Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3493-3498
DOI: 10.1039/C4OB00155A, PaperYaping Zhao, Lu Sun, Tieqiang Zeng, Jiayi Wang, Yanqing Peng, Gonghua Song
Copper-catalyzed direct olefination of benzaldehydes into unsymmetrical 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp3-H activation sequence using simpler substrates like benzaldehydes.
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Diastereoselective formation of aziridines from diazocarbonyl compounds and N-(O-pivaloylated D-galactosyl)benzylideneamines and ring-opening reactions with p-toluenethiol

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3362-3365
DOI: 10.1039/C4OB00443D, CommunicationYizhou Zhao, Gang Wang, Shanshan Zhou, Zhongjun Li, Xiangbao Meng
N-Galactosyl aziridines were synthesized, and the ring-opening reactions provided enantiometrically pure [small beta]-S-substituted phenylalanine derivatives with high regioselectivity.
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Synthesis and gene transfection activity of cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3484-3492
DOI: 10.1039/C4OB00384E, PaperBao-Quan Liu, Wen-Jing Yi, Ji Zhang, Qiang Liu, Yan-Hong Liu, Sheng-Di Fan, Xiao-Qi Yu
Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.
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Synthesis of N-alkyl isatins via oxidative cyclization of N-alkyl 2-bromo(chloro)acetanilides

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3349-3353
DOI: 10.1039/C4OB00118D, CommunicationQingwen Gui, Fenglin Dai, Jidan Liu, Peixing Chen, Zhiyong Yang, Xiang Chen, Ze Tan
N-Alkyl isatins were synthesized via oxidative cyclization of N-alkyl 2-bromo or 2-chloro acetanilides in DMSO.
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Carbohydrate-based first stereoselective total synthesis of bioactive cytospolide P

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3358-3361
DOI: 10.1039/C4OB00323C, CommunicationPathi Suman, Bhimapaka China Raju
A facile stereoselective approach has been developed for the total synthesis of cytospolide P via Yamaguchi macrolactonization.
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A simple structural hydrazide-based gelator as a fluoride ion colorimetric sensor

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3478-3483
DOI: 10.1039/C4OB00056K, PaperBinglian Bai, Jie Ma, Jue Wei, Jianxi Song, Haitao Wang, Min Li
The C8 organogel could show reversible gel-sol transition and color changes by the use of F- stimuli and proton control.
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Design, synthesis and evaluation of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease

17 May, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,3470-3477
DOI: 10.1039/C4OB00598H, PaperRomulo F. S. Canto, Flavio A. R. Barbosa, Vanessa Nascimento, Aldo S. de Oliveira, Ines M. C. Brighente, Antonio Luiz Braga
We report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease.
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Benzo[a]acridinylmethyl esters as pH sensitive fluorescent photoactive precursors: synthesis, photophysical, photochemical and biological applications

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3459-3469
DOI: 10.1039/C3OB42600A, PaperMohammed Ikbal, Biswajit Saha, Shrabani Barman, Sanghamitra Atta, Deb Ranjan Banerjee, Sudip Kumar Ghosh, N. D. Pradeep Singh
(Benzo[a]acridin-12-yl)methyl (BAM) chromophore has been shown to perform dual functions as a "pH sensitive fluorescent probe" and a "phototrigger" for acids.
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A multicomponent approach to the synthesis of N-sulfonyl [small beta]2,3-amino esters

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3423-3426
DOI: 10.1039/C3OB42353K, PaperErwan Le Gall, Stephane Sengmany, Issa Samb, Sabrina Benakrour, Christopher Colin, Antoine Pignon, Eric Leonel
The multicomponent synthesis of [small alpha],[small beta]-disubstituted N-sulfonyl [small beta]-amino esters is described.
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Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3446-3458
DOI: 10.1039/C3OB42186D, PaperHai-Xia Jiang, Dao-Min Zhuang, Ying Huang, Xing-Xin Cao, Jian-Hua Yao, Jing-Yun Li, Jian-Yong Wang, Chen Zhang, Biao Jiang
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
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Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3441-3445
DOI: 10.1039/C4OB00214H, PaperJian-Peng Yin, Chun-Lan Tang, Li-Xin Gao, Wei-Ping Ma, Jing-Ya Li, Ying Li, Jia Li, Fa-Jun Nan
Paracaseolide A analogues showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
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Synthesis of heterocyclic-fused benzopyrans via the Pd(II)-catalyzed C-H alkenylation/C-O cyclization of flavones and coumarins

