Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 13 hours ago

Interfacial catalysis of aldol reactions by prolinamide surfactants in reverse micelles

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,770-775
DOI: 10.1039/C4OB02074J, PaperPremkumar Rathinam Arivalagan, Yan Zhao
Aggregation of prolinamide surfactants in nonpolar solvents enhanced their catalytic activity and gave unusual substrate selectivity in aldol condensations.
The content of this RSS Feed (c) The Royal Society of Chemistry

1,1-Alkenylboration of diarylphosphino-enynes: convenient synthetic entry to vicinal P/B Lewis pairs at extended conjugated [small pi]-frameworks

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,764-769
DOI: 10.1039/C4OB02134G, PaperGuo-Qiang Chen, Gerald Kehr, Constantin G. Daniliuc, Gerhard Erker
Alkenylboranes R-CH[double bond, length as m-dash]CH-B(C6F5)2 undergo carbon-carbon coupling by means of 1,1-alkenylboration with diarylphosphino-enynes to give conjugated hexatriene derivatives that bear a vicinal pair of B(C6F5)2 and PAr2 functionalities at the framework.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of functionalized 2-salicyloylfurans, furo[3,2-b]chromen-9-ones and 2-benzoyl-8H-thieno[2,3-b]indoles by one-pot cyclizations of 3-halochromones with [small beta]-ketoamides and 1,3-dihydroindole-2-thiones

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,729-750
DOI: 10.1039/C4OB01730G, PaperIryna Savych, Tim Glasel, Alexander Villinger, Vyacheslav Ya. Sosnovskikh, Viktor O. Iaroshenko, Peter Langer
Domino reactions of 3-halochromones with [small beta]-ketoamides and 1,3-dihydroindole-2-thiones provided a convenient approach to various heterocyclic systems.
The content of this RSS Feed (c) The Royal Society of Chemistry

Exploiting the narrow gap of rearrangement between the substituents in the vicinal disubstitution reactions of diaryliodonium salts with pyridine N-sulfonamidates

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,751-763
DOI: 10.1039/C4OB01744G, PaperYong Wang, Ming Li, Lirong Wen, Peng Jing, Xiang Su, Chao Chen
The vicinal disubstitution reactions of diaryliodonium salts with pyridine N-sulfonamidates were studied fully to give o-pyridinium anilines.
The content of this RSS Feed (c) The Royal Society of Chemistry

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,706-716
DOI: 10.1039/C4OB01782J, PaperLorena Tizon, Maria Maneiro, Antonio Peon, Jose M. Otero, Emilio Lence, Sergio Poza, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepcion Gonzalez-Bello
Structural and computational studies carried out with two epoxides provide insight into the irreversible inhibition of type I dehydroquinase.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02311K, PaperDavid Fox, Michael S. Perryman, Matthew Earl, Sam Greatorex, Guy James Clarkson
Enantiomerically-enriched trichloromethyl-containing alcohols, obtained by asymmetric reduction, can be transformed regioselectively into 1-substituted piperazinones by modified Jocic reactions with little or no loss of stereochemical integrity. This methodology can be...
The content of this RSS Feed (c) The Royal Society of Chemistry

Effect of the amino acid composition of cyclic peptides on their self-assembly in lipid bilayers

24 December, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02041C, PaperMaarten Danial, Sebastien Perrier, Katrina A Jolliffe
The effect of amino acid composition on the formation of transmembrane channels in lipid bilayers upon self-assembly of alt-(L,D)-[small alpha]-cyclic octapeptides has been investigated. Cyclic peptides comprising D-leucine, alternating with different...
The content of this RSS Feed (c) The Royal Society of Chemistry

microRNA detection methods

24 December, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02104E, Review ArticleXiang Zhou, Tian Tian, Jiaqi Wang
MicroRNA (miRNA) detection is of considerable significance in both disease diagnosis and the study of miRNA function. The importance of miRNA itself is due to the complicated regulatory functions it...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis, Binding Affinity and Structure-Activity Relationships of Novel, Selective and Dual Targeting CCR2 and CCR5 Receptor Antagonists

24 December, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02397H, PaperBernhard Wuensch, Anna Junker, Artur K. Kokornaczyk, Annelien J. M. Zweemer, Bastian Frehland, Dirk Schempmann, Junichiro Yamaguchi, Kenichiro Itami, Andreas Faust, Hermann Sven, Stefan Wagner, Michael Schafers, Michael Koch, Christina Weiss, Laura H. Heitmann, Klaus Kopka
CCR2 and CCR5 receptors play a key role in the development and progression of several inflammatory, cardiovascular and autoimmune diseases. Therefore, dual targeting of both receptors appeals as a promising...
The content of this RSS Feed (c) The Royal Society of Chemistry

From [small alpha]-Nucleophiles to Functionalized Aggregates: Exploring the Reactivity of Hydroxamate Ion towards Esterolytic Reactions in Micelles

