Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Rhodium(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,612-619
DOI: 10.1039/C4OB01910E, PaperYu Tian, Yuanhao Wang, Hai Shang, Xudong Xu, Yefeng Tang
Rh(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles have been developed, which enable the efficient synthesis of various fused 2,5-dihydroazepines.
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A highly efficient and eco-friendly method for the synthesis of 1,3-indandione ring-fused 3-oxindoles bearing two contiguous quaternary stereocenters via an aldol reaction in aqueous media

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,601-611
DOI: 10.1039/C4OB02103G, PaperXiong-Li Liu, Bo-Wen Pan, Wen-Hui Zhang, Chao Yang, Jun Yang, Yang Shi, Ting-Ting Feng, Ying Zhou, Wei-Cheng Yuan
The synthesis and antitumor activity evaluation of 1,3-indandione ring-fused 3-oxindoles.
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Structural insight into the aggregation of L-prolyl dipeptides and its effect on organocatalytic performance

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,592-600
DOI: 10.1039/C4OB02003K, PaperCristina Berdugo, Beatriu Escuder, Juan F. Miravet
NMR and organocatalytic studies of four dipeptides derived from L-proline are described.
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Novel synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C-C and two-fold C-N coupling reactions

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,583-591
DOI: 10.1039/C4OB01723D, PaperTran Quang Hung, Soren Hancker, Alexander Villinger, Stefan Lochbrunner, Tuan Thanh Dang, Aleksej Friedrich, Wolfgang Breitsprecher, Peter Langer
A series of 5,10-dihydroindolo[3,2-b]indoles was successfully prepared by an efficient two-step strategy.
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Artificial metalloenzymes for the diastereoselective reduction of NAD+ to NAD2H

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,357-360
DOI: 10.1039/C4OB02071E, CommunicationTommaso Quinto, Daniel Haussinger, Valentin Kohler, Thomas R. Ward
Stereoselectively labelled isotopomers of NAD(P)H are highly relevant for mechanistic studies of enzymes which utilize them as redox equivalents.
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L-Valine derived chiral N-sulfinamides as effective organocatalysts for the asymmetric hydrosilylation of N-alkyl and N-aryl protected ketimines

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,577-582
DOI: 10.1039/C4OB01257G, PaperChao Wang, Xinjun Wu, Li Zhou, Jian Sun
L-Valine derived N-sulfinamides have been developed as efficient enantioselective Lewis basic organocatalysts for the asymmetric reduction of N-aryl and N-alkyl ketimines with trichlorosilane.
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Pd(II)-catalyzed C-H arylation of aryl and benzyl Weinreb amides

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,353-356
DOI: 10.1039/C4OB02039A, CommunicationYan Wang, Kai Zhou, Quan Lan, Xi-Sheng Wang
The first example of palladium-catalyzed ortho-C-H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter.
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Naphthalene diimides as red fluorescent pH sensors for functional cell imaging

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,570-576
DOI: 10.1039/C4OB02054E, PaperFilippo Doria, Marco Folini, Vincenzo Grande, Graziella Cimino-Reale, Nadia Zaffaroni, Mauro Freccero
Water-soluble naphthalene diimides have been designed and synthesized as cell permeable pH "turned-on" fluorescent sensors for cellular applications.
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Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,549-560
DOI: 10.1039/C4OB01734J, PaperMatthijs van Haren, Linda Quarles van Ufford, Ed E. Moret, Nathaniel I. Martin
PRMT inhibitors designed to simultaneously occupy both substrate binding sites display potent activity and surprising selectivity.
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Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,539-548
DOI: 10.1039/C4OB02061H, PaperWei Li, Zhoulong Fan, Kaijun Geng, Youjun Xu, Ao Zhang
Divergent ortho-selective C-H functionalization was successfully established using a pyridazinone moiety as an internal directing group.
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Indium-catalyzed intramolecular hydroarylation of aryl propargyl ethers

