Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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High-yielding sequential one-pot synthesis of chiral and achiral [small alpha]-substituted acrylates via a metal-free reductive coupling reaction

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5400-5406
DOI: 10.1039/C4OB00667D, PaperDhevalapally B. Ramachary, Chintalapudi Venkaiah, Y. Vijayendar Reddy
A variety of chiral and achiral [small alpha]-substituted acrylates were furnished in very good yields with excellent selectivity by using an organocatalytic reductive coupling reaction (TCRA) followed by an Eschenmoser methylenation.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5324-5330
DOI: 10.1039/C4OB00737A, PerspectiveLara Cala, Francisco J. Fananas, Felix Rodriguez
This perspective article summarizes the few and recently reported methods on catalytic asymmetric synthesis of spiroacetal derivatives from achiral substrates.
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Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5458-5463
DOI: 10.1039/C4OB00663A, PaperYu-Juan Guo, Pei-Jiang Chen, Bo Wang, Ai-Yun Peng
A series of phosphaisocoumarin amidates were synthesized via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters in good to excellent yields. In each case, the phostone ring was intact and only the exocyclic ethoxy group was amidated.
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Arylpyrrole oligomers as tunable anion receptors

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5492-5499
DOI: 10.1039/C4OB00357H, PaperWim Van Rossom, Tatyana G. Terentyeva, Keitaro Sodeyama, Yoshitaka Matsushita, Yoshitaka Tateyama, Katsuhiko Ariga, Jonathan P. Hill
A novel class of oligomeric arylpyrrole receptors has been designed, prepared and analysed for their affinity towards anionic guests.
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Comparison of backbone modification in protein [small beta]-sheets by [small alpha][rightward arrow][gamma] residue replacement and [small alpha]-residue methylation

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5375-5381
DOI: 10.1039/C4OB00886C, PaperGeorge A. Lengyel, Zachary E. Reinert, Brian D. Griffith, W. Seth Horne
Systematic backbone alteration of sheet secondary structure in a small protein yields unnatural mimics with native-like tertiary folding behavior.
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Synthesis and properties of fluorous benzoquinones and their application in deprotection of silyl ethers

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5442-5447
DOI: 10.1039/C4OB00783B, PaperHiroshi Matsubara, Takahiko Maegawa, Yasuaki Kita, Takato Yokoji, Akihiro Nomoto
1,4-Benzoquinone derivatives bearing perfluoroalkyl groups were prepared and used as a recyclable catalyst in the selective desilylation of silyl ethers.
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Efficient asymmetric synthesis of spiro-2(3H)-furanones via phase-transfer-catalyzed alkynylation

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5388-5392
DOI: 10.1039/C4OB00969J, PaperXiangfei Wu, Seiji Shirakawa, Keiji Maruoka
Efficient asymmetric synthesis of spiro-2(3H)-furanones was achieved via chiral phase-transfer-catalyzed alkynylation.
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Tuning of the HOMO-LUMO gap of donor-substituted symmetrical and unsymmetrical benzothiadiazoles

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5448-5457
DOI: 10.1039/C4OB00629A, PaperRajneesh Misra, Prabhat Gautam
This article reports the design and synthesis of donor-substituted symmetrical and unsymmetrical benzothiadiazoles (BTDs) 5-12 of type D-[small pi]-A-D, D1-[small pi]-A-D2, D1-A1-A2-D2, D-A1-A2-D and D-A1-A2-A1-D by Ullmann, Suzuki and cycloaddition-retroelectrocyclization reactions.
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Efficient C(sp3alkyl)-SCF3 bond formations via copper-mediated trifluoromethylthiolation of alkyl halides

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5500-5508
DOI: 10.1039/C4OB00403E, PaperQuanfu Lin, Li Chen, Yangjie Huang, Mingguang Rong, Yaofeng Yuan, Zhiqiang Weng
An efficient synthesis of alkyl trifluoromethyl sulfides via copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described.
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Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5427-5434
DOI: 10.1039/C4OB00744A, PaperXiu-Jiang Du, Qiang Bian, Hong-Xue Wang, Shu-Jing Yu, Jun-Jie Kou, Zhi-Peng Wang, Zheng-Ming Li, Wei-Guang Zhao
A series of valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good fungicidal activity.
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An intracellularly activatable, fluorogenic probe for cancer imaging

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5365-5374
DOI: 10.1039/C4OB00297K, PaperRuisong Tian, Mingjie Li, Jin Wang, Min Yu, Xiuqi Kong, Yupeng Feng, Zeming Chen, Yuxi Li, Weiqiang Huang, Wenjie Wu, Zhangyong Hong
A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.
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The metal tin promoted cascade reaction of ketones in aqueous media for the construction of 2-bromo-4-aryl-1,3-pentadiene

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5393-5399
DOI: 10.1039/C4OB00584H, PaperLingyan Liu, Yan Zhang, Hua Zhang, Kaimeng Huang, Bo-xin Gao, Min Zou, Xin Zhou, Hongkai Wang, Jing Li
A novel Barbier-type allenylation cascade reaction of carbonyl compounds promoted by tin was discovered, and afforded a new, highly functionalized 1,3-pentadiene.
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