Org. and Biomol. Chem.

Syndicate content RSC - Org. Biomol. Chem. latest articles
RSC - Org. Biomol. Chem. latest articles
Updated: 1 day 10 hours ago

Oxidative activation of dihydropyridine amides to reactive acyl donors

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01931H, PaperErik Daa Funder, Julie B. Trads, Kurt V. Gothelf
Amides of 1,4-dihydropyridine (DHP) are activated by oxidation for acyl transfer to amines, alcohols and thiols.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of maculalactone A and derivatives for environmental fate tracking studies

11 November, 2014 - 13:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02042A, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Samuel L. Bader, Michael U. Luescher, Karl Gademann
Labelled probes of the antifouling natural product, maculalactone A, allow for distribution studies in Artemia salina.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Sulfate recognition by a hexaaza cryptand receptor

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02027H, PaperPedro Mateus, Rita Delgado, Vania Andre, Maria Teresa Duarte
A hexamine macrobicycle with pyrrolyl spacers was evaluated as anion receptor in its protonated forms. The protonation constants of the receptor, as well as its association constants with Cl-, NO3-,...
The content of this RSS Feed (c) The Royal Society of Chemistry

PEGylation enhances the tumor selectivity of melanoma-targeted conjugates

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01751J, PaperMathieu Andre, Sophie Besse, Jean-Michel Chezal, Emmanuelle Mounetou
Three preselected conjugates of 5-iodo-2[prime or minute]-deoxyuridine (IUdR) to the ICF01012 melanoma-carrier, PEGylated and non-PEGylated, were radiolabelled with iodine-125, and their in vivo distribution profile was evaluated for potential intratumoural selective delivery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Interfacial Catalysis of Aldol Reactions by Prolinamide Surfactants in Reverse Micelles

11 November, 2014 - 13:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02074J, PaperPremkumar Rathinam Arivalagan, Yan Zhao
L-Proline and their derivatives are one of the most important class of organic catalysts. Three prolinamide surfactants were designed and synthesized. Although the surfactants carried identical catalytic groups, their headgroups...
The content of this RSS Feed (c) The Royal Society of Chemistry

A domino reaction of tetrahalo-7,7-dimethoxybicyclo[2.2.1]heptenyl alcohols leading to indenones and a de novo synthesis of ninhydrin derivatives

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01977F, PaperKaki Raveendra Babu, Faiz Ahmed Khan
An acid mediated synthesis of indenones and a de novo synthesis of ninhydrin derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Visible light-mediated dehydrogenative [small beta]-arylsulfonylation of tertiary aliphatic amines with arylsulfonyl chlorides

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9337-9340
DOI: 10.1039/C4OB01713G, CommunicationMin Chen, Zhi-Tang Huang, Qi-Yu Zheng
[small beta]-Arylsulfonyl enamines were synthesized exclusively in E-form by the reaction of tertiary aliphatic amines with arylsulfonyl chlorides under visible light open to air with 1 mol% Ru(bpy)3(PF6)2 as the photosensor.
The content of this RSS Feed (c) The Royal Society of Chemistry

Evaluation of a focused virtual library of heterobifunctional ligands for Clostridium difficile toxins

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01838A, PaperCarlos A. Sanhueza, Jonathan Cartmell, Amr El-Hawiet, Adam Szpacenko, Elena N. Kitova, Rambod Daneshfar, John S. Klassen, Dean E. Lang, Luiz Eugenio, Kenneth K.-S. Ng, Pavel I. Kitov, David R. Bundle
Higher activity glycopeptoid ligands for two large Clostridium difficile toxins TcdA and TcdB were discovered via modular fragment-based design and virtual screening.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01320D, PaperMonoranjan Ghosh, Subhajit Mishra, Kamarul Monir, Alakananda Hajra
A catalytic decarboxylative annulation has been developed for the regioselective synthesis of furans by the cycloaddition of ketones with [small alpha],[small beta]-unsaturated carboxylic acids in ambient air.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Bronsted acid promoted addition-cyclization and C-C bond cleavage: a convenient synthesis of 2-amino-5-aroylmethylthiazoles derivatives

