Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 7 hours ago

Linear dialdehydes as promising substrates for aminocatalyzed transformations

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1280-1293
DOI: 10.1039/C4OB01805B, Review ArticleIndresh Kumar, Panduga Ramaraju, Nisar A. Mir, Anoop Singh
Linear dialdehydes: This article summarizes the recent utilization of linear dialdehydes as appropriate substrates for amine catalyzed cascade/domino transformations.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1550-1557
DOI: 10.1039/C4OB02385D, PaperXiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li, Hong-Bin Zhang, Xiao-Dong Yang
A series of novel 2-substituted indoline imidazolium salt derivatives were synthesized and their antitumor structure-activity relationship studies were reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of [small delta]-lactones

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1313-1316
DOI: 10.1039/C4OB02330G, CommunicationJin-Tang Cheng, Xiang-Yu Chen, Song Ye
The NHC-catalyzed [4 + 2] cyclocondensation of 2-aryl carboxylic acids with enones was developed, giving [small delta]-lactones in good yields with high enantioselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pd-catalyzed Heck-conjoined amidation and concomitant chemoselective Michael-addition: an efficient tandem approach to highly functionalized tetrahydroquinazolines from o-haloanilines

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1521-1530
DOI: 10.1039/C4OB02286F, PaperRakesh K. Saunthwal, Monika Patel, Abhinandan K. Danodia, Akhilesh K. Verma
Efficient palladium-catalyzed tandem approach for the synthesis of highly functionalized tetrahydroquinazolines from o-haloanilines with acrylates and isothiocyanates/isocyanates via Heck-conjoined amidation/thioamidation and concomitant chemoselective Michael-addition is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

A robust synthesis of N-glycolyl muramyl dipeptide via azidonitration/reduction

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1515-1520
DOI: 10.1039/C4OB02147A, PaperShuo Xing, James L. Gleason
Glycal etherification followed by azidonitration/reduction solves a difficult SN2 step in the synthesis of N-glycolyl muramyl dipeptide.
The content of this RSS Feed (c) The Royal Society of Chemistry

Domino reaction involving the Bestmann-Ohira reagent and [small alpha],[small beta]-unsaturated aldehydes: efficient synthesis of functionalized pyrazoles

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1492-1499
DOI: 10.1039/C4OB02365J, PaperShakir Ahamad, Ashis Kumar Gupta, Ruchir Kant, Kishor Mohanan
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and [small alpha],[small beta]-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles.
The content of this RSS Feed (c) The Royal Society of Chemistry

A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1507-1514
DOI: 10.1039/C4OB01605J, PaperGaofei Wei, Weijing Luan, Shuai Wang, Shanshan Cui, Fengran Li, Yongxiang Liu, Yang Liu, Maosheng Cheng
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1500-1506
DOI: 10.1039/C4OB02260B, PaperYi-Chao Huang, Chao-Jian Guan, Xiang-Long Tan, Chen-Chen Chen, Qing-Xiang Guo, Yi-Ming Li
In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection.
The content of this RSS Feed (c) The Royal Society of Chemistry

Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1463-1469
DOI: 10.1039/C4OB02303J, PaperAaron Johnson, Matthew J. Saunders, Thomas G. Back
BIRT-377 was synthesized by enzymatic desymmetrization in conjunction with Curtius rearrangement, affording a key [small alpha]-quaternary amine intermediate in high ee.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1470-1480
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez-Bartulos, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The combination of the cell-penetrating peptide BP16 with the enzymatic cleavable sequence Gly-Phe-Leu-Gly constitutes a drug delivery system for the effective uptake and release of chlorambucil in cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cu-catalyzed arylation of the amino group in the indazole ring: regioselective synthesis of pyrazolo-carbazoles

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1481-1491
DOI: 10.1039/C4OB02044H, PaperK. Anil Kumar, Prakash Kannaboina, Devendra K. Dhaked, Ram A. Vishwakarma, Prasad V. Bharatam, Parthasarathi Das
Arylated aminoindazoles were synthesized by copper-catalyzed C-N bond cross-coupling with boronic acids. These were then transformed to pyrazolo-carbazoles by Pd-catalyzed regioselective cross-dehydrogenative coupling.
The content of this RSS Feed (c) The Royal Society of Chemistry

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1453-1462
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Systematic analyses of mutant LasR quorum-sensing receptors with its native ligand and a suite of synthetic analogues reveal the importance of specific polar interactions for native receptor activation.
The content of this RSS Feed (c) The Royal Society of Chemistry

The development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1446-1452
DOI: 10.1039/C4OB02197E, PaperA. L. Hurski, Yu. V. Ermolovich, V. N. Zhabinskii, V. A. Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. It was applied for the preparation of brassinolide and related brassinosteroids.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tris(triazole) tripodal receptors as selective probes for citrate anion recognition and multichannel transition and heavy metal cation sensing

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1429-1438
DOI: 10.1039/C4OB02135E, PaperMaria del Carmen Gonzalez, Francisco Oton, Arturo Espinosa, Alberto Tarraga, Pedro Molina
The preparation and binding properties towards citrate anions and cations of two three-armed triazole based receptors are described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1439-1445
DOI: 10.1039/C4OB01823K, PaperAlexander O. Terent'ev, Mikhail Yu. Sharipov, Igor B. Krylov, Darya V. Gaidarenko, Gennady I. Nikishin
Bisperoxidation of styrenes with tert-butyl hydroperoxide in the presence of a catalytic amount of Mn(OAc)3.
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1347-1357
DOI: 10.1039/C4OB02277G, PaperAhmed Kamal, Abdul Rahim, Sd Riyaz, Y. Poornachandra, Moku Balakrishna, C. Ganesh Kumar, Syed Mohammed Ali Hussaini, B. Sridhar, Pavan Kumar Machiraju
2-Styryl quinolines have been synthesized regioselectively from 2-methyl-quinoline using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains.
The content of this RSS Feed (c) The Royal Society of Chemistry

Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and aza-Henry reactions

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1420-1428
DOI: 10.1039/C4OB02233E, PaperV. M. Tkachuk, V. A. Sukach, K. V. Kovalchuk, M. V. Vovk, V. G. Nenajdenko
A simple control of temperature and time in the nitromethane addition to 4-trifluoromethylated pyrimidin-2-ones allowed regioselective synthesis of isomeric products.
The content of this RSS Feed (c) The Royal Society of Chemistry

Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1395-1403
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony C. Bishop, Artur Krezel
A library of biarsenical probes was developed, characterized and used to probe structure-activity relationships for inhibition of sensitized protein tyrosine phosphatases (PTPs), revealing the superior inhibitory properties of 2[prime or minute],7[prime or minute]-substituted biarsenicals.
The content of this RSS Feed (c) The Royal Society of Chemistry

Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1367-1374
DOI: 10.1039/C4OB02383H, PaperDikhi Firmansyah, Marzena Banasiewicz, Daniel T. Gryko
The intramolecular dehydrogenative coupling mediated by potassium constitutes the general methodology leading to weakly emitting [small pi]-expanded heterocycles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of the Passerini and Ugi reactions in [small beta]-lactam aldehydes. Synthetic applications

27 January, 2015 - 09:17

Org. Biomol. Chem., 2015, 13,1387-1394
DOI: 10.1039/C4OB02289K, PaperBenito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, M. Pilar Ruiz, M. Rosario Torres
Ugi and Passerini multicomponent reactions on 4-oxoazetidine-2-carboxaldehydes allow the straightforward synthesis of highly functionalized [small beta]-lactams.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.