Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Nazarov-like cyclization reactions

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5331-5345
DOI: 10.1039/C4OB00804A, Review ArticleMartin J. Di Grandi
This review discusses novel Nazarov cyclization variations and their application to the synthesis of complex molecules.
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Synthesis of 2,3-dihydro-1H-indazoles by Rh(III)-catalyzed C-H cleavage of arylhydrazines

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5469-5476
DOI: 10.1039/C4OB00921E, PaperJinzhong Yao, Ruokun Feng, Cong Lin, Zhanxiang Liu, Yuhong Zhang
A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro 1H-indazoles is described.
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In(OTf)3-catalysed one-pot versatile pyrrole synthesis through domino annulation of [small alpha]-oxoketene-N,S-acetals with nitroolefins

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5484-5491
DOI: 10.1039/C4OB00781F, PaperAbhijeet Srivastava, Gaurav Shukla, Anugula Nagaraju, Girijesh Kumar Verma, Keshav Raghuvanshi, Raymond C. F. Jones, Maya Shankar Singh
An operationally simple and efficient one-pot direct access to pyrroles has been achieved by annulation of [small alpha]-oxoketene-N,S-acetals with [small beta]-nitrostyrenes catalyzed by In(OTf)3 under solvent-free conditions.
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Synthesis and characterization of bisoxazolines- and pybox-copper(II) complexes and their application in the coupling of [small alpha]-carbonyls with functionalized amines

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5509-5516
DOI: 10.1039/C4OB01027B, PaperWei-Guo Jia, Dan-Dan Li, Yuan-Chen Dai, Hui Zhang, Li-Qin Yan, En-Hong Sheng, Yun Wei, Xiao-Long Mu, Kuo-Wei Huang
[(Dm-Pybox)CuBr2] is efficient in catalyzing [small alpha]-amination of ketones and esters, which tolerates functionality on the carbonyl and amine reaction components.
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Divergent synthesis of 2,3-dihydro-1H-pyrroles, 3-alkyl-1H-pyrroles and 3-alkenyl-1H-pyrroles from 2,4-pentadienenitriles and isocyanides

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5477-5483
DOI: 10.1039/C4OB00912F, PaperXiaoqing Xin, Xu Liu, Dingyuan Zhang, Rui Zhang, Yongjiu Liang, Fushe Han, Dewen Dong
A facile and divergent synthesis of 2,3-dihydro-1H-pyrroles, 3-alkyl-1H-pyrroles and 3-alkenyl-1H-pyrroles has been developed via a formal [2 + 3] annulation of 2,4-penta-dienenitriles and ethyl isocyanoacetate by the variation of reaction conditions.
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Dicyanobenzene and dicyanopyrazine derived X-shaped charge-transfer chromophores: comparative and structure-property relationship study

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5517-5527
DOI: 10.1039/C4OB00901K, PaperL. Dokladalova, F. Bures, W. Kuznik, I. V. Kityk, A. Wojciechowski, T. Mikysek, N. Almonasy, M. Ramaiyan, Z. Padelkova, J. Kulhanek, M. Ludwig
Structure-property relationships in X-shaped push-pull molecules with dicyanobenzene and dicyanopyrazine acceptors.
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Palladium-catalyzed annulation of benzynes with N-substituted-N-(2-halophenyl)formamides: synthesis of phenanthridinones

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5351-5355
DOI: 10.1039/C4OB00997E, CommunicationYuan Yang, Hui Huang, Lijun Wu, Yun liang
Palladium-catalyzed annulation of benzynes with N-(2-halophenyl)formamides afforded phenanthridinones via tandem C-C bond formation.
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Synthesis, antibacterial activities, and theoretical studies of dicoumarols

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5528-5535
DOI: 10.1039/C4OB00772G, PaperJing Li, Zheng Hou, Guang-Hui Chen, Fen Li, Ying Zhou, Xiao-Yan Xue, Zhou-Peng Li, Min Jia, Zi-Dan Zhang, Ming-Kai Li, Xiao-Xing Luo
In this work, we report the synthesis, evaluation of antibacterial activity and theoretical study of dicoumarols including DC, 2-PyDC, 3-PyDC and 4-PyDC.
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Base mediated 7-exo-dig intramolecular cyclization of Ugi-propargyl precursors: a highly efficient and regioselective synthetic approach toward diverse 1,4-benzoxazepine-5(2H)-ones

