Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 7 hours 47 min ago

Tandem metal relay catalysis: from cyclopropene to polysubstituted furan

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5802-5806
DOI: 10.1039/C4OB00987H, PerspectiveChuanling Song, Jianwu Wang, Zhenghu Xu
Transmetalation is a key step in traditional coupling reactions. An efficient synthetic methodology of tetrasubstituted furans from cyclopropenes with Cu-Pd transmetalation relay catalysis was presented.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 4-methyl-N[prime or minute]-(3-alkyl-2r,6c-diarylpiperidin-4-ylidene)-1,2,3-thiadiazole-5-carbohydrazides with antioxidant, antitumor and antimicrobial activities

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5911-5921
DOI: 10.1039/C4OB00739E, PaperKodisundaram Paulrasu, Arul Duraikannu, Manikandan Palrasu, Amirthaganesan Shanmugasundaram, Murugavel Kuppusamy, Balasankar Thirunavukkarasu
The structures of the newly synthesized 4-methyl-N[prime or minute]-(3-alkyl-2r,6c-diarylpiperidin-4-ylidene)-1,2,3-thiadiazole-5-carbohydrazide (5a-5l) were confirmed by spectral and elemental analysis.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile route to 5-methyl-5H-indeno[1,2-c]quinolones via palladium-catalyzed cyclization of 2-alkynylbromobenzenes with N,N-dimethyl-2-alkynylanilines

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5861-5865
DOI: 10.1039/C4OB00706A, PaperXiaolin Pan, Yong Luo, Yunyan Kuang, Guangming Li
A tandem reaction catalyzed by palladium is developed to provide a facile and simple route for the synthesis of 5-methyl-5H-indeno[1,2-c]quinolones.
The content of this RSS Feed (c) The Royal Society of Chemistry

Total synthesis of (+)-monocerin via tandem dihydroxylation-SN2 cyclization and a copper mediated tandem cyanation-lactonization approach

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5973-5980
DOI: 10.1039/C4OB00965G, PaperU. Nookaraju, Eeshwaraiah Begari, Pradeep Kumar
A simple and novel synthesis of (+)-monocerin was achieved from 3-buten-1-ol employing HKR, Julia olefination, intramolecular tandem Sharpless asymmetric dihydroxylation-SN2 cyclization and a novel copper mediated tandem cyanation-cyclization as the key steps.
The content of this RSS Feed (c) The Royal Society of Chemistry

Theoretical study of the reaction of hydroxyl radicals with uridine: the influence of ribose and solvent

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5891-5897
DOI: 10.1039/C4OB00168K, PaperYa Gao, Xiayu Chen, Li Zhong, Wei Yao, Shujin Li
The reaction of [radical dot]OH with uridine has been investigated. The influence of ribose and the solvent effect are presented.
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalytic synthesis of optically active [small beta]-branched [small alpha]-amino esters via asymmetric biomimetic transamination

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5856-5860
DOI: 10.1039/C4OB00684D, PaperCunxiang Su, Ying Xie, Hongjie Pan, Mao Liu, Hua Tian, Yian Shi
This paper describes an efficient asymmetric biomimetic transamination of [small alpha]-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of [small beta]-branched [small alpha]-amino esters in 50-96% yield and 87-95% ee.
The content of this RSS Feed (c) The Royal Society of Chemistry

Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5847-5855
DOI: 10.1039/C4OB00733F, PaperNaomu Miyamae, Naruhisa Watanabe, Maya Moritaka, Keiji Nakano, Yoshiyasu Ichikawa, Hiyoshizo Kotsuki
A highly diastereoselective and enantioselective method for the asymmetric desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure was developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

A powerful combination: recent achievements on using TBAI and TBHP as oxidation system

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5807-5817
DOI: 10.1039/C4OB00276H, Review ArticleXiao-Feng Wu, Jin-Long Gong, Xinxin Qi
Recent achievements in the use of TBAI and TBHP as an oxidation system have been summarized and discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5745-5751
DOI: 10.1039/C4OB00073K, PaperNicolai Stuhr-Hansen, Nicolai Bork, Kristian Stromgaard
Thiophenol catalysed formations of amides from alkyl thioesters and primary amines in DMF were studied experimentally and theoretically.
The content of this RSS Feed (c) The Royal Society of Chemistry

[Pd([small mu ]-Cl)Cl(IPr*)]2: a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5586-5589
DOI: 10.1039/C4OB01269K, CommunicationMathieu Lesieur, Alexandra M. Z. Slawin, Catherine S. J. Cazin
The new well-defined catalyst [Pd([small mu ]-Cl)Cl(IPr*)]2 enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls.
The content of this RSS Feed (c) The Royal Society of Chemistry

