Org. and Biomol. Chem.

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Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4632-4636
DOI: 10.1039/C5OB00378D, CommunicationTsumoru Morimoto, Tetsuji Fujii, Kota Miyoshi, Gouki Makado, Hiroki Tanimoto, Yasuhiro Nishiyama, Kiyomi Kakiuchi
The rhodium(I)/chiral Ph-bpe-catalyzed reaction of vinylarenes with formaldehyde provides an accessible protocol for asymmetric hydroformylation to enantioenriched aldehydes in high yields.
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An ab initio and DFT study of the autoxidation of THF and THP

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4686-4692
DOI: 10.1039/C5OB00012B, PaperHiroshi Matsubara, Syouhei Suzuki, Shun Hirano
Ab initio and DFT calculations were carried out to investigate the difference in reactivity for the autoxidation of THP (tetrahydropyran) and THF.
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Palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines with isocyanides through double sp2 C-H bonds cleavage: facile synthesis of 4-aminoquinoline derivatives

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4657-4660
DOI: 10.1039/C5OB00329F, CommunicationQiang Zheng, Puying Luo, Yuqing Lin, Wenfan Chen, Xiuxiu Liu, Yadong Zhang, Qiuping Ding
An efficient method for the synthesis of 4-aminoquinolines via palladium-catalyzed intermolecular oxidative cyclization of N-aryl enamines and isocyanides through double sp2 C-H bonds cleavage has been developed.
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A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]pyrimidines

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4668-4672
DOI: 10.1039/C5OB00380F, CommunicationNimmakuri Rajesh, Dipak Prajapati
A copper-catalyzed one-pot, atom/step-economical, three component method for the construction of pyrano[2,3-d]pyrimidines has been developed via a tandem conjugative alkynylation/6-endo cyclization sequence.
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Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4714-4726
DOI: 10.1039/C5OB00007F, PaperSai Fang, Lei Chen, Miao Yu, Bao Cheng, Yongsheng Lin, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Qiong Gu, Jun Xu
The design for 6-acrylic phenethyl ester 2-pyranone derivatives against five tumor cell lines is reported.
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Pyrimidine-based functional fluorescent organic nanoparticle probe for detection of Pseudomonas aeruginosa

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4673-4679
DOI: 10.1039/C5OB00206K, PaperGaganpreet Kaur, Tilak Raj, Navneet Kaur, Narinder Singh
Organic nanoparticles are developed for the sensing of Pseudomonas aeruginosa.
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An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4760-4768
DOI: 10.1039/C5OB00100E, PaperPrabhakar Cherkupally, Suhas Ramesh, Thavendran Govender, Hendrik G. Kruger, Beatriz G. de la Torre, Fernando Albericio
The first total synthesis of the naturally obtainable marine siderophores amphibactin-T and moanachelin ala-B on solid-phase using standard Fmoc-chemistry is reported.
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Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4706-4713
DOI: 10.1039/C5OB00301F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shiho Okazaki, Shinya Oishi, Tsukasa Mizuhara, Kazuya Shimura, Hiroto Murayama, Hiroaki Ohno, Masao Matsuoka, Nobutaka Fujii
PD 404182 and benzo[4,5]isothiazolo[2,3-a]pyrimidines are possible prodrug forms of the ring-opened thiophenols with anti-HIV activity.
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Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4642-4646
DOI: 10.1039/C5OB00409H, CommunicationZhengwei Ding, Qitao Tan, Mingchun Gao, Bin Xu
An efficient copper-catalyzed regioselective olefinic C(sp2)-H bond cycloamination and acyloxylation was developed to give acyloxylated pyrazoles under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step.
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Organocatalytic enantioselective Michael addition of cyclic hemiacetals to nitroolefins: a facile access to chiral substituted 5- and 6-membered cyclic ethers

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4769-4775
DOI: 10.1039/C5OB00202H, PaperYadong Zhu, Pengfei Qian, Jiyang Yang, Shaohua Chen, Yanwei Hu, Ping Wu, Wei Wang, Wei Zhang, Shilei Zhang
An efficient aminocatalytic enantioselective Michael addition of readily available cyclic hemiacetals to nitroolefins has been developed.
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Room temperature N-arylation of amino acids and peptides using copper(I) and [small beta]-diketone

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4637-4641
DOI: 10.1039/C5OB00288E, CommunicationKrishna K. Sharma, Swagat Sharma, Anurag Kudwal, Rahul Jain
A mild and efficient Cu-catalyzed procedure for the N-arylation of zwitterionic amino acids, amino acid esters and peptides is described.
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C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

20 April, 2015 - 05:54

Org. Biomol. Chem., 2015, 13,4627-4631
DOI: 10.1039/C5OB00044K, PerspectiveY. Wang, S. R. McAlpine
The cellular protection mechanism, the heat shock response, is only activated by classical heat shock 90 inhibitors (Hsp90) that "target" the N-terminus of the protein, but not by those that modulate the C-terminus.
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