Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Base-promoted annulation of alpha-hydroxy ketones and dimethyl but-2-ynedioate : straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01858C, CommunicationChaorong Qi, Haitao He, Yanglu Ou, Wenfang Xiong, Xiaohan HU, Yan-wei Ren, Huanfeng Jiang
A novel and efficient cascade annulation of tertiary alpha-hydroxy ketones and dimethyl but-2-ynedioate is reported. The reaction, which only requires a base as the promoter, provides a straightforward access to...
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Water-soluble NHC-Cu Catalysts: Applications in Click Chemistry, Bioconjugation and Mechanistic Analysis

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01350F, Paperfrancis verpoort, Heriberto Diaz Velazquez, Yara Ruiz Garcia, Matthias Vandichel, Annemieke Madder
Copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and terminal alkynes (CuAAC), better known as "Click" reaction, has triggered the use of 1,2,3-triazoles in bioconjugation, drug discovery, materials science and combinatorial chemistry. Here...
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Reversible Deactivation Radical Polymerization Mediated by Cobalt Complexes: Recent Progress and Perspectives

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01427H, Review ArticleChi-How Peng, Tsung-Yao Yang, Yaguang Zhao, Xuefeng Fu
Mediation of living radical polymerization (LRP) by cobalt(II) complexes (CMRP) is the most highly developed subcategory of organometallic mediated LRP (OMRP). Attention was drawn to CMRP by the unusual high...
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Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01510J, PaperSimona De Marino, Carmen Festa, Maria Valeria DAuria, Chiara Cassiano, Maria Chiara Monti, Cecile Debitus
The analysis of two Thorectidae sponges samples, Hyrtios sp. and Petrosaspongia sp., collected at Fiji Islands, led to the isolation of five new scalarane derivatives along with fifteen known derivatives....
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An Intermolecular C-H Functionalization Method for the Synthesis of 3-Hydroxy-2-oxindoles

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01643B, CommunicationJinsen Chen, Chao Song, Pei Chen, Jin Zhu
An intermolecular C-H functionalization method has been developed for the synthesis of 3-hydroxy-2-oxindoles. Rh(III)-catalyzed N-nitroso-directed C-H addition to ethyl 2-oxoacetate allows subsequent denitrosation-triggered cyclization construction of 3-hydroxy-2-oxindoles. The method features...
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Aerobic oxysulfonylation of alkenes using thiophenols: An efficient one-pot route to [small beta]-ketosulfones

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00776J, PaperAtul K. Singh, Ruchi Chawla, Twinkle Keshari, Vinod K. Yadav, L.D.S. Yadav
We have developed a highly efficient synthetic route to [small beta]-ketosulfones via AgNO3 catalyzed oxysulfonylation of alkenes using thiophenols in the presence of air (O2) and K2S2O8 as eco-friendly oxidants. Thiophenols...
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Regioselective [small pi]-Extension of Indoles With Rhodium Enalcarbenoids - Synthesis of Substituted Carbazoles

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01693A, PaperSreenivas Katukojvala, Kuldeep Singh Rathore, Mandeep Harode
An efficient Rh(II) carboxylate and Bronsted acid catalyzed direct [small pi]-extension of indoles to 4-substituted carbazoles has been developed. The reaction involves a regioselective C-3 functionalization of indole by a rhodium...
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Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01583E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Monica Dell'Acqua, Valentina Pirovano, Giorgio Confalonieri, Antonio Arcadi, Elisabetta Rossi, Giorgio Abbiati
An easy entry to uncommon 2-propargylbenzaldehydes was developed. 2-propargylbenzaldehydes demonstrated to be suitable building blocks for the synthesis of 3-benzyl isoquinolines by microwave promoted domino imination/cycloisomerisation in the presence of...
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Synthesis of Substituted Azafluorenones from Dihalogeno Diaryl Ketones by Palladium-Catalyzed Auto-Tandem Processes

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01629G, CommunicationNada MARQUISE, Vincent DORCET, Floris Chevallier, Florence Mongin
Substituted azafluorenones were synthesized from different dihalogeno diaryl ketones under palladium catalysis by combining either Suzuki or Heck coupling with direct cyclizing arylation. Conditions were identified to allow both auto-tandem...
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Insights into the programmed keto-reduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain

