Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Rapid and scalable assembly of firefly luciferase substrates

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02529F, PaperDavid McCutcheon, William Porterfield, Jennifer Prescher
Bioluminescence imaging with luciferase-luciferin pairs is a popular method for visualizing biological processes in vivo. Unfortunately, most luciferins are difficult to access and remain prohibitively expensive for some imaging applications....
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A BODIPY-luminol chemiluminescent resonance energy-transfer (CRET) cassette for imaging of cellular superoxide

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02413C, PaperS. Bag, J.-C. Tseng, J. Rochford
Chemiluminescent resonance energy transfer is investigated for a BODIPY-luminol dyad demonstrating in cellulo biochemiluminescence with reactive oxygen species in activated splenocytes.
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A short, rigid linker between pyrene and guanidiniocarbonyl-pyrrole induced a new set of spectroscopic responses to the ds-DNA secondary structure

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02169J, CommunicationMarijana Radic Stojkovic, Patryciusz Piotrowski, Carsten Schmuck, Ivo Piantanida
A DNA-targeting dye exhibited pH-dependent selectivity toward AT-DNA (pH 7) or GC-DNA (pH 5), accompanied by fluorimetric (pH 5) and ICD (pH 7) recognition.
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Synthesis, and QSAR analysis of anti-oncological active spiro-alkaloids

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02149E, PaperAdel S. Girgis, Siva S. Panda, I. S. Ahmed Farag, A. M. El-Shabiny, A. M. Moustafa, Nasser S. M. Ismail, Girinath G. Pillai, Chandramukhi S. Panda, C. Dennis Hall, Alan R. Katritzky
QSAR study describes the anti-neoplastic spiro-alkaloids with relevant molecular descriptors using CODESSA III software.
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Syntheses of arabinose-derived pyrrolidine catalysts and their applications in intramolecular Diels-Alder reactions

17 December, 2014 - 22:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02219J, PaperTony K. M. Shing, Kwun W. Wu, Ho T. Wu, Qicai Xiao
Six hydroxylated pyrrolidine catalysts were synthesized from D-arabinose and applied to asymmetric intramolecular Diels-Alder reactions with concomitant desymmetrization.
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[small beta]-Ketothioamides: efficient reagents in synthesis of heterocycles

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02024C, Review ArticleWei-Si Guo, Li-Rong Wen, Ming Li
[small beta]-ketothioamides (KTAs) are versatile building blocks for the rapid construction of various heterocyclic compounds. In the past decade, a number of successful reactions based on KTAs have been developed for...
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Asymmetric metal free [small beta]-boration of [small alpha],[small beta]-unsaturated imines assisted by (S)-MeBoPhoz

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02478H, CommunicationElena Fernandez, Andrew Whiting, Xavier Sanz, Carles Bo, Enrico LaCascia
The adduct [MeO[rightward arrow]Bpin-Bpin]- efficiently mediates the [small beta]-boration of [small alpha],[small beta]-unsaturated imines formed "in situ". The use of chiral phosphines as additives, and in particular the chiral phosphine (S)-MeBoPhoz, enables the catalytic...
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Synthesis and physico-chemical properties of the first water soluble Cu(II)@hemicryptophane complex

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02085E, PaperAlexandre Martinez, Aline schmitt, CHRISTOPHE BUCHER, Vincent MAUREL, Jean-Pierre Dutasta, Solene Collin
A hemicryptophane ligand soluble in water at neutral pH was obtained thanks to the derivatization of the cyclotribenzylene unit with three carboxylate groups. The corresponding Cu(II) complex was then synthesized...
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Bacterial Patterning Controlled by Light Exposure

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02483D, CommunicationWillem Velema, Jan Pieter Van der Berg, Wiktor C Szymanski, Arnold Driessen, Ben L Feringa
Patterning of multiple bacterial strains in one system is achieved by employing a single photo-activated antibiotic. Varying the light-exposure time results in zones with mixed and single populations.
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Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01380H, Review ArticleKamal Deep Paul, Vijay Luxami, Richa Goel
Imidazo[1,2-a]pyrazine acts as a versatile scaffold in organic synthesis and drug development. This review article is an effort to compile the progress in synthetic methods and to illustrate its reactivity...
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Near-instant surface-selective fluorogenic protein quantification using sulfonated triarylmethane dyes and fluorogen activating proteins

