Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4656-4662
DOI: 10.1039/C4OB00548A, PaperKarothu Durga Prasad, Jamma Trinath, Ansuman Biswas, Kanagaraj Sekar, Kithiganahalli N. Balaji, Tayur N. Guru Row
N-Alkyl substituted pyrazoloanthrone derivatives were synthesized, characterized and tested for their in vitro inhibitory activity over c-Jun N-terminal kinase (JNK) in regulating inflammation associated disorders.
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A coumarin-quinolinium-based fluorescent probe for ratiometric sensing of sulfite in living cells

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4637-4643
DOI: 10.1039/C4OB00132J, PaperLi Tan, Weiying Lin, Sasa Zhu, Lin Yuan, Kaibo Zheng
Based on a novel coumarin-quinolinium platform, compound 2 was rationally designed and synthesized as a novel ratiometric fluorescent sensor for sulfite anions.
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Utilization of whole cell mediated deracemization in a chemoenzymatic synthesis of enantiomerically enriched polycyclic chromeno[4,3-b] pyrrolidines

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4682-4690
DOI: 10.1039/C4OB00615A, PaperThangavelu Saravanan, Sushital Jana, Anju Chadha
Enantiomerically enriched pyrrolidines via chemoenzymatic synthesis.
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Synthesis of 2-C-substituted benzothiazoles via a copper-promoted domino condensation/S-arylation/heterocyclization process

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4633-4636
DOI: 10.1039/C4OB00564C, PaperHaoyue Xiang, Jin Qi, Qian He, Min Jiang, Chunhao Yang, Lianfu Deng
Two series of extremely useful 2-C-substituted benzothiazoles containing gem-bisphosphonates and aryl-substituted nitriles were synthesized here via a copper-promoted domino condensation/S-arylation/heterocyclization process.
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DABCO-mediated isocyanide-based multicomponent reaction: synthesis of highly substituted cyclopentenes

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4628-4632
DOI: 10.1039/C4OB00012A, PaperLi-Rong Wen, Ming-Chao Lan, Wen-Kui Yuan, Ming Li
Highly substituted cyclopentenes can be accessed rapidly from isocyanides, aldehydes and malononitrile or ethyl cyanoacetate (AB2C2) using DABCO as a catalyst under solvent-free conditions at 40 [degree]C within 30 min.
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Highly efficient and generalized asymmetric synthesis of quaternary stereogenic carbon-containing [small beta]-amino indanones/indanoles via Mannich-type additions between 1-indanones and N-tert-butanesulfinylketimines

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4620-4627
DOI: 10.1039/C4OB00489B, PaperLingmin Wu, Chen Xie, Haibo Mei, Vadim A. Soloshonok, Jianlin Han, Yi Pan
1-Indanone and acetophenone derived enolates undergo Mannich-type reactions with ketimines in up to 98% yields and >99 : 1 diastereoselectivities.
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Chiral Bronsted acid catalyzed enantioselective intermolecular allylic aminations

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4590-4593
DOI: 10.1039/C4OB00526K, CommunicationMinyang Zhuang, Haifeng Du
Bronsted acid-catalyzed asymmetric intermolecular amination of allylic alcohols was first achieved with moderate to high levels of reactivities and selectivities.
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Recent development of two-photon fluorescent probes for bioimaging

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4550-4566
DOI: 10.1039/C4OB00431K, Review ArticleDokyoung Kim, Hye Gun Ryu, Kyo Han Ahn
Fluorescent probes are essential tools for studying biological systems.
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Synthesis of 1-amino-2-aroyl/acetylnaphthalenes through a base mediated one pot inter and intramolecular C-C bond formation strategy

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4730-4737
DOI: 10.1039/C4OB00432A, PaperSurjeet Singh, Pratik Yadav, Satya Narayan Sahu, Ismail Althagafi, Abhinav Kumar, Brijesh Kumar, Vishnu Ji Ram, Ramendra Pratap
Base mediated synthesis of highly functionalized aroyl/acetylnaphthalenes by the reaction of 2-(1-cyano-2,2-bis(methylthio)vinyl)benzonitrile and aryl methyl ketone or acetone has been reported.
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Interaction of amphiphilic [small alpha]-helical cell-penetrating peptides with heparan sulfate

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4673-4681
DOI: 10.1039/C4OB00673A, PaperJi Yang, Hiroshi Tsutsumi, Tadaomi Furuta, Minoru Sakurai, Hisakazu Mihara
The binding of cell-penetrating peptides to heparan sulfate is investigated experimentally and computationally.
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Acetal-initiated Prins bicyclization for the synthesis of hexahydrofuro-[3,4-c]furan lignans and octahydropyrano[3,4-c]pyran derivatives