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3413-3422
DOI: 10.1039/C4OB00180J, PaperYechan Kim, Youngtaek Moon, Dahye Kang, Sungwoo Hong
An efficient and practical method for effecting a tandem C-H alkenylation/C-O cyclization has been achieved via the C-H functionalization of flavone derivatives.
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Dual-color imaging of cytosolic and mitochondrial zinc ions in live tissues with two-photon fluorescent probes

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3406-3412
DOI: 10.1039/C4OB00101J, PaperKailash Rathore, Chang Su Lim, Young Lee, Bong Rae Cho
We have developed TP probes for [Zn2+]cyto and [Zn2+]mito, which emit TPEF at widely-separated wavelength regions. The new probes can simultaneously detect [Zn2+]cyto and [Zn2+]mito in live cells, as well as in living tissues by dual-color TPM imaging.
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Regioselective synthesis of novel 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones via a non-Biginelli-type approach and evaluation of their in vitro anticancer activity

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3427-3440
DOI: 10.1039/C4OB00094C, PaperJacek G. Sosnicki, Lukasz Struk, Mateusz Kurzawski, Magdalena Peruzynska, Gabriela Maciejewska, Marek Drozdzik
A novel and regioselective approach to synthesize anticancer 4,5-diaryl functionalized 3,4-dihydropyrimidine-2(1H)-thiones is described.
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Palladium-catalyzed regioselective azidation of allylic C-H bonds under atmospheric pressure of dioxygen

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3340-3343
DOI: 10.1039/C4OB00442F, CommunicationHuoji Chen, Wanfei Yang, Wanqing Wu, Huanfeng Jiang
A palladium-catalyzed allylic azidation of alkenes with sodium azide under atmospheric pressure of dioxygen was developed.
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A cyclization-carbonylation-cyclization coupling reaction of (ortho-alkynyl phenyl) (methoxymethyl) sulfides with the palladium(II)-bisoxazoline catalyst

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3380-3385
DOI: 10.1039/C4OB00299G, PaperYiyun Jiang, Taichi Kusakabe, Keisuke Takahashi, Keisuke Kato
A CCC-coupling reaction of (o-alkynylphenyl) (methoxymethyl) sulfides, catalyzed by (box)PdII complexes, afforded symmetrical ketones bearing two benzo[b]thiophene groups in good to excellent yields.
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Asymmetric synthesis of chloroisothreonine derivatives via syn-stereoselective Mannich-type additions across N-sulfinyl-[small alpha]-chloroimines

15 May, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,3393-3405
DOI: 10.1039/C4OB00243A, PaperGert Callebaut, Filip Colpaert, Melinda Nonn, Lorand Kiss, Reijo Sillanpaa, Karl W. Tornroos, Ferenc Fulop, Norbert De Kimpe, Sven Mangelinckx
Mannich-type reactions across N-sulfinyl-[small alpha]-chloroaldimines resulted in syn-stereoselective synthesis of chloroisothreonine derivatives as excellent building blocks.
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Selective synthesis of (Z)-2-enynyl-2-hydroxy-imidazolidine-4,5-diones via Cu(I)-mediated multicomponent coupling of terminal alkynes, carbodiimides and oxalyl chloride

13 May, 2014 - 17:54

Org. Biomol. Chem., 2014, 12,3336-3339
DOI: 10.1039/C4OB00185K, CommunicationFei Zhao, Yuexing Li, Yang Wang, Wen-Xiong Zhang, Zhenfeng Xi
(Z)-2-Enynyl-2-hydroxy-imidazolidine-4,5-diones are synthesized via Cu(I)-mediated (Z)-selective geminal coupling among two terminal alkynes, carbodiimides, and oxalyl chloride. Further transformation is explored.
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Symmetry as a new element to control molecular switches

13 May, 2014 - 17:54

Org. Biomol. Chem., 2014, 12,3371-3379
DOI: 10.1039/C4OB00230J, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Luca Schweighauser, Daniel Haussinger, Markus Neuburger, Hermann A. Wegner
The switching of a tetraazocarbazole macrocycle was investigated and an interdependence of individual azo units was observed depending on their special relationship.
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Studies on the stereochemical assignment of 3-acylidene 2-oxindoles

5 May, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,3201-3210
DOI: 10.1039/C4OB00496E, PaperSteven J. Edeson, Julong Jiang, Stephen Swanson, Panayiotis A. Procopiou, Harry Adams, Anthony J. H. M. Meijer, Joseph P. A. Harrity
UV-Vis spectroscopy offers a convenient and reliable method for alkene stereochemical assignment of 3-acylidene 2-oxindoles.
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