Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Acyclic cucurbit[n]uril-type molecular containers: influence of glycoluril oligomer length on their function as solubilizing agents

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00184F, PaperLaura Gilberg, Ben Zhang, Peter Y. Zavalij, Vladimir Sindelar, Lyle Isaacs
A series of glycoluril molecular clips and acyclic CB[n]-type receptors are tested as solubilizing agents for insoluble drugs.
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X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02648A, PaperV. Alterio, M. Tanc, J. Ivanova, R. Zalubovskis, I. Vozny, S. M. Monti, A. Di Fiore, G. De Simone, C. T. Supuran
Sulfamoylated saccharin binds to human carbonic anhydrase II through the SO2NH2 and not CONHSO2 moiety.
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First total synthesis of the marine natural products clavulolactones II and III

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00074B, PaperCharlotte M. Miller, Tore Benneche, Marcus A. Tius
The first total synthesis of the marine prostanoids clavulolactones II and III is presented from an easily accessible chiral, non-racemic cyclopentenone intermediate.
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Palladium-catalyzed regio-selective oxidative C-H bond acylation of azoxybenzenes with alcohols

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00089K, CommunicationLekai Hou, Xiangxiang Chen, Shuang Li, Suxian Cai, Yanxia Zhao, Meng Sun, Xiao-Juan Yang
A novel catalytic system for the ortho-acetyl functionalization of azoxybenzenes via a regio-selective directing-group-assisted strategy was developed.
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Frontier orbitals and transition states in the oxidation and degradation of L-ascorbic acid: a DFT study

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00035A, PaperShinichi Yamabe, Noriko Tsuchida, Shoko Yamazaki, Shigeyoshi Sakaki
DFT calculations were carried out to investigate reaction paths of L-ascorbic acid, hydroxyl radicals and water clusters up to threonic, oxalic, xylonic and lyxonic acids.
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Reactivities of vinyl azides and their recent applications in nitrogen heterocycle synthesis

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00099H, Review ArticleBao Hu, Stephen G. DiMagno
This review categorizes the active intermediates generated from denitrogenation of vinyl azides under different reaction conditions, and highlights newly discovered transformations of vinyl azides that lead to convenient syntheses of N-heterocycles.
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DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1[prime or minute]-linked pyrroloindoline alkaloids

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00190K, CommunicationMasanori Tayu, Takako Ishizaki, Kazuhiro Higuchi, Tomomi Kawasaki
The cross-coupling of tryptamine with substituted aniline to C3a-nitrogen-linked pyrroloindolines has been developed via the consecutive cyclization of tryptamine with DMSO/Tf2O and the substitution of 3a-pyrroloindolylthionium intermediate with aniline.
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Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00048C, PaperSabine Andre, Shane O'Sullivan, Christiane Koller, Paul V. Murphy, Hans-Joachim Gabius
The trimeric C-type lectin MGL is involved in activating immune defence and virus uptake, thus becoming a target for inhibitor design. A tetravalent cluster with [small alpha]-S-GalNAc proved to be effective in the nM range.
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A polystyrene-supported 9-amino(9-deoxy)epi quinine derivative for continuous flow asymmetric Michael reactions

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00325C, PaperJavier Izquierdo, Carles Ayats, Andrea H. Henseler, Miquel A. Pericas
A polystyrene (PS)-supported 9-amino(9-deoxy)epi quinine derivative catalyzes Michael reactions affording excellent levels of conversion and enantioselectivity using different nucleophiles and structurally diverse enones under continuous flow conditions.
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Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02659D, CommunicationAbhishek Iyer, Dorien Van Lysebetten, Yara Ruiz Garcia, Benoit Louage, Bruno G. De Geest, Annemieke Madder
Facile synthesis of DNA binding stapled peptides which show enhanced cellular uptake is described considering the GCN4 transcription factor as a model protein.
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Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00120J, CommunicationGang Zhang, Stacie Lynn Richardson, Yunfei Mao, Rong Huang
A novel clicked bisubstrate analogue (NAM-TZ-SPKRIA) was designed and synthesized to be a potent, selective, and first NTMT1 inhibitor.
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Cytotoxic scalarane sesterterpenoids from the South China Sea sponge Carteriospongia foliascens

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02532F, PaperFei Cao, Ze-Hong Wu, Chang-Lun Shao, Sen Pang, Xiao-Yan Liang, Nicole J. de Voogd, Chang-Yun Wang
Cytotoxic scalarane sesterterpenoids from the sponge Carteriospongia foliascens collected from the South China Sea.
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Development of a flow method for the hydroboration/oxidation of olefins

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00170F, CommunicationJose A. Souto, Robert A. Stockman, Steven V. Ley
A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described.
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Ligand- and Bronsted acid/base-switchable reaction pathways in gold(I)-catalyzed cycloisomerizations of allenoic acids

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02640C, PaperSachin Handa, Sri S. Subramanium, Aaron A. Ruch, Joseph M. Tanski, LeGrande M. Slaughter
Competing gold-catalyzed cycloisomerizations of [gamma]-allenoic acids are optimized through ligand and Bronsted acid/base effects, affording three distinct classes of lactones.
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Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00052A, CommunicationJulia Mantaj, S. M. Abdur Rahman, Bishwajit Bokshi, Choudhury M. Hasan, Paul J. M. Jackson, Richard B. Parsons, Khondaker M. Rahman
Crispene E inhibited STAT3 dimerization in a cell-free fluorescent polarization assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes.
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Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02685C, PaperAlessandro Pratesi, Mauro Ginanneschi, Fabrizio Melani, Marco Chinol, Angela Carollo, Giovanni Paganelli, Marco Lumini, Mattia Bartoli, Marco Frediani, Luca Rosi, Giorgio Petrucci, Luigi Messori, Anna Maria Papini
Oligomeric architectures of avidin generated by a new class of bis-biotins.
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[gamma]-(S)-Trifluoromethyl proline: evaluation as a structural substitute of proline for solid state 19F-NMR peptide studies

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, 13,3171-3181
DOI: 10.1039/C5OB00034C, Review ArticleVladimir Kubyshkin, Sergii Afonin, Sezgin Kara, Nediljko Budisa, Pavel K. Mykhailiuk, Anne S. Ulrich
[gamma]-(S)-Trifluoromethyl proline has been evaluated as a structural label for solid state 19F-NMR studies of polypeptides.
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Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of [small alpha]-amino acid esters using TBAI/TBHP

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00109A, PaperJie Zhang, Ying Shao, Yaxiong Wang, Huihuang Li, Dongmei Xu, Xiaobing Wan
A new strategy has been developed for the synthesis of [small alpha]-amino acid esters via a tandem hydrolysis/decarboxylation/nucleophilic substitution using TBAI/TBHP.
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An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00257E, PaperRosa Vitale, Liliana Lista, Corinne Cerrone, Giorgio Caserta, Marco Chino, Ornella Maglio, Flavia Nastri, Vincenzo Pavone, Angela Lombardi
The rational refinement of function into the heme-protein model Mimochrome VI (MC6) resulted in a new analogue, FeIII-E2L(TD)-MC6, with an improved peroxidase activity.
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Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers

4 March, 2015 - 17:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02606C, PaperAhmed Kamal, G. Bharath Kumar, M. V. P. S. Vishnuvardhan, Anver Basha Shaik, Vangala Santhosh Reddy, Rasala Mahesh, Ibrahim Bin Sayeeda, Jeevak Sopanrao Kapure
A series of phenstatin/isocombretastatin-chalcones were synthesized and screened for their cytotoxic activity.
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