Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Coumarin based Gold(I)-Alkynyl Complex: A new class of Supramolecular Hydrogelator

15 December, 2014 - 22:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02077D, PaperArtur J Moro, Bertrand Rome, Elisabet Aguilo, Julia Arcau, Rakesh Puttreddy, Kari Rissanen, Joao Carlos Lima, Laura Rodriquez
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via Fluorescence Microscopy and Dynamic Light Scattering. The fibers presented strong blue...
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Rapid detection of hydrazine in naphthol-fused chromenyl loop and its effectiveness in human lung cancer cells: tuning remarkable selectivity via reaction altered pathway supported by theoretical studies

15 December, 2014 - 22:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01842G, PaperShyamaprosad Goswami, Avijit Kumar Das, Urmila Saha, Sibaprasad Maity, Kalyani Khanra, Nandan Bhattacharyya
Our designed and synthesized chemosensor naphthalene based chromenyl derivative (NAC) [1-(3-hydroxy-3 methyl-3H-benzo[f]chromen-2-yl) ethanone] has been used for fast ( < 30 Sec, DL = 0.14 ppb) and selective detection of...
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Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,374-378
DOI: 10.1039/C4OB02133A, CommunicationJohn Y. Ng, Jason W. H. Wong
A bioorthogonal method of transforming 3-nitrotyrosine to 3-azidotyrosine is described, providing new opportunities to study 3-nitrotyrosine in biological samples.
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Anion binding by biotin[6]uril in water

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,369-373
DOI: 10.1039/C4OB02211D, CommunicationMicke Lisbjerg, Bjarne E. Nielsen, Birgitte O. Milhoj, Stephan P. A. Sauer, Michael Pittelkow
We show that the newly discovered 6 + 6 biotin-formaldehyde macrocycle Biotin[6]uril binds a variety of anionic guest molecules in water. We discuss how and why the anions are bound based on data obtained using NMR spectroscopy, mass spectrometry, isothermal titrations calorimetry (ITC), computational calculations and single crystal X-ray crystallography.
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Cucurbituril-based supramolecular engineered nanostructured materials

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,330-347
DOI: 10.1039/C4OB02065K, Review ArticleSinem Gurbuz, Muazzam Idris, Donus Tuncel
Nanostructured materials, including nanoparticles, nanocomposites, vesicles, and rods, have been prepared by taking advantage of the interesting features of cucurbituril homologues.
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The direct electrophilic cyanation of [small beta]-keto esters and amides with cyano benziodoxole

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,365-368
DOI: 10.1039/C4OB02032D, CommunicationYao-Feng Wang, Jiashen Qiu, Dejie Kong, Yongtao Gao, Feipeng Lu, Pran Gopal Karmaker, Fu-Xue Chen
Electrophilic cyanating agent C1 accomplishes the direct cyanation of [small beta]-keto esters and amides without any catalyst and base.
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Fe-promoted radical cyanomethylation/arylation of arylacrylamides to access oxindoles via cleavage of the sp3 C-H of acetonitrile and the sp2 C-H of the phenyl group

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,361-364
DOI: 10.1039/C4OB02172J, CommunicationChangduo Pan, Honglin Zhang, Chengjian Zhu
Radical cyanomethylation/arylation of arylacrylamides to access oxindoles with acetonitrile as a radical precursor is described, involving dual C-H bond functionalization.
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Rhodium(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,612-619
DOI: 10.1039/C4OB01910E, PaperYu Tian, Yuanhao Wang, Hai Shang, Xudong Xu, Yefeng Tang
Rh(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles have been developed, which enable the efficient synthesis of various fused 2,5-dihydroazepines.
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A highly efficient and eco-friendly method for the synthesis of 1,3-indandione ring-fused 3-oxindoles bearing two contiguous quaternary stereocenters via an aldol reaction in aqueous media

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,601-611
DOI: 10.1039/C4OB02103G, PaperXiong-Li Liu, Bo-Wen Pan, Wen-Hui Zhang, Chao Yang, Jun Yang, Yang Shi, Ting-Ting Feng, Ying Zhou, Wei-Cheng Yuan
The synthesis and antitumor activity evaluation of 1,3-indandione ring-fused 3-oxindoles.
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Structural insight into the aggregation of L-prolyl dipeptides and its effect on organocatalytic performance