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02309A, PaperQi Yan, Brigitte Schmidt, Lydia A Perkins, Matharishwan Naganbabu, Saumya Saurabh, Susan Andreko, Marcel Bruchez
Agonist-promoted G-protein coupled receptor (GPCR) endocytosis and recycling plays an important role in many signaling events in the cell. However, the approaches that allow fast and quantitative analysis of such...
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N-Phosphonyl /Phosphinyl Imines and Group-Assisted Purification (GAP) Chemistry/Technology

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02254H, Review ArticleGuanghui An, Cole Seifert, Guigen Li
The development of environmentally benign, operationally simple, and economically viable synthetic methodologies has been a great challenge in organic synthesis. Group-Assisted Purification (GAP) chemistry was established to enable the synthesis...
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1H chemical shift differences of Prelog-Djerassi lactone derivatives: DFT and NMR conformational studies.

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02446J, PaperMarco AB Ferreira, Tulio Jardini Aimola, Dimas Jose da Paz Lima, Luiz Carlos Dias, Claudio Francisco Tormena
This work reports an experimental and theoretical study of the conformational preferences of several Prelog-Djerassi lactone derivatives, to elucidate the 1H NMR chemical shift differences in the lactonic core that...
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Chemoselective Efficient Synthesis of Functionalized [small beta]-oxonitriles through Cyanomethylation of Weinreb Amides

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02398F, CommunicationAshenafi Damtew Mamuye, Laura Castoldi, Ugo Azzena, Wolfgang Holzer, Vittorio Pace
A synthesis of [small beta]-oxonitriles is reported via the generation of R1R2CLiCN species followed by the trapping with variously decorated Weinreb amides. The optimization study revealed that lithiation of acetonitriles is...
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Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70.

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02531H, PaperYao Wang, Shelli Renee McAlpine
Both heat shock protein 90 and 70 (Hsp90, Hsp70) are cytoprotective proteins that regulate cell death by stabilizing and folding proteins. Taking a two-pronged approach involving simultaneous inhibition of Hsp90...
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In Tandem or Alone: a Remarkably Selective Transfer Hydrogenation of Alkenes Catalyzed by Ruthenium Olefin Metathesis Catalysts

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02480J, PaperKarol Grela, Grzegorz Krzysztof Zielinski, Cezary Samojlowicz, Tomasz Wdowik
A system for transfer hydrogenation of alkenes, composed from a ruthenium metathesis catalyst and HCOOH is presented. This operationally simple system can be formed directly after a metathesis reaction to...
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Synthesis of Novel Polyhydroxylated Pyrrolidine-Triazole/-Isoxazole Hybrid Molecules

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01934B, PaperCheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, wen-Yi Yun, wei-chieh cheng
A straightforward synthesis of novel, 2-heterocyclyl polyhydroxylated pyrrolidines is described. Stereocontrolled additions of nucleophiles to cyclic nitrones generated the corresponding 2,3-trans adducts, allowing the synthesis of the corresponding pyrrolidines via...
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Enabling the (3+2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of Gyrase ATPase domain: Lead optimization and structure activity profiling

17 December, 2014 - 22:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02049A, PaperJeankumar U Variam, Reshma R Srilakshmi, Renuka Janupally, Brahmam Medapi, Shalini Saxena, Jonnalagadda Padma Sridevi, Pushkar Kulkarni, Perumal Yogeeswari, Dharmarajan Sriram
DNA Gyrase, the sole type II topoisomerase present in Mycobacterium tuberculosis is absent in DNA Gyrase, the sole type II topoisomerase present in Mycobacterium tuberculosis is absent in humans and...
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Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,409-423
DOI: 10.1039/C4OB01951B, PaperLaurent Le Corre, Lotfi Tak-Tak, Arthur Guillard, Guillaume Prestat, Christine Gravier-Pelletier, Patricia Busca
The obtention of 4-amino-3-cyano-N-arylpyrazoles via a [small mu ]W mediated cyclization allowed the diversity oriented syntheses of various heteroyclic scaffolds.
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PEGylation enhances the tumor selectivity of melanoma-targeted conjugates

15 December, 2014 - 22:17

Org. Biomol. Chem., 2015, 13,388-397
DOI: 10.1039/C4OB01751J, PaperMathieu Andre, Sophie Besse, Jean-Michel Chezal, Emmanuelle Mounetou
Three preselected conjugates of 5-iodo-2[prime or minute]-deoxyuridine (IUdR) to the ICF01012 melanoma-carrier, PEGylated and non-PEGylated, were radiolabelled with iodine-125, and their in vivo distribution profile was evaluated for potential intratumoural selective delivery.
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