Diels-Alder reactions of 4-halo masked o-benzoquinones. Experimental and theoretical investigations

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5656-5668
DOI: 10.1039/C4OB00856A, PaperSeshi Reddy Surasani, Santosh Kumar Reddy Parumala, Rama Krishna Peddinti
The title reactions afforded densely substituted bicyclo-[2.2.2]octenones in high yields and high selectivities. The transition-state energies and global electronic indexes computed at the B3LYP/6-31G** theory level supported the observed selectivities of the reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5710-5718
DOI: 10.1039/C4OB00893F, PaperBo-Tao Xin, Gerjan de Bruin, Martijn Verdoes, Dmitri V. Filippov, Gijs A. van der Marel, Herman S. Overkleeft
Peptide epoxyketones are potent and selective proteasome inhibitors.
The content of this RSS Feed (c) The Royal Society of Chemistry

Selective recognition of anionic cell membranes using targeted liposomes coated with zinc(II)-bis(dipicolylamine) affinity units

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5645-5655
DOI: 10.1039/C4OB00924J, PaperSerhan Turkyilmaz, Douglas R. Rice, Rachael Palumbo, Bradley D. Smith
Liposomes containing phospholipid-PEG conjugates with terminal zinc([i without dot][i without dot])-bis(dipicolylamine) affinity units selectively target anionic membrane surfaces including the exterior of bacterial and dead/dying mammalian cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed oxidative carbonylative coupling of arylboronic acids with terminal alkynes to alkynones

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5590-5593
DOI: 10.1039/C4OB01128G, CommunicationKishore Natte, Jianbin Chen, Helfried Neumann, Matthias Beller, Xiao-Feng Wu
The first example of palladium-catalyzed oxidative carbonylation of arylboronic acids with terminal alkynes has been developed. By an appropriate combination of a palladium salt, a ligand, and an oxidant, the desired alkynones were isolated in moderate to good yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of tertiary propargylamines via a rationally designed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5597-5600
DOI: 10.1039/C4OB01055H, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jiayi Wang, Qiaoying Shen, Pinzhen Li, Yanqing Peng, Gonghua Song
A novel approach for the synthesis of tertiary propargylamines is achieved through a Cu(OAc)2-catalyzed multicomponent reaction of primary amines, formaldehyde, arylboronic acids and alkynes.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5733-5744
DOI: 10.1039/C4OB00759J, PaperDaniele Ragno, Olga Bortolini, Pier Paolo Giovannini, Alessandro Massi, Salvatore Pacifico, Anna Zaghi
Symmetrical-to-unsymmetrical benzil conversion is realized by a one-pot two-step procedure involving a chemoselective cross-benzoin reaction followed by microwave-assisted oxidation of the benzoylated benzoin intermediate.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of quinazolines via CuO nanoparticles catalyzed aerobic oxidative coupling of aromatic alcohols and amidines

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5752-5756
DOI: 10.1039/C4OB00569D, PaperWu Zhang, Fei Guo, Fei Wang, Na Zhao, Liang Liu, Jia Li, Zhenghua Wang
Quinazoline derivatives were obtained via CuO nanoparticles catalyzed reaction of N-arylamidines and aromatic alcohols in air.
The content of this RSS Feed (c) The Royal Society of Chemistry

Multivalent glycosylated nanoparticles for studying carbohydrate-protein interactions

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5563-5573
DOI: 10.1039/C4OB00827H, Review ArticleAvijit K. Adak, Hong-Jyune Lin, Chun-Cheng Lin
Glyconanoparticles decorated with multiple copies of various biologically relevant carbohydrates serve as scaffolds for protein binding assay, molecular imaging, targeted therapy, and bacterium detection.
The content of this RSS Feed (c) The Royal Society of Chemistry

A general approach to the synthesis of 5-S-functionalized pyrimidine nucleosides and their analogues

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5634-5644
DOI: 10.1039/C4OB00597J, PaperDzmitry G. Kananovich, Alli Reino, Kaja Ilmarinen, Marko Roomusoks, Mati Karelson, Margus Lopp
A palladium-catalyzed C-S coupling reaction has been used as a key step for the introduction of S-functionality at the C-5 position of the cytosine and uracil nucleosides and their analogues.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides

15 July, 2014 - 07:54

Org. Biomol. Chem., 2014, 12,5594-5596
DOI: 10.1039/C4OB00957F, CommunicationYoshihiro Miyake, Shin-ichi Ota, Masashi Shibata, Kazunari Nakajima, Yoshiaki Nishibayashi
The reactions of primary and secondary benzylic chlorides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding benzylic trifluoromethylated products in good to high yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.