Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 16 hours 52 min ago

Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5831-5834
DOI: 10.1039/C4OB00829D, CommunicationSujit Suwal, Thomas Kodadek
An efficient protocol for the solid-phase synthesis of diverse diketopiperazines is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mutation of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase at Trp-110 affects stereoselectivity of aromatic ketone reduction

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5905-5910
DOI: 10.1039/C4OB00794H, PaperJay M. Patel, Musa M. Musa, Luis Rodriguez, Dewey A. Sutton, Vladimir V. Popik, Robert S. Phillips
Secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus was mutated at Trp-110, and mutant enzymes with high activity and high stereoselectivity for aromatic ketone reduction were identified.
The content of this RSS Feed (c) The Royal Society of Chemistry

Breaking the dichotomy of reactivity vs. chemoselectivity in catalytic SN1 reactions of alcohols

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5990-5994
DOI: 10.1039/C4OB01265H, PaperMalik Hellal, Florian C. Falk, Elena Wolf, Marian Dryzhakov, Joseph Moran
B(C6F5)3 possesses a different reactivity/chemoselectivity profile than traditional Lewis and Bronsted acids and is effective at enabling catalytic SN1 reactions of alcohols in the presence of acid sensitive groups without compromising reaction rates, substrate scope or catalyst loadings.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to [small beta],[small beta]-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5883-5890
DOI: 10.1039/C4OB01085J, PaperJeffrey Buter, Renee Moezelaar, Adriaan J. Minnaard
Palladium catalyzed asymmetric conjugate addition of ortho-substituted arylboronic acids to cyclic enones and its application in natural product synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5995-6004
DOI: 10.1039/C4OB00830H, PaperXiaoli Wang, Linna Wang, Xiao Sheng, Zhangjian Huang, Tingting Li, Ming Zhang, Jinyi Xu, Hui Ji, Jian Yin, Yihua Zhang
Compound 8e protected against the collagen and adrenaline induced thrombosis in mice, and exhibited greater antithrombotic activity than NBP and aspirin in rats.
The content of this RSS Feed (c) The Royal Society of Chemistry

C 3-Symmetric chiral trisimidazoline-catalyzed Friedel-Crafts (FC)-type reaction

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,5827-5830
DOI: 10.1039/C4OB00925H, CommunicationShinobu Takizawa, Shuichi Hirata, Kenichi Murai, Hiromichi Fujioka, Hiroaki Sasai
The first imidazoline-catalyzed enantioselective Friedel-Crafts (FC)-type reaction was established using C3-symmetric chiral trisimidazolines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6028-6032
DOI: 10.1039/C4OB00920G, PerspectiveZhaobin Wang, Zhilong Chen, Jianwei Sun
Important progress has been made in catalytic asymmetric ring-opening of 3-substituted oxetanes, but significant challenges and opportunities remain.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot pseudo three-component reaction of nitroketene-N,S-acetals and aldehydes for synthesis of highly functionalized hexa-substituted 1,4-dihydropyridines

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6223-6238
DOI: 10.1039/C4OB00628C, PaperH. Surya Prakash Rao, A. Parthiban
Pseudo three-component condensation of aliphatic/aromatic/[small alpha],[small beta]-unsaturated aldehydes and nitroketene-N,S-acetals to afford diversely functionalized hexa-substituted 1,4-dihydropyridines under 2-aminopyridine catalysis was achieved.
The content of this RSS Feed (c) The Royal Society of Chemistry

CuI-catalyzed cross-coupling of terminal alkynes with dialkoxycarbenes: a general method for the synthesis of unsymmetrical propargylic acetals

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6215-6222
DOI: 10.1039/C4OB00614C, PaperTiebo Xiao, Ping Zhang, Yang Xie, Jun Wang, Lei Zhou
A general source of dialkoxycarbenes, 2,2-dialkoxy-5,5-dimethyl-[capital Delta]3-1,3,4-oxadiazolines, have been successfully employed as coupling partners in CuI-catalyzed cross-coupling reactions with terminal alkynes, which afforded various unsymmetrical propargylic acetals in good yields.
The content of this RSS Feed (c) The Royal Society of Chemistry

Organic synthetic transformations using organic dyes as photoredox catalysts

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6059-6071
DOI: 10.1039/C4OB00843J, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Shunichi Fukuzumi, Kei Ohkubo
This review article presents various photocatalytic transformation such as oxygenation, halogenation and C-C bond formation with organic photoredox catalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6094-6104
DOI: 10.1039/C4OB00707G, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Michael P. Storz, Giuseppe Allegretta, Benjamin Kirsch, Martin Empting, Rolf W. Hartmann
More than 60 derivatives of (2-nitrophenyl)methanol were synthesized and evaluated regarding their potency to inhibit PqsD. In vitro and in cellulo structure-activity relationships were derived.
The content of this RSS Feed (c) The Royal Society of Chemistry

