Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Decarboxylative allylations of ester enolate equivalents

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01752H, CommunicationYamuna Ariyarathna, Jon A. Tunge
A variety of ester enolate equivalents are generated in situ and undergo [small alpha]-allylation in high yields via palladium-catalyzed decarboxylative allylation.
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Preparation of indium nitronates and their Henry reactions

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01468E, CommunicationRaquel G. Soengas, Rita Acurcio, Artur M. S. Silva
Indium nitronates were readily prepared from commercially available nitroalkanes by transmetallation of the corresponding lithium nitronates with indium salts. The Henry reaction of this nitronates with aldehydes afforded [small beta]-nitroalkanols in moderate to high yields and excellent stereoselectivity (when using chiral aldehydes).
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Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01338G, PaperM. Angeles Bonache, Alessandro Alaimo, Covadonga Malo, Oscar Millet, Alvaro Villarroel, Rosario Gonzalez-Muniz
Small bis-conjugates helix A329-350-PEG-triazole-PEG-helix B508-526 (41 residues), prepared through click chemistry of PEGylated peptide derivatives, bind to CaM with nanomolar affinity, behaving as mimics of the Kv7.2 native fragment (239 residues).
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A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01829J, CommunicationChandrasekhar Challa, Jamsheena Vellekkatt, Jaice Ravindran, Ravi S. Lankalapalli
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes.
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Cross-strand histidine-aromatic interactions enhance acyl-transfer rates in beta-hairpin peptide catalysts

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01754D, PaperM. Matsumoto, S. J. Lee, M. R. Gagne, M. L. Waters
A His-aryl interaction in a beta-hairpin catalyst provides rate enhancements of up to 18 000 for acyl transfer catalysis.
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Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01669F, CommunicationTayo O. Olaleye, James A. Brannigan, Shirley M. Roberts, Robin J. Leatherbarrow, Anthony J. Wilkinson, Edward W. Tate
Peptidomimetic inhibitors of N-myristoyltransferase from malaria and leishmaniasis parasites have been designed with nanomolar potency, and reveal the first direct structural evidence for a ternary NMT/CoA/myristoyl peptide product complex.
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Silver-catalyzed carbonphosphonation of [small alpha],[small alpha]-diaryl allylic alcohols: synthesis of [small beta]-aryl-[gamma]-ketophosphonates

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01739K, CommunicationXia Mi, Chenyang Wang, Mengmeng Huang, Yusheng Wu, Yangjie Wu
Silver-catalyzed carbonphosphonation of [small alpha],[small alpha]-diaryl allylic alcohols is achieved.
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5-Nitroindole oligonucleotides with alkynyl side chains: universal base pairing, triple bond hydration and properties of pyrene "click" adducts

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01478B, PaperSachin A. Ingale, Peter Leonard, Haozhe Yang, Frank Seela
Universal base pairing of 5-nitroindole oligonucleotides with alkynyl and pyrene functionalized side chains was demonstrated.
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Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01525H, PaperBaobin Cai, Xiantao Yang, Lidan Sun, Xinmeng Fan, Liyu Li, Hongwei Jin, Yun Wu, Zhu Guan, Liangren Zhang, Lihe Zhang, Zhenjun Yang
D-/L-IsoT were used to modify the loop regions of TBA and greatly improved its bioactivity as well as stability.
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Highly enantioselective phosphination and hydrophosphonylation of azomethine imines: using chiral squaramide as a hydrogen bonding organocatalyst

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01472C, PaperLing-Pei Kong, Nai-Kai Li, Shao-Yun Zhang, Xiang Chen, Min Zhao, Ya-Fei Zhang, Xing-Wang Wang
Highly enantioselective phosphination and hydrophosphonylation reactions of azomethine imines are respectively reported in this paper.
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Utilizing electrostatic interactions to facilitate F-18 radiolabeling of poly(amido)amine (PAMAM) dendrimers

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01616E, PaperDong Zhou, Sung Hoon Kim, Vincent M. Carroll, Carmen S. Dence, John A. Katzenellenbogen
Electrostatic interactions facilitate conjugation reactions of cationic poly(amido)amine (PAMAM) dendrimers with anionic NHS reagents.
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Anion binding of a neutral bis(cyclopeptide) in water-methanol mixtures containing up to 95% water

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01497A, PaperFabian Sommer, Stefan Kubik
Selectivity of a synthetic anion receptor reverses from strongly coordinating sulfate to weakly coordinating iodide anions upon increasing the water content of the solution.
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The journey of L-tartaric acid in the world of enantiomerically pure bis- and trisadducts of C60 with the inherently chiral trans-3 and all-trans-3 addition patterns

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01666A, PerspectiveNikos Chronakis
The journey of L-tartaric acid through its derivative (-)-dimethyl-2,3-O-isopropylidene-L-tartrate in the synthesis of enantiomerically pure diols, cyclo-[n]-malonates and finally, inherently chiral trans-3 bisadducts and all-trans-3 trisadducts of C60 is presented.
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First principles calculation of electron ionization mass spectra for selected organic drug molecules

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01668H, PaperChristoph Alexander Bauer, Stefan Grimme
The QCEIMS method provides automated calculation of EI mass spectra and requires only structural information (3D coordinates) as the input.
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Thiophene-benzoquinones: synthesis, crystal structures and preliminary coordination chemistry of derived anilate ligands

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01582G, PaperMatteo Atzori, Flavia Pop, Thomas Cauchy, Maria Laura Mercuri, Narcis Avarvari
The Stille coupling strategy allowed the preparation of electron-rich substituted anilate derivatives, which were fully characterized, and their coordination ability was investigated.
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An efficient route to synthesize isatins by metal-free, iodine-catalyzed sequential C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01564A, PaperVenkatachalam Rajeshkumar, Selvaraj Chandrasekar, Govindasamy Sekar
A novel molecular I2-catalyzed synthesis of isatins through C(sp3)-H oxidation and intramolecular C-N bond formation of 2[prime or minute]-aminoacetophenones has been developed.
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Base-promoted annulation of [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01858C, CommunicationHaitao He, Chaorong Qi, Yanglu Ou, Wenfang Xiong, Xiaohan Hu, Yanwei Ren, Huanfeng Jiang
A novel direct synthesis of pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones from [small alpha]-hydroxy ketones and dimethyl but-2-ynedioate via a base-promoted cascade annulation has been developed.
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Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01350F, PaperHeriberto Diaz Velazquez, Yara Ruiz Garcia, Matthias Vandichel, Annemieke Madder, Francis Verpoort
A series of novel bis(NHC) Cu(I) catalysts enables the production of triazoles with different substitution patterns and bioconjugation via "click" chemistry under homogeneous and/or heterogeneous catalytic conditions in aqueous media.
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Reversible deactivation radical polymerization mediated by cobalt complexes: recent progress and perspectives

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01427H, Review ArticleChi-How Peng, Tsung-Yao Yang, Yaguang Zhao, Xuefeng Fu
The current status and future perspective of cobalt mediated radical polymerization that showed efficient control of vinyl acetate and acrylate polymerization are described.
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Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

30 September, 2014 - 04:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01510J, PaperCarmen Festa, Chiara Cassiano, Maria Valeria D'Auria, Cecile Debitus, Maria Chiara Monti, Simona De Marino
The chemical analysis of two Thorectidae sponges led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their binding capability to TDP-43 was assessed by bio-physical techniques and resulted in the identifications of potent inhibitors.
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