Org. and Biomol. Chem.

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LNA Units Present in (2'-OMe)-RNA Strand Stabilize Parallel Duplexes (2'-OMe)-RNA/[All-RP-PS]-DNA and Parallel Triplexes (2'-OMe)-RNA/[All-RP-PS]-DNA/RNA. An Improved Tool for Inhibition of Reverse Transcription.

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02364A, PaperPiotr Guga, Anna Maciaszek, Agnieszka Krakowiak, Magdalena Janicka, Agnieszka Tomaszewska-Antczak, Milena Sobczak, Barbara Mikolajczyk
Homopurine phosphorothioate analogs of DNA, possessing all phosphorus atoms of RP configuration ([All-RP-PS]-DNA), when interact with appropriate complementary RNA or (2'-OMe)-RNA templates, form parallel triplexes or parallel duplexes of very...
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Halogenated Boron-Dipyrromethenes: Synthesis, Properties and Applications

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02293A, Review ArticleMagalampalli Ravikanth, Lakshmi Vellanki, Rajeswara Rao M.
Boron-dipyrromethene dyes (BODIPYs) containing halogens at pyrrole carbons are very useful synthons for the synthesis of variety of BOIDPYs for a wide range of applications. Among the functional groups, halogens...
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Regulating Exocytosis of Nanoparticles via Host-Guest Chemistry

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02433H, PaperChaekyu Kim, Gulen Tonga, Bo Yan, Chang Soo Kim, Sung Tae Kim, Myoung-Hwan Park, Zhengjiang Zhu, Bradley Duncan, Brian Creran, Vincent M Rotello
Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis of the nanoparticles is a key factor in the...
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NBD-based Fluorescent Chemosensor for the Selective Quantification of Copper and Sulfide in Aqueous Solution and Living Cells

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02178A, PaperQingtao Meng, Yu Shi, Cuiping Wang, Hongmin Jia, Xue Gao, Run Zhang, Yongfei Wang, Zhiqiang Zhang
Chemosensors play important roles in cations and anions recognition in biological, industrial, and environmental processes. Although much efforts have been made to develop artificial fluorescent receptors for Cu2+ and S2-,...
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Highly efficient synthesis of novel methyl 132-methylene mesopyropheophorbide a via pH-dependent regioselective condensation with formaldehyde and its stereoselective Michael addition reaction

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02491E, CommunicationJiazhu Li, Yang Liu, Xi-Sen Xu, Yan-Long Li, Shan-Guo Zhang, IL YOON, Young Key Shim, Jin-Jun Wang, Jun-gang Yin
Treatment of methyl mesopyropheophorbide a with formaldehyde under basic condition gave a novel 132-methylene derivative in 85% yield; under acidic condition, the corresponding 20-hydroxymethyl derivative was obtained in 65% yield....
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Tandem Catalytic Oxidative Deacetylation of Acetoacetic Esters and Hetero Aromatic Cyclizations

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02441A, PaperYeming Ju, Di Miao, Ruiyang Yu, Sangho Koo
One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(III)/Co(II) catalysts and Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of...
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Copper-Catalyzed Oxidative Alkenylation of Thioethers via Csp3-H Functionalization

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02564D, CommunicationHao Cao, Dong Liu, Chao Liu, Xinquan Hu, Aiwen Lei
A novel copper-catalyzed oxidative alkenylation of thioethers via Csp3-H functionalization to construct allylic thioethers was first demonstrated. Different 1,1-disubstituted olefins could cross-couple with thioethers to generate the corresponding alkenylation products...
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Solvent- and Phase-Controlled Photochirogenesis. Enantiodifferentiating Photoisomerization of (Z)-Cyclooctene Sensitized by Cyclic Nigerosylnigerose-Based Nanosponges Crosslinked by Pyromellitate

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02390K, PaperXueqin Wei, Wenting Liang, Wanhua Wu, Cheng Yang, fabrizio caldera, Francesco Trotta, Andrea Mele, Tomoyuki Nishimoto, Yoshihisa Inoue
Cyclic nigerosylnigerose (CNN), a saucer-shaped cyclic tetrasaccharide with a shallow concave, was reacted with pyromellitic dianhydride in 1:2 and 1:4 ratios to give two CNN-based polymers of different degrees of...
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Tuning Viscoelastic Properties of Supramolecular Peptide Gels via Dynamic Covalent Crosslinking

