Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Palladium-catalyzed asymmetric allylic amination of racemic butadiene monoxide with isatin derivatives

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00663E, PaperGen Li, Xiangqing Feng, Haifeng Du
Pd-catalyzed asymmetric aminations of butadiene monoxide with isatin derivatives using P/alkene ligands gave high yields, ees and regioselectivity ratios.
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Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: a study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP)

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02384F, PaperAnn-Marie Fanning, Sally. E. Plush, Thorfinnur Gunnlaugsson
Lanthanide(III) complexes of 'pseudo' dipeptide ligands and 3'-pyridine ligands have been characterised as metallo-ribonuclease mimics.
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The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00548E, PaperPavel L. Padnya, Elena A. Andreyko, Olga A. Mostovaya, Ildar Kh. Rizvanov, Ivan I. Stoikov
The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA is reported.
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77 Se and 125Te NMR spectroscopy on a selectivity study of organochalcogenanes with L-amino acids

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00373C, PaperMarcio S. Silva, Leandro H. Andrade
Organochalcogenanes exhibited a remarkably high selectivity for L-cysteine which was monitored by 77Se and 125Te NMR spectroscopy.
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Copper-catalyzed aerobic oxidative amination of C(sp3)-H bonds: synthesis of imidazo[1,5-a]pyridines

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00381D, CommunicationDarapaneni Chandra Mohan, Sadu Nageswara Rao, Chitrakar Ravi, Subbarayappa Adimurthy
Copper-catalyzed synthesis of imidazo[1,5-a]pyridine-1-carboxylates through oxidative amination of C(sp3)-H bonds under mild aerobic conditions with broad substrate scope has been achieved.
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Copper(II)-catalyzed highly regio- and stereo-selective hydrosilylation of unactivated internal alkynes with silylborate in water

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00694E, CommunicationQing-Qing Xuan, Chuan-Li Ren, Li Liu, Dong Wang, Chao-Jun Li
The hydrosilylation of internal alkynes with Me2PhSiBpin catalyzed by Cu(OTf)2 in water provided multisubstituted vinylsilanes in high regio- and stereoselectivities.
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Divergent synthesis of 4,6-diarylated pyridin-2(1H)-ones from chalcones: novel access to 2,4,6-triaryl pyridines

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00545K, PaperRajni Khajuria, Prakash Kannaboina, Kamal K. Kapoor, Annah Gupta, Gaurav Raina, Amanpreet Kaur Jassal, Love Karan Rana, Maninder S. Hundal, Parthasarathi Das
A wide range of 4,6-diarylated-2(1H)-one derivatives were synthesized in excellent yields from chalcones in one pot. Further the designed 4,6-diarylated pyridin-2(1H)-one derivatives have been successfully utilized in synthesizing 2,4,6-triarylpyridines.
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Stereo-controlled synthesis of polyheterocycles via the diene-transmissive hetero-Diels-Alder reaction of [small beta],[gamma]-unsaturated [small alpha]-keto esters

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00503E, CommunicationTakashi Otani, Yumiko Tamai, Kazunori Seki, Tomohiro Kikuchi, Taiichiro Miyazawa, Takao Saito
Stereocontrolled synthesis of polyheterocycles via the diene-transmissive hetero Diels-Alder reaction of [small beta],[small chi]-unsaturated [small alpha]-keto esters is described.
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Stereoselective construction of functionalized tetracyclic and pentacyclic coumarinopyranpyrazole/pyrimidinedione/coumarin scaffolds using a solid-state melt reaction

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00442J, CommunicationManickam Bakthadoss, Damodharan Kannan, Nagappan Sivakumar, Palani Malathi, Vasudevan Manikandan
An assembly of tetra / pentacyclic hybrid scaffolds have been synthesized for the first time using a solid-state melt reaction in a stereoselective fashion with excellent yields.
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Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5158-5174
DOI: 10.1039/C5OB00427F, PaperMunmun Maiti, Mohitosh Maiti, Jef Rozenski, Steven De Jonghe, Piet Herdewijn
A series of novel nucleoside phosphoramidate protides has been synthesized and shown as potent inhibitors of hepatitis C virus replication. The conjugates are having a diverse structural variation in the promoiety part and can be catalytically processed to deliver active nucleotides.
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Photocleavable ligands for protein decoration of DNA nanostructures

