Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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[small beta]-Ketothioamides: efficient reagents in the synthesis of heterocycles

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,1942-1953
DOI: 10.1039/C4OB02024C, Review ArticleWei-Si Guo, Li-Rong Wen, Ming Li
[small beta]-Ketothioamides (KTAs) are versatile building blocks for the rapid construction of various heterocyclic compounds.
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Synthesis and physico-chemical properties of the first water soluble Cu(II)@hemicryptophane complex

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2157-2161
DOI: 10.1039/C4OB02085E, PaperAline Schmitt, Solene Collin, Christophe Bucher, Vincent Maurel, Jean-Pierre Dutasta, Alexandre Martinez
A water-soluble metallo-enzyme model featuring a copper(II) site encaged in a closed-shell cavity of a hemicryptophane has been synthesized and studied.
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Chemoselective efficient synthesis of functionalized [small beta]-oxonitriles through cyanomethylation of Weinreb amides

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,1969-1973
DOI: 10.1039/C4OB02398F, CommunicationAshenafi Damtew Mamuye, Laura Castoldi, Ugo Azzena, Wolfgang Holzer, Vittorio Pace
Homologation of Weinreb amides with cyanomethyllithium: a new route to [small beta]-oxonitriles.
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1H chemical shift differences of Prelog-Djerassi lactone derivatives: DFT and NMR conformational studies

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2140-2145
DOI: 10.1039/C4OB02446J, PaperTulio J. Aimola, Dimas J. P. Lima, Luiz C. Dias, Claudio F. Tormena, Marco A. B. Ferreira
This work reports an experimental and theoretical study of the conformational preferences of several Prelog-Djerassi lactone derivatives, to elucidate the 1H NMR chemical shift differences in the lactonic core that are associated with the relative stereochemistry of these derivatives.
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Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2146-2152
DOI: 10.1039/C4OB02186J, PaperYu-Chang Liu, Yan Liu, Zhong-Liu Wu
An enzymatic cascade reaction employing an S-specific ketoreductase and a styrene monooxygenase to synthesize enantiopure glycidol derivatives is described.
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Rapid detection of hydrazine in a naphthol-fused chromenyl loop and its effectiveness in human lung cancer cells: tuning remarkable selectivity via the reaction altered pathway supported by theoretical studies

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2134-2139
DOI: 10.1039/C4OB01842G, PaperShyamaprosad Goswami, Avijit Kumar Das, Urmila Saha, Sibaprasad Maity, Kalyani Khanra, Nandan Bhattacharyya
A new chemosensor (NAC) is reported for fast and selective detection of N2H4 in a novel way.
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Rapid and scalable assembly of firefly luciferase substrates

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2117-2121
DOI: 10.1039/C4OB02529F, PaperDavid C. McCutcheon, William B. Porterfield, Jennifer A. Prescher
Improved access to luciferins will bolster bioluminescence imaging applications.
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Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2108-2116
DOI: 10.1039/C4OB02531H, PaperY. Wang, S. R. McAlpine
Both heat shock protein 90 and 70 (Hsp90, Hsp70) are cytoprotective proteins that regulate cell function and faciliate cell growth by stabilizing and folding proteins.
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Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2100-2107
DOI: 10.1039/C4OB01934B, PaperCheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun, Wei-Chieh Cheng
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described.
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A Sc(OTf)3-catalyzed cascade reaction of o-aminoacetophenone with methanamine: construction of dibenzo[b,h][1,6]naphthyridine derivatives

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2122-2128
DOI: 10.1039/C4OB02220C, PaperDan Mao, Jun Tang, Wenbo Wang, Xin Liu, Shengying Wu, Jianjun Yu, Limin Wang
A Sc(OTf)3-catalyzed and air-mediated cascade reaction was discovered as an efficient approach to the novel fluorescent fused-four-ring dibenzo[b,h][1,6]naphthyridine derivatives.
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Transition metal catalyzed meta-C-H functionalization of aromatic compounds

