Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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A versatile synthesis of "tafuramycin A": a potent anticancer and parasite attenuating agent

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4260-4264
DOI: 10.1039/C4OB00842A, PaperIbrahim M. El-Deeb, Faith J. Rose, Peter C. Healy, Mark von Itzstein
An improved and versatile synthesis of tafuramycin A, a potent anticancer and parasite-attenuating agent, is reported.
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A model study for tethering of (bio)active molecules to biomaterial surfaces through arginine

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4089-4092
DOI: 10.1039/C4OB00160E, CommunicationF. Taraballi, L. Russo, C. Battocchio, G. Polzonetti, F. Nicotra, L. Cipolla
A new approach for tethering of bioactive molecules to proteins via arginine side chains is proposed.
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Synthesis and complexation study of new ExTTF-based hosts for fullerenes

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4117-4123
DOI: 10.1039/C3OB42477D, PaperHassan Iden, Frederic-Georges Fontaine, Jean-Francois Morin
New exTTF-based hosts with different linkers have been prepared and their ability to complex fullerenes was studied in diluted solution using various solvents.
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Investigating peptide sequence variations for 'double-click' stapled p53 peptides

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4074-4077
DOI: 10.1039/C4OB00742E, CommunicationYu Heng Lau, Peterson de Andrade, Niklas Skold, Grahame J. McKenzie, Ashok R. Venkitaraman, Chandra Verma, David P. Lane, David R. Spring
Evaluating the influence of staple position, azido amino acid side-chain length and point mutation on the activity of 'double-click' stapled p53 peptides.
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Carbonate phosphonium salts as catalysts for the transesterification of dialkyl carbonates with diols. The competition between cyclic carbonates and linear dicarbonate products

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4143-4155
DOI: 10.1039/C4OB00655K, PaperMaurizio Selva, Alessio Caretto, Marco Noe, Alvise Perosa
Methylcarbonate and bicarbonate methyltrioctylphosphonium salts were excellent catalysts for the transesterification of dialkyl carbonates with diols: cyclic or linear carbonates are obtained.
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A Pd-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4084-4088
DOI: 10.1039/C4OB00652F, CommunicationDong Ding, Xiaobing Lv, Jian Li, Lin Qiu, Guangyang Xu, Jiangtao Sun
A palladium-catalyzed cascade reaction of N-H insertion and oxidative dehydrogenative aromatization under an air atmosphere has been developed under relatively mild conditions.
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Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4124-4131
DOI: 10.1039/C4OB00268G, PaperSarah J. Pike, James Raftery, Simon J. Webb, Jonathan Clayden
The effect of Schellman motifs on the adoption of stable 310 helical conformations in a series of aminoisobutyric (Aib) oligomers has been studied in the solid state and solution.
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Palladium-catalyzed tandem reaction of 2-hydroxyarylacetonitriles with sodium sulfinates: one-pot synthesis of 2-arylbenzofurans

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4078-4083
DOI: 10.1039/C4OB00575A, CommunicationJiuxi Chen, Jianjun Li, Weike Su
Palladium-catalyzed desulfinative addition and intramolecular annulation tandem reactions of 2-hydroxyarylacetonitriles with sodium sulfinates for one-pot synthesis of 2-arylbenzofurans.
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Rigid tetrazine fluorophore conjugates with fluorogenic properties in the inverse electron demand Diels-Alder reaction

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4177-4185
DOI: 10.1039/C4OB00245H, PaperAchim Wieczorek, Tiago Buckup, Richard Wombacher
1,2,4,5-Tetrazine fluorophore derivatives with structurally rigid molecular designs were synthesized using Sonogashira and Stille cross-coupling as well as copper-catalyzed azide-alkyne cycloaddition.
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Metal-free (Boc)2O-mediated C4-selective direct indolation of pyridines using TEMPO

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4252-4259
DOI: 10.1039/C4OB00356J, PaperWen-Bing Qin, Jia-Yi Zhu, Yu-Bo Kong, Yun-Hong Bao, Zheng-Wang Chen, Liang-Xian Liu
Metal-free C-4-selective indolation of pyridines using (Boc)2O as an activating agent.
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Synthesis of 1,4-dihydroquinoline derivatives under transition-metal-free conditions and their diverse applications

