Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 21 hours 4 min ago

Gorlos-Phos for palladium-catalyzed borylation of aryl chlorides

19 May, 2014 - 19:17

Org. Biomol. Chem., 2014, 12,3604-3610
DOI: 10.1039/C4OB00293H, PaperPengbin Li, Chunling Fu, Shengming Ma
Using a readily available form of the mono-phosphine ligand, Gorlos-Phos[middle dot]HBF4, Pd-catalyzed borylation of aryl chlorides afforded aryl boronates in high yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Self-assembly of peptides to nanostructures

19 May, 2014 - 19:17

Org. Biomol. Chem., 2014, 12,3544-3561
DOI: 10.1039/C4OB00447G, Review ArticleDindyal Mandal, Amir Nasrolahi Shirazi, Keykavous Parang
The formation of well-ordered nanostructures through self-assembly of diverse organic and inorganic building blocks has drawn much attention owing to their potential applications in biology and chemistry.
The content of this RSS Feed (c) The Royal Society of Chemistry

Microwave-assisted one-pot synthesis and anti-biofilm activity of 2-amino-1H-imidazole/triazole conjugates

19 May, 2014 - 19:17

Org. Biomol. Chem., 2014, 12,3671-3678
DOI: 10.1039/C3OB42282H, PaperHans Steenackers, Denis Ermolat'ev, Tran Thi Thu Trang, Bharat Savalia, Upendra K. Sharma, Ami De Weerdt, Anamik Shah, Jozef Vanderleyden, Erik V. Van der Eycken
A microwave-assisted protocol was developed for the construction of 2-amino-1H-imidazole/triazole conjugates with anti-biofilm activity.
The content of this RSS Feed (c) The Royal Society of Chemistry

A novel synthetic approach to the bicyclo[5.3.1]undecan-11-one framework of vinigrol

19 May, 2014 - 19:17

Org. Biomol. Chem., 2014, 12,3562-3566
DOI: 10.1039/C4OB00046C, CommunicationXian-Lei Wang, Yun-Yu Lu, Jie Wang, Xuan Wang, He-Quan Yao, Guo-Qiang Lin, Bing-Feng Sun
A unique approach to the [5.3.1] bicyclic core of vinigrol is described featuring highly stereoselective C-C bond forming reactions through exploring the inherent conformational bias of the cyclooctane-ring system.
The content of this RSS Feed (c) The Royal Society of Chemistry

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3386-3392
DOI: 10.1039/C4OB00236A, PaperRobert F. Anderson, Pooja Yadav, Deepa Patel, Johannes Reynisson, Smitha R. Tipparaju, Christopher P. Guise, Adam V. Patterson, William A. Denny, Andrej Maroz, Sujata S. Shinde, Michael P. Hay
One-electron bioreduction of SN30000, a triazine 1,4-dioxide anticancer drug, forms reactive aryl and carbon-centred radicals.
The content of this RSS Feed (c) The Royal Society of Chemistry

Strategies for the construction of tetrahydropyran rings in the synthesis of natural products

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3323-3335
DOI: 10.1039/C4OB00423J, Review ArticleNadiah Mad Nasir, Kristaps Ermanis, Paul A. Clarke
This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years.
The content of this RSS Feed (c) The Royal Society of Chemistry

Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3493-3498
DOI: 10.1039/C4OB00155A, PaperYaping Zhao, Lu Sun, Tieqiang Zeng, Jiayi Wang, Yanqing Peng, Gonghua Song
Copper-catalyzed direct olefination of benzaldehydes into unsymmetrical 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp3-H activation sequence using simpler substrates like benzaldehydes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diastereoselective formation of aziridines from diazocarbonyl compounds and N-(O-pivaloylated D-galactosyl)benzylideneamines and ring-opening reactions with p-toluenethiol

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3362-3365
DOI: 10.1039/C4OB00443D, CommunicationYizhou Zhao, Gang Wang, Shanshan Zhou, Zhongjun Li, Xiangbao Meng
N-Galactosyl aziridines were synthesized, and the ring-opening reactions provided enantiometrically pure [small beta]-S-substituted phenylalanine derivatives with high regioselectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3484-3492
DOI: 10.1039/C4OB00384E, PaperBao-Quan Liu, Wen-Jing Yi, Ji Zhang, Qiang Liu, Yan-Hong Liu, Sheng-Di Fan, Xiao-Qi Yu
Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of N-alkyl isatins via oxidative cyclization of N-alkyl 2-bromo(chloro)acetanilides

