Org. and Biomol. Chem.

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Fluorescent organic nanoparticles of dihydropyrimidone derivatives for selective recognition of iodide using a displacement assay: application of the sensors in water and biological fluids

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1204-1212
DOI: 10.1039/C4OB02152E, PaperAmanpreet Kaur, Tilak Raj, Simanpreet Kaur, Narinder Singh, Navneet Kaur
Fluorescent organic nanoparticles (FON's) derived from dihydropyrimidone derivatives (1-4) were developed and evaluated for their sensor properties.
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Probing coiled-coil assembly by paramagnetic NMR spectroscopy

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1159-1168
DOI: 10.1039/C4OB02125H, PaperTingTing Zheng, Aimee Boyle, Hana Robson Marsden, Dayenne Valdink, Giuliana Martelli, Jan Raap, Alexander Kros
Here a new method to determine the orientation of coiled-coil peptide motifs is described.
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Gold-catalyzed spiro-N,O-ketal synthesis

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1169-1178
DOI: 10.1039/C4OB02050B, PaperM. Grammatikopoulou, S. Thysiadis, V. Sarli
An efficient method for the synthesis of spiro-N,O-ketals with 5- and 6-membered rings was developed via a gold-catalyzed spiroamidoketalization of alkynyl amidoalcohols under mild conditions.
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Label-free fluorescence detection of kinase activity using a gold nanoparticle based indicator displacement assay

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1198-1203
DOI: 10.1039/C4OB02052A, PaperCristian Pezzato, Davide Zaramella, Massimiliano Martinelli, Gregory Pieters, Mario A. Pagano, Leonard J. Prins
A straightforward fluorescence indicator-displacement assay (IDA) has been developed for the quantitative analysis of ATP[rightward arrow]ADP conversion.
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Synthesis of isoxazolidine-containing uridine derivatives as caprazamycin analogues

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1187-1197
DOI: 10.1039/C4OB02142H, PaperMayumi Yamaguchi, Akira Matsuda, Satoshi Ichikawa
Simplification of caprazamycins was conducted by scaffold-hopping of the structurally complex diazepanone moiety to the isoxazolidine scaffold.
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Enantioselective synthesis of benzoindolizidine derivatives using chiral phase-transfer catalytic intramolecular domino aza-Michael addition/alkylation

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1179-1186
DOI: 10.1039/C4OB02227K, PaperJiajia Guo, Shouyun Yu
An efficient and enantioselective strategy to synthesize benzoindolizidines via domino intramolecular aza-Michael addition/alkylation was developed.
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Synthesis and tautomerization of hydroxylated isoflavones bearing heterocyclic hemi-aminals

13 January, 2015 - 04:54

Org. Biomol. Chem., 2015, 13,1053-1067
DOI: 10.1039/C4OB02137A, PaperMykhaylo S. Frasinyuk, Svitlana P. Bondarenko, Volodymyr P. Khilya, Chunming Liu, David S. Watt, Vitaliy M. Sviripa
Aminomethylation of 7-hydroxy isoflavones with C2-C5 [small omega]-aminoalcohols led to tautomers 4 and 5 that were interconverted as confirmed by NMR studies.
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Characterizations of cationic [gamma]-carbolines binding with double-stranded DNA by spectroscopic methods and AFM imaging

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1234-1242
DOI: 10.1039/C4OB01905A, PaperTao Jia, Jing Wang, Peng Guo, Junping Yu
Because of differences in their structures, cationic [gamma]-carbolines intercalate into DNA with different activities.
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Unprecedented one-pot sequential thiolate substitutions under mild conditions leading to a red emissive BODIPY dye 3,5,8-tris(PhS)-BODIPY

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,995-999
DOI: 10.1039/C4OB01892C, CommunicationRobinson I. Roacho, Alejandro Metta-Magana, Eduardo Pena-Cabrera, Keith Pannell
Phenylthiol performs a thiol exchange with 8-MeS-BODIPY and activates/substitutes the 3,5 positions forming a tri-thiolated BODIPY.
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[gamma]-Cyclodextrin modulates the chemical reactivity by multiple complexation

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1213-1224
DOI: 10.1039/C4OB02113D, PaperJ. Fernandez-Rosas, M. Pessego, M. Cepeda-Plaza, N. Basilio, M. Parajo, P. Rodriguez-Dafonte, L. Garcia-Rio
Multiple recognition by cooperative/competitive mechanisms to form a 1 : 1 : 1 inclusion complex plays a crucial role in determining the chemical reactivity in the [gamma]-CD cavity.
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Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1150-1158
DOI: 10.1039/C4OB02207F, PaperStefan Oschatz, Tom Brunzel, Xiao-Feng Wu, Peter Langer
A convenient and facile procedure for the synthesis of dihydroquinazolinthiones from 2-aminobenzothioamide with aldehydes has been developed. The reactions took place in water without the need of any additive.
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Design and synthesis of Troger's base ditopic receptors: host-guest interactions, a combined theoretical and experimental study

