Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 16 hours ago

Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony Bishop, Artur Krezel
Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein...
The content of this RSS Feed (c) The Royal Society of Chemistry

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Quorum sensing (QS) via the synthesis and detection of N-acyl L-homoserine lactone (AHL) signals regulates important pathogenic and mutualistic phenotypes in many bacteria. Over the past two decades, the development...
The content of this RSS Feed (c) The Royal Society of Chemistry

Reactivity of aldehydes at the Air-Water Interface. Insights from molecular dynamics simulations and ab initio calculations.

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02029D, PaperMarilia T.C. Martins-Costa, Francisco F. Garcia-Prieto, Manuel F. Ruiz-Lopez
Understanding the influence of solute-solvent interactions on chemical reactivity has been a subject of intense research in the last decades. Theoretical studies have focused on bulk solvation phenomena and a...
The content of this RSS Feed (c) The Royal Society of Chemistry

Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02383H, PaperDaniel Gryko, Marzena Banasiewicz, Dikhi Firmansyah
Anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles in reasonable yields. The yield of the key step (K, toluene, O2)...
The content of this RSS Feed (c) The Royal Society of Chemistry

Domino Reaction Involving the Bestmann-Ohira Reagent and [small alpha],[small beta]-Unsaturated Aldehydes: Efficient Synthesis of functionalized pyrazoles

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02365J, PaperShakir Ahamad, Ashis Kumar Gupta, Ruchir Kant, Kishor Mohanan
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and [small alpha],[small beta]-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles. This reaction demonstrates the dual...
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02277G, PaperAhmed Kamal, Rahim Abdul, Sd Riyaz, Poornachandra Y, Balakrishna Moku, Ganesh Kumar C., Ali S. M. Hussaini, Sridhar Balasubramanian, Pavan Kumar Machiraju
2-Styryl quinolines (9a-l) have been synthesized regioselectively from 2-methyl-quinoline by using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains....
The content of this RSS Feed (c) The Royal Society of Chemistry

Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and nitro-Mannich reactions

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02233E, PaperValentine Nenajdenko, M Vovk, Volodymyr Andriyovych Sukach, Viktor Mykolayovych Tkachuk, K Kovalchuk
Regioselective base-catalyzed addition of nitromethane to 2-oxo-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylates is reported. It was found that Michael-like pathway is highly reversible and substantially dominating under conditions of kinetic control (0-5 [degree]C, 10 h)...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02385D, PaperXiao-Liang Xu, Chun-Lei Yu, Wen Chen, Ying-Chao Li, Li-Juan Yang, Yan Li, Hong-Bin Zhang, Xiao-Dong Yang
A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence...
The content of this RSS Feed (c) The Royal Society of Chemistry

Investigation of the Passerini and Ugi Reactions in [small beta]-Lactam Aldehydes. Synthetic Applications

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02289K, PaperBenito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, Maria Pilar Ruiz, M. Rosario Torres
Passerini (P-3CR) and Ugi (U-4CR) reactions were investigated in 4-oxoazetidine-2-carboxaldehydes affording the corresponding Passerini and Ugi adducts with moderate diastereoselectivity in high yields. Fortunately, the obtained mixtures of isomers syn/anti...
The content of this RSS Feed (c) The Royal Society of Chemistry

Molecular recognition of upper rim functionalized cavitand and its unique dimeric capsule in the solid state

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02251C, PaperTakeharu HAINO, Ryo Sekiya, Mutsumi Kobayashi, Mei Takatsuka
Cavitand 1 possesses four 2,2'-bipirydyl pillars on its upper rim that encapsulate small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form...
The content of this RSS Feed (c) The Royal Society of Chemistry

Development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02197E, PaperAlaksiej L. Hurski, Yuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii, Vladimir Aleksandrovich Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. An efficient one-pot procedure for the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Identification of Benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Ting Pan, Bing Chen, Qianwen Li, Hui Zhang, Chuan Bai
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclodextrin- and Calixarene-based Polycationic Amphiphiles as Gene Delivery Systems: A Structure-Activity Relationship Study

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02204A, PaperLaura Gallego-Yerga, Michela Lomazzi, Valentina Franceschi, Francesco Sansone, Carmen Ortiz Mellet, Gaetano Donofrio, Alessandro Casnati, Jose Manuel Garcia Fernandez
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular...
The content of this RSS Feed (c) The Royal Society of Chemistry

Quinoline-derived two-photon sensitive quadrupolar probes

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9899-9908
DOI: 10.1039/C4OB01551G, PaperPetra Dunkel, Christine Tran, Thibault Gallavardin, Hamid Dhimane, David Ogden, Peter I. Dalko
Quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile approach to spirocyclic 2-azido indolines via azidation of indoles with ceric ammonium nitrate

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9769-9772
DOI: 10.1039/C4OB01549E, CommunicationJing Li, Mao Liu, Qi Li, Hua Tian, Yian Shi
This paper describes azidation of indoles with NaN3 and ceric ammonium nitrate (CAN), giving a variety of spirocyclic 2-azido indolines in good yields and moderate diastereoselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of [small alpha]-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9853-9863
DOI: 10.1039/C4OB01476F, PaperThibaut Denoel, Astrid Zervosen, Christian Lemaire, Bernard Joris, Mireille Herve, Didier Blanot, Guillermo Zaragoza, Andre Luxen
The synthesis of modified tripeptides (S)-Ala-[gamma]-(R)-Glu-X, where X = (R,S) or (R,R) diastereomers of [small alpha]-benzyl or [small alpha]-(4-azidobenzyl)lanthionine, was carried out.
The content of this RSS Feed (c) The Royal Society of Chemistry

Contributions of pocket depth and electrostatic interactions to affinity and selectivity of receptors for methylated lysine in water

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02231A, PaperJoshua Beaver, Brendan Peacor, Julianne Bain, Lindsey Ingerman, Marcey Waters
Dynamic combinatorial chemistry was used to generate a set of receptors for peptides containing methylated lysine (KMen, n = 0=3) and study the contribution of electrostatic effects and pocket depth...
The content of this RSS Feed (c) The Royal Society of Chemistry

An expedient approach to 1, 2-dihydroisoquinoline derivatives via Cobalt catalysed 6-endo dig cyclization followed by Mannich condensation of o-alkynylarylaldimines

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02036G, CommunicationUrvashi ., Gaurav Kumar Rastogi, Sandeep K Ginotra, Alka Agarwal, Vibha Tandon
A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1, 2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9793-9796
DOI: 10.1039/C4OB01981D, CommunicationJunyan Han, Tae Hoon Lee, Ching-Hsuan Tung, Daniel Y. Lee
A novel mitochondria-targeting carrier QCy7HA was developed, which transported the covalently attached doxorubicin (DOX) to mitochondria specifically, resulting in the limitation of the effects of P-glycoprotein efflux pumps of multidrug-resistant cells on DOX.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly efficient modular metal-free synthesis of 3-substituted 2-quinolones

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9786-9788
DOI: 10.1039/C4OB02131B, CommunicationAlexander V. Aksenov, Alexander N. Smirnov, Nicolai A. Aksenov, Inna V. Aksenova, Asiyat S. Bijieva, Michael Rubin
A modular approach to 3-substituted 2-quinolones via a cascade annulation reaction between 4-nitroketones and hydrazines has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.