB01727G, Review ArticleJessy Aziz, Samir Messaoudi, Mouad Alami, Abdallah Hamze
Recent advances in the preparation and synthetic uses of sulfinic acids and their derivatives are highlighted in this review. They are used as versatile partners in sulfonylative and desulfitative reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9781-9785
DOI: 10.1039/C4OB01807A, CommunicationGuohua Chen, Qiang Yin, Jian Yin, Xiangying Gu, Xiao Liu, Qidong You, Yue-Lei Chen, Bing Xiong, Jingkang Shen
Tf2O mediated dehydrative glycosylation was enabled by strained olefins, including beta-(-)-pinene, and inhibited by other typical bases.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium catalyzed dual C-H functionalization of indoles with cyclic diaryliodoniums, an approach to ring fused carbazole derivatives

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9777-9780
DOI: 10.1039/C4OB02170C, CommunicationYongcheng Wu, Xiaopeng Peng, Bingling Luo, Fuhai Wu, Bo Liu, Fenyun Song, Peng Huang, Shijun Wen
As the tile reaction shows, an array of dibenzocarbazoles were obtained via dual C-H functionalization of indoles with cyclic diaryliodoniums in a single operation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9881-9886
DOI: 10.1039/C4OB02035A, PaperChuan-Li Ren, Tao Zhang, Xing-Yong Wang, Tao Wu, Jing Ma, Qing-Qing Xuan, Feng Wei, Hong-Yan Huang, Dong Wang, Li Liu
An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective [small alpha]-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9864-9880
DOI: 10.1039/C4OB01930J, PaperAhmed Kamal, A. V. Subba Rao, V. Lakshma Nayak, N. V. Subba Reddy, Konderu Swapna, G. Ramakrishna, Mallika Alvala
Imidazo[1,5-a]pyridine-benzimidazole hybrids are firstly reported herein to induce cytotoxicity by targeting microtubules.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.