Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4841-4847
DOI: 10.1039/C4OB00059E, PaperMonika Nowakowska, Joanna Kowalska, Franck Martin, Arnaud d'Orchymont, Joanna Zuberek, Maciej Lukaszewicz, Edward Darzynkiewicz, Jacek Jemielity
Novel photo-crosslinking reagents for the analysis of biomolecules binding mRNA 5[prime or minute] end.
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Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00517A, PaperHazit Zayas, Clovia I. Holdsworth, Michael C. Bowyer, Adam McCluskey
Six novel functional monomers (M1-M6) were examined for their ability to imprint theophylline (1). The best selectivity was observed with M2.
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Asymmetric synthesis of substituted NH-piperidines from chiral amines

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00657G, PaperLekh Nath Gautam, Yijin Su, Novruz G. Akhmedov, Jeffrey L. Petersen, Xiaodong Shi
Previously, we reported an efficient asymmetric synthesis of substituted piperidines through an exocyclic chirality induced nitroalkene/amine/enone (NAE) condensation reaction.
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Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPAR[gamma] modulator

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00637B, PaperJingjing Shi, Guanguan Zhao, Xiaowei Wang, H. Eric Xu, Wei Yi
Here an efficient rhodium(III)-catalyzed C2-amidation of indoles and its synthetic application to a new PPAR[gamma] modulator have been developed.
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Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,4776-4806
DOI: 10.1039/C4OB00164H, Review ArticleChung Yen Ang, Si Yu Tan, Yanli Zhao
This review highlights recent advances in multifunctional nanocarriers for controlled and targeted drug delivery in cancer therapy.
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Copper(II)-catalyzed C-O coupling of aryl bromides with aliphatic diols: synthesis of ethers, phenols, and benzo-fused cyclic ethers

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4747-4753
DOI: 10.1039/C4OB00649F, PaperYajun Liu, Se Kyung Park, Yan Xiao, Junghyun Chae
An efficient copper(II)-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed.
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The self-disproportionation of the enantiomers (SDE) of methyl n-pentyl sulfoxide via achiral, gravity-driven column chromatography: a case study

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4738-4746
DOI: 10.1039/C4OB00831F, PaperAlicja Wzorek, Karel D. Klika, Jozef Drabowicz, Azusa Sato, Jose Luis Acena, Vadim A. Soloshonok
The practicality of the SDE phenomenon is demonstrated herein for the preparation of enantiomerically pure methyl n-pentyl sulfoxide.
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Incrementally increasing the length of a peptide backbone: effect on macrocyclisation efficiency

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4598-4601
DOI: 10.1039/C4OB00492B, CommunicationMd. Iqbal Ahmed, Jason B. Harper, Luke Hunter
Three novel analogues of the cyclic pentapeptide sansalvamide A have been synthesised in high yield.
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Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4571-4575
DOI: 10.1039/C4OB00400K, CommunicationTeerawat Songsichan, Jaturong Promsuk, Vatcharin Rukachaisirikul, Juthanat Kaeobamrung
Enaminones, as imine equivalents, show a potential-synthetic use in copper-catalyzed domino reactions with a variety of benzamides to produce quinazolinone derivatives.
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Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4544-4549
DOI: 10.1039/C4OB00616J, PerspectiveStephen G. Davies, Ai M. Fletcher, James E. Thomson
This review highlights the H-bond directed diastereoselective epoxidation of allylic alcohols and amines, and contrasts the diastereoselectivity in different cyclic and acyclic systems.
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Towards aryl C-N bond formation in dynamic thin films

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4594-4597
DOI: 10.1039/C4OB00926F, CommunicationMichael N. Gandy, Colin L. Raston, Keith A. Stubbs
A thin film microfluidic vortex fluidic device (VFD) operating under confined mode affords N-aryl compounds from the corresponding amine and aryl chloride, without the need for a transition metal catalyst.
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Structure-based de novo design and identification of D816V mutant-selective c-KIT inhibitors

