Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 16 hours ago

Regioselective synthesis of 3,4,5-trisubstituted 2-aminofurans

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5098-5101
DOI: 10.1039/C4OB01037J, CommunicationThi Ngoc Tram Huynh, Pascal Retailleau, Clement Denhez, Kim Phi Phung Nguyen, Dom Guillaume
Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5089-5093
DOI: 10.1039/C4OB00418C, CommunicationTakayoshi Watanabe, Tomoko Hoshida, Jun Sakyo, Mariko Kishi, Satoshi Tanabe, Junichi Matsuura, Shingo Akiyama, Makiko Nakata, Yasuaki Tanabe, Akinobu Z. Suzuki, Soichiro Watanabe, Toshiaki Furuta
A nucleobase-caged peptide nucleic acid (PNA) having a (6-bromo-7-methoxycoumarin)-4-ylmethoxycarbonyl (Bmcmoc) caging group was newly synthesized.
The content of this RSS Feed (c) The Royal Society of Chemistry

Evaluation of the effect of fluorination on the property of monofluorinated dimyristoylphosphatidylcholines

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5126-5135
DOI: 10.1039/C4OB00934G, PaperMarie-Claude Gagnon, Bianka Turgeon, Jean-Daniel Savoie, Jean-Francois Parent, Michele Auger, Jean-Francois Paquin
The synthesis and characterization of three monofluorinated dimyristoylphosphatidylcholines, with the fluorine atom located at the extremities of the acyl chain in position 2 of the glycerol (sn-2), is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5082-5088
DOI: 10.1039/C4OB00945B, CommunicationAlistair J. MacNair, Ming-Ming Tran, Jennifer E. Nelson, G. Usherwood Sloan, Alan Ironmonger, Stephen P. Thomas
An operationally simple and environmentally benign formal hydrogenation protocol has been developed using a highly abundant iron(III) salt and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A new synthetic approach to 6-unsubstituted phenanthridine and phenanthridine-like compounds under mild and metal-free conditions

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5077-5081
DOI: 10.1039/C4OB00797B, CommunicationJumreang Tummatorn, Suppachai Krajangsri, Krissada Norseeda, Charnsak Thongsornkleeb, Somsak Ruchirawat
A tandem azide rearrangement/intramolecular annulation and oxidation reactions of biarylmethyl azides provides a new and mild approach for the synthesis of 6-unsubstituted phenanthridine and phenanthridine-like compounds.
The content of this RSS Feed (c) The Royal Society of Chemistry

Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5304-5310
DOI: 10.1039/C4OB00717D, PaperJ. M. Botubol-Ares, M. J. Duran-Pena, A. J. Macias-Sanchez, J. R. Hanson, I. G. Collado, R. Hernandez-Galan
Four new highly oxygenated 11-membered lactones (11-14) were synthesized by a combination of metabolic engineering techniques with complex chemical substrate synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalytic enantioselective allylic alkylation of MBH carbonates with [small beta]-keto esters

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5071-5076
DOI: 10.1039/C4OB00682H, CommunicationM. Kamlar, S. Hybelbauerova, I. Cisarova, J. Vesely
The highly stereoselective allylic alkylation of Morita-Baylis-Hillman carbonates with [small beta]-ketoesters catalysed by [small beta]-ICD is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5260-5266
DOI: 10.1039/C4OB00603H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jens M. Stadler, Thorsten Stafforst
Peptide nucleic acids carrying various pyrene chromophores have been investigated to reverse psoralen DNA interstrand crosslinks in a photolyase-like manner.
The content of this RSS Feed (c) The Royal Society of Chemistry

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5295-5303
DOI: 10.1039/C4OB00553H, PaperAsmaa A. Sallam, Mohamed M. Mohyeldin, Ahmed I. Foudah, Mohamed R. Akl, Sami Nazzal, Sharon A. Meyer, Yong-Yu Liu, Khalid A. El Sayed
The synthetic marine-inspired PMH analog 7 showed promising in vitro and in vivo antitumor effects against breast cancer via targeting Brk and FAK signaling pathways.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5052-5070
DOI: 10.1039/C4OB00777H, Review ArticleArkady Khashper, William D. Lubell
Growth in the field of peptide mimicry over the past few decades has resulted in the synthesis of many new compounds and the investigation of novel pharmacological agents.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5212-5221
DOI: 10.1039/C4OB00787E, PaperJeremy Ruiz, Sonia Mallet-Ladeira, Marjorie Maynadier, Henri Vial, Christiane Andre-Barres
New tricyclic endoperoxides were obtained by a diastereoselective autoxidation; combined with 7-chloro-4-aminoquinoline, they display good antiplasmodial activities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, characterization and biological evaluation of carboranylmethylbenzo[b]acridones as novel agents for boron neutron capture therapy

