Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 20 hours 55 min ago

Investigation of the Passerini and Ugi Reactions in [small beta]-Lactam Aldehydes. Synthetic Applications

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02289K, PaperBenito Alcaide, Pedro Almendros, Cristina Aragoncillo, Ricardo Callejo, Maria Pilar Ruiz, M. Rosario Torres
Passerini (P-3CR) and Ugi (U-4CR) reactions were investigated in 4-oxoazetidine-2-carboxaldehydes affording the corresponding Passerini and Ugi adducts with moderate diastereoselectivity in high yields. Fortunately, the obtained mixtures of isomers syn/anti...
The content of this RSS Feed (c) The Royal Society of Chemistry

Bleomycin-induced trans lipid formation in cell membranes and in liposome models

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01924E, PaperAysegul Cort, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos Chatgilialoglu, Carla Ferreri
Bleomycin-iron complexes cause lipid cis-trans isomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Determination of the absolute configuration of phosphinic analogues of glutamate

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01960A, PaperBruno Commare, Delphine Rigault, Isabelle A. Lemasson, Patrick Deschamps, Alain Tomas, Pascal Roussel, Isabelle Brabet, Cyril Goudet, Jean-Philippe Pin, Frederic R. Leroux, Francoise Colobert, Francine C. Acher
Stereomers of LSP1-2111 have been separated, their absolute configuration and agonist activity at mGlu4R determined.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01602E, PaperMaria Vetro, Barbara Costa, Giulia Donvito, Noemi Arrighetti, Laura Cipolla, Paola Perego, Federica Compostella, Fiamma Ronchetti, Diego Colombo
Long chain GlcADG analogues synthesized as PI3P mimics inhibited isolated Akt and proliferation of human ovarian carcinoma IGROV-1 cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Molecular recognition of upper rim functionalized cavitand and its unique dimeric capsule in the solid state

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02251C, PaperTakeharu HAINO, Ryo Sekiya, Mutsumi Kobayashi, Mei Takatsuka
Cavitand 1 possesses four 2,2'-bipirydyl pillars on its upper rim that encapsulate small guests, such as nitromethane, acetonitrile, methyl acetate, ethyl acetate, and N-methylacetamide, into a deep cavity to form...
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis and tautomerization of hydroxylated isoflavones bearing heterocyclic hemi-aminals

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02137A, PaperMykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Volodymyr P. Khilya, Chunming Liu, David S. Watt, Vitaliy M. Sviripa
Aminomethylation of 7-hydroxy isoflavones with C2-C5 [small omega]-aminoalcohols led to tautomers 4 and 5 that were interconverted as confirmed by NMR studies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

1,4 Addition of unprotected pyrrole onto chiral acrylamides: toward synthesis of new polypeptidic architectures

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01920B, PaperAlexander Gratais, Xavier Pannecoucke, Samir Bouzbouz
A variety of new chiral functionalized pyrroloamides have been synthesized by a simple and robust process involving Lewis acids. Unprotected pyrrole could be selectively monoalkylated or dialkylated.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Niosomes based on synthetic cationic lipids for gene delivery: the influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02087A, PaperE. Ojeda, G. Puras, M. Agirre, J. Zarate, S. Grijalvo, R. Pons, R. Eritja, G. Martinez-Navarrete, C. Soto-Sanchez, E. Fernandez, J. L. Pedraz
We designed niosomes based on three lipids that differed only in the polar-head group to analyze their influence on the transfection efficiency.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Development and use of a general route to brassinolide, its biosynthetic precursors, metabolites and analogues

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02197E, PaperAlaksiej L. Hurski, Yuri V. Ermolovich, Vladimir Nikolaevich Zhabinskii, Vladimir Aleksandrovich Khripach
A new method for the construction of steroid side chains through the addition of lithium salts of dithianes to a C-22 aldehyde was developed. An efficient one-pot procedure for the...
The content of this RSS Feed (c) The Royal Society of Chemistry

Modulation of the charge transfer and photophysical properties in non-fused tetrathiafulvalene-benzothiadiazole derivatives

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02100B, PaperFlavia Pop, Sabine Seifert, Jihane Hankache, Jie Ding, Andreas Hauser, Narcis Avarvari
Stille and Sonogashira coupling strategies allowed the preparation of luminescent TTF-benzothiadiazole donor-acceptor compounds with direct linkage or an acetylenic spacer.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02185A, PaperRalph Appel, Sebastian Tacke, Jurgen Klingauf, Pol Besenius
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character and describe their self-assembly into supramolecular nanorods using pH and ionic strength dependent state diagrams.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Allylic and benzylic sp3 C-H oxidation in water