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,379-387
DOI: 10.1039/C4OB02033B, PaperLorena Alonso-Maranon, M. Montserrat Martinez, Luis A. Sarandeses, Jose Perez Sestelo
Indium(III) halides are efficient and selective catalysts for the intramolecular hydroarylation of aryl propargyl ethers.
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Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,527-538
DOI: 10.1039/C4OB01465K, PaperRosa M. Suarez, Pedro Bosch, David Sucunza, Ana M. Cuadro, Alberto Domingo, Francisco Mendicuti, Juan J. Vaquero
The fluorescence, DNA binding and DNA sequence selectivity properties of a library of azonia aromatic cations have been studied.
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Developing a targeting system for bacterial membranes: measuring receptor-phosphatidylglycerol interactions with 1H NMR, ITC and fluorescence correlation spectroscopy

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,502-512
DOI: 10.1039/C4OB01895H, PaperAmanda Alliband, Zifan Wang, Christopher Thacker, Douglas S. English, Dennis H. Burns
We report the development of a potential targeting system for bacterial membranes containing phosphatidylglycerol.
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Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-[small beta]-enaminonitriles

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,513-519
DOI: 10.1039/C4OB01801J, PaperYing-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang, Ying-ming Pan
In this work, a novel and highly stereoselective synthesis of Z-[small beta]-enaminonitriles from azides and [small alpha],[small beta]-unsaturated nitriles is reported.
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Synthesis and antifungal activity of 1,2,3-triazole phenylhydrazone derivatives

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,477-486
DOI: 10.1039/C4OB01758G, PaperZhi-Cheng Dai, Yong-Fei Chen, Mao Zhang, Sheng-Kun Li, Ting-Ting Yang, Li Shen, Jian-Xin Wang, Shao-Song Qian, Hai-Liang Zhu, Yong-Hao Ye
A series of 1,2,3-triazole phenylhydrazone derivatives were designed and synthesized as antifungal agents.
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Chiral recognition with a benzofuran receptor that mimics an oxyanion hole

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,493-501
DOI: 10.1039/C4OB01954G, PaperAngel L. Fuentes de Arriba, Angel Gomez Herrero, Omayra H. Rubio, Laura M. Monleon, Luis Simon Rubio, Victoria Alcazar, Francisca Sanz, Joaquin R. Moran
Chiral resolution of a novel tripodal oxyanion-hole receptor with application in amino acid derivatives enantioselective extraction.
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Mixed non-covalent assemblies of ethynyl nile red and ethynyl pyrene along oligonucleotide templates

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,487-492
DOI: 10.1039/C4OB01860E, PaperPhilipp Ensslen, Yannic Fritz, Hans-Achim Wagenknecht
The mixture makes the difference: the assemblies of ethynyl pyrene and ethynyl nile red along oligonucleotide templates are highly ordered and yield dual fluorescence.
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A peptide topological template for the dispersion of [60]fullerene in water

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,348-352
DOI: 10.1039/C4OB02102A, CommunicationS. Bartocci, D. Mazzier, A. Moretto, M. Mba
Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL-1 have been obtained using a peptide topological template as the carrier.
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The synthesis of 3-hydroxy-2,4,8-trimethyldec-8-enolides and an approach to 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,465-476
DOI: 10.1039/C4OB01792G, PaperJ. M. Botubol-Ares, M. J. Duran-Pena, A. J. Macias-Sanchez, J. R. Hanson, I. G. Collado, R. Hernandez-Galan
The enantioselective synthesis of 3, (E)-8, (Z)-8, 20a and 20b is reported using RCM as key step. Based in spectroscopic differences, the structure assigned to the natural product has been revised to that of a [gamma]-butyrolactone.
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Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,452-464
DOI: 10.1039/C4OB01925C, PaperGerard Artigas, Paula Lopez-Senin, Carlos Gonzalez, Nuria Escaja, Vicente Marchan
Ligands with a preferred binding site in the bulged region of the stem-loop structure of Tau pre-mRNA have been identified by dynamic combinatorial chemistry.
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