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1141-1149
DOI: 10.1039/C4OB02266A, PaperManda Bhaskar Reddy, Myadaraboina Shailaja, Alla Manjula, Joseph Richard Premkumar, Garikapati Narahari Sastry, Katukuri Sirisha, Akella Venkata Subrahmanya Sarma
The host-guest interaction between flexible ditopic receptors and bisammonium ion has been investigated experimentally and computationally. The conformation folding of guest bisammonium ion molecules leads to the oscillation of the host-guest interaction.
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The synthesis of [18F]pitavastatin as a tracer for hOATP using the Suzuki coupling

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1113-1121
DOI: 10.1039/C4OB01953A, PaperYusuke Yagi, Hiroyuki Kimura, Kenji Arimitsu, Masahiro Ono, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Kajimoto, Yuichi Sugiyama, Hideo Saji
Fluorine-18 labeled radiotracers, such as [18F]fluorodeoxyglucose, can be used as practical diagnostic agents in positron emission tomography (PET).
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The development of a complementary pathway for the synthesis of aliskiren

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1133-1140
DOI: 10.1039/C4OB01963F, PaperLe-Le Li, Jin-Ying Ding, Lian-Xun Gao, Fu-She Han
We present an alternative pathway for the synthesis of aliskiren by applying the Evans chiral auxiliary-aided asymmetric allylation and the Julia-Kocienski olefination as the key transformations.
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Modulation of the charge transfer and photophysical properties in non-fused tetrathiafulvalene-benzothiadiazole derivatives

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1040-1047
DOI: 10.1039/C4OB02100B, PaperFlavia Pop, Sabine Seifert, Jihane Hankache, Jie Ding, Andreas Hauser, Narcis Avarvari
Stille and Sonogashira coupling strategies allowed the preparation of luminescent TTF-benzothiadiazole donor-acceptor compounds with direct linkage or an acetylenic spacer.
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Tuning the pH-triggered self-assembly of dendritic peptide amphiphiles using fluorinated side chains

11 January, 2015 - 04:17

Org. Biomol. Chem., 2015, 13,1030-1039
DOI: 10.1039/C4OB02185A, PaperRalph Appel, Sebastian Tacke, Jurgen Klingauf, Pol Besenius
We report the synthesis of a series of anionic dendritic peptide amphiphiles of increasing hydrophobic character and describe their self-assembly into supramolecular nanorods using pH and ionic strength dependent state diagrams.
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Synthesis of Imidazoles via Cascade Reaction of Nitroallylic Acetates with Amidines and Studies on Their Trypanocidal Activity

9 January, 2015 - 03:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02561J, CommunicationTarun Kumar, Deepti Verma, Rubem F. S. Menna-Barreto, Wagner O. Valenca, Eufranio Silva Junior, Irishi N Namboothiri
A one-pot, two step synthesis of highly substituted imidazoles has been carried out in good to excellent yield for the first time via a cascade intermolecular aza-SN2'-intramolecular aza-Michael addition involving...
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Photocontrol of Ion Permeation in Lipid Vesicles with Amphiphilic Dithienylethenes

9 January, 2015 - 03:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02382J, PaperYamuna S. Kandasamy, Jianxin Cai, Alisha Beler, M.-S. Jemeli Sang, Patrick D. Andrews, R. Scott Murphy
The integration of photochromic dithienylethenes (DTEs) with lipid vesicles as photoresponsive membrane disruptors for ion transport applications has been examined. We have synthesized three amphiphilic DTEs 1-3 that incorporate a...
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Cationic dialkylarylphosphates: a new family of bio-inspired cationic lipids for gene delivery

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1122-1132
DOI: 10.1039/C4OB01770F, PaperStephanie S. Le Corre, Nawal Belmadi, Mathieu Berchel, Tony Le Gall, Jean-Pierre Haelters, Pierre Lehn, Tristan Montier, Paul-Alain Jaffres
The synthesis of mono- and di-cationic lipophosphates is reported. These cationic lipids were formulated as liposomal solutions, and their capacity to transfect cells was evaluated on three cell lines.
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Bleomycin-induced trans lipid formation in cell membranes and in liposome models

9 January, 2015 - 03:54

Org. Biomol. Chem., 2015, 13,1100-1105
DOI: 10.1039/C4OB01924E, PaperAysegul Cort, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos Chatgilialoglu, Carla Ferreri
Bleomycin-iron complexes cause lipid cis-trans isomerisation through thiyl radical formation and reactivity with unsaturated phospholipids, revealing membranes as a relevant and novel site of drug effect.
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