Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 8 hours ago

Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing

30 October, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01925C, PaperGerard Artigas, Paula Lopez-Senin, Carlos Gonzalez, Nuria Escaja, Vicente Marchan
Tau pre-mRNA contains a stem-loop structure involved in the regulation of the alternative splicing of tau protein. We describe here a new family of Tau RNA ligands selected by a...
The content of this RSS Feed (c) The Royal Society of Chemistry

Novel Synthesis of 5-methyl-5,10-dihydroindolo[3,2-b]indoles by Pd-catalyzed C-C and two-fold C-N coupling reactions

30 October, 2014 - 10:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01723D, PaperTran Quang Hung, Soren Hancker, Alexander Villinger, Stefan Lochbrunner, Tuan T Dang, Aleksey Friedrich, Wolfgang Breitsprecher, Peter Langer
A series of 5,10-dihydroindolo[3,2-b]indoles was successfully prepared by an efficient two-step strategy based on site-selective Pd-catalyzed cross-coupling reaction with N-methyl-2,3-dibromoindole and subsequent cyclization by two-fold Pd-catalyzed C-N coupling with amines....
The content of this RSS Feed (c) The Royal Society of Chemistry

Asymmetric synthesis of axially chiral anilides by Pd-catalyzed allylic substitutions with P/olefin ligands

30 October, 2014 - 10:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01087F, PaperYilin Liu, Xiangqing Feng, Haifeng Du
Palladium-catalyzed allylic substitutions of ortho-substituted anilides using P/olefin ligands were achieved to afford chiral anilides with up to 84% ee.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of fully functionalized aglycone of lycoperdinoside A and B

30 October, 2014 - 10:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01716A, PaperBalla Chandrasekhar, Sudhakar Athe, P. Purushotham Reddy, Subhash Ghosh
Synthesis of fully functionalized aglycone of lycoperdinoside A and B is achieved via Pd-catalyzed Stille-Migita cross coupling and Evans syn- and anti aldol reactions as key steps.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Pd-catalyzed oxidative C-H alkenylation for synthesizing arylvinyltriazole nucleosides

30 October, 2014 - 10:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01836B, PaperJingjie Tang, Mei Cong, Yi Xia, Gilles Quelever, Yuting Fan, Fanqi Qu, Ling Peng
Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides in good yields and with large functional group tolerance.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Indium-Catalyzed Intramolecular Hydroarylation of Aryl Propargyl Ethers

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02033B, PaperLorena Alonso-Maranon, M. Montserrat Martinez, Luis Sarandeses, Jose Perez Sestelo
Indium(III) halides catalyze efficiently the intramolecular hydroarylation (IMHA) of aryl propargyl ethers. The reaction proceeds regioselectively with a variety of electron-rich and electron-deficient benzenes and with terminal and internal alkynes...
The content of this RSS Feed (c) The Royal Society of Chemistry

Preparation of Cycloheptane Ring by Nucleophilic Cyclopropanation of 1,2-Diketones with Bis(iodozincio)methane

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01474J, PaperSeijiro Matsubara, Ryosuke Haraguchi, Yoshiaki Takada
We used a microflow system to study the nucleophilic cyclopropanation of hexa-1,5-diene-3,4-diones with bis(iodozincio)methane. This reaction afforded the zinc alkoxides of cis-dialkenylcylopropane-1,2-diols stereoselectively. The subsequent oxy-Cope rearrangement of cis-dialkenylcylopropane-1,2-diols afforded...
The content of this RSS Feed (c) The Royal Society of Chemistry

Targeting DNA with small molecules: a comparative study of a library of azonia aromatic chromophores

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01465K, PaperJuan J. Vaquero, Rosa Suarez, Pedro Bosch, Dr. David Sucunza, Ana M. Cuadro, Alberto Domingo, Francisco Mendicuti
A library of azonia aromatic cations has been studied in order to gain an insight into the role of the size, shape and charge distribution on the fluorescence, DNA interactions...
The content of this RSS Feed (c) The Royal Society of Chemistry

Irriversible Covalent Modification of Type I Dehydroquinase by a Stable Schiff Base

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01782J, PaperLorena Tizon, Maria Maneiro, Antonio Peon, Jose Otero, Emilio Lence, Sergio Poza, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepcion Gonzalez-Bello
The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, has been investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics...
The content of this RSS Feed (c) The Royal Society of Chemistry

Improved synthesis of the super antioxidant, ergothioneine and its biosynthetic pathway intermediates.

