Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia

13 January, 2016 - 21:17

Org. Biomol. Chem., 2016, 14,957-962
DOI: 10.1039/C5OB02296G, PaperHua Zhang, Jia Liu, Li-She Gan, Seema Dalal, Maria B. Cassera, Jian-Min Yue
Five new diterpenoid dimers of a rare structure class were discovered from Aphanamixis grandifolia. These compounds showed moderate antimalarial activities.
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Synthetic and theoretical investigation on the one-pot halogenation of [small beta]-amino alcohols and nucleophilic ring opening of aziridinium ions

13 January, 2016 - 21:17

Org. Biomol. Chem., 2016, 14,920-939
DOI: 10.1039/C5OB01692D, PaperYunwei Chen, Xiang Sun, Ningjie Wu, Jingbai Li, Shengnan Jin, Yongliang Zhong, Zirui Liu, Andrey Rogachev, Hyun-Soon Chong
One-pot formation and nucleophilic ring opening of aziridinium ions are reported.
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Synthesis of the AB ring system of clifednamide utilizing Claisen rearrangement and Diels-Alder reaction as key steps

13 January, 2016 - 21:17

Org. Biomol. Chem., 2016, 14,884-894
DOI: 10.1039/C5OB01491C, PaperInga Loke, Guillaume Bentzinger, Julia Holz, Aruna Raja, Aman Bhasin, Florenz Sasse, Andreas Kohn, Rainer Schobert, Sabine Laschat
A synthesis to the functionalized AB ring system of clifednamide, member of macrocyclic tetramic acid lactams, was developed involving an Ireland-Claisen rearrangement and an intramolecular Diels-Alder reaction.
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Iodine-catalyzed thiolation of electron-rich aromatics using sulfonyl hydrazides as sulfenylation reagents

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,1131-1137
DOI: 10.1039/C5OB02193F, PaperXia Zhao, Tianjiao Li, Lipeng Zhang, Kui Lu
Iodine-catalyzed thiolation of electron-rich aromatics, including substituted anisole, thioanisole, phenol, toluene, and naphthalene, using sulfonyl hydrazides as sulfenylation reagents was carried out.
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Efficient access to conjugated 4,4[prime or minute]-bipyridinium oligomers using the Zincke reaction: synthesis, spectroscopic and electrochemical properties

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,980-988
DOI: 10.1039/C5OB02211H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Long Chen, Helen Willcock, Christopher J. Wedge, Frantisek Hartl, Howard M. Colquhoun, Barnaby W. Greenland
We have synthesised conjugated viologen-containing oligomers. They exhibit discrete, redox processes accompanied by changes in electronic absorption spectra.
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Gold-catalyzed cyclization and cycloisomerization of yne-tethered ynamide: the significance of a masked enol-equivalent of an amide

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,803-807
DOI: 10.1039/C5OB02262B, PerspectiveSanatan Nayak, B. Prabagar, Akhila K. Sahoo
The enol-equivalent of an amide: a tool useful to construct novel N-heterocycles.
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The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,947-956
DOI: 10.1039/C5OB02229K, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mark C. Bagley, Jessica E. Dwyer, Mohammed Baashen, Matthew C. Dix, Paola G. S. Murziani, Michal J. Rokicki, David Kipling, Terence Davis
Microwave-assisted synthesis of the p38[small alpha] MAPK inhibitor RO3201195 and its effect on the proliferation of Werner syndrome cells.
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Facile synthesis of the NNRTI microbicide MC-1220 and synthesis of its phosphoramidate prodrugs

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,940-946
DOI: 10.1039/C5OB02055G, PaperYasser M. Loksha, Erik B. Pedersen, Paolo La Colla, Roberta Loddo
A facile and novel synthetic route to MC-1220 was achieved by condensation of 4,6-dichloro-N,N-5-trimethylpyrimidin-2-amine (1) with the sodium salt of 2,6-difluorophenylacetonitrile, followed by methylation and strong acidic hydrolysis.
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Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl-ene reaction toward oxazole derivatives

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,826-829
DOI: 10.1039/C5OB02158H, CommunicationBin Wang, Ying Chen, Ling Zhou, Jianwu Wang, Zhenghu Xu
A novel tandem metal relay catalytic system combining Zn(II)-catalyzed cycloisomerization and a Sc(III)-catalyzed carbonyl-ene reaction has been successfully developed.
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A concise synthesis of tubuphenylalanine and epi-tubuphenylalanine via a diastereoselective Mukaiyama aldol reaction of silyl ketene acetal

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,913-919
DOI: 10.1039/C5OB02239H, PaperYunjeong Park, Mikyung Sim, Tong-Shin Chang, Jae-Sang Ryu
A concise auxiliary-free synthetic route towards tBu-tubuphenylalanine (tBu-Tup) and tBu-epi-tubuphenylalanine (tBu-epi-Tup) has been developed via a diastereoselective Mukaiyama aldol reaction of silyl ketene acetal.
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An efficient route to regioselective functionalization of benzo[b]thiophenes via palladium-catalyzed decarboxylative Heck coupling reactions: insights from experiment and computation

