Org. and Biomol. Chem.

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CoPc-catalyzed selective radical arylation of anilines with arylhydrazines for synthesis of 2-aminobiaryls

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6922-6926
DOI: 10.1039/C4OB00798K, PaperTao Jiang, Sheng-Yan Chen, Guo-Yu Zhang, Run-Sheng Zeng, Jian-Ping Zou
CoPc-catalyzed selective radical arylation of anilines with arylhydrazines to afford 2-aminobiaryls in moderate to good yields is described.
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Orthogonal functionalisation of [small alpha]-helix mimetics

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6794-6799
DOI: 10.1039/C4OB00915K, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Barnard, Kerya Long, David J. Yeo, Jennifer A. Miles, Valeria Azzarito, George M. Burslem, Panchami Prabhakaran, Thomas A. Edwards, Andrew J. Wilson
We present methodology to modify N-alkylated aromatic oligoamide [small alpha]-helix mimetics using 'click' chemistry.
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Direct intermolecular C-H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6820-6823
DOI: 10.1039/C4OB01211A, CommunicationYinuo Wu, Pui Ying Choy, Fuk Yee Kwong
A general C-H arylation of unactivated arenes by aryl/heteroaryl bromides in the presence of 2-pyridyl carbinol and potassium tert-butoxide is described.
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L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6816-6819
DOI: 10.1039/C4OB01362J, CommunicationFan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll, Bing Xu
The nanofibrils of an L-rhamnose-based hydrogelator illustrate the first example of the supramolecular assemblies of a saccharide to suppress immunity.
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New reagents for detecting free radicals and oxidative stress

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6757-6766
DOI: 10.1039/C4OB01172D, Review ArticleMina Barzegar Amiri Olia, Carl H. Schiesser, Michelle K. Taylor
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6842-6854
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
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Total synthesis of putative montamine and a proposed structural reassignment

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6878-6884
DOI: 10.1039/C4OB01304B, PaperLachlan M. Blair, Elizabeth A. Colby Davie, Jonathan Sperry
The spectroscopic data for synthetic montamine does not match the proposed N,N[prime or minute]-linked structure and closely resembles a known 4,4[prime or minute]-bismoschamine natural product.
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6901-6907
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E. Nielsen
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
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A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

20 August, 2014 - 17:17

Org. Biomol. Chem., 2014, 12,6944-6952
DOI: 10.1039/C4OB00846D, PaperHui Peng, Ya-Qin Chen, Shu-Lan Mao, Yun-Xiao Pi, You Chen, Ze-Yu Lian, Tong Meng, Sheng-Hua Liu, Guang-Ao Yu
An air-stable sulfonated indenyl phosphine/Pd-catalyst system was used in Suzuki-Miyaura and Sonogashira coupling reactions in water.
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Highly efficient synthesis of a tristable molecular shuttle and its controlled motion under chemical stimuli

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6937-6943
DOI: 10.1039/C4OB01283F, PaperZheng Meng, Chuan-Feng Chen
A tristable molecular shuttle could be efficiently synthesized in 76% yield by exploiting a K+ ion template and a bulky isocyanate stopper.
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Monopyrrolotetrathiafulvalene-succinamide conjugates and their TCNQ charge transfer complex based supramolecular gels with multiple stimulus responsiveness

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6927-6936
DOI: 10.1039/C4OB01397B, PaperYucun Liu, Ningjuan Zheng, Tie Chen, Longyi Jin, Bingzhu Yin
Monopyrrolotetrathiafulvalene-succinamide conjugates and their TCNQ charge transfer (CT) complexes have been developed as LMOGs. The native gels and CT complex gels exhibit smart multiple stimulus responsiveness.
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A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6895-6900
DOI: 10.1039/C4OB00871E, PaperShuai Fang, Xiaoyi Niu, Zeyuan Zhang, Yan Sun, Xiaomeng Si, Cuicui Shan, Lei Wei, Aiqing Xu, Lei Feng, Chen Ma
A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed.
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Recent advances in heterobimetallic palladium(II)/copper(II) catalyzed domino difunctionalization of carbon-carbon multiple bonds

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6767-6789
DOI: 10.1039/C4OB00610K, Review ArticleEgle M. Beccalli, Gianluigi Broggini, Silvia Gazzola, Alberto Mazza
The Pd(II)/Cu(II)-catalysed double functionalization of carbon-carbon multiple bonds in domino processes has emerged in recent years as a fruitful tool for the rapid synthesis of complex molecular scaffolds.
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A self-replicating peptide nucleic acid

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6908-6914
DOI: 10.1039/C4OB01168F, PaperTobias A. Ploger, Gunter von Kiedrowski
This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
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Formal synthesis of (+)-3-epi-eupomatilone-6 and the 3,5-bis-epimer

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6885-6894
DOI: 10.1039/C4OB01078G, PaperSariya Yodwaree, Darunee Soorukram, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul, Manat Pohmakotr
The formal synthesis of (+)-3-epi-eupomatilone-6 and the 3,5-bis-epimer has been accomplished using stereoselective conjugate addition of vinylmagnesium chloride to a chiral [small alpha],[small beta]-unsaturated N-acyl oxazolidinone followed by [small alpha]-methylation as the key steps.
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Ligand-free MCR for linking quinoxaline framework with a benzimidazole nucleus: a new strategy for the identification of novel hybrid molecules as potential inducers of apoptosis

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6800-6805
DOI: 10.1039/C4OB01268B, CommunicationRajnikanth Sunke, P. Vijaya Babu, Swapna Yellanki, Raghavender Medishetti, Pushkar Kulkarni, Manojit Pal
A Cu-catalyzed MCR afforded novel hybrid molecules as potential inducers of apoptosis in zebrafish.
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An enzymatic approach to bifunctional chelating agents

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6915-6921
DOI: 10.1039/C4OB00810C, PaperPaolo Minazzi, Luciano Lattuada, Ivan G. Menegotto, Giovanni B. Giovenzana
Three novel BFCAs are obtained through an original protocol involving an enzymatic hydrolysis as the key step.
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Highly selective fluorescence off-on probes for biothiols and imaging in live cells

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6837-6841
DOI: 10.1039/C4OB01031K, PaperDi Zhang, Wei Chen, Jianming Kang, Yong Ye, Yufen Zhao, Ming Xian
Three sulfonyl benzothiazole-based fluorescence off-on probes for biothiols are developed and applied for visualizing endogenous thiols in living cells.
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Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of [small alpha]-glucosidase inhibitors

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6855-6868
DOI: 10.1039/C4OB00486H, PaperInderpreet Arora, Vivek Kr. Kashyap, Alok Kumar Singh, Arunava Dasgupta, Brijesh Kumar, Arun K. Shaw
Selective inhibition by conformational restriction of pyrrolidine iminosugars. Click conceived pyrrolidotriazoles incorporate essential features to access the mimicry of the transition state of carbohydrate processing enzymes.
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Scandium-catalyzed tandem selective oxirane ring-opening/Friedel-Crafts alkylation: a facile access to [1,4]oxazino[4,3-a]indoles and 3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazines

18 August, 2014 - 16:54

Org. Biomol. Chem., 2014, 12,6869-6877
DOI: 10.1039/C4OB01057D, PaperLai Wei, Lu Liu, Junliang Zhang
An efficient Lewis acid-catalyzed tandem selective ring-opening and Friedel-Crafts alkylation of 1H-indol-1-yl derived oxiranes was developed.
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