Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Aryl-bis-(scorpiand)-aza receptors differentiate between nucleotide monophosphates by combination of aromatic, hydrogen bond and electrostatic interactions

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02084G, PaperJorge Gonzalez, Sanja Tomic, Alberto Lopera, Lluis Guijarro, Ivo Piantanida, Enrique Garcia-Espana
Bis-polyaza pyridinophane scorpiands bind nucleotides in aqueous medium by 10-100 micromolar affinity, dominantly by electrostatic interactions between nucleotide phosphates and protonated aliphatic amines and assisted by aromatic stacking interactions. By...
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Pd-catalyzed Heck-conjoined amidation and concomitant chemoselective Michael-addition: An efficient tandem approach to highly functionalized tetrahydroquinazolines from o-haloanilines

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02286F, PaperAkhilesh K. Verma, Rakesh K Saunthwal, monika patel, abhinandan K. Danodia
An efficient palladium-catalyzed tandem approach for the synthesis of highly functionalized tetrahydroquinazolines 4a-q, and 5a-f by the reaction of o-haloanilines 1a-g with acrylates 2a-d and isothiocyanates 3aa-3ah/isocyanates 3ba-3bf via heck-conjoined...
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Tris(triazole) tripodal receptors as selective probes for citrate anion recognition and multichannel transition and heavy metal cations sensing

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02135E, PaperPedro Molina, Alberto Tarraga, Francisco Oton, Arturo Espinosa, Maria del Carmen Gonzalez
The three-armed pyrenyl-triazole receptor 1 behaves as highly selective fluorescent molecular sensor for citrate anion over similar carboxylates such as malate or tartrate. In addition, this receptor senses Cu2+ cations...
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Highly selective and sensitive detection of GSH using mesoporous silica nanoparticles capped with disulfide-containing oligo(ethylene glycol) chains

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02083A, CommunicationSameh Elsayed, Cristina Gimenez, Elena Aznar, Ramon Martinez-Manez, Felix Sancenon, Maurizio Licchelli
Mesoporous silica nanoparticles loaded with safranin O and capped with disulfide-containing oligo(ethylene glycol) chains were used for the selective and sensitive fluorimetric detection of GSH
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Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01849D, PaperBrett Schwartz, Tina Skinner-Adams, Katherine T Andrews, Mark Coster, Michael Edstein, Donna MacKenzie, Susan Charman, Maria Koltun, Scott Blundell, Anna Campbell, Rebecca Pouwer, Ron Quinn, Karren Beattie, Peter C Healy, Rohan A Davis
A series of amide (8-32, 40-45) and urea (33, 34, 36-39) analogues based on the thiaplakortone A natural product scaffold were synthesised and screened for in vitro antimalarial activity against...
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Linear dialdehydes as promising substrates for aminocatalyzed transformations

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01805B, Review ArticleIndresh Kumar, Panduga Ramaraju, Nisar A. Mir, Anoop Singh
Organocatalytic domino reactions involving amine activation of carbonyl compounds have become the latest chemical technology towards the designing and development of useful synthetic methods. In this direction, linear dialdehydes such...
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Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01875C, PaperMarta Soler, Marta Gonzalez, Eduard Figueras, Xavi Ribas, Miquel Costas, Anna Massaguer, Marta Planas, Lidia Feliu
The undecapeptide KKLFKKILKKL-NH2 (BP16) is a non-toxic cell-penetrating peptide (CPP) that mainly internalizes cancer cells through a clathrin dependent endocytic mechanism and localizes in late endosomes. Moreover, this CPP is...
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Manganese triacetate as an efficient catalyst for bisperoxidation of styrenes

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01823K, PaperAlexander Olegovich Terent'ev, Mikhail Yur'evich Sharipov, Igor Krylov, Darya V. Gaidarenko, Gennady Nikishin
A method was developed for the bisperoxidation of styrenes with tert-butyl hydroperoxide in the presence of a catalytic amount of manganese(III) acetate. It was shown that compounds of manganese in...
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Investigation of end processing and degradation of premature tRNAs and their application to stabilization of in vitro transcripts in wheat germ extract

