Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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High-yielding sequential one-pot synthesis of chiral and achiral [small alpha]-substituted acrylates via a metal-free reductive coupling reaction

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5400-5406
DOI: 10.1039/C4OB00667D, PaperDhevalapally B. Ramachary, Chintalapudi Venkaiah, Y. Vijayendar Reddy
A variety of chiral and achiral [small alpha]-substituted acrylates were furnished in very good yields with excellent selectivity by using an organocatalytic reductive coupling reaction (TCRA) followed by an Eschenmoser methylenation.
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Enantioselective synthesis of spiroacetals: the conquest of a long-sought goal in asymmetric catalysis

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5324-5330
DOI: 10.1039/C4OB00737A, PerspectiveLara Cala, Francisco J. Fananas, Felix Rodriguez
This perspective article summarizes the few and recently reported methods on catalytic asymmetric synthesis of spiroacetal derivatives from achiral substrates.
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Synthesis of phosphaisocoumarin amidates via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5458-5463
DOI: 10.1039/C4OB00663A, PaperYu-Juan Guo, Pei-Jiang Chen, Bo Wang, Ai-Yun Peng
A series of phosphaisocoumarin amidates were synthesized via DIBAL-H-mediated selective amidation of phosphaisocoumarin esters in good to excellent yields. In each case, the phostone ring was intact and only the exocyclic ethoxy group was amidated.
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Arylpyrrole oligomers as tunable anion receptors

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5492-5499
DOI: 10.1039/C4OB00357H, PaperWim Van Rossom, Tatyana G. Terentyeva, Keitaro Sodeyama, Yoshitaka Matsushita, Yoshitaka Tateyama, Katsuhiko Ariga, Jonathan P. Hill
A novel class of oligomeric arylpyrrole receptors has been designed, prepared and analysed for their affinity towards anionic guests.
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Comparison of backbone modification in protein [small beta]-sheets by [small alpha][rightward arrow][gamma] residue replacement and [small alpha]-residue methylation

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5375-5381
DOI: 10.1039/C4OB00886C, PaperGeorge A. Lengyel, Zachary E. Reinert, Brian D. Griffith, W. Seth Horne
Systematic backbone alteration of sheet secondary structure in a small protein yields unnatural mimics with native-like tertiary folding behavior.
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Synthesis and properties of fluorous benzoquinones and their application in deprotection of silyl ethers

9 July, 2014 - 06:17

Org. Biomol. Chem., 2014, 12,5442-5447
DOI: 10.1039/C4OB00783B, PaperHiroshi Matsubara, Takahiko Maegawa, Yasuaki Kita, Takato Yokoji, Akihiro Nomoto
1,4-Benzoquinone derivatives bearing perfluoroalkyl groups were prepared and used as a recyclable catalyst in the selective desilylation of silyl ethers.
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RANEY[registered sign] cobalt - an underutilised reagent for the selective cleavage of C-X and N-O bonds

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00917G, Review ArticleMartin G. Banwell, Matthew T. Jones, Tristan A. Reekie, Brett D. Schwartz, Shen H. Tan, Lorenzo V. White
The first comprehensive survey of the application of the catalyst RANEY[registered sign] cobalt in chemical synthesis is presented. Its capacity to effect chemoselective reductive cyclisation reactions under mild conditions is highlighted.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Efficient asymmetric synthesis of spiro-2(3H)-furanones via phase-transfer-catalyzed alkynylation

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5388-5392
DOI: 10.1039/C4OB00969J, PaperXiangfei Wu, Seiji Shirakawa, Keiji Maruoka
Efficient asymmetric synthesis of spiro-2(3H)-furanones was achieved via chiral phase-transfer-catalyzed alkynylation.
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Tuning of the HOMO-LUMO gap of donor-substituted symmetrical and unsymmetrical benzothiadiazoles

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5448-5457
DOI: 10.1039/C4OB00629A, PaperRajneesh Misra, Prabhat Gautam
This article reports the design and synthesis of donor-substituted symmetrical and unsymmetrical benzothiadiazoles (BTDs) 5-12 of type D-[small pi]-A-D, D1-[small pi]-A-D2, D1-A1-A2-D2, D-A1-A2-D and D-A1-A2-A1-D by Ullmann, Suzuki and cycloaddition-retroelectrocyclization reactions.
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Efficient C(sp3alkyl)-SCF3 bond formations via copper-mediated trifluoromethylthiolation of alkyl halides