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,592-600
DOI: 10.1039/C4OB02003K, PaperCristina Berdugo, Beatriu Escuder, Juan F. Miravet
NMR and organocatalytic studies of four dipeptides derived from L-proline are described.
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Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C-C and two-fold C-N coupling reactions

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,583-591
DOI: 10.1039/C4OB01723D, PaperTran Quang Hung, Soren Hancker, Alexander Villinger, Stefan Lochbrunner, Tuan Thanh Dang, Aleksej Friedrich, Wolfgang Breitsprecher, Peter Langer
A series of 5,10-dihydroindolo[3,2-b]indoles was successfully prepared by an efficient two-step strategy.
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Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,357-360
DOI: 10.1039/C4OB02071E, CommunicationTommaso Quinto, Daniel Haussinger, Valentin Kohler, Thomas R. Ward
Stereoselectively labelled isotopomers of NAD(P)H are highly relevant for mechanistic studies of enzymes which utilize them as redox equivalents.
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L-Valine derived chiral N-sulfinamides as effective organocatalysts for the asymmetric hydrosilylation of N-alkyl and N-aryl protected ketimines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,577-582
DOI: 10.1039/C4OB01257G, PaperChao Wang, Xinjun Wu, Li Zhou, Jian Sun
L-Valine derived N-sulfinamides have been developed as efficient enantioselective Lewis basic organocatalysts for the asymmetric reduction of N-aryl and N-alkyl ketimines with trichlorosilane.
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Pd(II)-catalyzed C-H arylation of aryl and benzyl Weinreb amides

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,353-356
DOI: 10.1039/C4OB02039A, CommunicationYan Wang, Kai Zhou, Quan Lan, Xi-Sheng Wang
The first example of palladium-catalyzed ortho-C-H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter.
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Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,570-576
DOI: 10.1039/C4OB02054E, PaperFilippo Doria, Marco Folini, Vincenzo Grande, Graziella Cimino-Reale, Nadia Zaffaroni, Mauro Freccero
Water-soluble naphthalene diimides have been designed and synthesized as cell permeable pH "turned-on" fluorescent sensors for cellular applications.
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Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,549-560
DOI: 10.1039/C4OB01734J, PaperMatthijs van Haren, Linda Quarles van Ufford, Ed E. Moret, Nathaniel I. Martin
PRMT inhibitors designed to simultaneously occupy both substrate binding sites display potent activity and surprising selectivity.
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Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,539-548
DOI: 10.1039/C4OB02061H, PaperWei Li, Zhoulong Fan, Kaijun Geng, Youjun Xu, Ao Zhang
Divergent ortho-selective C-H functionalization was successfully established using a pyridazinone moiety as an internal directing group.
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Indium-catalyzed intramolecular hydroarylation of aryl propargyl ethers

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,379-387
DOI: 10.1039/C4OB02033B, PaperLorena Alonso-Maranon, M. Montserrat Martinez, Luis A. Sarandeses, Jose Perez Sestelo
Indium(III) halides are efficient and selective catalysts for the intramolecular hydroarylation of aryl propargyl ethers.
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Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,527-538
DOI: 10.1039/C4OB01465K, PaperRosa M. Suarez, Pedro Bosch, David Sucunza, Ana M. Cuadro, Alberto Domingo, Francisco Mendicuti, Juan J. Vaquero
The fluorescence, DNA binding and DNA sequence selectivity properties of a library of azonia aromatic cations have been studied.
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Developing a targeting system for bacterial membranes: measuring receptor-phosphatidylglycerol interactions with 1H NMR, ITC and fluorescence correlation spectroscopy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,502-512
DOI: 10.1039/C4OB01895H, PaperAmanda Alliband, Zifan Wang, Christopher Thacker, Douglas S. English, Dennis H. Burns
We report the development of a potential targeting system for bacterial membranes containing phosphatidylglycerol.
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