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5346-5350
DOI: 10.1039/C4OB00793J, CommunicationShashi Pandey, S. Vinod Kumar, Ruchir Kant, Prem M. S. Chauhan
A metal-free facile and efficient two-step synthetic protocol for the preparation of 1,4-benzoxazepine-5(2H)-one derivatives has been developed.
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Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5536-5543
DOI: 10.1039/C4OB00760C, PaperIsidore E. Decostaire, Dominique Lelievre, Vincent Aucagne, Agnes F. Delmas
All on-resin! An efficient C-to-N iterative strategy for solid phase chemical ligations (SPCL).
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High-yielding sequential one-pot synthesis of chiral and achiral [small alpha]-substituted acrylates via a metal-free reductive coupling reaction

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5400-5406
DOI: 10.1039/C4OB00667D, PaperDhevalapally B. Ramachary, Chintalapudi Venkaiah, Y. Vijayendar Reddy
A variety of chiral and achiral [small alpha]-substituted acrylates were furnished in very good yields with excellent selectivity by using an organocatalytic reductive coupling reaction (TCRA) followed by an Eschenmoser methylenation.
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Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5324-5330
DOI: 10.1039/C4OB00737A, PerspectiveLara Cala, Francisco J. Fananas, Felix Rodriguez
This perspective article summarizes the few and recently reported methods on catalytic asymmetric synthesis of spiroacetal derivatives from achiral substrates.
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Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5458-5463
DOI: 10.1039/C4OB00663A, PaperYu-Juan Guo, Pei-Jiang Chen, Bo Wang, Ai-Yun Peng
A series of phosphaisocoumarin amidates were synthesized via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters in good to excellent yields. In each case, the phostone ring was intact and only the exocyclic ethoxy group was amidated.
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Arylpyrrole oligomers as tunable anion receptors

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5492-5499
DOI: 10.1039/C4OB00357H, PaperWim Van Rossom, Tatyana G. Terentyeva, Keitaro Sodeyama, Yoshitaka Matsushita, Yoshitaka Tateyama, Katsuhiko Ariga, Jonathan P. Hill
A novel class of oligomeric arylpyrrole receptors has been designed, prepared and analysed for their affinity towards anionic guests.
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Comparison of backbone modification in protein [small beta]-sheets by [small alpha][rightward arrow][gamma] residue replacement and [small alpha]-residue methylation

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5375-5381
DOI: 10.1039/C4OB00886C, PaperGeorge A. Lengyel, Zachary E. Reinert, Brian D. Griffith, W. Seth Horne
Systematic backbone alteration of sheet secondary structure in a small protein yields unnatural mimics with native-like tertiary folding behavior.
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Synthesis and properties of fluorous benzoquinones and their application in deprotection of silyl ethers

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5442-5447
DOI: 10.1039/C4OB00783B, PaperHiroshi Matsubara, Takahiko Maegawa, Yasuaki Kita, Takato Yokoji, Akihiro Nomoto
1,4-Benzoquinone derivatives bearing perfluoroalkyl groups were prepared and used as a recyclable catalyst in the selective desilylation of silyl ethers.
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Efficient asymmetric synthesis of spiro-2(3H)-furanones via phase-transfer-catalyzed alkynylation

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5388-5392
DOI: 10.1039/C4OB00969J, PaperXiangfei Wu, Seiji Shirakawa, Keiji Maruoka
Efficient asymmetric synthesis of spiro-2(3H)-furanones was achieved via chiral phase-transfer-catalyzed alkynylation.
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Tuning of the HOMO-LUMO gap of donor-substituted symmetrical and unsymmetrical benzothiadiazoles

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5448-5457
DOI: 10.1039/C4OB00629A, PaperRajneesh Misra, Prabhat Gautam
This article reports the design and synthesis of donor-substituted symmetrical and unsymmetrical benzothiadiazoles (BTDs) 5-12 of type D-[small pi]-A-D, D1-[small pi]-A-D2, D1-A1-A2-D2, D-A1-A2-D and D-A1-A2-A1-D by Ullmann, Suzuki and cycloaddition-retroelectrocyclization reactions.
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Efficient C(sp3alkyl)-SCF3 bond formations via copper-mediated trifluoromethylthiolation of alkyl halides

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5500-5508
DOI: 10.1039/C4OB00403E, PaperQuanfu Lin, Li Chen, Yangjie Huang, Mingguang Rong, Yaofeng Yuan, Zhiqiang Weng
An efficient synthesis of alkyl trifluoromethyl sulfides via copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described.
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Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5427-5434
DOI: 10.1039/C4OB00744A, PaperXiu-Jiang Du, Qiang Bian, Hong-Xue Wang, Shu-Jing Yu, Jun-Jie Kou, Zhi-Peng Wang, Zheng-Ming Li, Wei-Guang Zhao
A series of valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good fungicidal activity.
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