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,895-904
DOI: 10.1039/C5OB01905B, PaperDaoshan Yang, Yuxia Liu, Pengfei Sun, Ning Zhang, Wei Wei, Mingyang Sun, Guang Chen, Siwei Bi, Hua Wang
This study reports the Pd-catalyzed decarboxylative Heck-type coupling of 3-chlorobenzo[b]thiophene-2-carboxylic acids with styrenes.
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The interaction of Mozobil[trade mark sign] with carboxylates

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,905-912
DOI: 10.1039/C5OB01704A, PaperValeria Amendola, Greta Bergamaschi, Luigi Fabbrizzi, Maurizio Licchelli, Carlo Mangano
Mozobil[trade mark sign] interacts with linear dicarboxylates as a pentammonium cation, providing a model for binding to CXCR4 coreceptor.
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Synthesis and anti-cancer activity of 1,4-disubstituted imidazo[4,5-c]quinolines

11 January, 2016 - 20:54

Org. Biomol. Chem., 2016, 14,876-883
DOI: 10.1039/C5OB01650A, PaperYadagiri Thigulla, Mahesh Akula, Prakruti Trivedi, Balaram Ghosh, Mukund Jha, Anupam Bhattacharya
Synthesis of 4-substituted imidazo[4,5-c]quinolines using a Yb(OTf)3 catalyzed modified Pictet-Spengler reaction as the key final step.
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Catalytic Asymmetric Hetero-Diels-Alder Reactions of Enones with Isatins to Access Functionalized Spirooxindole Tetrahydropyrans: Scope, Derivatization, and Discovery of Bioactives

9 January, 2016 - 20:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB02393A, PaperHai-Lei Cui, Pandurang V Chouthaiwale, Feng Yin, Fujie Tanaka
The development of concise methods for the synthesis of functionalized small molecules is important in the search of new bioactive molecules. To contribute to this, we have developed oxa-hetero-Diels-Alder reactions...
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Development of Stable Phosphoarginine Analog for Producing Phosphoarginine Antibodies

9 January, 2016 - 20:17
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB02603B, CommunicationHan Ouyang, Chuan Fu, Songsen Fu, Zhe Ji, Ying Sun, Peiran Deng, Yufen Zhao
Protein phosphorylation is one of the most common and extensively studied posttranslational modifications (PTMs). Compared to the O-phosphorylation on Ser, Thr and Tyr residues, our understanding of arginine phosphorylation is...
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The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry

9 January, 2016 - 20:17

Org. Biomol. Chem., 2016, Advance Article
DOI: 10.1039/C5OB01892G, Review ArticlePaul M. Murray, Fiona Bellany, Laure Benhamou, Dejan-Kresimir Bucar, Alethea B. Tabor, Tom D. Sheppard
This article outlines the benefits of using 'Design of Experiments' (DoE) for optimisation and solvent selection during the development of new synthetic methodology.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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STD NMR and molecular modelling insights into interaction of novel mannose-based ligands with DC-SIGN

9 January, 2016 - 20:17

Org. Biomol. Chem., 2016, 14,862-875
DOI: 10.1039/C5OB01916H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anita Kotar, Tihomir Tomasic, Martina Lenarcic Zivkovic, Gregor Jug, Janez Plavec, Marko Anderluh
STD-NMR and molecular modelling study of four [small alpha]-D-mannosides show new contacts in DC-SIGN binding site to help develop potent DC-SIGN antagonists.
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Target-Specific Identification and Characterization of the Putative Gene Cluster for Brasilinolide Biosynthesis Revealing Mechanistic Insights and Combinatorial Synthetic Utility of 2-Deoxy-L-Fucose Biosynthetic Enzymes

7 January, 2016 - 19:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB02292D, PaperHsien-Tai Chiu, Chien-Pao Weng, Yu-Chin Lin, Kuan-Hung Chen
Brasilinolides exhibiting potent immunosuppressive and antifungal activities with remarkably low toxicity are structurally characterized by an unusual modified 2-deoxy-L-fucose (2dF) attached to a type I polyketide (PK-I) macrolactone. From the...
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Ultrasound accelerated organogel: application for visual discrimination of Hg2+ from Ag+

7 January, 2016 - 19:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB02261D, PaperYan Qiu Wang, Zengyao Wang, Zhice Xu, Xudong Yu, Kun Zhao, Yajuan Li, xue lei pang
a new kind of naphthalimide based organolator TN was designed and synthesized. The intramolecular guanylation of TN promoted by Hg2+ or Ag+ in both solution and gel state was studied...
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Correction: Multivalent presentation of carbohydrates by 314-helical peptide templates: synthesis, conformational analysis using CD spectroscopy and saccharide recognition

7 January, 2016 - 19:54
Org. Biomol. Chem., 2016, 14,785-785
DOI: 10.1039/C5OB90206A, CorrectionOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nitin J. Pawar, Ulf Diederichsen, Dilip. D. Dhavale
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