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02221A, CommunicationAtsushi Ogawa, Yasunori Doi
We investigated the end processing and degradation of premature tRNAs in wheat germ extract (WGE), which led to the discovery of end protectors useful for stabilizing an in vitro transcript...
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Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02324B, CommunicationRui Wang, John R. Falck
An efficient and asymmetric synthesis approach towards the biologically interesting molecule 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) was developed. This protocol mainly relied on our mild cross-coupling and asymmetric stannylation.
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Divergolide Congeners Illuminate Alternative Reaction Channels for Ansamycin Diversification

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02244K, CommunicationLing Ding, Jakob Franke, Christian Hertweck
Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring...
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Cu-Catalyzed arylation of amino group in the indazole ring: Regioselective synthesis of pyrazolo-carbazoles

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02044H, PaperK AnilKumar, Prakash Kannaboina, Devendra Kumar Dhaked, Ram A Vishwakarma, Prasad. V. Bharatam, Parthasarathi Das
Cu (II)-Catalyzed cross-coupling of various aryl boronic acids with 5 and 6-amino indazoles has resulted the (arylamino)-indazoles. These resulted (arylamino)-indazoles have been utilized in synthesizing medicinally important pyrazole fused-carbazoles via...
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Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01898B, PaperLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
Hansen solubility parameters (HSP) have found their greatest use in the evaluation of solvent-polymer chemical interactions. Given their great interest in the scientific community, host-guest interactions in metal-organic frameworks (MOFs),...
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Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02256D, PaperAdam Pomorski, Justyna Adamczyk, Anthony Bishop, Artur Krezel
Selective control of enzyme activity is critical for elucidating the roles of specific proteins in signaling pathways. One potential means for developing truly target-specific inhibitors involves the use of protein...
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Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02252A, PaperJoseph P. Gerdt, Christine E. McInnis, Trevor L. Schell, Helen E. Blackwell
Quorum sensing (QS) via the synthesis and detection of N-acyl L-homoserine lactone (AHL) signals regulates important pathogenic and mutualistic phenotypes in many bacteria. Over the past two decades, the development...
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Reactivity of aldehydes at the Air-Water Interface. Insights from molecular dynamics simulations and ab initio calculations.

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02029D, PaperMarilia T.C. Martins-Costa, Francisco F. Garcia-Prieto, Manuel F. Ruiz-Lopez
Understanding the influence of solute-solvent interactions on chemical reactivity has been a subject of intense research in the last decades. Theoretical studies have focused on bulk solvation phenomena and a...
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Vertically-expanded imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridine via dehydrogenative coupling

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02383H, PaperDaniel Gryko, Marzena Banasiewicz, Dikhi Firmansyah
Anion-radical coupling of structurally diverse series of aromatic compounds possessing biaryl linkages led to seven fused, polycyclic heterocycles in reasonable yields. The yield of the key step (K, toluene, O2)...
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Domino Reaction Involving the Bestmann-Ohira Reagent and [small alpha],[small beta]-Unsaturated Aldehydes: Efficient Synthesis of functionalized pyrazoles

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02365J, PaperShakir Ahamad, Ashis Kumar Gupta, Ruchir Kant, Kishor Mohanan
A mild, efficient and rapid domino reaction involving the Bestmann-Ohira reagent (BOR) and [small alpha],[small beta]-unsaturated aldehydes has been developed for the synthesis of densely functionalized vinylpyrazoles. This reaction demonstrates the dual...
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Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02277G, PaperAhmed Kamal, Rahim Abdul, Sd Riyaz, Poornachandra Y, Balakrishna Moku, Ganesh Kumar C., Ali S. M. Hussaini, Sridhar Balasubramanian, Pavan Kumar Machiraju
2-Styryl quinolines (9a-l) have been synthesized regioselectively from 2-methyl-quinoline by using NaOAc in water acetic acid binary solvents and evaluated for their antibacterial activity against both Gram-positive and Gram-negative strains....
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Development of an efficient route to CF3-substituted pyrrolopyrimidines through understanding the competition between Michael and nitro-Mannich reactions

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02233E, PaperValentine Nenajdenko, M Vovk, Volodymyr Andriyovych Sukach, Viktor Mykolayovych Tkachuk, K Kovalchuk
Regioselective base-catalyzed addition of nitromethane to 2-oxo-4-trifluoromethyl-1,2-dihydropyrimidine-5-carboxylates is reported. It was found that Michael-like pathway is highly reversible and substantially dominating under conditions of kinetic control (0-5 [degree]C, 10 h)...
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