Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 5 hours 15 min ago

Multicomponent reaction for the first synthesis of 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines as scaffolds for various 3,4-dihydro-2H-1,3-thiazine derivatives

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5168-5181
DOI: 10.1039/C4OB00866A, PaperFabian Brockmeyer, Robin Schoemaker, Marc Schmidtmann, Jurgen Martens
2H-1,3-thiazines, prepared via a novel and efficient multicomponent reaction, can be used as scaffolds for the synthesis of diverse 3,4-dihydro-2H-1,3-thiazines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Methylthiodeoxynivalenol (MTD): insight into the chemistry, structure and toxicity of thia-Michael adducts of trichothecenes

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5144-5150
DOI: 10.1039/C4OB00458B, PaperPhilipp Fruhmann, Theresa Weigl-Pollack, Hannes Mikula, Gerlinde Wiesenberger, Gerhard Adam, Elisabeth Varga, Franz Berthiller, Rudolf Krska, Christian Hametner, Johannes Frohlich
Synthesis and investigation of MTD revealed characteristic hemiketalisation and partial detoxification as effects of thia-Michael addition to type B trichothecenes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mercuration of thiacalix[4]arenes in the cone and 1,3-alternate conformations

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5136-5143
DOI: 10.1039/C4OB00799A, PaperF. Botha, S. Bohm, H. Dvorakova, V. Eigner, P. Lhotak
A monomercuration reaction of thiacalix[4]arenes immobilized in the cone or 1,3-alternate conformations gave a mixture of two regioisomers (meta and para) in approx. 4 : 1 and 2 : 1 ratios, respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5235-5242
DOI: 10.1039/C4OB00149D, PaperM. Scuotto, M. Persico, M. Bucci, V. Vellecco, N. Borbone, E. Morelli, G. Oliviero, E. Novellino, G. Piccialli, G. Cirino, M. Varra, C. Fattorusso, L. Mayol
Optically pure modified acyclic nucleosides offer unique advantages in exploring the effect on thrombin inhibition of single residue modifications at key positions of TBA.
The content of this RSS Feed (c) The Royal Society of Chemistry

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5151-5157
DOI: 10.1039/C4OB00761A, PaperAyumi Tsutsui, Rie Imamaki, Shinobu Kitazume, Shinya Hanashima, Yoshiki Yamaguchi, Masato Kaneda, Shinya Oishi, Nobutaka Fujii, Almira Kurbangalieva, Naoyuki Taniguchi, Katsunori Tanaka
Polyamines were found to react with acrolein to produce 1,5-diazacyclooctane.
The content of this RSS Feed (c) The Royal Society of Chemistry

A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5115-5125
DOI: 10.1039/C4OB00285G, PaperLing Zhang, Sai Li, Mei Hong, Yuqing Xu, Shuaishuai Wang, Yi Liu, Yong Qian, Jing Zhao
A naphthalimide-azide based colorimetric and ratiometric fluorescent probe has been developed for the selective and sensitive detection of hydrogen sulphide.
The content of this RSS Feed (c) The Royal Society of Chemistry

Impact of mono- and disubstitution on the colorimetric dynamic covalent switching chalcone/flavanone scaffold

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5108-5114
DOI: 10.1039/C4OB00398E, PaperBrian M. Muller, Jesse Mai, Reid A. Yocum, Marc J. Adler
The impact of substitution on a novel colorimetric dynamic covalent switching scaffold was investigated using UV/Vis and NMR spectroscopy.
The content of this RSS Feed (c) The Royal Society of Chemistry

An ESIPT fluorescent probe sensitive to protein [small alpha]-helix structures

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5250-5259
DOI: 10.1039/C4OB00405A, PaperNan Jiang, Chanli Yang, Xiongwei Dong, Xianglang Sun, Dan Zhang, Changlin Liu
A benzazole derivative, 1, was observed to undergo the excited-state intramolecular proton transfer (ESIPT) process with [small alpha]-helical proteins. The cell images showed a difference in the staining of normal and cancerous prostate cells by 1, which might be due to the different membrane protein levels.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pd-catalyzed carbonylation for the construction of tertiary and quaternary carbon centers with sp3 carbon partners

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5243-5249
DOI: 10.1039/C4OB00568F, PaperWei Lu, Yang Li, Chao Wang, Dong Xue, Jian-Gang Chen, Jianliang Xiao
The first examples of a Pd-catalyzed carbonylation of aryl boronic acids with sp3 carbon partners are presented.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.