Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,265-268
DOI: 10.1039/C4OB02120G, PaperThomas C. Pijper, Jort Robertus, Wesley R. Browne, Ben L. Feringa
Rapid conversion of thio-ethers to thio-acetates using TiCl4 that tolerates a wide variety of functionalities, in good to excellent yields.
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Multivalent helix mimetics for PPI-inhibition

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,258-264
DOI: 10.1039/C4OB02066A, PaperAnna Barnard, Jennifer A. Miles, George M. Burslem, Amy M. Barker, Andrew J. Wilson
A multivalent helix mimetic is developed that inhibits the p53/hDM2 and induces dimerization/aggregation of its target - hDM2.
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Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing [small pi]-extended diarylacetylene motifs

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,68-72
DOI: 10.1039/C4OB02081B, CommunicationSara De Ornellas, John M. Slattery, Robert M. Edkins, Andrew Beeby, Christoph G. Baumann, Ian J. S. Fairlamb
A novel series of C-modified [small pi]-extended 7-deazaadenosines exhibit promising fluorescence properties.
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An enantioselective total synthesis of Sch-725674

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,234-240
DOI: 10.1039/C4OB02136C, PaperKota Ramakrishna, Krishna P. Kaliappan
An enantioselective total synthesis of Sch-725674 using dithiane alkylation, cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction as key steps is described.
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Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,64-67
DOI: 10.1039/C4OB02060J, CommunicationNicolas Chuard, Giulio Gasparini, Aurelien Roux, Naomi Sakai, Stefan Matile
We report that, with the increasing length, cell-penetrating poly(disulfide)s preferably accumulate in the endosomes, cytosol and then the nucleoli.
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Oxidative activation of dihydropyridine amides to reactive acyl donors

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,185-198
DOI: 10.1039/C4OB01931H, PaperErik Daa Funder, Julie B. Trads, Kurt V. Gothelf
Amides of 1,4-dihydropyridine (DHP) are activated by oxidation for acyl transfer to amines, alcohols and thiols.
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Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides

9 December, 2014 - 20:54

Org. Biomol. Chem., 2015, 13,59-63
DOI: 10.1039/C4OB01883D, CommunicationBani Kanta Sarma, Xiaodan Liu, Hao Wu, Yu Gao, Thomas Kodadek
Solid phase synthesis of 1,3,4-oxadiazin-5(6R)-one and 1,3,4-oxadiazol-2-one scaffolds from resin-bound acyl hydrazides is described.
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Amino acid-linked porphyrin-nitroimidazole antibiotics targeting Porphyromonas gingivalis

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,98-109
DOI: 10.1039/C4OB01841A, PaperSimon A. Dingsdag, Benjamin C-M. Yap, Neil Hunter, Maxwell J. Crossley
Amino acid-linked porphyrin-nitroimidazole adducts, as potent as metronidazole, are highly selective for Porphyromonas gingivalis.
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A domino reaction of tetrahalo-7,7-dimethoxybicyclo[2.2.1]heptenyl alcohols leading to indenones and a de novo synthesis of ninhydrin derivatives

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,299-308
DOI: 10.1039/C4OB01977F, PaperKaki Raveendra Babu, Faiz Ahmed Khan
An acid mediated synthesis of indenones and a de novo synthesis of ninhydrin derivatives.
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Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,283-298
DOI: 10.1039/C4OB01838A, PaperCarlos A. Sanhueza, Jonathan Cartmell, Amr El-Hawiet, Adam Szpacenko, Elena N. Kitova, Rambod Daneshfar, John S. Klassen, Dean E. Lang, Luiz Eugenio, Kenneth K.-S. Ng, Pavel I. Kitov, David R. Bundle
Higher activity glycopeptoid ligands for two large Clostridium difficile toxins TcdA and TcdB were discovered via modular fragment-based design and virtual screening.
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Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,309-314
DOI: 10.1039/C4OB01320D, PaperMonoranjan Ghosh, Subhajit Mishra, Kamarul Monir, Alakananda Hajra
A catalytic decarboxylative annulation has been developed for the regioselective synthesis of furans by the cycloaddition of ketones with [small alpha],[small beta]-unsaturated carboxylic acids in ambient air.
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Cationic azacryptands as selective three-way DNA junction binding agents

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,215-222
DOI: 10.1039/C4OB01846J, PaperJana Novotna, Aurelien Laguerre, Anton Granzhan, Marc Pirrotta, Marie-Paule Teulade-Fichou, David Monchaud
Azacryptands are promising candidates for assessing the therapeutic potential of three-way DNA junctions.
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Corrin-based chemosensors for the ASSURED detection of endogenous cyanide

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,14-17
DOI: 10.1039/C4OB01889C, PerspectiveFelix Zelder, Lucas Tivana
Cassava (Manihot esculenta Crantz) is a staple food for more than 500 million people, especially in Africa and South America.
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Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,269-276
DOI: 10.1039/C4OB01837K, PaperEwa Radzikowska, Janina Baraniak
Chimeric oligonucleotides containing stereoregular phosphorothioate and natural phosphodiester linkages have been obtained on the solid phase support using nucleoside oxathiaphospholanes and commercially available nucleoside phosphoramidites.
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Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,277-282
DOI: 10.1039/C4OB01959H, PaperOrazio A. Attanasi, Linda A. Campisi, Lucia De Crescentini, Gianfranco Favi, Fabio Mantellini
Synthesis of symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines]: a novel example of spirocyclic oxindoles bearing a quaternary centre at the 3-position.
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Improving catalyst activity in secondary amine catalysed transformations

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,133-141
DOI: 10.1039/C4OB01916D, PaperJohn B. Brazier, Timothy J. K. Gibbs, Julian H. Rowley, Leopold Samulis, Sze Chak Yau, Alan R. Kennedy, James A. Platts, Nicholas C. O. Tomkinson
Improved catalytic efficiency has been observed in the Diels-Alder cycloaddition by modification of the imidazolidinone architecture.
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Synthesis of highly functionalized C60 fullerene derivatives and their applications in material and life sciences

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,25-54
DOI: 10.1039/C4OB01663G, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Weibo Yan, Stefan M. Seifermann, Philippe Pierrat, Stefan Brase
Highly functionalized fullerenes can be efficiently constructed by various techniques.
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Asymmetric synthesis of axially chiral anilides by Pd-catalyzed allylic substitutions with P/olefin ligands

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,125-132
DOI: 10.1039/C4OB01087F, PaperYilin Liu, Xiangqing Feng, Haifeng Du
Palladium-catalyzed allylic substitutions of ortho-substituted anilides using P/olefin ligands were achieved to afford chiral anilides with up to 84% ee.
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Synthesis of fully functionalized aglycone of lycoperdinoside A and B

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,115-124
DOI: 10.1039/C4OB01716A, PaperBalla Chandrasekhar, Sudhakar Athe, P. Purushotham Reddy, Subhash Ghosh
Synthesis of fully functionalized aglycone of lycoperdinoside A and B is achieved via Pd-catalyzed Stille-Migita cross coupling and Evans syn- and anti aldol reactions as key steps.
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Pd-catalyzed oxidative C-H alkenylation for synthesizing arylvinyltriazole nucleosides

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,110-114
DOI: 10.1039/C4OB01836B, PaperJingjie Tang, Mei Cong, Yi Xia, Gilles Quelever, Yuting Fan, Fanqi Qu, Ling Peng
Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides in good yields and with large functional group tolerance.
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