Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel-Crafts benzylation

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2243-2246
DOI: 10.1039/C4OB02655A, CommunicationJustine Desroches, Pier Alexandre Champagne, Yasmine Benhassine, Jean-Francois Paquin
The Friedel-Crafts benzylation of arenes using benzyl alcohols activated in situ with XtalFluor-E is described. A wide range of 1,1-diarylmethanes and 1,1,1-triarylmethanes were prepared under simple and mild conditions, without the need for a transition metal or a strong Lewis acid.
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Functional chromatographic technique for natural product isolation

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2255-2259
DOI: 10.1039/C4OB02292K, CommunicationEric C. Lau, Damian J. Mason, Nicole Eichhorst, Pearce Engelder, Celestina Mesa, E. M. Kithsiri Wijeratne, G. M. Kamal B. Gunaherath, A. A. Leslie Gunatilaka, James J. La Clair, Eli Chapman
Natural product discovery arises through a unique interplay between chromatographic purification and protein affinity.
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Copper-catalyzed oxidative alkenylation of thioethers via Csp3-H functionalization

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2264-2266
DOI: 10.1039/C4OB02564D, CommunicationHao Cao, Dong Liu, Chao Liu, Xinquan Hu, Aiwen Lei
The first copper-catalyzed oxidative alkenylation of thioethers via Csp3-H functionalization to construct allylic thioethers is demonstrated.
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Validating the alkene and alkyne hydrophosphonylation as an entry to organophosphonates

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2212-2215
DOI: 10.1039/C4OB02501F, PerspectiveAlessandro Dondoni, Alberto Marra
The hydrophosphonylation of terminal alkenes and alkynes by H-phosphonates affords Markovnikov and/or anti-Markovnikov adducts depending on the catalyst (a metal or a radical initiator) and the reaction conditions.
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Sweetness and light: design and applications of photo-responsive glycoconjugates

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2216-2225
DOI: 10.1039/C4OB02296C, Review ArticleYingxue Hu, Rico F. Tabor, Brendan L. Wilkinson
Photoswitchable glycoconjugates are promising tools for studying biomolecular interactions and for the development of stimuli-responsive materials.
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A review: microRNA detection methods

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2226-2238
DOI: 10.1039/C4OB02104E, Review ArticleTian Tian, Jiaqi Wang, Xiang Zhou
MicroRNA (miRNA) detection is of considerable significance in both disease diagnosis and in the study of miRNA function.
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Regulating exocytosis of nanoparticles via host-guest chemistry

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2474-2479
DOI: 10.1039/C4OB02433H, PaperChaekyu Kim, Gulen Yesilbag Tonga, Bo Yan, Chang Soo Kim, Sung Tae Kim, Myoung-Hwan Park, Zhengjiang Zhu, Bradley Duncan, Brian Creran, Vincent M. Rotello
Regulating exocytosis of AuNPs by using host-guest interactions between AuNPs and CB[7] molecules.
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Palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with H-phosphonates

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2432-2436
DOI: 10.1039/C4OB02410A, PaperXiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu, Yangjie Wu
A new and generally practical synthesis of alkynylphosphonates through a palladium-catalyzed consecutive Sonogashira/deacetonative process using aryl bromides, 2-methyl-3-butyn-2-ol and H-phosphonates is developed.
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Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2464-2473
DOI: 10.1039/C4OB02041C, PaperMaarten Danial, Sebastien Perrier, Katrina A. Jolliffe
The effect of amino acid composition on the formation of transmembrane channels in lipid bilayers upon self-assembly of alt-(L,D)-[small alpha]-cyclic octapeptides has been investigated.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2407-2422
DOI: 10.1039/C4OB02397H, PaperAnna Junker, Artur K. Kokornaczyk, Annelien J. M. Zweemer, Bastian Frehland, Dirk Schepmann, Junichiro Yamaguchi, Kenichiro Itami, Andreas Faust, Sven Hermann, Stefan Wagner, Michael Schafers, Michael Koch, Christina Weiss, Laura H. Heitman, Klaus Kopka, Bernhard Wunsch
Late-stage diversification led to selective chemokine CCR2 receptor antagonists and dual-targeting CCR2/CCR5 receptor antagonists.
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Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2423-2431
DOI: 10.1039/C4OB02049A, PaperVariam Ullas Jeankumar, Rudraraju Srilakshmi Reshma, Renuka Janupally, Shalini Saxena, Jonnalagadda Padma Sridevi, Brahmam Medapi, Pushkar Kulkarni, Perumal Yogeeswari, Dharmarajan Sriram
Exploring the Gyrase ATPase platform to tailor novel anti-tubercular leads.
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Asymmetric Michael addition of [small alpha]-fluoro-[small alpha]-nitro esters to nitroolefins: towards synthesis of [small alpha]-fluoro-[small alpha]-substituted amino acids

