Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 1 hour ago

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,77-80
DOI: 10.1039/C4OB02155J, CommunicationMuhammet Tanc, Fabrizio Carta, Andrea Scozzafava, Claudiu T. Supuran
A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms.
The content of this RSS Feed (c) The Royal Society of Chemistry

Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,73-76
DOI: 10.1039/C4OB01810A, CommunicationHyeon Seok Kim, Woon Young Song, Hak Joong Kim
A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays.
The content of this RSS Feed (c) The Royal Society of Chemistry

Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: application to the synthesis of chiral [small alpha]-substituted carboxylic acids from [small alpha]-substituted [small alpha],[small beta]-unsaturated aldehydes

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,223-233
DOI: 10.1039/C4OB02282C, PaperTanja Knaus, Francesco G. Mutti, Luke D. Humphreys, Nicholas J. Turner, Nigel S. Scrutton
The development of hydrogen-borrowing biocatalytic cascades is presented and applied to the synthesis of diverse [small alpha]-chiral substituted carboxylic acids.
The content of this RSS Feed (c) The Royal Society of Chemistry

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,207-214
DOI: 10.1039/C4OB02105C, PaperSteffen Glockner, Duc N. Tran, Richard J. Ingham, Sabine Fenner, Zoe E. Wilson, Claudio Battilocchio, Steven V. Ley
A flow process to access oxazolines and oxazoles via a rapid and practical protocol is described.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of maculalactone A and derivatives for environmental fate tracking studies

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,199-206
DOI: 10.1039/C4OB02042A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samuel L. Bader, Michael U. Luescher, Karl Gademann
Labelled probes of the antifouling natural product, maculalactone A, allow for distribution studies in Artemia salina.
The content of this RSS Feed (c) The Royal Society of Chemistry

Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,178-184
DOI: 10.1039/C4OB01857E, PaperJelena Pesek, Jiri Svoboda, Martina Sattler, Stefan Bartram, Wilhelm Boland
8-HQA is generated in the gut of Noctuid larvae from tryptophan as an iron chelator to control the gut microbiome.
The content of this RSS Feed (c) The Royal Society of Chemistry

Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-mannich reaction

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,170-177
DOI: 10.1039/C4OB01793E, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.James C. Anderson, Ian B. Campbell, Sebastien Campos, Jonathan Shannon, Derek A. Tocher
The sequential use of the conjugate addition nitro-Mannich reaction, nitro reduction and then Pd-catalyzed intramolecular cyclisation allows the concise, stereodivergent synthesis of complex indolines.
The content of this RSS Feed (c) The Royal Society of Chemistry

The stability of nitrogen-centered radicals

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,157-169
DOI: 10.1039/C4OB01656D, PaperJohnny Hioe, Davor Sakic, Valerije Vrcek, Hendrik Zipse
Radical stabilization energies (RSEs) for a large variety of aminyl and protonated amine radical cations have been calculated using high-level composite procedures.
The content of this RSS Feed (c) The Royal Society of Chemistry

Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,55-58
DOI: 10.1039/C4OB02106A, CommunicationMinoru Ueda, Gangqiang Yang, Yuuki Nukadzuka, Yasuhiro Ishimaru, Satoru Tamura, Yoshiyuki Manabe
Importance of the D-glycopyranoside structure for the bioactivity and target affinity of jasmonic acid glucoside.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

7 December, 2014 - 20:17

Org. Biomol. Chem., 2015, 13,142-156
DOI: 10.1039/C4OB01516A, PaperJose Maria Zapico, Anna Puckowska, Kamila Filipiak, Claire Coderch, Beatriz de Pascual-Teresa, Ana Ramos
Triazole-based inhibitors with high potency and selectivity for MMP-2 were obtained through a click chemistry approach.
The content of this RSS Feed (c) The Royal Society of Chemistry

Ruthenium-catalyzed direct C3 alkylation of indoles with [small alpha],[small beta]-unsaturated ketones