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5201-5211
DOI: 10.1039/C4OB00644E, PaperA. Filipa F. da Silva, Raquel S. G. R. Seixas, Artur M. S. Silva, Joana Coimbra, Ana C. Fernandes, Joana P. Santos, Antonio Matos, Jose Rino, Isabel Santos, Fernanda Marques
Acridone derivatives bearing carboranyl moieties as fluorescent probes for boron neutron capture therapy (BNCT) of the glioblastoma.
The content of this RSS Feed (c) The Royal Society of Chemistry

Multicomponent reaction for the first synthesis of 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines as scaffolds for various 3,4-dihydro-2H-1,3-thiazine derivatives

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5168-5181
DOI: 10.1039/C4OB00866A, PaperFabian Brockmeyer, Robin Schoemaker, Marc Schmidtmann, Jurgen Martens
2H-1,3-thiazines, prepared via a novel and efficient multicomponent reaction, can be used as scaffolds for the synthesis of diverse 3,4-dihydro-2H-1,3-thiazines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Methylthiodeoxynivalenol (MTD): insight into the chemistry, structure and toxicity of thia-Michael adducts of trichothecenes

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5144-5150
DOI: 10.1039/C4OB00458B, PaperPhilipp Fruhmann, Theresa Weigl-Pollack, Hannes Mikula, Gerlinde Wiesenberger, Gerhard Adam, Elisabeth Varga, Franz Berthiller, Rudolf Krska, Christian Hametner, Johannes Frohlich
Synthesis and investigation of MTD revealed characteristic hemiketalisation and partial detoxification as effects of thia-Michael addition to type B trichothecenes.
The content of this RSS Feed (c) The Royal Society of Chemistry

Mercuration of thiacalix[4]arenes in the cone and 1,3-alternate conformations

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5136-5143
DOI: 10.1039/C4OB00799A, PaperF. Botha, S. Bohm, H. Dvorakova, V. Eigner, P. Lhotak
A monomercuration reaction of thiacalix[4]arenes immobilized in the cone or 1,3-alternate conformations gave a mixture of two regioisomers (meta and para) in approx. 4 : 1 and 2 : 1 ratios, respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5235-5242
DOI: 10.1039/C4OB00149D, PaperM. Scuotto, M. Persico, M. Bucci, V. Vellecco, N. Borbone, E. Morelli, G. Oliviero, E. Novellino, G. Piccialli, G. Cirino, M. Varra, C. Fattorusso, L. Mayol
Optically pure modified acyclic nucleosides offer unique advantages in exploring the effect on thrombin inhibition of single residue modifications at key positions of TBA.
The content of this RSS Feed (c) The Royal Society of Chemistry

Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: a previously unrecognized mechanism for acrolein-mediated oxidative stress

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5151-5157
DOI: 10.1039/C4OB00761A, PaperAyumi Tsutsui, Rie Imamaki, Shinobu Kitazume, Shinya Hanashima, Yoshiki Yamaguchi, Masato Kaneda, Shinya Oishi, Nobutaka Fujii, Almira Kurbangalieva, Naoyuki Taniguchi, Katsunori Tanaka
Polyamines were found to react with acrolein to produce 1,5-diazacyclooctane.
The content of this RSS Feed (c) The Royal Society of Chemistry

A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5115-5125
DOI: 10.1039/C4OB00285G, PaperLing Zhang, Sai Li, Mei Hong, Yuqing Xu, Shuaishuai Wang, Yi Liu, Yong Qian, Jing Zhao
A naphthalimide-azide based colorimetric and ratiometric fluorescent probe has been developed for the selective and sensitive detection of hydrogen sulphide.
The content of this RSS Feed (c) The Royal Society of Chemistry

Impact of mono- and disubstitution on the colorimetric dynamic covalent switching chalcone/flavanone scaffold

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5108-5114
DOI: 10.1039/C4OB00398E, PaperBrian M. Muller, Jesse Mai, Reid A. Yocum, Marc J. Adler
The impact of substitution on a novel colorimetric dynamic covalent switching scaffold was investigated using UV/Vis and NMR spectroscopy.
The content of this RSS Feed (c) The Royal Society of Chemistry

An ESIPT fluorescent probe sensitive to protein [small alpha]-helix structures

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5250-5259
DOI: 10.1039/C4OB00405A, PaperNan Jiang, Chanli Yang, Xiongwei Dong, Xianglang Sun, Dan Zhang, Changlin Liu
A benzazole derivative, 1, was observed to undergo the excited-state intramolecular proton transfer (ESIPT) process with [small alpha]-helical proteins. The cell images showed a difference in the staining of normal and cancerous prostate cells by 1, which might be due to the different membrane protein levels.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.