Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Developing a targeting system for bacterial membranes: measuring receptor-phosphatidylglycerol interactions with 1H NMR, ITC and fluorescence correlation spectroscopy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,502-512
DOI: 10.1039/C4OB01895H, PaperAmanda Alliband, Zifan Wang, Christopher Thacker, Douglas S. English, Dennis H. Burns
We report the development of a potential targeting system for bacterial membranes containing phosphatidylglycerol.
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Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-[small beta]-enaminonitriles

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,513-519
DOI: 10.1039/C4OB01801J, PaperYing-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang, Ying-ming Pan
In this work, a novel and highly stereoselective synthesis of Z-[small beta]-enaminonitriles from azides and [small alpha],[small beta]-unsaturated nitriles is reported.
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Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,477-486
DOI: 10.1039/C4OB01758G, PaperZhi-Cheng Dai, Yong-Fei Chen, Mao Zhang, Sheng-Kun Li, Ting-Ting Yang, Li Shen, Jian-Xin Wang, Shao-Song Qian, Hai-Liang Zhu, Yong-Hao Ye
A series of 1,2,3-triazole phenylhydrazone derivatives were designed and synthesized as antifungal agents.
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Chiral recognition with a benzofuran receptor that mimics an oxyanion hole

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,493-501
DOI: 10.1039/C4OB01954G, PaperAngel L. Fuentes de Arriba, Angel Gomez Herrero, Omayra H. Rubio, Laura M. Monleon, Luis Simon Rubio, Victoria Alcazar, Francisca Sanz, Joaquin R. Moran
Chiral resolution of a novel tripodal oxyanion-hole receptor with application in amino acid derivatives enantioselective extraction.
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Mixed non-covalent assemblies of ethynyl nile red and ethynyl pyrene along oligonucleotide templates

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,487-492
DOI: 10.1039/C4OB01860E, PaperPhilipp Ensslen, Yannic Fritz, Hans-Achim Wagenknecht
The mixture makes the difference: the assemblies of ethynyl pyrene and ethynyl nile red along oligonucleotide templates are highly ordered and yield dual fluorescence.
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A peptide topological template for the dispersion of [60]fullerene in water

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,348-352
DOI: 10.1039/C4OB02102A, CommunicationS. Bartocci, D. Mazzier, A. Moretto, M. Mba
Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL-1 have been obtained using a peptide topological template as the carrier.
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The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,465-476
DOI: 10.1039/C4OB01792G, PaperJ. M. Botubol-Ares, M. J. Duran-Pena, A. J. Macias-Sanchez, J. R. Hanson, I. G. Collado, R. Hernandez-Galan
The enantioselective synthesis of 3, (E)-8, (Z)-8, 20a and 20b is reported using RCM as key step. Based in spectroscopic differences, the structure assigned to the natural product has been revised to that of a [gamma]-butyrolactone.
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Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,452-464
DOI: 10.1039/C4OB01925C, PaperGerard Artigas, Paula Lopez-Senin, Carlos Gonzalez, Nuria Escaja, Vicente Marchan
Ligands with a preferred binding site in the bulged region of the stem-loop structure of Tau pre-mRNA have been identified by dynamic combinatorial chemistry.
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Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,447-451
DOI: 10.1039/C4OB02138J, PaperInna Perepichka, Soumen Kundu, Zoe Hearne, Chao-Jun Li
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp3 and sp C-H bonds with the assistance of a photocatalyst and visible light.
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Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,428-437
DOI: 10.1039/C4OB01869A, PaperAline Alves dos Santos Naujorks, Adriano Olimpio da Silva, Rosangela da Silva Lopes, Sergio de Albuquerque, Adilson Beatriz, Maria Rita Marques, Denis Pires de Lima
Novel naphthoquinone derivatives were synthesized and tested for trypanocidal and leishmanicidal activities. Compound 11a was the most active against T. cruzi.
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Bidirectional macrocyclization of peptides by double multicomponent reactions

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,438-446
DOI: 10.1039/C4OB01915F, PaperManuel G. Ricardo, Fidel E. Morales, Hilda Garay, Osvaldo Reyes, Dimitar Vasilev, Ludger A. Wessjohann, Daniel G. Rivera
Peptide macrocyclization by multicomponent reactions.
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Preparation of asymmetrical polyynes by a solid-supported Glaser-Hay reaction