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5500-5508
DOI: 10.1039/C4OB00403E, PaperQuanfu Lin, Li Chen, Yangjie Huang, Mingguang Rong, Yaofeng Yuan, Zhiqiang Weng
An efficient synthesis of alkyl trifluoromethyl sulfides via copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described.
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Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5427-5434
DOI: 10.1039/C4OB00744A, PaperXiu-Jiang Du, Qiang Bian, Hong-Xue Wang, Shu-Jing Yu, Jun-Jie Kou, Zhi-Peng Wang, Zheng-Ming Li, Wei-Guang Zhao
A series of valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good fungicidal activity.
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An intracellularly activatable, fluorogenic probe for cancer imaging

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5365-5374
DOI: 10.1039/C4OB00297K, PaperRuisong Tian, Mingjie Li, Jin Wang, Min Yu, Xiuqi Kong, Yupeng Feng, Zeming Chen, Yuxi Li, Weiqiang Huang, Wenjie Wu, Zhangyong Hong
A newly designed, dual-functional probe based on intracellular activation has been successfully developed for the detection of cancer cells.
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The metal tin promoted cascade reaction of ketones in aqueous media for the construction of 2-bromo-4-aryl-1,3-pentadiene

7 July, 2014 - 05:54

Org. Biomol. Chem., 2014, 12,5393-5399
DOI: 10.1039/C4OB00584H, PaperLingyan Liu, Yan Zhang, Hua Zhang, Kaimeng Huang, Bo-xin Gao, Min Zou, Xin Zhou, Hongkai Wang, Jing Li
A novel Barbier-type allenylation cascade reaction of carbonyl compounds promoted by tin was discovered, and afforded a new, highly functionalized 1,3-pentadiene.
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Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5094-5097
DOI: 10.1039/C4OB00627E, CommunicationPeter C. Knipe, Martin D. Smith
A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(II) catalyst.
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Modular synthesis of cyclic cis- and trans-1,2-diamine derivatives

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5267-5277
DOI: 10.1039/C4OB00913D, PaperAnna K. Weber, Josef Schachtner, Robert Fichtler, Timo M. Leermann, Jorg M. Neudorfl, Axel Jacobi von Wangelin
Structurally diverse carbocycles with two vicinal nitrogen-substituents were prepared in expedient three-component reactions from simple amines, aldehydes, and nitroalkenes.
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Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5158-5167
DOI: 10.1039/C4OB00904E, PaperChristopher P. Lawson, Anke Dierckx, Francois-Alexandre Miannay, Eric Wellner, L. Marcus Wilhelmsson, Morten Grotli
Novel fluorescent triazole adenine derivatives have been synthesised and their photo-physical properties characterised.
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Unusual regio- and stereo-selectivity in Diels-Alder reactions between bulky N-phenylmaleimides and anthracene derivatives

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5102-5107
DOI: 10.1039/C4OB01052C, CommunicationHao Chen, Erdong Yao, Chi Xu, Xiao Meng, Yuguo Ma
Unusual regio- and stereo-selectivity in Diels-Alder (D-A) reactions were achieved between bulky N-phenylmaleimides and anthracene derivatives.
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1,2-cis Alkyl glycosides: straightforward glycosylation from unprotected 1-thioglycosyl donors

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5182-5191
DOI: 10.1039/C4OB00626G, PaperBo Meng, Zhenqian Zhu, David C. Baker
A simple, straightforward 1,2-cis-selective glycosidation method from an unprotected 1-thioglycoside is presented.
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A survey of enoldiazo nucleophilicity in selective C-C bond forming reactions for the synthesis of natural product-like frameworks

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5227-5234
DOI: 10.1039/C4OB00709C, PaperYuxiao Liu, Yu Liu, Charles S. Shanahan, Xichen Xu, Michael P. Doyle
Sc(OTf)3-catalyzed SN1-like couplings of enoldiazo compounds with carbocations for construction of carbocyclic and heterocyclic scaffolds has been realised.
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An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

1 July, 2014 - 04:17

Org. Biomol. Chem., 2014, 12,5192-5200
DOI: 10.1039/C4OB00679H, PaperLiangfeng Fu, Qi-Xian Lin, Karen T. Liby, Michael B. Sporn, Gordon W. Gribble
An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).
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