Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 6 hours 18 min ago

Sc(OTf)3-Catalyzed Cascade Reaction of o-Aminoacetophenone with Methanamine: Construction of Dibenzo[b,h][1,6]naphthyridine Derivatives

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02220C, PaperDan Mao, Jun Tang, Wenbo Wang, Xin Liu, Shengying Wu, Jianjun Yu, Limin Wang
An unexpected Sc(OTf)3-catalyzed and air-mediated cascade reaction of o-aminoacetophenones with methanamines was discovered as an efficient synthetic approach to a novel class of fluorescent fused-four-ring dibenzo[b,h][1,6]naphthyridine derivatives. Two possible mechanisms...
The content of this RSS Feed (c) The Royal Society of Chemistry

Transition metal catalyzed meta-C-H functionalization of aromatic compounds

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02171A, Review ArticleJiong Yang
Direct functionalization of C-H bonds represents a powerful strategy for the synthesis of complex organic compounds due to its inherent efficiency. Among various approaches, transition metal-catalyzed direct activation of unreactive...
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02321H, PaperStefano Roelens, Oscar Francesconi, Matteo Gentili, Francesco Bartoli, Andrea Bencini, Luca Conti, Claudia Giorgi
In this work we have investigated the binding properties of a new synthetic receptor for phosphate anions that combines metal ion coordination with electrostatic and H-bonding interactions. The described receptor...
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective detection of Al3+ and citric acid with a fluorescent amphiphile

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,252-257
DOI: 10.1039/C4OB02095B, PaperZiya Kostereli, Kay Severin
The assembly and disassembly of a fluorescent amphiphile by Al3+ and citrate, respectively, can be used to sense these analytes by fluorescence spectroscopy.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium(0)-catalyzed synthesis of cyclic glucosides

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,248-251
DOI: 10.1039/C4OB01975J, PaperXin Huang, Chunling Fu, Shengming Ma
A highly regio- and stereo-selective synthesis of cyclic [small beta]-D-glucosides 3via Pd(0)-catalyzed coupling cyclization of allenyl [small beta]-D-glucoside 1 and organic iodides in 20-38% yields is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,265-268
DOI: 10.1039/C4OB02120G, PaperThomas C. Pijper, Jort Robertus, Wesley R. Browne, Ben L. Feringa
Rapid conversion of thio-ethers to thio-acetates using TiCl4 that tolerates a wide variety of functionalities, in good to excellent yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Multivalent helix mimetics for PPI-inhibition

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,258-264
DOI: 10.1039/C4OB02066A, PaperAnna Barnard, Jennifer A. Miles, George M. Burslem, Amy M. Barker, Andrew J. Wilson
A multivalent helix mimetic is developed that inhibits the p53/hDM2 and induces dimerization/aggregation of its target - hDM2.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing [small pi]-extended diarylacetylene motifs

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,68-72
DOI: 10.1039/C4OB02081B, CommunicationSara De Ornellas, John M. Slattery, Robert M. Edkins, Andrew Beeby, Christoph G. Baumann, Ian J. S. Fairlamb
A novel series of C-modified [small pi]-extended 7-deazaadenosines exhibit promising fluorescence properties.
The content of this RSS Feed (c) The Royal Society of Chemistry

An enantioselective total synthesis of Sch-725674

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,234-240
DOI: 10.1039/C4OB02136C, PaperKota Ramakrishna, Krishna P. Kaliappan
An enantioselective total synthesis of Sch-725674 using dithiane alkylation, cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction as key steps is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,64-67
DOI: 10.1039/C4OB02060J, CommunicationNicolas Chuard, Giulio Gasparini, Aurelien Roux, Naomi Sakai, Stefan Matile
We report that, with the increasing length, cell-penetrating poly(disulfide)s preferably accumulate in the endosomes, cytosol and then the nucleoli.
The content of this RSS Feed (c) The Royal Society of Chemistry

Oxidative activation of dihydropyridine amides to reactive acyl donors

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,185-198
DOI: 10.1039/C4OB01931H, PaperErik Daa Funder, Julie B. Trads, Kurt V. Gothelf
Amides of 1,4-dihydropyridine (DHP) are activated by oxidation for acyl transfer to amines, alcohols and thiols.
The content of this RSS Feed (c) The Royal Society of Chemistry

Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,59-63
DOI: 10.1039/C4OB01883D, CommunicationBani Kanta Sarma, Xiaodan Liu, Hao Wu, Yu Gao, Thomas Kodadek
Solid phase synthesis of 1,3,4-oxadiazin-5(6R)-one and 1,3,4-oxadiazol-2-one scaffolds from resin-bound acyl hydrazides is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,98-109
DOI: 10.1039/C4OB01841A, PaperSimon A. Dingsdag, Benjamin C-M. Yap, Neil Hunter, Maxwell J. Crossley
Amino acid-linked porphyrin-nitroimidazole adducts, as potent as metronidazole, are highly selective for Porphyromonas gingivalis.
The content of this RSS Feed (c) The Royal Society of Chemistry

A domino reaction of tetrahalo-7,7-dimethoxybicyclo[2.2.1]heptenyl alcohols leading to indenones and a de novo synthesis of ninhydrin derivatives

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,299-308
DOI: 10.1039/C4OB01977F, PaperKaki Raveendra Babu, Faiz Ahmed Khan
An acid mediated synthesis of indenones and a de novo synthesis of ninhydrin derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry

Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,283-298
DOI: 10.1039/C4OB01838A, PaperCarlos A. Sanhueza, Jonathan Cartmell, Amr El-Hawiet, Adam Szpacenko, Elena N. Kitova, Rambod Daneshfar, John S. Klassen, Dean E. Lang, Luiz Eugenio, Kenneth K.-S. Ng, Pavel I. Kitov, David R. Bundle
Higher activity glycopeptoid ligands for two large Clostridium difficile toxins TcdA and TcdB were discovered via modular fragment-based design and virtual screening.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,309-314
DOI: 10.1039/C4OB01320D, PaperMonoranjan Ghosh, Subhajit Mishra, Kamarul Monir, Alakananda Hajra
A catalytic decarboxylative annulation has been developed for the regioselective synthesis of furans by the cycloaddition of ketones with [small alpha],[small beta]-unsaturated carboxylic acids in ambient air.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cationic azacryptands as selective three-way DNA junction binding agents

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,215-222
DOI: 10.1039/C4OB01846J, PaperJana Novotna, Aurelien Laguerre, Anton Granzhan, Marc Pirrotta, Marie-Paule Teulade-Fichou, David Monchaud
Azacryptands are promising candidates for assessing the therapeutic potential of three-way DNA junctions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Corrin-based chemosensors for the ASSURED detection of endogenous cyanide

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,14-17
DOI: 10.1039/C4OB01889C, PerspectiveFelix Zelder, Lucas Tivana
Cassava (Manihot esculenta Crantz) is a staple food for more than 500 million people, especially in Africa and South America.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,269-276
DOI: 10.1039/C4OB01837K, PaperEwa Radzikowska, Janina Baraniak
Chimeric oligonucleotides containing stereoregular phosphorothioate and natural phosphodiester linkages have been obtained on the solid phase support using nucleoside oxathiaphospholanes and commercially available nucleoside phosphoramidites.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,277-282
DOI: 10.1039/C4OB01959H, PaperOrazio A. Attanasi, Linda A. Campisi, Lucia De Crescentini, Gianfranco Favi, Fabio Mantellini
Synthesis of symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines]: a novel example of spirocyclic oxindoles bearing a quaternary centre at the 3-position.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.