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,1930-1941
DOI: 10.1039/C4OB02171A, Review ArticleJiong Yang
This review summarizes synthetic methods for directing group guided, transition metal catalyzed meta-C-H functionalization of aromatic compounds.
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Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2022-2025
DOI: 10.1039/C4OB02535K, PaperKenji Usui, Arisa Okada, Keita Kobayashi, Naoki Sugimoto
A regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an enzyme-responsive functionality, depending on the protease activity was constructed.
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Near-instant surface-selective fluorogenic protein quantification using sulfonated triarylmethane dyes and fluorogen activating proteins

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2078-2086
DOI: 10.1039/C4OB02309A, PaperQi Yan, Brigitte F. Schmidt, Lydia A. Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan K. Andreko, Marcel P. Bruchez
A bis-sulfonate linker modified malachite green fluorogen improves its specificity and allows rapid, no-wash labeling of receptors on living cells.
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Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2064-2077
DOI: 10.1039/C4OB02459A, PaperMatthias Winkler, Marjorie Maynadier, Sharon Wein, Marie-Ange Lespinasse, Giovanna Boumis, Adriana E. Miele, Henri Vial, Yung-Sing Wong
An expedient synthesis of aculeatin-like analogues results in finding PfTrxR as putative cellular target and a promising new antimalarial chemotype.
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Copper(II)-catalyzed coupling reaction: an efficient and regioselective approach to N[prime or minute],N[prime or minute]-diaryl acylhydrazines

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2055-2063
DOI: 10.1039/C4OB02343A, PaperJi-Quan Zhang, Gong-Bin Huang, Jiang Weng, Gui Lu, Albert S. C. Chan
An efficient and regioselective copper(II)-catalyzed coupling reaction of N[prime or minute]-aryl acylhydrazines for the synthesis of N[prime or minute],N[prime or minute]-diaryl acylhydrazines has been developed.
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A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2044-2054
DOI: 10.1039/C4OB02417F, PaperMarc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant, Luke R. Odell
A series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a novel cascade imine/cyclization/aza-Henry reaction in moderate to excellent yields.
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Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2034-2043
DOI: 10.1039/C4OB02340D, PaperLuis R. Domingo, Jose A. Saez, Saeed R. Emamian
The elimination of HCl and CO2 in the corresponding cycloadducts makes the unfavourable polar Diels-Alder reaction of 3-chloroindole irreversible.
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A coumarin based gold(I)-alkynyl complex: a new class of supramolecular hydrogelators

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2026-2033
DOI: 10.1039/C4OB02077D, PaperArtur J. Moro, Bertrand Rome, Elisabet Aguilo, Julia Arcau, Rakesh Puttreddy, Kari Rissanen, Joao Carlos Lima, Laura Rodriguez
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via fluorescence microscopy and dynamic light scattering.
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Conformational modulation of peptides using [small beta]-amino benzenesulfonic acid (SAnt)

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2087-2091
DOI: 10.1039/C4OB02421D, PaperGowri Priya, Amol S. Kotmale, Debamitra Chakravarty, Vedavati G. Puranik, Pattuparambil R. Rajamohanan, Gangadhar J. Sanjayan
This communication describes the utility of the conformationally restricted aromatic [small beta]-amino acid (2-aminobenzenesulfonic acid, SAnt) for inducing various folding interactions in short peptides.
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Asymmetric syntheses of three-membered heterocycles using chiral amide-based ammonium ylides

10 February, 2015 - 12:54

Org. Biomol. Chem., 2015, 13,2092-2099
DOI: 10.1039/C4OB02318H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mathias Pichler, Johanna Novacek, Raphael Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Muller, Mario Waser
Phenylglycinol serves as a powerful chiral auxiliary in ammonium ylide-mediated reactions to obtain chiral epoxides/aziridines with excellent stereoselectivities.
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