Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Enhancing circularly polarised luminescence by extending the [small pi]-conjugation of axially chiral compounds

11 June, 2014 - 00:54

Org. Biomol. Chem., 2014, 12,4342-4346
DOI: 10.1039/C4OB00340C, PaperYoko Kitayama, Tomoyuki Amako, Nozomu Suzuki, Michiya Fujiki, Yoshitane Imai
[small pi]-Conjugated (R)- and (S)-2,2[prime or minute]-diphenyl-4-biphenanthrol (VAPOL) exhibited an efficient circularly polarised luminescence (CPL) ([similar]1.3 [times] 10-3) at 376 nm. By comparison, (R)- and (S)-3,3-diphenyl-2,2-bi-1-naphthol (VANOL) exhibited no CPL.
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Aggregation-induced emission enhancement upon Al3+ complexation with a tetrasulfonated calix[4]bisazacrown fluorescent molecular sensor

11 June, 2014 - 00:54

Org. Biomol. Chem., 2014, 12,4335-4341
DOI: 10.1039/C4OB00187G, PaperYi-Bin Ruan, Alexis Depauw, Isabelle Leray
A new water-soluble ligand bearing a tetrasulfonated calix[4]arene was constructed for ratiometric detection of Al3+ based on an aggregation-induced fluorescence enhancement mechanism.
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Synthesis and antimalarial activity of prodigiosenes

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4132-4142
DOI: 10.1039/C3OB42548G, PaperEstelle Marchal, Deborah A. Smithen, Md. Imam Uddin, Andrew W. Robertson, David L. Jakeman, Vanessa Mollard, Christopher D. Goodman, Kristopher S. MacDougall, Sherri A. McFarland, Geoffrey I. McFadden, Alison Thompson
Dibutyl tin complexes of prodigiosenes exhibit nanomolar IC50 values against 3D7 Plasmodium falciparum, with general toxicity demonstrably lower than that of the natural product.
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Versatile post-functionalization of the external shell of cowpea chlorotic mottle virus by using click chemistry

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4065-4069
DOI: 10.1039/C4OB00505H, CommunicationC. A. Hommersom, B. Matt, A. van der Ham, J. J. L. M. Cornelissen, N. Katsonis
We present the modification of the outer protein shell of cowpea chlorotic mottle virus (CCMV) with linear and strained alkyne groups for post-functionalization by click chemistry.
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Improving alkynyl(aryl)iodonium salts: 2-anisyl as a superior aryl group

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4156-4162
DOI: 10.1039/C4OB00556B, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.David J. Hamnett, Wesley J. Moran
This article describes the effects of varying this iodoarene building block on the synthesis, reactivity and stability of these salts.
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A versatile synthesis of "tafuramycin A": a potent anticancer and parasite attenuating agent

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4260-4264
DOI: 10.1039/C4OB00842A, PaperIbrahim M. El-Deeb, Faith J. Rose, Peter C. Healy, Mark von Itzstein
An improved and versatile synthesis of tafuramycin A, a potent anticancer and parasite-attenuating agent, is reported.
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A model study for tethering of (bio)active molecules to biomaterial surfaces through arginine

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4089-4092
DOI: 10.1039/C4OB00160E, CommunicationF. Taraballi, L. Russo, C. Battocchio, G. Polzonetti, F. Nicotra, L. Cipolla
A new approach for tethering of bioactive molecules to proteins via arginine side chains is proposed.
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Synthesis and complexation study of new ExTTF-based hosts for fullerenes

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4117-4123
DOI: 10.1039/C3OB42477D, PaperHassan Iden, Frederic-Georges Fontaine, Jean-Francois Morin
New exTTF-based hosts with different linkers have been prepared and their ability to complex fullerenes was studied in diluted solution using various solvents.
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Investigating peptide sequence variations for 'double-click' stapled p53 peptides

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4074-4077
DOI: 10.1039/C4OB00742E, CommunicationYu Heng Lau, Peterson de Andrade, Niklas Skold, Grahame J. McKenzie, Ashok R. Venkitaraman, Chandra Verma, David P. Lane, David R. Spring
Evaluating the influence of staple position, azido amino acid side-chain length and point mutation on the activity of 'double-click' stapled p53 peptides.
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Carbonate phosphonium salts as catalysts for the transesterification of dialkyl carbonates with diols. The competition between cyclic carbonates and linear dicarbonate products

