Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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A colorimetric and ratiometric fluorescent probe for distinguishing cysteine from biothiols in water and living cells

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,5023-5030
DOI: 10.1039/C4OB00463A, PaperQingxin Han, Zhaohua Shi, Xiaoliang Tang, Lizi Yang, Zuolin Mou, Jing Li, Jinmin Shi, Chunyang Chen, Wei Liu, Huan Yang, Weisheng Liu
A highly selective merocyanine-based fluorescent probe was developed, which can significantly distinguish Cys from Hcy and GSH by their kinetic profiles in water and respond to the intracellular Cys.
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A study of allosteric binding behaviour of a 1,3-alternate thiacalix[4]arene-based receptor using fluorescence signal

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4917-4923
DOI: 10.1039/C4OB00551A, PaperHirotsugu Tomiyasu, Cheng-Cheng Jin, Xin-Long Ni, Xi Zeng, Carl Redshaw, Takehiko Yamato
The allosteric binding behaviour of a receptor L bearing a 1,3-alternate conformation based thiacalix[4]arene has been evaluated by fluorescence and 1H NMR titration experiments.
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Recent advances in dearomatization of heteroaromatic compounds

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4807-4815
DOI: 10.1039/C4OB00371C, Review ArticleQiuping Ding, Xiaoli Zhou, Renhua Fan
This review summarizes the recent developments in dearomatization reactions of indoles, pyridines, quinolines, isoquinolines, and some other heteroaromatic compounds.
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'Clickable' 2,5-diketopiperazines as scaffolds for ligation of biomolecules: their use in A[small beta] inhibitor assembly

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4964-4974
DOI: 10.1039/C4OB00541D, PaperE. Dufour, L. Moni, L. Bonnat, S. Chierici, J. Garcia
The synthesis of 1,3,6-trisubstituted-2,5-diketopiperazine scaffolds bearing up to three 'clickable' sites for further oxime bond or alkyne-azide cycloaddition ligations is described.
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Experimental and theoretical studies on the effect of the oxo group in 1,4-benzodiazepines

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4905-4916
DOI: 10.1039/C4OB00444B, PaperPablo Pertejo, Maria Garcia-Valverde, Pablo Pena, Nicolas A. Cordero, Tomas Torroba, Alfonso Gonzalez-Ortega
Two families of regioisomeric 1,4-benzodiazepines have been synthesized through a similar Ugi/reduction cyclization sequence. Their conformation and stability depend on the relative position of the carbonyl group adjacent to the nitrogen at the 4-position in the benzodiazepine system.
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Tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the synthesis of S-linked glycosides and glyco-conjugates

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4816-4819
DOI: 10.1039/C4OB00741G, CommunicationS. Mandal, U. J. Nilsson
Tri-isopropylsilyl thio-glycosides (TIPS S-glycosides), readily synthesized from glycosyl halides, glycosyl acetates, or p-methoxyphenyl glycosides, were in one-pot de-silylated and S-alkylated, -acylated, or -glycosylated in high yields and short time.
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Enthalpy-driven nuclease-like activity and mechanism of peptide-chlorambucil conjugates

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4890-4904
DOI: 10.1039/C4OB00123K, PaperRobin C. K. Yang, Jonathan T. B. Huang, Yu-Ling Chen, Chia-Chun Hung, Mokai Liao, Wen-Chen Yao, Chiu-Heng Chen, Chien-Chung Liou, Michael J. Waring, Leung Sheh
The chemical nuclease activity, energetics, and stepwise cleavage mechanism of chlorambucil-peptide conjugates are presented.
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Iodine-catalyzed aromatization of tetrahydrocarbazoles and its utility in the synthesis of glycozoline and murrayafoline A: a combined experimental and computational investigation

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4832-4836
DOI: 10.1039/C4OB00635F, CommunicationVivek Humne, Yuvraj Dangat, Kumar Vanka, Pradeep Lokhande
A new protocol for the aromatization of tetrahydrocarbazoles has been achieved using a catalytic amount of iodine. The role of iodine has been explained by DFT, and its scope is extended to the total synthesis of glycozoline and murrayafoline A.
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N[1,3]-sigmatropic shift in the benzidine rearrangement: experimental and theoretical investigation

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4952-4963
DOI: 10.1039/C4OB00080C, PaperShili Hou, Xinyao Li, Jiaxi Xu
The N[1,3]-sigmatropic shift with an inversion of the configuration in the migrating nitrogen atom exists in the formation of semidines and diphenyline.
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An easy route to synthetic analogues of radicamine B, codonopsine and codonopsinine from D-mannitol