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3349-3353
DOI: 10.1039/C4OB00118D, CommunicationQingwen Gui, Fenglin Dai, Jidan Liu, Peixing Chen, Zhiyong Yang, Xiang Chen, Ze Tan
N-Alkyl isatins were synthesized via oxidative cyclization of N-alkyl 2-bromo or 2-chloro acetanilides in DMSO.
The content of this RSS Feed (c) The Royal Society of Chemistry

Carbohydrate-based first stereoselective total synthesis of bioactive cytospolide P

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3358-3361
DOI: 10.1039/C4OB00323C, CommunicationPathi Suman, Bhimapaka China Raju
A facile stereoselective approach has been developed for the total synthesis of cytospolide P via Yamaguchi macrolactonization.
The content of this RSS Feed (c) The Royal Society of Chemistry

A simple structural hydrazide-based gelator as a fluoride ion colorimetric sensor

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3478-3483
DOI: 10.1039/C4OB00056K, PaperBinglian Bai, Jie Ma, Jue Wei, Jianxi Song, Haitao Wang, Min Li
The C8 organogel could show reversible gel-sol transition and color changes by the use of F- stimuli and proton control.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3470-3477
DOI: 10.1039/C4OB00598H, PaperRomulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Ines M. C. Brighente, Antonio Luiz Braga
We report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
The content of this RSS Feed (c) The Royal Society of Chemistry

Benzo[a]acridinylmethyl esters as pH sensitive fluorescent photoactive precursors: synthesis, photophysical, photochemical and biological applications

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3459-3469
DOI: 10.1039/C3OB42600A, PaperMohammed Ikbal, Biswajit Saha, Shrabani Barman, Sanghamitra Atta, Deb Ranjan Banerjee, Sudip Kumar Ghosh, N. D. Pradeep Singh
(Benzo[a]acridin-12-yl)methyl (BAM) chromophore has been shown to perform dual functions as a "pH sensitive fluorescent probe" and a "phototrigger" for acids.
The content of this RSS Feed (c) The Royal Society of Chemistry

A multicomponent approach to the synthesis of N-sulfonyl [small beta]2,3-amino esters

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3423-3426
DOI: 10.1039/C3OB42353K, PaperErwan Le Gall, Stephane Sengmany, Issa Samb, Sabrina Benakrour, Christopher Colin, Antoine Pignon, Eric Leonel
The multicomponent synthesis of [small alpha],[small beta]-disubstituted N-sulfonyl [small beta]-amino esters is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3446-3458
DOI: 10.1039/C3OB42186D, PaperHai-Xia Jiang, Dao-Min Zhuang, Ying Huang, Xing-Xin Cao, Jian-Hua Yao, Jing-Yun Li, Jian-Yong Wang, Chen Zhang, Biao Jiang
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3441-3445
DOI: 10.1039/C4OB00214H, PaperJian-Peng Yin, Chun-Lan Tang, Li-Xin Gao, Wei-Ping Ma, Jing-Ya Li, Ying Li, Jia Li, Fa-Jun Nan
Paracaseolide A analogues showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of heterocyclic-fused benzopyrans via the Pd(II)-catalyzed C-H alkenylation/C-O cyclization of flavones and coumarins

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3413-3422
DOI: 10.1039/C4OB00180J, PaperYechan Kim, Youngtaek Moon, Dahye Kang, Sungwoo Hong
An efficient and practical method for effecting a tandem C-H alkenylation/C-O cyclization has been achieved via the C-H functionalization of flavone derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry

Dual-color imaging of cytosolic and mitochondrial zinc ions in live tissues with two-photon fluorescent probes

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3406-3412
DOI: 10.1039/C4OB00101J, PaperKailash Rathore, Chang Su Lim, Young Lee, Bong Rae Cho
We have developed TP probes for [Zn2+]cyto and [Zn2+]mito, which emit TPEF at widely-separated wavelength regions. The new probes can simultaneously detect [Zn2+]cyto and [Zn2+]mito in live cells, as well as in living tissues by dual-color TPM imaging.
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones via a non-Biginelli-type approach and evaluation of their in vitro anticancer activity

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3427-3440
DOI: 10.1039/C4OB00094C, PaperJacek G. Sosnicki, Lukasz Struk, Mateusz Kurzawski, Magdalena Peruzynska, Gabriela Maciejewska, Marek Drozdzik
A novel and regioselective approach to synthesize anticancer 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.