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4644-4655
DOI: 10.1039/C4OB00053F, PaperHwangseo Park, Soyoung Lee, Suhyun Lee, Sungwoo Hong
New 7-azaindole-based c-KIT inhibitors with nanomolar inhibitory activity and high selectivity for the gain-of-function D816V mutant were identified through the structure-based de novo design using the scoring function improved by implementing an accurate solvation free energy.
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Access to novel imidazo[1,5-a]pyrazine scaffolds by the combined use of a three-component reaction and a base-assisted intramolecular cyclization

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4610-4619
DOI: 10.1039/C4OB00676C, PaperOrazio A. Attanasi, Gianfranco Favi, Gianluca Giorgi, Roberta Majer, Francesca Romana Perrulli, Stefania Santeusanio
A novel and practical two-step approach to an intriguing class of imidazo[1,5-a]pyrazines with exocyclic C[double bond, length as m-dash]X (X = CH2, O) bonds is described.
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RNA-peptide conjugate synthesis by inverse-electron demand Diels-Alder reaction

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4701-4707
DOI: 10.1039/C4OB00076E, PaperSandeep Ameta, Juliane Becker, Andres Jaschke
We present an efficient method to synthesize RNA-peptide conjugates employing inverse Diels-Alder cycloaddition. Different dienophiles are enzymatically incorporated into RNA and then conjugated with a tetrazine peptide at 1 : 1 stoichiometry.
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A hydrophobic disordered peptide spontaneously anchors a covalently bound RNA hairpin to giant lipidic vesicles

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00721B, PaperAlexandra Le Chevalier Isaad, Paolo Carrara, Pasquale Stano, Kollappillil S. Krishnakumar, Dominique Lafont, Alexandra Zamboulis, Rene Buchet, Denis Bouchu, Florian Albrieux, Peter Strazewski
Exergonic compartmentation of nucleic acids to liposomes through conjugation with peptides lends experimental support to early evolvable RNA-peptide 'collaboration'.
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B-DNA structure and stability: the role of hydrogen bonding, [small pi]-[small pi] stacking interactions, twist-angle, and solvation

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4691-4700
DOI: 10.1039/C4OB00427B, PaperJordi Poater, Marcel Swart, F. Matthias Bickelhaupt, Celia Fonseca Guerra
Insight into structure and stability of B-DNA is obtained through systematic quantum chemical analyses of the roles played by hydrogen bonding, [small pi]-[small pi] stacking, solvation, and twist-angle.
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A two-step tandem reaction to prepare hydroxamic acids directly from alcohols

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4582-4585
DOI: 10.1039/C4OB00693C, CommunicationGiovanna Dettori, Silvia Gaspa, Andrea Porcheddu, Lidia De Luca
The first synthesis of hydroxamic acids from alcohols has been developed.
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19F NMR monitoring of the eukaryotic 20S proteasome chymotrypsin-like activity: an investigative tool for studying allosteric regulation

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4576-4581
DOI: 10.1039/C4OB00962B, CommunicationM. Keita, J. Kaffy, C. Troufflard, E. Morvan, B. Crousse, S. Ongeri
A novel bimodal fluorescent and fluorinated substrate of the chymotrypsin-like proteolytic activity has been developed.
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TEMPO-mediated allylic C-H amination with hydrazones

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4567-4570
DOI: 10.1039/C4OB00839A, CommunicationXu Zhu, Shunsuke Chiba
TEMPO-mediated reactions of alkenyl hydrazones afforded azaheterocycles via sp3 C-H allylic amination. The transformation is featured by a sequence of remote allylic H-radical shift and allylic homolytic substitution with hydrazone radicals.
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Dammarane-type triterpenoids as 11[small beta]-HSD1 inhibitors from Homonoia riparia

17 June, 2014 - 01:17

Org. Biomol. Chem., 2014, 12,4716-4722
DOI: 10.1039/C4OB00807C, PaperJin-Hai Yu, Yu Shen, Hong-Bing Liu, Ying Leng, Hua Zhang, Jian-Min Yue
The chemistry and bioactivity of a series of dammarane-type triterpenoids from Homonoia riparia were reported in this article.
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