Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 7 hours 4 min ago

Cooperative N-heterocyclic carbene (NHC)-Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3009-3015
DOI: 10.1039/C4OB00145A, CommunicationYu Zhang, Yingyan Lu, Weifang Tang, Tao Lu, Ding Du
A novel synthesis of spirooxindoles has been developed by cooperative NHC-Lewis acid-mediated formal [3 + 2] annulations of alkynyl aldehydes with isatins.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the dinoflagellate Alexandrium tamarense (Axat-2)

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3016-3020
DOI: 10.1039/C4OB00071D, CommunicationShigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
We synthesized the genetically predicted biosynthetic intermediates of saxitoxin (STX) (1), 2, 6 and 7, and identified 2 and 6 in microorganisms.
The content of this RSS Feed (c) The Royal Society of Chemistry

Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3163-3166
DOI: 10.1039/C4OB00203B, CommunicationYulong Liu, Xie Wang, Xiaoyun Wang, Wei He
Both enantiomers of diethyl 2-(3-oxo-1,3-arylpropyl)malonate are easily prepared by a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived organocatalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tetrathiafulvalene mono- and bis-1,2,3-triazole precursors by click chemistry: structural diversity and reactivity

29 April, 2014 - 14:17

Org. Biomol. Chem., 2014, 12,3167-3174
DOI: 10.1039/C4OB00148F, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas Biet, Narcis Avarvari
The ruthenium-catalyzed alkyne-azide cycloaddition reaction allowed the synthesis of electroactive TTF-mono and -bis(1,2,3-triazoles) which were structurally characterized and investigated in protonation and alkylation reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A selenium-contained aggregation-induced "turn-on" fluorescent probe for hydrogen peroxide

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3004-3008
DOI: 10.1039/C4OB00206G, CommunicationYe-Xin Liao, Kun Li, Ming-Yu Wu, Tong Wu, Xiao-Qi Yu
A novel selenium-contained aggregation-induced "turn-on" fluorescent probe was presented, which could selectively respond to hydrogen peroxide over other ROS in aqueous solution.
The content of this RSS Feed (c) The Royal Society of Chemistry

Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3026-3036
DOI: 10.1039/C4OB00115J, PaperOleg V. Larionov, David Stephens, Adelphe M. Mfuh, Hadi D. Arman, Anastasia S. Naumova, Gabriel Chavez, Behije Skenderi
Mechanistic and synthetic studies of the Mo/P-catalyzed N-oxidation of N-heterocycles with hydrogen peroxide shed light on the role and nature of the catalytically active species.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic amounts of triarylaminium salt initiated aerobic oxidative coupling of N-aryl tetrahydroisoquinolines

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3123-3128
DOI: 10.1039/C3OB42454E, PaperCongde Huo, Cheng Wang, Mingxia Wu, Xiaodong Jia, Xicun Wang, Yong Yuan, Haisheng Xie
A novel, efficient in catalytic amounts, stable radical cation triarylaminium salt induced aerobic oxidative [small alpha]-C-H functionalization of tertiary amines has been developed.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquinolines

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3114-3122
DOI: 10.1039/C4OB00231H, PaperChen Xu, Hong-Mei Li, Xiao-Er Yuan, Zhi-Qiang Xiao, Zhi-Qiang Wang, Wei-Jun Fu, Bao-Ming Ji, Xin-Qi Hao, Mao-Ping Song
An efficient NHC-modulated Pd/Cu cocatalyzed three-component coupling reaction for the synthesis of 2,6-diarylquinolines via oxidation, cyclization and Suzuki reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A versatile approach for site-directed spin labeling and structural EPR studies of RNAs

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3129-3136
DOI: 10.1039/C3OB42154F, PaperElena S. Babaylova, Anton V. Ivanov, Alexey A. Malygin, Maria A. Vorobjeva, Alia G. Venyaminova, Yuliya F. Polienko, Igor A. Kirilyuk, Olesya A. Krumkacheva, Matvey V. Fedin, Galina G. Karpova, Elena G. Bagryanskaya
We propose and validate a new site-directed spin labeling approach affording EPR distance measurements in long RNAs.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Bromosuccinimide as an oxidant for the transition-metal-free synthesis of 2-aminobenzoxazoles from benzoxazoles and secondary amines

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3108-3113
DOI: 10.1039/C4OB00386A, PaperXiaoe Wang, Daqian Xu, Chengxia Miao, Qiaohong Zhang, Wei Sun
A facile and transition-metal-free method was developed through merging the ring opening of benzoxazoles with secondary amines and N-bromosuccinimide mediated oxidative cyclization toward the synthesis of 2-aminobenzoxazoles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3100-3107
DOI: 10.1039/C4OB00228H, PaperHui-Jing Li, Ying-Ying Wu, Qin-Xi Wu, Rui Wang, Chun-Yang Dai, Zhi-Lun Shen, Cheng-Long Xie, Yan-Chao Wu
Water-promoted ortho-selective monohydroxymethylation of phenols in the NaBO2 system generates salicyl alcohols in excellent yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to enals, enones and enoates. The remarkable [small alpha]-effect of silicon