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2350-2359
DOI: 10.1039/C4OB02486A, PaperJacek Kwiatkowski, Yixin Lu
[small alpha]-Fluoro-[small alpha]-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities.
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LNA units present in the (2[prime or minute]-OMe)-RNA strand stabilize parallel duplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA and parallel triplexes (2[prime or minute]-OMe)-RNA/[All-RP-PS]-DNA/RNA. An improved tool for the inhibition of reverse t

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2375-2384
DOI: 10.1039/C4OB02364A, PaperAnna Maciaszek, Agnieszka Krakowiak, Magdalena Janicka, Agnieszka Tomaszewska-Antczak, Milena Sobczak, Barbara Mikolajczyk, Piotr Guga
LNA units stabilize (RNA/LNA)/RP-PS-DNA/RNA triplexes and efficiently inhibit reverse transcription of target RNA.
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Vanadyl species-catalyzed complementary [small beta]-oxidative carbonylation of styrene derivatives with aldehydes

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2385-2392
DOI: 10.1039/C4OB02621G, PaperWen-Chieh Yang, Shiue-Shien Weng, Anandhan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao, Chien-Tien Chen
By judicious choice of the counter anions in the vanadyl catalysts, we can achieve [small beta]-hydroxylated and t-butyl peroxylated carbonylation of styrenes by aromatic 1[degree] and 2[degree] alkyl aldehydes in a complementary manner.
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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2453-2463
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
A novel [small pi]-extended NiII-porphyrin shows a high selectivity towards human telomeric G-quadruplexes.
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2366-2374
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, Venkitasamy Kesavan, Kurt V. Gothelf
Homopyrimidine acyclic (L)-threoninol nucleic acid (aTNA) was synthesized and found to form highly stable (L)-aTNA-DNA-(L)-aTNA and (L)-aTNA-RNA-(L)-aTNA triple helical structures.
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Benzosulfones as photochemically activated sulfur dioxide (SO2) donors

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2399-2406
DOI: 10.1039/C4OB02466D, PaperSatish R. Malwal, Harinath Chakrapani
A series of benzosulfones were synthesized and found to undergo photolysis to generate sulfur dioxide in aqueous buffer.
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Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2360-2365
DOI: 10.1039/C4OB02311K, PaperMichael S. Perryman, Matthew W. M. Earl, Sam Greatorex, Guy J. Clarkson, David J. Fox
Enantiomerically-enriched trichloromethyl-containing alcohols are transformed regioselectively into enantiomerically-enriched 1-substituted piperazinones by modified Jocic reactions.
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Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2393-2398
DOI: 10.1039/C4OB02046D, PaperYahya E. Jad, Gerardo A. Acosta, Sherine N. Khattab, Beatriz G. de la Torre, Thavendran Govender, Hendrik G. Kruger, Ayman El-Faham, Fernando Albericio
To date, DMF has been considered as the only solvent suitable for peptide synthesis.
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[small alpha]-Tocopherol derived lipid dimers as efficient gene transfection agents. Mechanistic insights into lipoplex internalization and therapeutic induction of apoptotic activity

16 February, 2015 - 14:17

Org. Biomol. Chem., 2015, 13,2444-2452
DOI: 10.1039/C4OB02063D, PaperKrishan Kumar, Bappa Maiti, Paturu Kondaiah, Santanu Bhattacharya
Dimeric cationic tocopheryl lipids for efficacious therapeutic pDNA delivery in cancer cell lines.
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