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02023E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anwar Jardine, Peguy Lutete Khonde
Ergothioneine along with mycothiol, are low molecular mass redox protective thiols present in Actinomycetes, in particular mycobacteria. We report the improved chemical synthesis of ergothioneine (ESH) and biosynthetic pathway intermediates...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and Antifungal Activity of 1,2,3-Triazole Phenylhydrazone Derivatives

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01758G, PaperZhicheng Dai, Yongfei Chen, Mao Zhang, Shengkun Li, Tingting Yang, Li Shen, Jianxin Wang, Shao-Song Qian, Hai-Liang Zhu, Yonghao Ye
A series of 1,2,3-triazole phenylhydrazone were designed and synthesized as antifungal agents. Their structures were determined based on 1H-NMR spectroscopy, MS, elemental analysis and X-ray single-crystal diffraction. The antifungal activities...
The content of this RSS Feed (c) The Royal Society of Chemistry

Chiral recognition with a benzofuran receptor which mimics an oxyanion hole

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01954G, PaperAngel L. Fuentes de Arriba, Angel Gomez Herrero, Omayra Hernandez Rubio, Laura Marcos Monleon, Luis Simon, Victoria Alcazar, Francisca Sanz, Joaquin Rodriguez Moran
A new chiral benzofuran receptor has been synthesized and its properties in the association of amino acid derivatives have been studied. X-ray structures were obtained and these corroborate the presence...
The content of this RSS Feed (c) The Royal Society of Chemistry

Mixed non-covalent assemblies of ethynyl nile red and ethynyl pyrene along oligonucleotide templates

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01860E, PaperPhilipp Ensslen, Yannic Fritz, Hans-Achim Wagenknecht
Ethynyl pyrene and ethynyl nile red as modifications at the 5-position of 2'-deoxuridines self-assemble non-covalently and specifically along oligo-2'-deoxyadenosines as templates. Oligo-2'-deoxyadenosines of the lengths (dA)10 - (dA)20 are able...
The content of this RSS Feed (c) The Royal Society of Chemistry

Efficient Merging of Copper and Photoredox Catalysis for the Asymmetric Cross-Dehydrogenative-Coupling of Alkynes and Tetrahydroisoquinolines

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02138J, PaperInna Perepichka, Soumen Kundu, Zoe Hearne, Chao-Jun Li
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp3 and sp C-H bonds with the assistance of a photocatalyst...
The content of this RSS Feed (c) The Royal Society of Chemistry

Correction: Non-isoprenoid polyene natural products - structures and synthetic strategies

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, 12,9029-9031
DOI: 10.1039/C4OB90153C, CorrectionKatrina S. Madden, Fathia A. Mosa, Andrew Whiting
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of highly functionalized C60 fullerene derivatives and their applications in material and life sciences

28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01663G, Review ArticleWeibo Yan, Stefan M. Seifermann, Philippe Pierrat, Stefan Brase
Highly functionalized fullerenes can be efficiently constructed by various techniques.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Correction: Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: investigation into the role of the aziridine nitrogen stereodynamics

28 October, 2014 - 10:17
Org. Biomol. Chem., 2014, 12,9028-9028
DOI: 10.1039/C4OB90144D, CorrectionRosmara Mansueto, Leonardo Degennaro, Jean-Francois Briere, Karen Griffin, Michael Shipman, Saverio Florio, Renzo Luisi
The content of this RSS Feed (c) The Royal Society of Chemistry

Organocatalytic Michael addition-lactonisation of carboxylic acids using [small alpha],[small beta]-unsaturated trichloromethyl ketones as [small alpha],[small beta]-unsaturated ester equivalents

28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,9016-9027
DOI: 10.1039/C4OB01788A, PaperLouis C. Morrill, Daniel G. Stark, James E. Taylor, Siobhan R. Smith, James A. Squires, Agathe C. A. D'Hollander, Carmen Simal, Peter Shapland, Timothy J. C. O'Riordan, Andrew D. Smith
Isothiourea HBTM-2.1 catalyses the Michael addition-lactonisation of 2-aryl and 2-alkenylacetic acids and [small alpha],[small beta]-unsaturated trichloromethyl ketones.
The content of this RSS Feed (c) The Royal Society of Chemistry

Templated DNA ligation with thiol chemistry

28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8823-8827
DOI: 10.1039/C4OB01552E, CommunicationDadong Li, Xiaojian Wang, Fubo Shi, Ruojie Sha, Nadrian C. Seeman, James W. Canary
Templated DNA ligation reactions are useful in a variety of contexts and have drawn much attention recently. Herein we describe two different DNA-templated ligation systems based on thiols and thiol-mediated chemistry. One system follows the principle of native chemical ligation reaction, and the other utilizes a thiol-disulfide exchange reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry

A short designed semi-aromatic organic nanotube - synthesis, chiroptical characterization, and host properties

28 October, 2014 - 10:17

Org. Biomol. Chem., 2014, 12,8930-8941
DOI: 10.1039/C4OB01683A, PaperTorbjorn Wixe, Niels Johan Christensen, Sven Lidin, Peter Fristrup, Kenneth Warnmark
A short helical nanotube having its aromatic system perpendicular to its axis of propagation was synthesized and its properties were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.