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3021-3025
DOI: 10.1039/C4OB00139G, CommunicationXincui Ye, Xianwei Sun, Zhenggang Huang, Na Yang, Zhishan Su, Changwei Hu, Zhenlei Song
The remarkable [small alpha]-effect of silicon leads to a regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to [small alpha],[small beta]-unsaturated carbonyl compounds.
The content of this RSS Feed (c) The Royal Society of Chemistry

A unique dithiocarbamate chemistry during design & synthesis of novel sperm-immobilizing agents

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3090-3099
DOI: 10.1039/C4OB00005F, PaperSantosh Jangir, Veenu Bala, Nand Lal, Lalit Kumar, Amit Sarswat, Lokesh Kumar, Bhavana Kushwaha, Pratiksha Singh, Praveen Kumar Shukla, Jagdamba Prasad Maikhuri, Gopal Gupta, Vishnu Lal Sharma
Unusual loss of CS2 observed in benzyl substituted dithiocarbamates during synthesis of double edged spermicides which acted through sulfhydryl binding.
The content of this RSS Feed (c) The Royal Society of Chemistry

Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3045-3061
DOI: 10.1039/C4OB00031E, PaperS. Sarath Chand, S. Saranya, P. Preethanuj, B. P. Dhanya, E. Jijy, Praveen Prakash, B. S. Sasidhar, Jan Szymoniak, P. V. Santhini, K. V. Radhakrishnan
Lewis acid catalyzed ring-opening of pentafulvene derived diazabicyclic olefins with various ortho-functionalized aryl iodides is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

A fluorescent probe for estimation of adenosine diphosphate and monitoring of glucose metabolism

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3071-3079
DOI: 10.1039/C3OB42505C, PaperArun Kumar, Parteek Prasher, Palwinder Singh
An ADP selective fluorescent probe working in aqueous medium was identified and the change in fluorescence as a function of ADP concentration was standardized.
The content of this RSS Feed (c) The Royal Society of Chemistry

Discovery of 2[prime or minute]-hydroxychalcones as autophagy inducer in A549 lung cancer cells

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3062-3070
DOI: 10.1039/C3OB42429D, PaperFang-Wu Wang, Sheng-Qing Wang, Bao-Xiang Zhao, Jun-Ying Miao
A series of 2[prime or minute]-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective imine reduction catalyzed by imine reductases and artificial metalloenzymes

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,2989-2992
DOI: 10.1039/C3OB42205D, Review ArticleDaniela Gamenara, Pablo Dominguez de Maria
Adding value to organic synthesis. Novel imine reductases enable the enantioselective reduction of imines to afford chiral amines. Likewise, novel bioinspired artificial metalloenzymes can perform the same reaction as well. Remarkable recent examples are herein discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry

The versatile enzyme Araf51 allowed efficient synthesis of rare pathogen-related [small beta]-D-galactofuranosyl-pyranoside disaccharides

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3080-3089
DOI: 10.1039/C3OB42519C, PaperIlona Chlubnova, Blanka Kralova, Hana Dvorakova, Petr Hosek, Vojtech Spiwok, Dominik Filipp, Caroline Nugier-Chauvin, Richard Daniellou, Vincent Ferrieres
A chemo-enzymatic approach was developed for the synthesis of galactofuranosyl-containing disaccharides. The biocatalyst Araf51 was efficient in producing various rare pathogen-related [small beta]-D-galactofuranosyl-pyranosides.
The content of this RSS Feed (c) The Royal Society of Chemistry

A new pyrene based highly sensitive fluorescence probe for copper(II) and fluoride with living cell application

27 April, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,3037-3044
DOI: 10.1039/C4OB00067F, PaperShyamaprosad Goswami, Shampa Chakraborty, Sima Paul, Sandipan Halder, Sukanya Panja, Subhra Kanti Mukhopadhyay
A new pyrene based fluorescence probe has been synthesized for fluorogenic detection of Cu2+ in acetonitrile-aqueous media (7:3 CH3CN-HEPES buffer v/v, pH 7.5) with the bioimaging in both prokaryotic and eukaryotic living cells.
The content of this RSS Feed (c) The Royal Society of Chemistry

Five additional macrocycles that allow Na+ ion-templated threading of guest units featuring a single urea or amide functionality

21 April, 2014 - 12:17

Org. Biomol. Chem., 2014, 12,2907-2917
DOI: 10.1039/C3OB42418A, PaperYou-Han Lin, Chien-Chen Lai, Sheng-Hsien Chiu
Five analogues of the macrocycle BPX26C6 are also capable of recognizing single urea and/or amide functionalities in the presence of templating Na+ ions.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.