Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02128B, CommunicationMarielle M. E. Delville, Kaspar Koch, Jan C. M. van Hest, Floris P. J. T. Rutjes
Integrated two-step chemoenzymatic continuous flow process for the synthesis of protected cyanohydrins from aldehydes.
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A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02417F, PaperMarc Y. Stevens, Krzysztof Wieckowski, Peng Wu, Rajiv T. Sawant, Luke R. Odell
A series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a novel cascade imine/cyclization/aza-Henry reaction in moderate to excellent yields.
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Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02340D, PaperLuis R. Domingo, Jose A. Saez, Saeed R. Emamian
The elimination of HCl and CO2 in the corresponding cycloadducts makes the unfavourable polar Diels-Alder reaction of 3-chloroindole irreversible.
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A coumarin based gold(I)-alkynyl complex: a new class of supramolecular hydrogelators

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02077D, PaperArtur J. Moro, Bertrand Rome, Elisabet Aguilo, Julia Arcau, Rakesh Puttreddy, Kari Rissanen, Joao Carlos Lima, Laura Rodriguez
A phosphine-gold(I)-alkynyl-coumarin complex, [Au{7-(prop-2-ine-1-yloxy)-1-benzopyran-2-one}(DAPTA)] (1), was synthesized and the formation of long luminescent fibers in solution was characterized via fluorescence microscopy and dynamic light scattering.
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Conformational modulation of peptides using [small beta]-amino benzenesulfonic acid (SAnt)

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02421D, PaperGowri Priya, Amol S. Kotmale, Debamitra Chakravarty, Vedavati G. Puranik, Pattuparambil R. Rajamohanan, Gangadhar J. Sanjayan
This communication describes the utility of the conformationally restricted aromatic [small beta]-amino acid (2-aminobenzenesulfonic acid, SAnt) for inducing various folding interactions in short peptides.
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Asymmetric syntheses of three-membered heterocycles using chiral amide-based ammonium ylides

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02318H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mathias Pichler, Johanna Novacek, Raphael Robiette, Vanessa Poscher, Markus Himmelsbach, Uwe Monkowius, Norbert Muller, Mario Waser
Phenylglycinol serves as a powerful chiral auxiliary in ammonium ylide-mediated reactions to obtain chiral epoxides/aziridines with excellent stereoselectivities.
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Studies on the diastereoselective oxidation of 1-thio-[small beta]-D-glucopyranosides: synthesis of the usually less favoured RS sulfoxide as a single diastereoisomer

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02030H, PaperJuan Francisco Moya-Lopez, Eleonora Elhalem, Rocio Recio, Eleuterio Alvarez, Inmaculada Fernandez, Noureddine Khiar
The exo-anomeric effect paves the way for the synthesis of the usually less favored RS-[small beta]-sulfinyl glycoside as a single diastereoisomer.
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Binding modes of a core-extended metalloporphyrin to Human Telomeric DNA G-quadruplexes

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02097A, PaperJenifer Rubio-Magnieto, Florent Di Meo, Mamadou Lo, Cecile Delcourt, Sebastien Clement, Patrick Norman, Sebastien Richeter, Mathieu Linares, Mathieu Surin
The molecular recognition of Human telomeric G-quadruplexes by a novel cationic [small pi]-extended NiII-porphyrin (NiII-TImidP4, Chart 1) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting...
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Styryl ether formation from benzyl alcohols under transition-metal-free basic DMSO conditions

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02358G, PaperKai Yang, Qiuling Song
A phenol-catalyzed aerobic oxidative styryl ether formation method was developed with benzyl alcohol under basic DMSO.
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Mixed Alkyl Aryl Phosphonate Esters as Quenched Fluorescent Activity-Based Probes for Serine Proteases

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02444C, PaperSevnur Serim, Philipp Baer, Steven H.L. Verhelst
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging,...
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Highly stable triple helix formation by homopyrimidine (L)-acyclic threoninol nucleic acids with single stranded DNA and RNA

