Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin

12 August, 2014 - 16:17

Org. Biomol. Chem., 2014, 12,6590-6597
DOI: 10.1039/C4OB00935E, PaperMasato Niwa, Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa
A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds were developed to visualize transferrin-delivered intracellular labile iron.
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Light-driven artificial enzymes for selective oxidation of guanosine triphosphate using water-soluble POSS network polymers

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6500-6506
DOI: 10.1039/C4OB01115E, PaperJong-Hwan Jeon, Kazuo Tanaka, Yoshiki Chujo
The light-driven artificial enzymes were constructed to realize unnatural reactions concerning biomolecules. The guanosine triphosphate-selective oxidation was accomplished using the network polymers in which the molecular recognition via hydrogen bonds can be enhanced.
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TBAI-catalyzed oxidative synthesis of benzamides from acetophenones and carbinols

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6359-6362
DOI: 10.1039/C4OB01203H, CommunicationMuhammad Sharif, Jianbin Chen, Peter Langer, Matthias Beller, Xiao-Feng Wu
An interesting and convenient procedure for the oxidative transformation of acetophenones and carbinols to primary benzamides has been developed.
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Catalytic control over the formation of supramolecular materials

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6292-6296
DOI: 10.1039/C4OB01108B, PerspectiveRienk Eelkema, Jan H. van Esch
Catalytic formation of self-assembling building blocks provides control over the morphology, mechanical properties and spatial distribution of soft supramolecular materials.
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Access to novel functionalized trifluoromethyl [small beta]-lactams by ring expansion of aziridines

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6345-6348
DOI: 10.1039/C4OB01262C, CommunicationS. Decamps, L. Sevaille, S. Ongeri, B. Crousse
A wide variety of CF3-[small beta]-lactams functionalized at position C-3 were obtained stereoselectively by ring expansion of aziridines.
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Copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with arylsulfonohydrazides: synthesis of sulfonated oxindoles

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6349-6353
DOI: 10.1039/C4OB01231C, CommunicationQingshan Tian, Ping He, Chunxiang Kuang
A copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with sulfonylhydrazides through a tandem radical process was developed.
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Comparison of the substrate selectivity and biochemical properties of human and bacterial [gamma]-butyrobetaine hydroxylase

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6354-6358
DOI: 10.1039/C4OB01167H, CommunicationAnna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik, Luc Henry, Michael A. McDonough, Timothy D. W. Claridge, Christopher J. Schofield
BBOX is a 2-oxoglutarate dependent oxygenase that can catalyse formation of vicinal diols and amino alcohols.
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Total synthesis of the cyclic monoterpenoid pyrano[3,2-a]carbazole alkaloids derived from 2-hydroxy-6-methylcarbazole

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6490-6499
DOI: 10.1039/C4OB01151A, PaperCemena Gassner, Ronny Hesse, Arndt W. Schmidt, Hans-Joachim Knolker
The synthesis of seven pyrano[3,2-a]carbazole alkaloids has been achieved using their putative biogenetic precursor 2-hydroxy-6-methylcarbazole as key intermediate.
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Stereoselective one-pot synthesis of [small beta]-alkylsulfide enol esters. Base-triggered rearrangement under mild conditions

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6516-6526
DOI: 10.1039/C4OB01011F, PaperAdrian A. Heredia, Silvia M. Soria-Castro, Lydia M. Bouchet, Gabriela Oksdath-Mansilla, Cecilia A. Barrionuevo, Daniel A. Caminos, Fabricio R. Bisogno, Juan E. Arguello, Alicia B. Penenory
(Z)-Vinyl sulfides are easily synthesised through a multicomponent reaction. An intramolecular S,O-acyl migration accounts for the observed stereoselectivity.
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Synthesis of 3,3-disubstituted-2,3-dihydroazanaphthoquinones via simultaneous alkyne oxidation and nitrile hydration of ortho-alkynylarenenitriles

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6440-6446
DOI: 10.1039/C4OB00852A, PaperKaruppusamy Sakthivel, Kannupal Srinivasan
Simultaneous activation of alkynes and nitriles in o-alkynylarenenitriles in the presence of Pd(OAc)2/H2O/(+/-)-CSA afforded 3,3-disubstituted-2,3-dihydroazanaphthoquinones in moderate to excellent yields.
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C-H arylation of azaheterocycles: a direct ligand-free and Cu-catalyzed approach using diaryliodonium salts