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4754-4762
DOI: 10.1039/C4OB00305E, PaperB. V. Subba Reddy, M. Ramana Reddy, B. Sridhar, Kiran Kumar Singarapu
The stereoselective synthesis of hexahydrofuro[3,4-c]furan lignans and octahydropyrano[3,4-c]pyran derivatives is reported through a Prins bicyclization.
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Marine bacteria from the Roseobacter clade produce sulfur volatiles via amino acid and dimethylsulfoniopropionate catabolism

15 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4318-4323
DOI: 10.1039/C4OB00719K, CommunicationNelson L. Brock, Markus Menke, Tim A. Klapschinski, Jeroen S. Dickschat
The biosynthesis of sulfur volatiles in marine bacteria was studied by feeding of 34S-labelled DMSP and some unnatural derivatives.
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N,N-Dimethylaminobenzoates enable highly enantioselective Sharpless dihydroxylations of 1,1-disubstituted alkenes

15 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4314-4317
DOI: 10.1039/C4OB00621F, CommunicationYaohong Zhao, Xiangyou Xing, Shaolong Zhang, David Zhigang Wang
Exploration of beneficial catalyst-substrate interactions in the classical Sharpless asymmetric dihydroxylations (SAD) led to the identification of allylic N,N-dimethylaminobenzoate as an efficient auxiliary for inducing high levels of enantioselectivity in 1,1-disubstituted aliphatic alkenes.
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An iterative in silico and modular synthetic approach to aqueous soluble tercyclic [small alpha]-helix mimetics

15 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4432-4444
DOI: 10.1039/C4OB00647J, PaperZelong Lim, Peter J. Duggan, Adam G. Meyer, Kellie L. Tuck
Tercyclic scaffolds, designed to have improved synthetic accessibility and aqueous solubility, were evaluated as structural [small alpha]-helix mimetics by using an iterative in silico approach.
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Novel one-pot synthesis of diverse [gamma],[small delta]-unsaturated [small beta]-ketoesters by thermal cascade reactions of diazodicarbonyl compounds and enol ethers: transformation into substituted 3,5-diketoesters

15 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4407-4411
DOI: 10.1039/C4OB00664J, PaperRameshwar Prasad Pandit, Yong Rok Lee
Novel and efficient synthesis of diverse [gamma],[small delta]-unsaturated [small beta]-ketoesters was accomplished by thermal cascade reactions of diazodicarbonyl compounds with enol ethers and the synthesized compounds were further transformed into the corresponding 3,5-diketoesters.
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Catalyst-controlled regio- and stereoselective synthesis of diverse 12H-6,12-methanodibenzo[d,g][1,3]dioxocines

13 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4386-4396
DOI: 10.1039/C4OB00691G, PaperLikai Xia, Hongyun Cai, Yong Rok Lee
Regio- and stereoselective synthesis of 12H-6,12-methanodibenzo[d,g][1,3]dioxocines has been accomplished by the EDDA and PTSA-catalyzed cascade reactions of resorcinols and 2-hydroxychalcones.
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A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5

13 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4310-4313
DOI: 10.1039/C4OB00773E, CommunicationKarunakaran A. Kalesh, Edward W. Tate
A succinylation-specific photo-cross-linking peptide probe has been developed for the NAD+-dependent hydrolase Sirtuin 5.
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Transition-metal-free oxidative carboazidation of acrylamides via cascade C-N and C-C bond-forming reactions

13 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4329-4334
DOI: 10.1039/C4OB00720D, CommunicationJun Qiu, Ronghua Zhang
A novel transition-metal-free oxidative carboazidation of acrylamides using inexpensive NaN3 and K2S2O8 was achieved, which not only provided an efficient method to prepare various N3-substituted oxindoles, but also represented a novel strategy for C-N and C-C bond formation via a free-radical cascade process.
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Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

13 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4421-4431
DOI: 10.1039/C3OB42379D, PaperWenhua Chu, Andre Chepetan, Dong Zhou, Kooresh I. Shoghi, Jinbin Xu, Laura L. Dugan, Robert J. Gropler, Mark A. Mintun, Robert H. Mach
Non-invasive imaging of reactive oxygen species (ROS) in vivo was investigated using a dihydroethidium analog [18F]12 as a PET radiotracer. The data shown indicates that [18F]12 is a promising PET tracer for non-invasive imaging of ROS in vivo.
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A chemoselective oxidation of monosubstituted ethylene glycol: facile synthesis of optically active [small alpha]-hydroxy acids

13 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4305-4309
DOI: 10.1039/C4OB00601A, CommunicationKiran Chinthapally, Sundarababu Baskaran
A mild and efficient method for the chemoselective oxidation of monosubstituted ethylene glycols to optically active [small alpha]-hydroxy acids has been achieved using the TEMPO-NaOCl reagent system.
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