Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1113-1121
DOI: 10.1039/C4OB01953A, PaperYusuke Yagi, Hiroyuki Kimura, Kenji Arimitsu, Masahiro Ono, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Kajimoto, Yuichi Sugiyama, Hideo Saji
Fluorine-18 labeled radiotracers, such as [18F]fluorodeoxyglucose, can be used as practical diagnostic agents in positron emission tomography (PET).
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The development of a complementary pathway for the synthesis of aliskiren

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1133-1140
DOI: 10.1039/C4OB01963F, PaperLe-Le Li, Jin-Ying Ding, Lian-Xun Gao, Fu-She Han
We present an alternative pathway for the synthesis of aliskiren by applying the Evans chiral auxiliary-aided asymmetric allylation and the Julia-Kocienski olefination as the key transformations.
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Modulation of the charge transfer and photophysical properties in non-fused tetrathiafulvalene-benzothiadiazole derivatives

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1040-1047
DOI: 10.1039/C4OB02100B, PaperFlavia Pop, Sabine Seifert, Jihane Hankache, Jie Ding, Andreas Hauser, Narcis Avarvari
Stille and Sonogashira coupling strategies allowed the preparation of luminescent TTF-benzothiadiazole donor-acceptor compounds with direct linkage or an acetylenic spacer.
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Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1030-1039
DOI: 10.1039/C4OB02185A, PaperRalph Appel, Sebastian Tacke, Jurgen Klingauf, Pol Besenius
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character and describe their self-assembly into supramolecular nanorods using pH and ionic strength dependent state diagrams.
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Synthesis of Imidazoles via Cascade Reaction of Nitroallylic Acetates with Amidines and Studies on Their Trypanocidal Activity

9 January, 2015 - 03:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02561J, CommunicationTarun Kumar, Deepti Verma, Rubem F. S. Menna-Barreto, Wagner O. Valenca, Eufranio Silva Junior, Irishi N Namboothiri
A one-pot, two step synthesis of highly substituted imidazoles has been carried out in good to excellent yield for the first time via a cascade intermolecular aza-SN2'-intramolecular aza-Michael addition involving...
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Photocontrol of Ion Permeation in Lipid Vesicles with Amphiphilic Dithienylethenes

9 January, 2015 - 03:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02382J, PaperYamuna S. Kandasamy, Jianxin Cai, Alisha Beler, M.-S. Jemeli Sang, Patrick D. Andrews, R. Scott Murphy
The integration of photochromic dithienylethenes (DTEs) with lipid vesicles as photoresponsive membrane disruptors for ion transport applications has been examined. We have synthesized three amphiphilic DTEs 1-3 that incorporate a...
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Cationic dialkylarylphosphates: a new family of bio-inspired cationic lipids for gene delivery

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1122-1132
DOI: 10.1039/C4OB01770F, PaperStephanie S. Le Corre, Nawal Belmadi, Mathieu Berchel, Tony Le Gall, Jean-Pierre Haelters, Pierre Lehn, Tristan Montier, Paul-Alain Jaffres
The synthesis of mono- and di-cationic lipophosphates is reported. These cationic lipids were formulated as liposomal solutions, and their capacity to transfect cells was evaluated on three cell lines.
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Bleomycin-induced trans lipid formation in cell membranes and in liposome models

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1100-1105
DOI: 10.1039/C4OB01924E, PaperAysegul Cort, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos Chatgilialoglu, Carla Ferreri
Bleomycin-iron complexes cause lipid cis-trans isomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.
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Determination of the absolute configuration of phosphinic analogues of glutamate

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1106-1112
DOI: 10.1039/C4OB01960A, PaperBruno Commare, Delphine Rigault, Isabelle A. Lemasson, Patrick Deschamps, Alain Tomas, Pascal Roussel, Isabelle Brabet, Cyril Goudet, Jean-Philippe Pin, Frederic R. Leroux, Francoise Colobert, Francine C. Acher
Stereomers of LSP1-2111 have been separated, their absolute configuration and agonist activity at mGlu4R determined.
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Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1091-1099
DOI: 10.1039/C4OB01602E, PaperMaria Vetro, Barbara Costa, Giulia Donvito, Noemi Arrighetti, Laura Cipolla, Paola Perego, Federica Compostella, Fiamma Ronchetti, Diego Colombo
Long chain GlcADG analogues synthesized as PI3P mimics inhibited isolated Akt and proliferation of human ovarian carcinoma IGROV-1 cells.
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1,4 Addition of unprotected pyrrole onto chiral acrylamides: toward synthesis of new polypeptidic architectures