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,424-427
DOI: 10.1039/C4OB02196G, PaperJessica S. Lampkowski, Corinn E. Durham, Marshall S. Padilla, Douglas D. Young
A novel approach to the synthesis of asymmetrical polyynes utilizing solid-supported chemistry.
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E. coli cells expressing the Baeyer-Villiger Monooxygenase 'MO14' (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01441C, PaperBenjamin D Summers, Muhiadin Omar, Thomas Ronson, Jared Cartwright, Michael Lloyd, Gideon Grogan
The Baeyer-Villiger monooxygenase (BVMO) 'MO14' from Rhodococcus jostii RHA1, is an enantioselective BVMO that catalyses the resolution of the model ketone substrate bicyclo[3.2.0]hept-2-en-6-one to the (1S, 5R)-2-oxa lactone and the...
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Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02348J, PaperRobert Wodtke, Gloria Ruiz Gomez , Manuela Kuchar, Teresa Pisabarro, Pavlina Novotna, Marie Urbanova, Jorg Steinbach, Jens Pietzsch, Reik Loser
The collagen telopeptides play an important role for lysyl oxidase-mediated crosslinking, a process which is deregulated during tumour progression. The DEKS motif which is located within the N-terminal telopeptide of...
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Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition

13 December, 2014 - 21:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02267J, CommunicationSu-Ying Xu, Xiaolong Sun, Rory L. Arrowsmith, Habo Ge, John S Fossey, Sofia I Pascu, Yun-Bao Jiang, Tony D James
A fluoride receptor has been developed where the interaction between the boronic acid and amine (NH) result in fluoride selectivity and enhanced fluorescence quenching.
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Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02258K, PaperSamuel Furse, LokHang Mak, Edward William Tate, Richard Templer, Oscar Ces, Rudiger Woscholski, Piers R J Gaffney
In this paper evidence is presented that the fatty acid component of an inositide substrate affects the kinetic parameters of the lipid phosphatase Salmonella Outer Protein B (SopB). A succinct...
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Fixation of sulfur dioxide into small molecules

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02139H, Review ArticleGang Liu, Congbin Fan, Jie Wu
Sulfonyl-derived functional groups can be found in a broad range of natural products, pharmaceuticals, and materials. Among the methods for the introduction of sulfonyl group into small molecules, the approach...
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N-Heterocyclic carbene-catalyzed [4+2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: an efficient assembly of spirocarbocyclic oxindole

11 December, 2014 - 21:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01706D, PaperYuanwei Xie, Yonglei Que, Tuanjie Li, Ling Zhu, Chenxia Yu, Changsheng Yao
A NHC-catalyzed [4+2] cyclization of 2-bromo-2-enal bearing [gamma]-H with 3-alkylenyloxindoles under mild reaction conditions gives spirocarbocyclic oxindoles containing one quaternary carbon in moderate to good yields with high diastereoselectivies. The...
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Copper-Catalyzed O-Arylation of N-Protected 1,2-Aminoalcohols Using Functionalized Trivalent Organobismuth Reagents

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02497D, CommunicationAlexandre Gagnon, Pauline Petiot, Julien Dansereau, Hebert Martin, Khene Imene, Tabinda Ahmad, Samira Samaali, Maxime Leroy, Pinsonneault Francis, Claude Y. Legault
The O-arylation of 1,2-aminoalcohols using functionalized triarylbismuth reagents is reported. The reaction can be performed using substoichiometric amounts of copper acetate and operates under mild conditions. Good functional group tolerance...
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Trigonal Scaffolds for Multivalent Targeting of Melanocortin Receptors

9 December, 2014 - 20:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02094D, PaperN. G. R. Dayan Elshan, Thanuja Jayasundera, Bobbi L. Anglin, Craig S. Weber, Ronald M. Lynch, Eugene A Mash
Melanocortin receptors can be used as biomarkers to detect and possibly treat melanoma. To these ends, molecules bearing one, two, or three copies of the weakly binding ligand MSH(4) were...
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