1 December, 2014 - 18:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02017K, PaperWei Jie Ang, Yulin Lam
A copper-catalyzed method for the oxidation of allylic and benzylic sp3 C-H by aqueous tert-butyl hydroperoxide (T-Hydro) in water using a recyclable fluorous ligand has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Identification of Benzenesulfonamide quinoline derivatives as potent HIV-1 replication inhibitors targeting Rev protein

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02247E, PaperFudi Zhong, Guannan Geng, Ting Pan, Bing Chen, Qianwen Li, Hui Zhang, Chuan Bai
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry

Cyclodextrin- and Calixarene-based Polycationic Amphiphiles as Gene Delivery Systems: A Structure-Activity Relationship Study

1 December, 2014 - 18:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02204A, PaperLaura Gallego-Yerga, Michela Lomazzi, Valentina Franceschi, Francesco Sansone, Carmen Ortiz Mellet, Gaetano Donofrio, Alessandro Casnati, Jose Manuel Garcia Fernandez
Multi-head/multi-tail facial amphiphiles built on cyclodextrin (CD) and calixarene (CA) scaffolds are paradigmatic examples of monodisperse gene delivery systems. The possibility to precisely control the architectural features at the molecular...
The content of this RSS Feed (c) The Royal Society of Chemistry

Quinoline-derived two-photon sensitive quadrupolar probes

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9899-9908
DOI: 10.1039/C4OB01551G, PaperPetra Dunkel, Christine Tran, Thibault Gallavardin, Hamid Dhimane, David Ogden, Peter I. Dalko
Quadrupolar 8-dimethylaminoquinoline-derived photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry

A facile approach to spirocyclic 2-azido indolines via azidation of indoles with ceric ammonium nitrate

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9769-9772
DOI: 10.1039/C4OB01549E, CommunicationJing Li, Mao Liu, Qi Li, Hua Tian, Yian Shi
This paper describes azidation of indoles with NaN3 and ceric ammonium nitrate (CAN), giving a variety of spirocyclic 2-azido indolines in good yields and moderate diastereoselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Enantioselective synthesis of [small alpha]-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan

1 December, 2014 - 18:54

Org. Biomol. Chem., 2014, 12,9853-9863
DOI: 10.1039/C4OB01476F, PaperThibaut Denoel, Astrid Zervosen, Christian Lemaire, Bernard Joris, Mireille Herve, Didier Blanot, Guillermo Zaragoza, Andre Luxen
The synthesis of modified tripeptides (S)-Ala-[gamma]-(R)-Glu-X, where X = (R,S) or (R,R) diastereomers of [small alpha]-benzyl or [small alpha]-(4-azidobenzyl)lanthionine, was carried out.
The content of this RSS Feed (c) The Royal Society of Chemistry

Contributions of pocket depth and electrostatic interactions to affinity and selectivity of receptors for methylated lysine in water

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02231A, PaperJoshua Beaver, Brendan Peacor, Julianne Bain, Lindsey Ingerman, Marcey Waters
Dynamic combinatorial chemistry was used to generate a set of receptors for peptides containing methylated lysine (KMen, n = 0=3) and study the contribution of electrostatic effects and pocket depth...
The content of this RSS Feed (c) The Royal Society of Chemistry

An expedient approach to 1, 2-dihydroisoquinoline derivatives via Cobalt catalysed 6-endo dig cyclization followed by Mannich condensation of o-alkynylarylaldimines

29 November, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02036G, CommunicationUrvashi ., Gaurav Kumar Rastogi, Sandeep K Ginotra, Alka Agarwal, Vibha Tandon
A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1, 2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This...
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

29 November, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,9793-9796
DOI: 10.1039/C4OB01981D, CommunicationJunyan Han, Tae Hoon Lee, Ching-Hsuan Tung, Daniel Y. Lee
A novel mitochondria-targeting carrier QCy7HA was developed, which transported the covalently attached doxorubicin (DOX) to mitochondria specifically, resulting in the limitation of the effects of P-glycoprotein efflux pumps of multidrug-resistant cells on DOX.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.