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5102-5104
DOI: 10.1039/C5OB00316D, CommunicationJosipa Brglez, Ishtiaq Ahmed, Christof M. Niemeyer
Amino-reactive, photocleavable modifiers bearing small-molecule hapten groups were incorporated into DNA origami to control binding of cognate proteins.
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Convenient synthesis of functionalized spiro[indoline-3,2[prime or minute]-pyrrolizines] or spiro[indoline-3,3[prime or minute]-pyrrolidines] via multicomponent reactions

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00437C, PaperJing Sun, Liang Chen, Hui Gong, Chao-Guo Yan
Multicomponent reactions of [small alpha]-amino acids, dialkyl acetylenedicarboxylates and 3-methyleneoxindoles afforded diverse functionalized spiro[indoline-3,2[prime or minute]-pyrrolizines], spiro[indoline-3,3[prime or minute]-pyrrolidines] and spiro[indoline-3,6[prime or minute]-pyrrolo[1,2-c]thiazoles].
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Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of [small beta]-fluoroketones

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5105-5109
DOI: 10.1039/C5OB00632E, CommunicationShichao Ren, Chao Feng, Teck-Peng Loh
The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed.
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Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5098-5101
DOI: 10.1039/C5OB00462D, CommunicationBaolin Wu, Na Wei, Vireak Thon, Mohui Wei, Zaikuan Yu, Yongmei Xu, Xi Chen, Jian Liu, Peng George Wang, Tiehai Li
A biotinylated heparosan hexasaccharide was synthesized by a facile chemoenzymatic approach in a one-pot multi-enzyme fashion.
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Organocatalytic diastereoselective synthesis of chiral decalines through the domino Claisen-Schmidt/Henry reaction

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5110-5114
DOI: 10.1039/C5OB00562K, CommunicationAdluri B. Shashank, Dhevalapally B. Ramachary
General and operative domino Claisen-Schmidt/Henry (CS/H) reaction has been revealed to obtain highly substituted chiral decalines in good yields with excellent ees and des by using push-pull enamine catalysis.
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Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5265-5272
DOI: 10.1039/C5OB00549C, PaperK. F. Morgan, I. A. Hollingsworth, J. A. Bull
A library of 2-sulfonyl oxetane fragments has been synthesised and elaborated into lead-like compounds. The oxetane derivatives were stable to acidic and basic conditions and have 3-preferred conformations.
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Cyclodextrin-peptide conjugates for sequence specific DNA binding

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5273-5278
DOI: 10.1039/C5OB00609K, PaperYara Ruiz Garcia, Jan Zelenka, Y. Vladimir Pabon, Abhishek Iyer, Milos Budesinsky, Tomas Kraus, C. I. Edvard Smith, Annemieke Madder
CD-peptide conjugates were synthesized via CuAAC. Though the CD cavity size was shown to influence the binding affinity of the compounds, all constructs recognize and bind the cognate CRE dsDNA.
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Unique photophysical properties of 9-styryl-1,2-dihydropyrrolo[3,4-[small beta]]indolizin-3-one and its efficient synthesis via direct C-H activation

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5202-5208
DOI: 10.1039/C5OB00551E, PaperEun Joung Choi, Seung Bum Park
A styryl Seoul-Fluor (SF) skeleton was rationally designed by introducing an olefin unit at the C-9 of 1,2-dihydropyrrolo[3,4-[small beta]]indolizin-3-one via regioselective direct C-H activation, affording average 39 nm of bathochromic shift.
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Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5279-5284
DOI: 10.1039/C5OB00211G, PaperDuncan C. Miller, Benoit Carbain, Gary S. Beale, Sari F. Alhasan, Helen L. Reeves, Ulrich Baisch, David R. Newell, Bernard T. Golding, Roger J. Griffin
An improved synthesis from D-glucosamine of a purported Sulf-2 inhibitor is described, with assay data for this compound and analogues showing only weak inhibition of Sulf-2, and sulfatases ARSA or ARSB.
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Size-optimized galactose-capped gold nanoparticles for the colorimetric detection of heat-labile enterotoxin at nanomolar concentrations

6 May, 2015 - 09:54

Org. Biomol. Chem., 2015, 13,5215-5223
DOI: 10.1039/C5OB00447K, PaperVivek Poonthiyil, Vladimir B. Golovko, Antony J. Fairbanks
Galactose-capped gold nanoparticles size-dependently sense the bacterial lectin, heat-labile enterotoxin, allowing selective colorimetric toxin detection at 100 nM.
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