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4143-4155
DOI: 10.1039/C4OB00655K, PaperMaurizio Selva, Alessio Caretto, Marco Noe, Alvise Perosa
Methylcarbonate and bicarbonate methyltrioctylphosphonium salts were excellent catalysts for the transesterification of dialkyl carbonates with diols: cyclic or linear carbonates are obtained.
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A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4084-4088
DOI: 10.1039/C4OB00652F, CommunicationDong Ding, Xiaobing Lv, Jian Li, Lin Qiu, Guangyang Xu, Jiangtao Sun
A palladium-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization under an air atmosphere has been developed under relatively mild conditions.
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Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4124-4131
DOI: 10.1039/C4OB00268G, PaperSarah J. Pike, James Raftery, Simon J. Webb, Jonathan Clayden
The effect of Schellman motifs on the adoption of stable 310 helical conformations in a series of aminoisobutyric (Aib) oligomers has been studied in the solid state and solution.
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Palladium-catalyzed tandem reaction of 2-hydroxyarylacetonitriles with sodium sulfinates: one-pot synthesis of 2-arylbenzofurans

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4078-4083
DOI: 10.1039/C4OB00575A, CommunicationJiuxi Chen, Jianjun Li, Weike Su
Palladium-catalyzed desulfinative addition and intramolecular annulation tandem reactions of 2-hydroxyarylacetonitriles with sodium sulfinates for one-pot synthesis of 2-arylbenzofurans.
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Rigid tetrazine fluorophore conjugates with fluorogenic properties in the inverse electron demand Diels-Alder reaction

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4177-4185
DOI: 10.1039/C4OB00245H, PaperAchim Wieczorek, Tiago Buckup, Richard Wombacher
1,2,4,5-Tetrazine fluorophore derivatives with structurally rigid molecular designs were synthesized using Sonogashira and Stille cross-coupling as well as copper-catalyzed azide-alkyne cycloaddition.
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Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4252-4259
DOI: 10.1039/C4OB00356J, PaperWen-Bing Qin, Jia-Yi Zhu, Yu-Bo Kong, Yun-Hong Bao, Zheng-Wang Chen, Liang-Xian Liu
Metal-free C-4-selective indolation of pyridines using (Boc)2O as an activating agent.
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Synthesis of 1,4-dihydroquinoline derivatives under transition-metal-free conditions and their diverse applications

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4243-4251
DOI: 10.1039/C4OB00475B, PaperXue-Qiang Chu, You Zi, Hua Meng, Xiao-Ping Xu, Shun-Jun Ji
A transition-metal-free process for the synthesis of 1,4-dihydroquinoline derivatives starting from simple enaminones with aldehydes via intermolecular cascade cyclization in a one-pot protocol is developed.
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A theoretical study on the catalytic mechanism of the retaining [small alpha]-1,2-mannosyltransferase Kre2p/Mnt1p: the impact of different metal ions on catalysis

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4201-4210
DOI: 10.1039/C4OB00286E, PaperAdela Bobovska, Igor Tvaroska, Juraj Kona
The catalysis of the glycosyltransferase Kre2p/Mnt1p in the presence of various metal ions (Mn2+, Mg2+, Zn2+ and Ca2+) is predicted as a stepwise SNi-like reaction.
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Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4233-4242
DOI: 10.1039/C4OB00175C, PaperAna I. Sanchez, Ricardo Meneses, Jose M. Minguez, Araceli Nunez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Alvarez-Builla, Alvaro Cortes-Cabrera, Federico Gago, Emma Terricabras, Victor Segarra
Thienopyrimidin-4-amines have been synthesized, evaluated and modelled as phosphodiesterase inhibitors.
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Preparation of functionalized heteroaromatics using an intramolecular Wittig reaction

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4044-4050
DOI: 10.1039/C4OB00464G, PerspectiveUtpal Das, Yi-Ling Tsai, Wenwei Lin
An approach for the synthesis of heteroaromatics starting from electron-deficient olefins (or aldehydes and acylimines), acyl chlorides and phosphines using an intramolecular Wittig reaction as the key step is described.
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The asymmetric Cu(II)-indolinylmethanol complex catalyzed Diels-Alder reaction of 2-vinylindoles with [small beta],[gamma]-unsaturated [small alpha]-ketoesters: an efficient route to functionalized tetrahydrocarbazoles

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4172-4176
DOI: 10.1039/C4OB00196F, PaperBanlai Ouyang, Tingting Yu, Renshi Luo, Gui Lu
An efficient asymmetric Diels-Alder reaction of 2-vinylindoles with [small beta],[gamma]-unsaturated [small alpha]-ketoesters for the synthesis of functionalized tetrahydrocarbazoles.
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