Catalytic functionalization of tertiary alcohols to fully substituted carbon centres

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6033-6048
DOI: 10.1039/C4OB00718B, Review ArticleLong Chen, Xiao-Ping Yin, Cui-Hong Wang, Jian Zhou
This review summarizes the recent progresses in the catalytic nucleophilic substitution of tertiary alcohols using carbon or heteroatom based nucleophiles for the efficient, diverse and atom economical construction of fully substituted carbon centres, and discusses synthetic opportunities that are still open.
The content of this RSS Feed (c) The Royal Society of Chemistry

Recent advances in the synthesis of nitroolefin compounds

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6049-6058
DOI: 10.1039/C4OB00573B, Review ArticleGuobing Yan, Arun Jyoti Borah, Lianggui Wang
This review focuses on recent achievements in nitroolefin synthesis and the mechanisms of the reactions are also discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium mediated intramolecular multiple C-X/C-H cross coupling and C-H activation: synthesis of carbazole alkaloids calothrixin B and murrayaquinone A

29 July, 2014 - 11:17

Org. Biomol. Chem., 2014, 12,6105-6113
DOI: 10.1039/C4OB00493K, PaperSrinivasan A. Kaliyaperumal, Shyamapada Banerjee, Syam Kumar U. K.
Straightforward palladium mediated syntheses of calothrixin B and murrayaquinone A are described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mercaptobenzoic acid-palladium(0) complexes as active catalysts for S-benzylation with benzylic alcohols via ([small eta]3-benzyl)palladium(II) cations in water

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5964-5972
DOI: 10.1039/C4OB00688G, PaperHidemasa Hikawa, Isao Azumaya
Mercaptobenzoic acid-palladium(0) complexes show high catalytic activity for S-benzylation with benzylic alcohols via the ([small eta]3-benzyl)palladium(II) cation in water. The catalytic system can be performed using only 2.5 mol% Pd2(dba)3 without the phosphine ligand or other additives.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5835-5838
DOI: 10.1039/C4OB01103A, CommunicationJianbin Chen, Helfried Neumann, Matthias Beller, Xiao-Feng Wu
The first example of palladium-catalyzed carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates, the products were isolated in moderate to good yields with the installation of two molecules of CO.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5954-5963
DOI: 10.1039/C4OB01176G, PaperRanfeng Sun, Huangdong Wang, Jianfeng Hu, Jiudong Zhao, Hao Zhang
A new phosphinimine ligand was used in the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines (not active in traditional CuAAC reactions) and alkynes for the first time and a series of 1-(pyridin-2-yl)-1,2,3-triazole derivatives were prepared.
The content of this RSS Feed (c) The Royal Society of Chemistry

Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5876-5882
DOI: 10.1039/C4OB00853G, PaperHongguang Li, Chi-Fai Chan, Wai-Lun Chan, Sam Lear, Steven L. Cobb, Nai-Ki Mak, Terrence Chi-Kong Lau, Rongfeng Lan, Wai-Kwok Wong, Ka-Leung Wong
Polo-like kinase 1 (Plk1) is well-known for taking part in cell cycle progression and regulation.
The content of this RSS Feed (c) The Royal Society of Chemistry

One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5822-5826
DOI: 10.1039/C4OB01019A, CommunicationHai-Lei Cui, Fujie Tanaka
Polysubstituted 3-acylpyrroles were synthesized from readily available unsaturated ketones and N-substituted propargylated amines via an aza-Michael/alkyne carbocyclization cascade followed by oxidation in one pot.
The content of this RSS Feed (c) The Royal Society of Chemistry

An unnatural amino acid based fluorescent probe for phenylalanine ammonia lyase

27 July, 2014 - 10:54

Org. Biomol. Chem., 2014, 12,5818-5821
DOI: 10.1039/C4OB00914B, CommunicationZhenlin Tian, Weiping Zhu, Yufang Xu, Xuhong Qian
An unnatural amino acid based fluorescent probe 2a-LP was designed and synthesized. 2a-LP exhibited an excellent response to phenylalanine ammonia lyase both in Tris-HCl buffer and tomato samples, and was used as an intracellular sensor for phenylalanine ammonia lyase imaging.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.