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4243-4251
DOI: 10.1039/C4OB00475B, PaperXue-Qiang Chu, You Zi, Hua Meng, Xiao-Ping Xu, Shun-Jun Ji
A transition-metal-free process for the synthesis of 1,4-dihydroquinoline derivatives starting from simple enaminones with aldehydes via intermolecular cascade cyclization in a one-pot protocol is developed.
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A theoretical study on the catalytic mechanism of the retaining [small alpha]-1,2-mannosyltransferase Kre2p/Mnt1p: the impact of different metal ions on catalysis

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4201-4210
DOI: 10.1039/C4OB00286E, PaperAdela Bobovska, Igor Tvaroska, Juraj Kona
The catalysis of the glycosyltransferase Kre2p/Mnt1p in the presence of various metal ions (Mn2+, Mg2+, Zn2+ and Ca2+) is predicted as a stepwise SNi-like reaction.
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Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4233-4242
DOI: 10.1039/C4OB00175C, PaperAna I. Sanchez, Ricardo Meneses, Jose M. Minguez, Araceli Nunez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Alvarez-Builla, Alvaro Cortes-Cabrera, Federico Gago, Emma Terricabras, Victor Segarra
Thienopyrimidin-4-amines have been synthesized, evaluated and modelled as phosphodiesterase inhibitors.
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Preparation of functionalized heteroaromatics using an intramolecular Wittig reaction

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4044-4050
DOI: 10.1039/C4OB00464G, PerspectiveUtpal Das, Yi-Ling Tsai, Wenwei Lin
An approach for the synthesis of heteroaromatics starting from electron-deficient olefins (or aldehydes and acylimines), acyl chlorides and phosphines using an intramolecular Wittig reaction as the key step is described.
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The asymmetric Cu(II)-indolinylmethanol complex catalyzed Diels-Alder reaction of 2-vinylindoles with [small beta],[gamma]-unsaturated [small alpha]-ketoesters: an efficient route to functionalized tetrahydrocarbazoles

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4172-4176
DOI: 10.1039/C4OB00196F, PaperBanlai Ouyang, Tingting Yu, Renshi Luo, Gui Lu
An efficient asymmetric Diels-Alder reaction of 2-vinylindoles with [small beta],[gamma]-unsaturated [small alpha]-ketoesters for the synthesis of functionalized tetrahydrocarbazoles.
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sp3 C-H oxidation by remote H-radical shift with oxygen- and nitrogen-radicals: a recent update

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4051-4060
DOI: 10.1039/C4OB00469H, Review ArticleShunsuke Chiba, Hui Chen
This review updates on recent advances in aliphatic sp3 C-H bond oxidation by remote H-radical abstraction with oxygen- and nitrogen-radicals classifying by the type of the radical precursors.
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Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4098-4103
DOI: 10.1039/C4OB00300D, PaperK. Kashinath, Prakash D. Jadhav, D. Srinivasa Reddy
Total synthesis of a norsesquiterpene alkaloid has been achieved in racemic and enantiopure forms for the first time.
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Cascade nitrosation and addition-elimination of nitroacetanilides for the highly efficient synthesis of 1,4,2,5-dioxadiazine derivatives

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4192-4200
DOI: 10.1039/C3OB42487A, PaperShanyan Mo, Peipei Huang, Jiaxi Xu
An efficient synthesis of 1,4,2,5-dioxadiazine-3,6-dicarboxamides via cascade nitrosation and addition-elimination of nitroacetanilides.
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Rhodium(III)-catalyzed formal oxidative [4 + 1] cycloaddition of benzohydroxamic acids and [small alpha]-diazoesters. A facile synthesis of functionalized benzolactams

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4112-4116
DOI: 10.1039/C4OB00512K, PaperHon-Wah Lam, Ka-Yi Man, Wai-Wing Chan, Zhongyuan Zhou, Wing-Yiu Yu
A mild and regioselective Rh(III)-catalyzed oxidative [4 + 1] cycloaddition of benzohydroxamic acids and [small alpha]-diazoesters for the synthesis of benzolactam is described.
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Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

2 June, 2014 - 22:54

Org. Biomol. Chem., 2014, 12,4218-4232
DOI: 10.1039/C3OB42586J, PaperCharles Gauthier, Pierre Chassagne, Francois-Xavier Theillet, Catherine Guerreiro, Francoise Thouron, Farida Nato, Muriel Delepierre, Philippe J. Sansonetti, Armelle Phalipon, Laurence A. Mulard
Synthetic functional mimics of the O-antigen from Shigella flexneri 2a are seen as promising vaccine components against endemic shigellosis.
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