Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 6 hours 51 min ago

Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1634-1638
DOI: 10.1039/C4OB02128B, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marielle M. E. Delville, Kaspar Koch, Jan C. M. van Hest, Floris P. J. T. Rutjes
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studies on the diastereoselective oxidation of 1-thio-[small beta]-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1904-1914
DOI: 10.1039/C4OB02030H, PaperJuan Francisco Moya-Lopez, Eleonora Elhalem, Rocio Recio, Eleuterio Alvarez, Inmaculada Fernandez, Noureddine Khiar
The exo-anomeric effect paves the way for the synthesis of the usually less favored RS-[small beta]-sulfinyl glycoside as a single diastereoisomer.
The content of this RSS Feed (c) The Royal Society of Chemistry

Differentiation of small alkane and alkyl halide constitutional isomers via encapsulation

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1869-1877
DOI: 10.1039/C4OB02357A, PaperMatthew R. Sullivan, Bruce C. Gibb
Previously we have demonstrated that host 1 is capable of hydrocarbon gas separation by selective sequestration of butane from a mixture with propane in the headspace above a solution of the host (C. L. D. Gibb, B. C. Gibb, J. Am. Chem. Soc., 2006, 128, 16498-16499).
The content of this RSS Feed (c) The Royal Society of Chemistry

E. coli cells expressing the Baeyer-Villiger monooxygenase 'MO14' (ro03437) from Rhodococcus jostii RHA1 catalyse the gram-scale resolution of a bicyclic ketone in a fermentor

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1897-1903
DOI: 10.1039/C4OB01441C, PaperBenjamin D. Summers, Muhiadin Omar, Thomas O. Ronson, Jared Cartwright, Michael Lloyd, Gideon Grogan
(1S,5R)-2-Oxalactone of >99% ee and (1S,5R)-ketone of 96% ee are produced after approximately 14 h at a temperature of 16 [degree]C.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1878-1896
DOI: 10.1039/C4OB02348J, PaperRobert Wodtke, Gloria Ruiz-Gomez, Manuela Kuchar, M. Teresa Pisabarro, Pavlina Novotna, Marie Urbanova, Jorg Steinbach, Jens Pietzsch, Reik Loser
The conformational stabilisation of the DEKS motif at the [small alpha]1(I) collagen N-telopeptide within a cyclic hexapeptide together with its conformational analysis is described. This sequence is critical for lysyl oxidase-mediated collagen crosslinking, a process which is deregulated during tumour progression.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fixation of sulfur dioxide into small molecules

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1592-1599
DOI: 10.1039/C4OB02139H, Review ArticleGang Liu, Congbin Fan, Jie Wu
Recent advances in the insertion of sulfur dioxide under transition metal catalysis or metal-free conditions via a radical process are presented.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-heterocyclic carbene-catalyzed [4 + 2] cyclization of 2-bromo-2-enal with 3-alkylenyloxindoles: efficient assembly of spirocarbocyclic oxindole

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1829-1835
DOI: 10.1039/C4OB01706D, PaperYuanwei Xie, Yonglei Que, Tuanjie Li, Ling Zhu, Chenxia Yu, Changsheng Yao
A NHC-catalyzed [4 + 2] cyclization of 2-bromo-2-enal bearing [gamma]-H with 3-alkylenyloxindoles under mild reaction conditions gives spirocarbocyclic oxindoles containing one quaternary carbon with high diastereoselectivies.
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1860-1868
DOI: 10.1039/C4OB02321H, PaperOscar Francesconi, Matteo Gentili, Francesco Bartoli, Andrea Bencini, Luca Conti, Claudia Giorgi, Stefano Roelens
Excellent affinities and selectivities toward triphosphates are achieved through an adaptive ditopic receptor featuring a metal ion and a macrocyclic polyammonium cation binding sites, concertedly bridging phosphate anions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Amphiphilic benzothiadiazole-triphenylamine-based aggregates that emit red light in water

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1818-1828
DOI: 10.1039/C4OB02181A, PaperTsutomu Ishi-i, Ikumi Kitahara, Shimpei Yamada, Yusuke Sanada, Kazuo Sakurai, Asami Tanaka, Naoya Hasebe, Toshitada Yoshihara, Seiji Tobita
An amphiphilic donor-acceptor dye can provide red light emission in water in an aggregate state.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studies towards the synthesis of bielschowskysin. Construction of the highly functionalized bicyclo[3.2.0]heptane segment

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1846-1859
DOI: 10.1039/C4OB02182G, PaperAnupam Jana, Sujit Mondal, Subrata Ghosh
A stereocontrolled approach for the construction of a highly functionalized bicyclo[3.2.0]heptane derivative embodying the bridged lactone present in the diterpene bielschowskysin is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Ambient temperature synthesis of [small beta],[small beta][prime or minute]-fused nickel(II) pyrrolo[1,2-a]pyrazinoporphyrins via a DBSA-catalyzed Pictet-Spengler approach