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6340-6344
DOI: 10.1039/C4OB01061B, CommunicationDalip Kumar, Meenakshi Pilania, V. Arun, Savita Pooniya
An efficient and high yielding Cu-catalyzed direct C-H arylation of oxadiazoles, thiadiazoles, benzoxazoles and benzothiazoles has been achieved by employing easily accessible diaryliodonium salts.
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P,N,N-Pincer nickel-catalyzed cross-coupling of aryl fluorides and chlorides

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6414-6424
DOI: 10.1039/C4OB01041H, PaperDan Wu, Zhong-Xia Wang
P,N,N-Pincer nickel was demonstrated to effectively catalyze cross-coupling of aryl fluorides and chlorides with aryl magnesium or zinc reagents.
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A "click" chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6470-6475
DOI: 10.1039/C4OB01005A, PaperYang Wang, Zeinab Assaf, Xinjun Liu, Fabio Ziarelli, Amel Latifi, Otmane Lamrabet, Gilles Quelever, Fanqi Qu, Cheng-Cai Zhang, Ling Peng
An ingenious and robust affinity resin to capture the 2-oxoglutaric acid binding proteins was constructed via "click" chemistry and validated using a known 2-OG receptor in cell lysate.
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Facile access to amides and hydroxamic acids directly from nitroarenes

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6465-6469
DOI: 10.1039/C4OB01155D, PaperShreyans K. Jain, K. A. Aravinda Kumar, Sandip B. Bharate, Ram A. Vishwakarma
Herein, we report a new method for synthesis of amides and hydroxamic acids directly from nitroarenes and aldehydes.
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Synthesis and properties of oligonucleotides modified with 2[prime or minute]-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6457-6464
DOI: 10.1039/C4OB01260G, PaperTakeshi Yamada, Yoshiaki Masaki, Natsuki Okaniwa, Takashi Kanamori, Akihiro Ohkubo, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
2[prime or minute]-O-Methyl oligoribonucleotides with four kinds of 2[prime or minute]-O-modified uridine derivatives were synthesised.
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Multicomponent reaction of chalcones, malononitrile and DMF leading to [gamma]-ketoamides

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6389-6392
DOI: 10.1039/C4OB00971A, PaperEnxiang Wei, Bing Liu, Shaoxia Lin, Fushun Liang
An efficient synthesis of [gamma]-ketoamides was developed by the one-pot multicomponent reaction of chalcones, malononitrile and DMF (as both the reactant and solvent) in the presence of NaOH (3.0 equiv.). The reaction features high atom economy, easily available starting materials, operational simplicity, and good tolerance with diverse functional groups.
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Tautomerisation of thymine acts against the Huckel 4N + 2 rule. The effect of metal ions and H-bond complexations on the electronic structure of thymine

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6476-6483
DOI: 10.1039/C4OB00964A, PaperOlga A. Stasyuk, Halina Szatylowicz, Tadeusz M. Krygowski
Not necessarily the [small pi]-electron delocalization is responsible for the stability of thymine tautomers.
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Rational design of a new fluorescent 'ON/OFF' xanthene dye for phosphate detection in live cells

10 August, 2014 - 15:54

Org. Biomol. Chem., 2014, 12,6432-6439
DOI: 10.1039/C4OB00951G, PaperA. Martinez-Peragon, D. Miguel, A. Orte, A. J. Mota, M. J. Ruedas-Rama, J. Justicia, J. M. Alvarez-Pez, J. M. Cuerva, L. Crovetto
A new fluorescein derivative with ON/OFF features, 9-[1-(4-tert-butyl-2-methoxyphenyl)]-6-hydroxy-3H-xanthen-3-one (Granada Green, GG), was designed and synthesised.
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An efficient, Schiff-base derivative for selective fluorescence sensing of Zn2+ ions: quantum chemical calculation appended by real sample application and cell imaging study

8 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6447-6456
DOI: 10.1039/C4OB00732H, PaperSayantani Chall, Soumya Sundar Mati, Saugata Konar, Dipti Singharoy, Subhash Chandra Bhattacharya
Fluorescence based sensitive detection of the second most abundant metal ion (Zn2+) was established using a newly synthesized Schiff-base ligand, PyHP.
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Enantioselective synthesis of [small alpha],[small alpha]-difluoro-[small beta]-lactams using amino alcohol ligands

8 August, 2014 - 15:17

Org. Biomol. Chem., 2014, 12,6484-6489
DOI: 10.1039/C4OB01184H, PaperAtsushi Tarui, Takeshi Ikebata, Kazuyuki Sato, Masaaki Omote, Akira Ando
A practical and highly enantioselective Reformatsky reaction of ethyl bromodifluoroacetate with imines using a cheap and commercially available amino alcohol ligand is described.
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