Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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PtI2-catalyzed cyclization of 3-acyloxy-1,5-enynes with the elimination of HOAc and a benzyl shift: synthesis of unsymmetrical m-terphenyls

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4486-4493
DOI: 10.1039/C4OB02336F, PaperKaimeng Huang, Xiaona Ke, Hongkai Wang, Junying Wang, Chenchen Zhou, Xiufang Xu, Lingyan Liu, Jing Li
A new cyclization of 1,5-enyne was developed to synthesize the m-terphenyls via the elimination of HOAc and a benzyl shift.
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Synthesis of novel tryptamine-based macrocycles using an Ugi 4-CR/microwave assisted click-cycloaddition reaction protocol

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4408-4412
DOI: 10.1039/C5OB00067J, CommunicationLizbeth Chavez-Acevedo, Luis D. Miranda
A practical synthesis of novel tryptamine-based macrocycles using an Ugi 4-CR/click-cycloaddition sequential reaction protocol is described.
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Palladium-catalyzed oxidative C-H/C-H cross-coupling of 1-substituted 1,2,3-triazoles with furans and thiophenes

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4459-4465
DOI: 10.1039/C5OB00102A, PaperXin Yu, ZhenDong Huang, Wei Liu, SuPing Shi, ChunXiang Kuang
Palladium-catalyzed heteroarylation of 1-substituted 1,2,3-triazoles with furans and thiophenes has been developed in the presence of pyridine and Ag2CO3.
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Chirality extension of an oxazine building block en route to total syntheses of (+)-hyacinthacine A2 and sphingofungin B

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4539-4550
DOI: 10.1039/C5OB00251F, PaperSeok-Hwi Park, Xiangdan Jin, Jong-Cheol Kang, Changyoung Jung, Seong-Soo Kim, Sung-Soo Kim, Kee-Young Lee, Won-Hun Ham
Concise total syntheses of (+)-hyacinthacine A2 and sphingofungin B were achieved by palladium(0)-catalyzed intramolecular oxazine formation and diastereoselective nucleophilic additions.
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Near-infrared emission of dibenzoxanthenium and its application in the design of nitric oxide probes

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4532-4538
DOI: 10.1039/C5OB00042D, PaperWu Liu, Chen Fan, Ru Sun, Yu-Jie Xu, Jian-Feng Ge
The application of a diaminodibenzoxanthenium skeleton in chemosensors was reported, and it can work with near-infrared excitation and near-infrared emission.
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Synthesis of 2,4-diarylsubstituted-pyridines through a Ru-catalyzed four component reaction

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4404-4407
DOI: 10.1039/C5OB00162E, CommunicationYang Bai, Lichang Tang, Huawen Huang, Guo-Jun Deng
2,4-Diarylsubstituted pyridines were prepared from acetophenones, ammonium acetate and DMF under an oxygen atmosphere.
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Efficient access to enantiopure 1,3-disubstituted isoindolines from selective catalytic fragmentation of an original desymmetrized rigid overbred template

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4438-4448
DOI: 10.1039/C5OB00229J, PaperGanesh Pandey, Rajesh Varkhedkar, Divya Tiwari
Enantiopure 1,3-disubstituted isoindolines are synthesized from selective C-C bond fragmentation of a rigid overbred template, obtained through an asymmetric desymmetrization reaction.
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Regioselective solid-phase synthesis of N-mono-hydroxylated and N-mono-methylated acylpolyamine spider toxins using an 2-(ortho-nitrophenyl)ethanal-modified resin

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4473-4485
DOI: 10.1039/C5OB00108K, PaperDenise Pauli, Stefan Bienz
Spider toxins such as AG432g and LF487A were divergently prepared by SPS and used for correlation with the natural products.
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An IDB-containing low molecular weight short peptide as an efficient DNA cleavage reagent

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4524-4531
DOI: 10.1039/C4OB02518K, PaperChunying Ma, Huan Chen, Chao Li, Jin Zhang, Renzhong Qiao
We present poly(aspartic acid) grafting bis-amine conjugates as artificial nucleases, which can effectively induce double-strand DNA cleavage.
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Sodium periodate mediated oxidative transformations in organic synthesis

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4374-4394
DOI: 10.1039/C5OB00238A, Review ArticleArumugam Sudalai, Alexander Khenkin, Ronny Neumann
The investigation of new oxidative transformations for the synthesis of carbon-heteroatom and heteroatom-heteroatom bonds is of fundamental importance in the synthesis of numerous bioactive molecules and fine chemicals.
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N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4449-4458
DOI: 10.1039/C4OB02265C, PaperDana Hockova, Sarka Rosenbergova, Petra Menova, Ondrej Pav, Radek Pohl, Pavel Novak, Ivan Rosenberg
The solid phase synthesis of nonamers containing a highly flexible acyclic central unit was performed and their hybridization properties were evaluated.
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Synthesis and complementary self-association of novel lipophilic [small pi]-conjugated nucleoside oligomers