16 September, 2014 - 00:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01777C, PaperIshin soehano, lifeng Yang, feiqing Ding, Huihua Sun, Zhenjie Low, Xuewei Liu, Zhao-Xun Liang
One of the hallmarks of iterative polyketide synthases (PKS) is the programming mechanism which is essential for the generation of structurally diverse polyketide products. In partially reducing iterative PKSs (PR-PKS),...
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Enantioselective total syntheses of the proposed structures of prevezol B and evaluation of anti-cancer activity

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01662A, PaperAnna E. Leung, Riccardo Rubbiani, Gilles Gasser, Kellie L. Tuck
The first enantioselective total syntheses of the proposed structures of the natural product prevezol B are reported. This work has shown that the proposed structures of prevezol B are incorrect.
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Estimating the shape and size of supramolecular assemblies by variable temperature diffusion ordered spectroscopy

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01373E, CommunicationBenjamin M. Schulze, Davita L. Watkins, Jing Zhang, Ion Ghiviriga, Ronald K. Castellano
Reported is characterization of the self-assembly of [small pi]-conjugated oligomers, molecules studied recently in photovoltaic devices, using variable temperature diffusion ordered spectroscopy; the approach has allowed estimation of assembly size, shape, and molecularity.
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Synthesis of meta and para-substituted aromatic sulfonate derivatives of polydentate phenylazaphosphinate ligands: enhancement of the water solubility of emissive europium(III) EuroTracker[registered sign] dyes

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01143K, PaperMartina Delbianco, Laurent Lamarque, David Parker
The use of a trifluoroethyl ester group to protect sulfonic acid moieties is used in the synthesis of a short series of water-soluble, very bright europium(III) complexes.
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Conformational effects due to stereochemistry and C3-substituents in xylopyranoside derivatives as studied by NMR spectroscopy

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01422G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jerk Ronnols, Sophie Manner, Ulf Ellervik, Goran Widmalm
Dynamic NMR spectroscopy revealed an unequally populated equilibrium at low temperature for a 3-deoxygenated compound.
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Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00978A, PaperJiuxi Chen, Leping Ye, Weike Su
Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines and 7-benzoylindoles.
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Subtle Mitsunobu couplings under super-heating: the role of high-throughput continuous flow and microwave strategies

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01432D, Review ArticleAtul Manvar, Anamik Shah
Fragile Mitsunobu reaction can efficiently be performed under super-heating.
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Regiodivergent and short total synthesis of calothrixins

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01309C, PaperDipakranjan Mal, Joyeeta Roy, Kumar Biradha
The anionic annulation of MOM-protected furoindolone with 4-bromoquinoline followed by deprotection of the N-MOM group provides calothrixin B, whereas that with 3-bromoquinoline yields isocalothrixin B. The outcomes are explained by the divergence of the reaction mechanism from the commonly perceived 3,4-didehydroquinoline. A sequence of addition-cyclization-elimination is proposed to account for the formation of calothrixin from 4-bromoquinoline.
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Development of chemosensor for Sr2+ using organic nanoparticles: application of sensor in product analysis for oral care

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01234H, PaperSimanpreet Kaur, Amanpreet Kaur, Navneet Kaur, Narinder Singh
Organic nanoparticles have been developed and used to investigate the level of Sr2+ in an oral gel and toothpastes.
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Synthesis and spectroscopic properties of novel meso-cyano boron-pyridyl-isoindoline dyes

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01077A, PaperHui Liu, Hua Lu, Fan Wu, Zhifang Li, Nagao Kobayashi, Zhen Shen
The synthesis of meso-cyano boron-pyridyl-isoindoline dyes, a novel type of BODIPY analogue, involving a facile two-step reaction, is reported.
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Stereoselective intermolecular [2 + 2]-photocycloaddition reactions of maleic anhydride: stereocontrolled and regiocontrolled access to 1,2,3-trifunctionalized cyclobutanes

16 September, 2014 - 00:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01383B, PaperFlorian Hernvann, Gloria Rasore, Valerie Declerck, David J. Aitken
1,2,3-Trisubstituted cyclobutanes with three differentiated substituents and complementary stereochemical patterns were obtained by [2 + 2]-photocycloaddition reactions of maleic anhydride with allyl alcohol or propargyl alcohol.
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