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One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones

11 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5435-5441
DOI: 10.1039/C4OB00715H, PaperJiabin Li, Yuanyuan Li, Qiaoqiao He, Yiming Li, Haitao Li, Lei Liu
One of the rising demands in the field of protein chemical synthesis is the development of facile strategies that yield the protein in workable quantities and homogeneity, with fewer handling steps.
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