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1082-1090
DOI: 10.1039/C4OB01920B, PaperAlexander Gratais, Xavier Pannecoucke, Samir Bouzbouz
A variety of new chiral functionalized pyrroloamides have been synthesized by a simple and robust process involving Lewis acids. Unprotected pyrrole could be selectively monoalkylated or dialkylated.
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Niosomes based on synthetic cationic lipids for gene delivery: the influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1068-1081
DOI: 10.1039/C4OB02087A, PaperE. Ojeda, G. Puras, M. Agirre, J. Zarate, S. Grijalvo, R. Pons, R. Eritja, G. Martinez-Navarrete, C. Soto-Sanchez, E. Fernandez, J. L. Pedraz
We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency.
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Allylic and benzylic sp3 C-H oxidation in water

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1048-1052
DOI: 10.1039/C4OB02017K, PaperWei Jie Ang, Yulin Lam
A copper-catalyzed method for the oxidation of allylic and benzylic sp3 C-H by aqueous tert-butyl hydroperoxide (T-Hydro) in water using a recyclable fluorous ligand has been developed.
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One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,970-973
DOI: 10.1039/C4OB02143F, PerspectiveK. Kashinath, D. Srinivasa Reddy
Multiple reactions in one pot has always been a useful technique for synthetic organic chemists, as it can minimizes solvent usage, time and the number of purification steps when compared to individual multi-step syntheses.
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Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,974-989
DOI: 10.1039/C4OB01796J, Review ArticleOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Atsushi Arakaki, Katsuhiko Shimizu, Mayumi Oda, Takeshi Sakamoto, Tatsuya Nishimura, Takashi Kato
Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials. Molecularly controlled mechanisms of biomineralization and application of the processes towards future material synthesis are introduced.
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Contrasting anion recognition behaviour exhibited by halogen and hydrogen bonding rotaxane hosts

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02547D, PaperStuart Philip Cornes, Charles Davies, David Blyghton, Mark Sambrook, P D Beer
A rotaxane host system containing a novel halogen bonding (XB) 5-iodo-1,2,3-triazole functionalised pyridinium motif, within its axle component, has been prepared via a ring closing metathesis reaction, using chloride as...
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Synthesis of a novel water-soluble cylindrical macrotricyclic host and its complexation with N-methylquinolinium and N-methylisoquinolinium salts: formation of 1:2 complexes in water

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02533D, CommunicationFei Zeng, Chuan-Feng Chen
A novel water-soluble cylindrical macrotricyclic host containing one central cavity and two dibenzo-24-crown-8 lateral cavities was synthesized. It could form 1:2 complexes with N-methylquinolinium salts or N-methylisoquinolinium salts in water...
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Direct construction of 2-alkylbenzo-1,3-azoles via C-H activation of alkanes for C-C and C-X (X = O, S) bond formation

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02488E, PaperArvind K. Yadav, L.D.S. Yadav
Copper catalyzed straightforward synthesis of 2-alkylbenzoxa(thia)azoles from aryl isocyanates/isothiocyanates and simple alkanes is reported. The protocol utilizes ditertiarybutylproxide (DTBP) as a radical initiator and involves sequential formation of C-C and...
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Ligand orientation in a membrane-embedded receptor site revealed by solid-state NMR with paramagnetic relaxation enhancement.

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02427C, PaperChristopher Whittaker, Simon G. Patching, Mikael Esmann, David Middleton
NMR relaxation enhancement by paramagnetic metals provides powerful restraints on the three-dimensional structures of proteins in solution, and this approach has recently been utilized in several NMR structural investigations of...
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Sweetness and Light: Design and Applications of Photoswitchable Glycoconjugates.

7 January, 2015 - 03:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02296C, Review Articleyingxue Hu, Rico Tabor, Brendan L. Wilkinson
Carbohydrate-protein binding is supramolecular recognition process that underpins myriad biological events. However, the precise conformational and configurational requirements for biomolecular recognition are often poorly understood, since such phenomena often occur...
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