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4983-4998
DOI: 10.1039/C4OB00503A, PaperSuresh Dharuman, Ashok Kumar Palanivel, Yashwant D. Vankar
Analogues of radicamine B, codonopsinine and codonopsine were synthesized from D-mannitol and found to be good inhibitors of various glycosidases.
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Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4941-4951
DOI: 10.1039/C4OB00589A, PaperHu Ge, Jinggong Liu, Wenxia Zhao, Yu Wang, Qingqing He, Ruibo Wu, Ding Li, Jun Xu
The mechanism for lowering cholesterol using green tea polyphenols (ECG and EGCG) by the tri-targeted inhibition of FPPS, MVK and MDD.
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Novel 3-arylethynyl-substituted thieno[3,4-b]pyrazine derivatives as human transglutaminase 2 inhibitors

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4932-4940
DOI: 10.1039/C4OB00179F, PaperNayeon Kim, Se Hun Kwak, Seon-Hyeong Lee, Vinayak Juvekar, Byung-Il Lee, Hee-Chul Ahn, Soo-Youl Kim, Young-Dae Gong
In the process of optimization, we developed a novel core skeleton of thieno[3,4-b]pyrazine viaGK-13.
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Synthesis of benzofuro[2,3-c]pyridines via a one-pot three-component reaction

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4885-4889
DOI: 10.1039/C4OB00670D, PaperJiaxing Hu, Zhihong Deng, Xueqiong Zhang, Fanglin Zhang, Hua Zheng
A convenient one-pot synthesis of polysubstituted benzofuro[2,3-c]pyridines by three-component is developed. It provides a flexible and rapid synthetic route for the construction of benzofuro[2,3-c]pyridines under mild and metal-free reaction conditions in moderate to good yields (up to 83%).
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Construction of rotacatenanes using rotaxane and catenane frameworks

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4862-4871
DOI: 10.1039/C4OB00602J, PaperWen Xue, Ziyong Li, Guoxing Liu, Xiaoqiang Chen, Tingting Li, Sheng Hua Liu, Jun Yin
The construction of novel mechanically interlocked structures has become a topic of great current interest due to the requirements of topology and their potential application in molecular machines and devices.
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Cap analogs containing 6-thioguanosine - reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

25 June, 2014 - 02:54

Org. Biomol. Chem., 2014, 12,4841-4847
DOI: 10.1039/C4OB00059E, PaperMonika Nowakowska, Joanna Kowalska, Franck Martin, Arnaud d'Orchymont, Joanna Zuberek, Maciej Lukaszewicz, Edward Darzynkiewicz, Jacek Jemielity
Novel photo-crosslinking reagents for the analysis of biomolecules binding mRNA 5[prime or minute] end.
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Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00517A, PaperHazit Zayas, Clovia I. Holdsworth, Michael C. Bowyer, Adam McCluskey
Six novel functional monomers (M1-M6) were examined for their ability to imprint theophylline (1). The best selectivity was observed with M2.
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Asymmetric synthesis of substituted NH-piperidines from chiral amines

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00657G, PaperLekh Nath Gautam, Yijin Su, Novruz G. Akhmedov, Jeffrey L. Petersen, Xiaodong Shi
Previously, we reported an efficient asymmetric synthesis of substituted piperidines through an exocyclic chirality induced nitroalkene/amine/enone (NAE) condensation reaction.
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Rhodium(III)-catalyzed regioselective C2-amidation of indoles with N-(2,4,6-trichlorobenzoyloxy)amides and its synthetic application to the development of a novel potential PPAR[gamma] modulator

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00637B, PaperJingjing Shi, Guanguan Zhao, Xiaowei Wang, H. Eric Xu, Wei Yi
Here an efficient rhodium(III)-catalyzed C2-amidation of indoles and its synthetic application to a new PPAR[gamma] modulator have been developed.
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Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapy

23 June, 2014 - 02:17

Org. Biomol. Chem., 2014, 12,4776-4806
DOI: 10.1039/C4OB00164H, Review ArticleChung Yen Ang, Si Yu Tan, Yanli Zhao
This review highlights recent advances in multifunctional nanocarriers for controlled and targeted drug delivery in cancer therapy.
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Copper(II)-catalyzed C-O coupling of aryl bromides with aliphatic diols: synthesis of ethers, phenols, and benzo-fused cyclic ethers

19 June, 2014 - 01:54

Org. Biomol. Chem., 2014, 12,4747-4753
DOI: 10.1039/C4OB00649F, PaperYajun Liu, Se Kyung Park, Yan Xiao, Junghyun Chae
An efficient copper(II)-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed.
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