24 December, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02067G, Review ArticleNamrata Singh, Yevgen Karpichev, Rahul Sharma, Bhanushree Gupta, Arvind Kumar Sahu, Manmohan Lal Satnami, Kallol Ghosh
Owing to the rising threats of neurotoxic organophosphosphorus compounds, facile and efficient decontamination systems are required. Since the last few decades, search of promising [small alpha]-nuclophiles for straightforward and eco-friendly decontamination...
The content of this RSS Feed (c) The Royal Society of Chemistry

Peptide Synthesis Beyond DMF: THF and ACN as Excellent and Friendlier Alternatives

24 December, 2014 - 00:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02046D, PaperFernando Albericio, Yahya Jad, Gerardo Acosta, Sherine Khattab, Beatriz G. De la Torre, Thavendran Govender, Gert Kruger, Ayman El-Faham
To date, DMF has been considered the only solvent suitable for peptide synthesis. Here we demonstrate the capacity of THF and ACN, which are friendlier solvents than DMF, to yield...
The content of this RSS Feed (c) The Royal Society of Chemistry

Stereoelectronic effects: A simple yet powerful tool to manipulate anion affinity

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02470B, PaperMasoud Samet, S R Kass, Alireza Fattahi
Different strategies are employed in designing strong and selective anion receptors but stereoelectronic effects have been largely ignored. In this work, the stereo configuration of a non-interacting ether is found...
The content of this RSS Feed (c) The Royal Society of Chemistry

Construction of the Tricyclic Core of Steenkrotin-Type Diterpenoids via Intramolecular [3+2] Cycloaddition

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02439G, CommunicationHanfeng Ding, Jun Xuan, Saiyong Pan, Yuanbao Zhang, Bin Ye
A concise and diastereoselective route to the angularly fused [5‒6‒7] tricyclic carbon framework of the steenkrotin-type diterpenoids was reported. The key features of the strategy are based on an intramolecular...
The content of this RSS Feed (c) The Royal Society of Chemistry

Phosphate Modulates Receptor Sulfotyrosine Recognition by the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1/CCL2)

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02262A, PaperJustin Peter Ludeman, Mahdieh Nazari-Robati, Brendan L. Wilkinson, Cheng Huang, Richard J Payne, Martin Jeremy Stone
Tyrosine sulfation is a widespread post-translational modification that mediates the interactions of secreted and membrane-associated proteins in such varied biological processes as peptide hormone action, adhesion, blood coagulation, complement activation...
The content of this RSS Feed (c) The Royal Society of Chemistry

Pd-Catalyzed Benzylic C-H Oxidation of Cyclotriveratrylene - Product Diversity

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02469A, PaperBeeran Senthilkumar, Rajesh Gonnade, Chepuri Ramana
The inner-rim functionalization of CTV has been examined by employing Pd-catalyzed benzylic oxidation. The outcome of the oxidation depends upon the solvent and co-oxidants employed. An interesting array of CTV...
The content of this RSS Feed (c) The Royal Society of Chemistry

Diastereoselective desymmetrization of diarylphosphinous acid-borane amides under Birch reduction

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02440K, PaperMarek Stankevic
Treatment of diarylphosphinous acid-borane amides possessing a chiral amido functionality with a solution of an alkali metal in liquid ammonia induced a preferential dearomatization of one aryl substituent at phosphorus...
The content of this RSS Feed (c) The Royal Society of Chemistry

A supramolecular topical gel derived from a non steroidal anti-inflammatory drug-fenoprofen capable of treating skin inflammation in mice

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02344G, PaperP. Dastidar, Joydeb Majumder, Pavni Yedoti
A new series of bioconjugates derived from a non-steroidal-anti-inflammatory drug (NSAID) namely fenoprofen has been synthesised by amidation with various biogenic molecules such as -alanine, aminocaproic acid and tyramine with...
The content of this RSS Feed (c) The Royal Society of Chemistry

Fluoride binding in water with the use of micellar nanodevices based on salophen complexes

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02298J, PaperFlore Keymeulen, Paolo De Bernardin, ilaria Giannicchi, Luciano Galantini, Kristin Bartik, Antonella Dalla Cort
The use of micelles to transpose lipophilic receptors, such as uranyl-salophen complexes, into an aqueous environment is a valuable and versatile tool. Receptor 1 incorporated in CTABr micelles forms a...
The content of this RSS Feed (c) The Royal Society of Chemistry

In situ intramolecular catalytic 1,2-addition of allenoates to cyclic ketones towards polycyclic allenoates

21 December, 2014 - 23:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02451F, PaperClement F. HEINRICH, Michel Miesch, Laurence Miesch
Sequential deprotonation, isomerization of 3-alkynoates and subsequent 1,2-addition led to bicyclic allenoate in the presence of a catalytic amount of Cs2CO3. Cyclization proceeds in a stereoselective manner in the case...
The content of this RSS Feed (c) The Royal Society of Chemistry

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

21 December, 2014 - 23:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB02452D, PaperClara Brieke, Veronika Kratzig, Kristina Haslinger, Andreas Winkler, Max J. Cryle
One Cytochrome P450 enzyme performs the phenolic crosslinking of a range of chemically synthesized, carrier-protein loaded glycopeptide antibiotic precursor peptides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.