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4506-4513
DOI: 10.1039/C5OB00098J, PaperJ. Camacho-Garcia, C. Montoro-Garcia, A. M. Lopez-Perez, N. Bilbao, S. Romero-Perez, D. Gonzalez-Rodriguez
A series of lipophilic nucleosides comprising natural and non-natural bases that are [small pi]-conjugated to a short oligophenylene-ethynylene fragment has been synthesized and their respective association constants measured.
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A benzotriazole-mediated route to protected marine-derived hetero-2,5-diketopiperazines containing proline

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4399-4403
DOI: 10.1039/C5OB00023H, CommunicationOlivier Nsengiyumva, Sadra Hamedzadeh, James McDaniel, Jocelyn Macho, Grant Simpson, Siva S. Panda, Khanh Ha, Iryna Lebedyeva, Hassan M. Faidallah, Manal Metgen AL-Mohammadi, C. Dennis Hall, Alan R. Katritzky
Dipeptidoyl benzotriazolides containing proline were cyclized by triethylamine into 2,5-diketopiperazines.
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Organocatalytic enantioselective Friedel-Crafts reaction: an efficient access to chiral isoindolo-[small beta]-carboline derivatives

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4395-4398
DOI: 10.1039/C5OB00175G, CommunicationFang Fang, Genghong Hua, Feng Shi, Pengfei Li
An organocatalytic asymmetric Friedel-Crafts reaction between indole and indole-derived hydroxylactams has been realized to furnish isoindolo-[small beta]-carbolines in good to excellent yields (up to >99%) and generally high enantioselectivities (up to >99% ee).
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Efficiency of [2 + 2] photodimerization of various stilbene derivatives within the DNA duplex scaffold

8 April, 2015 - 02:54

Org. Biomol. Chem., 2015, 13,4430-4437
DOI: 10.1039/C4OB02520B, PaperTetsuya Doi, Hiromu Kashida, Hiroyuki Asanuma
[2 + 2] photodimerization of various stilbene derivatives successfully proceeded within the DNA duplex scaffold.
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Correction: A novel Prins cascade process for the stereoselective synthesis of oxa-bicycles

31 March, 2015 - 00:54
Org. Biomol. Chem., 2015, 13,4351-4351
DOI: 10.1039/C5OB90045J, CorrectionB. V. Subba Reddy, A. Venkateswarlu, B. Sridevi, Kanakaraju Marumudi, A. C. Kunwar, G. Gayatri
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Linchpin dienes: key building-blocks in the synthesis of polyenic frameworks

31 March, 2015 - 00:54

Org. Biomol. Chem., 2015, 13,4129-4142
DOI: 10.1039/C5OB00154D, Review ArticleJ. Cornil, A. Guerinot, J. Cossy
This review focuses on the preparation of dienic linchpin reagents and on their use in the synthesis of polyenic frameworks.
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Mitsunobu mischief: neighbor-directed histidine N([small tau])-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles

31 March, 2015 - 00:54

Org. Biomol. Chem., 2015, 13,4221-4225
DOI: 10.1039/C5OB00171D, PaperWen-Jian Qian, Terrence R. Burke
Selective on-resin histidine N([small tau])-alkylation under Mitsunobu conditions is achieved by the coordinated participation of a proximal acidic residue.
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Synthesis of chitin and chitosan stereoisomers by thermostable [small alpha]-glucan phosphorylase-catalyzed enzymatic polymerization of [small alpha]-D-glucosamine 1-phosphate

31 March, 2015 - 00:54

Org. Biomol. Chem., 2015, 13,4336-4343
DOI: 10.1039/C5OB00167F, PaperJun-ichi Kadokawa, Riko Shimohigoshi, Kento Yamashita, Kazuya Yamamoto
Chitosan and chitin stereoisomers were successfully synthesized by thermostable [small alpha]-glucan phosphorylase-catalyzed enzymatic polymerization of [small alpha]-D-glucosamine 1-phosphate and subsequent N-acetylation.
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Chemical synthesis of the outer core oligosaccharide of Escherichia coli R3 and immunological evaluation

31 March, 2015 - 00:54

Org. Biomol. Chem., 2015, 13,4321-4330
DOI: 10.1039/C5OB00177C, PaperWenjing Shang, Zhongying Xiao, Zaikuan Yu, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang, Tiehai Li
An all [small alpha]-linked Escherichia coli R3 outer core pentasaccharide was first synthesized. Its corresponding glycoconjugate can elicit specific anti-pentasaccharide antibodies with in vitro bactericidal activity.
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