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02217C, CommunicationAref Khalily, Melis Goktas, Mustafa O. Guler
Dynamic covalent crosslinking approach is used to crosslink supramolecular peptide gels. This novel approach facilitates tuning viscoelastic properties of the gel and enhances mechanical stability (storage modulus exceeding 105 Pa)...
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Phototriggerable peptidomimetics for the inhibition of Mycobacterium turberculosis ribonucleotide reductase by targeting protein-protein binding

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01926A, PaperChristoffer Karlsson, Magnus Blom, Miranda Johansson, Anna M Jansson, Enzo Scifo, Anders Karlen, Thavendran Govender, Adolf Gogoll
Incorporation of an artificial amino acid 2 with a stilbene chromophore into peptidomimetics with three to nine amino acids yields phototriggerable candidates for inhibition of the binding between the R1...
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Vanadyl Species-Catalyzed, Complementary [small beta]-Oxidative Carbonylation of Styrene Derivatives with Aldehydes

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02621G, PaperShiue-Shien Weng, Wen-Chieh Yang, Ananthan Ramasamy, Gobi Rajeshwaren, Yi-Ya Liao, Chien-Tien Chen
A series of oxometallic species and metal acetylacetonates (acac) was examined as catalysts for oxidative carbonylation of styrene with benzaldehyde by using t-butylhydroperoxide as co-oxidant in warm acetonitrile. Among them,...
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Preassembly-driven ratiometric sensing of H2PO4-anions in organic and aqueous environments

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02498B, CommunicationWeitao Gong, Duo Na, Le Fang, Hassan Mehdi, Guiling Ning
Gemini surfactant-like receptor R1 is designed and synthesized. The special preassembly phenomenon of R1 in nonpolar solvent facilitate the novel ratiometric fluorescence sensing of H2PO4- via anion-induced reassembly process in...
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Palladium-Catalyzed Oxidative Deacetonative Coupling of 4-Aryl-2-methyl-3-butyn-2-ols with H-phosphonates

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02410A, PaperXiang Li, Suyan Sun, Fan Yang, Jianxun Kang, Yusheng Wu, Yangjie Wu
An efficient and general applicable protocol for palladium-catalyzed oxidative deacetonative coupling of 4-aryl-2-methyl-3-butyn-2-ols with dialkyl H-phosphonates has been developed. This methodology provides a new and practical route to alkynylphosphonates using...
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Tetrahydrofuranyl and Tetrahydropyranyl Protection of Amino Acid Side-Chains Enables Synthesis of a Hydroxamate-Containing Aminoacylated tRNA

5 January, 2015 - 02:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02212B, PaperLester J. Lambert, Marvin Miller, Paul W. Huber
The ability to specifically engineer metal binding sites into target proteins has far-reaching consequences ranging from the development of new biocatalysts and imaging reagents to the production of proteins with...
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Binding modes of a core-extended metalloporphyrin to Human Telomeric DNA G-quadruplexes

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
The molecular recognition of Human telomeric G-quadruplexes by a novel cationic [small pi]-extended NiII-porphyrin (NiII-TImidP4, Chart 1) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting...
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Mixed Alkyl Aryl Phosphonate Esters as Quenched Fluorescent Activity-Based Probes for Serine Proteases

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02444C, PaperSevnur Serim, Philipp Baer, Steven H.L. Verhelst
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging,...
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, KESAVAN Venkitasamy, Kurt Vesterager Gothelf
Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The...
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Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02267J, CommunicationSu-Ying Xu, Xiaolong Sun, Haobo Ge, Rory L. Arrowsmith, John S. Fossey, Sofia I. Pascu, Yun-Bao Jiang, Tony D. James
A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching.
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Short and efficient synthesis of fluorinated [small delta]-lactams

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,717-728
DOI: 10.1039/C4OB01547A, PaperThomas J. Cogswell, Craig S. Donald, De-Liang Long, Rodolfo Marquez
The diastereoselective synthesis of fluorinated [small delta]-lactams.
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Benzosulfones as Photochemically Activated Sulfur Dioxide (SO2) Donors

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02466D, PaperSatish Malwal, Harinath Chakrapani
Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic...
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