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1836-1845
DOI: 10.1039/C4OB02370F, PaperDileep Kumar Singh, Mahendra Nath
Synthesis of novel [small beta],[small beta][prime or minute]-fused nickel(II) pyrrolo[1,2-a]pyrazinoporphyrins is accomplished for the first time at ambient temperature via a DBSA-catalyzed Pictet-Spengler approach.
The content of this RSS Feed (c) The Royal Society of Chemistry

An asymmetric pericyclic cascade approach to 3-alkyl-3-aryloxindoles: generality, applications and mechanistic investigations

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1807-1817
DOI: 10.1039/C4OB02526A, PaperEdward Richmond, Kenneth B. Ling, Nicolas Duguet, Lois B. Manton, Nihan Celebi-Olcum, Yu-Hong Lam, Sezen Alsancak, Alexandra M. Z. Slawin, K. N. Houk, Andrew D. Smith
The reaction of L-serine derived N-arylnitrones with alkylarylketenes generates 3-alkyl-3-aryloxindoles in good yields and excellent enantioselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Multicomponent one-pot synthesis of highly-functionalized pyrrole-3-carbonitriles in aqueous medium and their computational study

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1800-1806
DOI: 10.1039/C4OB02229G, PaperRamakanth Pagadala, Devendar Reddy Kommidi, Shravankumar Kankala, Suresh Maddila, Parvesh Singh, Brenda Moodley, N. A. Koorbanally, Sreekantha B. Jonnalagadda
A one-pot protocol involving four-components in water is developed to synthesize functionalized pyrroles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Identification of benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1792-1799
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Bing Chen, Ting Pan, Qianwen Li, Hui Zhang, Chuan Bai
A benzenesulfonamide quinoline compound with potent anti-HIV-1 replication activity and low toxicity by targeting HIV-1 Rev protein was identified with high-throughput screening and SAR studies.
The content of this RSS Feed (c) The Royal Society of Chemistry

Trigonal scaffolds for multivalent targeting of melanocortin receptors

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1778-1791
DOI: 10.1039/C4OB02094D, PaperN. G. R. Dayan Elshan, Thanuja Jayasundera, Bobbi L. Anglin, Craig S. Weber, Ronald M. Lynch, Eugene A. Mash
Short, efficient syntheses of multivalent molecules targeted to the human melanocortin 4 receptor based on phloroglucinol, tripropargylamine, and 1,4,7-triazacyclononane are described.
The content of this RSS Feed (c) The Royal Society of Chemistry

A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1768-1777
DOI: 10.1039/C4OB02376E, PaperMaria Victoria Rojo, Lucie Guetzoyan, Ian. R. Baxendale
An immobilised iridium hydrogen transfer catalyst has been developed for use in flow based processing by incorporation of a ligand into a porous polymeric monolithic flow reactor.
The content of this RSS Feed (c) The Royal Society of Chemistry

A BODIPY-luminol chemiluminescent resonance energy-transfer (CRET) cassette for imaging of cellular superoxide

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1763-1767
DOI: 10.1039/C4OB02413C, PaperS. Bag, J.-C. Tseng, J. Rochford
Chemiluminescent resonance energy transfer is investigated for a BODIPY-luminol dyad demonstrating in cellulo biochemiluminescence with reactive oxygen species in activated splenocytes.
The content of this RSS Feed (c) The Royal Society of Chemistry

A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1629-1633
DOI: 10.1039/C4OB02169J, CommunicationMarijana Radic Stojkovic, Patryciusz Piotrowski, Carsten Schmuck, Ivo Piantanida
A DNA-targeting dye exhibited pH-dependent selectivity toward AT-DNA (pH 7) or GC-DNA (pH 5), accompanied by fluorimetric (pH 5) and ICD (pH 7) recognition.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, and QSAR analysis of anti-oncological active spiro-alkaloids

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1741-1753
DOI: 10.1039/C4OB02149E, PaperAdel S. Girgis, Siva S. Panda, I. S. Ahmed Farag, A. M. El-Shabiny, A. M. Moustafa, Nasser S. M. Ismail, Girinath G. Pillai, Chandramukhi S. Panda, C. Dennis Hall, Alan R. Katritzky
QSAR study describes the anti-neoplastic spiro-alkaloids with relevant molecular descriptors using CODESSA III software.
The content of this RSS Feed (c) The Royal Society of Chemistry

Syntheses of arabinose-derived pyrrolidine catalysts and their applications in intramolecular Diels-Alder reactions

4 February, 2015 - 11:17

Org. Biomol. Chem., 2015, 13,1754-1762
DOI: 10.1039/C4OB02219J, PaperTony K. M. Shing, Kwun W. Wu, Ho T. Wu, Qicai Xiao
Six hydroxylated pyrrolidine catalysts were synthesized from D-arabinose and applied to asymmetric intramolecular Diels-Alder reactions with concomitant desymmetrization.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.