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02124J, PaperShuai-Shuai Li, Hui Lin, Xiao-Mei Zhang, Lin Dong
In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various [small alpha],[small beta]-unsaturated ketones without chelation assistance has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01844C, PaperHaipin Zhou, Kuo Gai, Aijun Lin, Jinyi Xu, Xiaoming Wu, Hequan Yao
A palladium-catalyzed oxidative cross-coupling reaction between azole-4-carboxylates and indoles forming 5-(3-indolyl)azoles with excellent regioselectivity has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02377C, PaperH. Muchalski, L. Xu, N. A. Porter
We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins. In TMP of 7-DHC and deuterium-reinforced 7-DHC, the KIE of removing hydrogen/deuterium at C9 was found to be 21 +/- 1.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Characterizations of cationic [gamma]-carbolines binding with double-stranded DNA by spectroscopic methods and AFM imaging

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01905A, PaperTao Jia, Jing Wang, Peng Guo, Junping Yu
Because of differences in their structures, cationic [gamma]-carbolines intercalate into DNA with different activities.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Studies on the diastereoselective oxidation of 1-thio-[small beta]-D-glucopyranosides: Synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer .

3 December, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02030H, PaperNoureddine Khiar, Juan Francisco Moya-Lopez, Eleonora Elhalem, Rocio Recio, Eleuterio Alvarez, Fernandez Inmaculada
Abstract: A detailed study on the diastereoselective oxidation of 1-thio--D-glucopyranosides is reported. It has been shown that the sense and the degree of stereochemical outcome of the oxidation is highly...
The content of this RSS Feed (c) The Royal Society of Chemistry

A Chiral Borane Catalyzed Asymmetric Hydrosilylation of Imines

3 December, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02419B, CommunicationXiaxia Zhu, HAIFENG DU
An enantioselective hydrosilylation of imines was successfully achieved using a chiral borane catalyst generated by the in situ hydroboration of a binaphthyl-based chiral diene with Piers' borane HB(C6F5)2 to furnish...
The content of this RSS Feed (c) The Royal Society of Chemistry

A case of oxoanion recognition based on combined cationic and neutral C-H hydrogen bond interactions

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02288B, PaperFabiola Zapata, Paula Sabater, Antonio Caballero, Pedro Molina
A bidentate bis-(benzimidazolium) receptor containing pyrene as fluorescent signaling units recognizes sulphate and hydrogenpyrophosphate in a competitive water-DMSO medium through combinations of cationic and neutral C-H hydrogen bonding.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Metal-catalyzed formation of 1,3-cyclohexadienes: a catalyst-dependent reaction

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01922A, PaperShifa Zhu, Xiaobing Huang, Tian-Qi Zhao, Tongmei Ma, Huanfeng Jiang
A metal-dependent and complementary catalytic method to synthesize the cyclohexadienes has been developed. When gold or indium salts were used as catalysts, 1,3-cyclohexadiene (1,3-CHD) could be obtained; when Cu(OTf)2 was used as the catalyst, however, another isomer 2,4-cyclohexadiene (2,4-CHD) was furnished instead.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

N-Heterocyclic Carbene-Catalyzed Cyclocondensation of 2-Aryl Carboxylic Acid and Enones: Highly Enantioselective Synthesis of [small delta]-Lactones

3 December, 2014 - 19:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02330G, CommunicationJin-Tang Cheng, Xiang-Yu Chen, Song Ye
The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of 2-aryl carboxylic acids and enones was developed, affording the corresponding chiral [small delta]-lactones in good yields with good diastereo- and high enantioselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry

Fluorescent organic nanoparticles of dihydropyrimidone derivatives for selective recognition of iodide using a displacement assay: application of the sensors in water and biological fluids

3 December, 2014 - 19:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02152E, PaperAmanpreet Kaur, Tilak Raj, Simanpreet Kaur, Narinder Singh, Navneet Kaur
Fluorescent organic nanoparticles (FON's) derived from dihydropyrimidone derivatives (1-4) were developed and evaluated for their sensor properties.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.