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02328E, PaperVipin Kumar, KESAVAN Venkitasamy, Kurt Vesterager Gothelf
Acyclic (L)-threoninol nucleic acid (aTNA) containing thymine, cytosine and adenine nucleobases were synthesized and shown to form surprisingly stable triplexes with complementary single stranded homopurine DNA or RNA targets. The...
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Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02267J, CommunicationSu-Ying Xu, Xiaolong Sun, Haobo Ge, Rory L. Arrowsmith, John S. Fossey, Sofia I. Pascu, Yun-Bao Jiang, Tony D. James
A biocompatible fluoride receptor has been developed where the interaction between the boronic acid ester and amine (NH) results in fluoride ion selectivity and enhanced fluorescence quenching.
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Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02258K, PaperSamuel Furse, LokHang Mak, Edward W. Tate, Richard H. Templer, Oscar Ces, Rudiger Woscholski, Piers R. J. Gaffney
Single enantiomers of PI-4-P, with a range of sn-2-fatty acid esters, were prepared efficiently. The effects of the degree of sn-2-unsaturation on the kinetic parameters of SopB were determined.
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Short and efficient synthesis of fluorinated [small delta]-lactams

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,717-728
DOI: 10.1039/C4OB01547A, PaperThomas J. Cogswell, Craig S. Donald, De-Liang Long, Rodolfo Marquez
The diastereoselective synthesis of fluorinated [small delta]-lactams.
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Benzosulfones as Photochemically Activated Sulfur Dioxide (SO2) Donors

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02466D, PaperSatish Malwal, Harinath Chakrapani
Sulfur dioxide (SO2) is a gaseous environmental pollutant which is routinely used in industry as a preservative and antimicrobial. Recent data suggests that SO2 may have value as a therapeutic...
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Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: kinetic and thermodynamic control

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02329C, PaperDaniele Castagnolo, Leonardo Degennaro, RENZO LUISI, Jonathan Clayden
The addition of n-butyllithium to alkenylthiocarbamates in the presence of (-)-sparteine or the (+)-sparteine surrogate leads to asymmetric carbolithiation, and returns enantiomerically enriched thiocarbamate derivatives of secondary thiols. In THF,...
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Energy Transfer Between Amphiphilic Porphyrin Polymer Shells and Upconverting Nanoparticle Cores in Water-Dispersible Nano-assemblies

1 January, 2015 - 02:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02401J, PaperTuoqi Wu, Sandeep Kaur, Neil R. Branda
The synthesis of water-dispersible nano-assemblies containing upconverting nanoparticles (UCNPs) and porphyrin molecules using a one-pot method is described. When the nano-assemblies are excited by 980 nm near-infrared light, the intensity...
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Rhodium-catalysed arylative annulation of 1,4-enynes with arylboronic acids

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,702-705
DOI: 10.1039/C4OB02210F, CommunicationTakanori Matsuda, Shoichi Watanuki
Rhodium(I)-catalysed arylative annulation of 1,4-enynes with arylboronic acids affords 1,1-disubstituted 3-(arylmethylene)indanes via an addition-1,4-rhodium migration-addition sequence.
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Palladium-catalyzed unactivated [small beta]-methylene C(sp3)-H bond alkenylation of aliphatic amides and its application in a sequential C(sp3)-H/C(sp2)-H bond alkenylation

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,697-701
DOI: 10.1039/C4OB02389G, CommunicationGang Shan, Guiyi Huang, Yu Rao
A palladium(II)-catalyzed [small beta]-methylene C(sp3)-H bond alkenylation of acyclic aliphatic amides with alkenyl halides has been developed. Solvent effect-promoted sequential C(sp3)-H bond alkenylation and C(sp2)-H bond alkenylation has also been studied.
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A mild copper-catalyzed aerobic oxidative thiocyanation of arylboronic acids with TMSNCS

1 January, 2015 - 02:17

Org. Biomol. Chem., 2015, 13,691-696
DOI: 10.1039/C4OB02208D, CommunicationNan Sun, Liusheng Che, Weimin Mo, Baoxiang Hu, Zhenlu Shen, Xinquan Hu
A facile and generalized synthesis of aryl thiocyanates has been established via the CuCl-catalyzed oxidative coupling of arylboronic acids with TMSNCS. The reaction could be conducted at RT and under an O2 atmosphere.
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