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9466-9470
DOI: 10.1039/C4OB01519C, PaperFan Ni, Yan Yang, Wen-Ming Shu, Jun-Rui Ma, An-Xin Wu
A Bronsted acid promoted synthesis of 2-amino-5-aroylmethylthiazoles has been developed via C-C bond cleavage reaction. The products can be easily transformed into PLTP and CETP inhibitor, and are useful precursors to access novel biheterocycles.
The content of this RSS Feed (c) The Royal Society of Chemistry

Cationic azacryptands as selective three-way DNA junction binding agents

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01846J, PaperJana Novotna, Aurelien Laguerre, Anton Granzhan, Marc Pirrotta, Marie-Paule Teulade-Fichou, David Monchaud
Azacryptands are promising candidates for assessing the therapeutic potential of three-way DNA junctions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Design strategies for bioorthogonal smart probes

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9307-9320
DOI: 10.1039/C4OB01632G, Review ArticlePeyton Shieh, Carolyn R. Bertozzi
This review covers approaches used to develop probes activated by bioorthogonal ligation reactions.
The content of this RSS Feed (c) The Royal Society of Chemistry

Solution structure of a cucurbit[8]uril induced compact supramolecular protein dimer

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9341-9344
DOI: 10.1039/C4OB01729C, CommunicationDung T. Dang, Ralph P. G. Bosmans, Christian Moitzi, Ilja K. Voets, Luc Brunsveld
Cucurbit[8]uril induces protein dimerization of fluorescent proteins with a flexible FGG-tagged N-terminus into a compact z-shaped dimer revealed by SAXS.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01837K, PaperEwa Radzikowska, Janina Baraniak
Chimeric oligonucleotides containing stereoregular phosphorothioate and natural phosphodiester linkages have been obtained on the solid phase support using nucleoside oxathiaphospholanes and commercially available nucleoside phosphoramidites.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Construction of dispirocyclohexanes via amine-catalyzed [2 + 2 + 2] annulations of Morita-Baylis-Hillman acetates with exocyclic alkenes

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01927J, PaperRongshun Chen, Silong Xu, Xia Fan, Hanyuan Li, Yuhai Tang, Zhengjie He
Divergent amine-catalyzed [2 + 2 + 2] annulations of Morita-Baylis-Hillman acetates with exocyclic alkenes were developed for the convergent construction of multistereogenic dispirocyclohexanes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01959H, PaperOrazio A. Attanasi, Linda A. Campisi, Lucia De Crescentini, Gianfranco Favi, Fabio Mantellini
Synthesis of symmetrical 2-oxo-spiro[indole-3,4[prime or minute]-pyridines]: a novel example of spirocyclic oxindoles bearing a quaternary centre at the 3-position.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Copper-catalysed [small alpha]-selective allylic alkylation of heteroaryllithium reagents

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9321-9323
DOI: 10.1039/C4OB01896F, CommunicationCarlos Vila, Valentin Hornillos, Martin Fananas-Mastral, Ben L. Feringa
2-Allyl-substituted thiophenes and furans are synthesised efficiently in a direct procedure using 2-heteroaryllithium reagents and allyl bromides and chlorides catalysed by ligand-free copper(I). The reactions take place under mild conditions, with excellent [small alpha]-selectivity, high functional group tolerance and good yields for the SN2 products.
The content of this RSS Feed (c) The Royal Society of Chemistry

First total synthesis of ganglioside DSG-A possessing neuritogenic activity

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9345-9349
DOI: 10.1039/C4OB01882F, CommunicationYu-Fa Wu, Yow-Fu Tsai, Jhe-Ruei Guo, Cheng-Ping Yu, Hui-Ming Yu, Chun-Chen Liao
The first total synthesis of ganglioside DSG-A (1) is achieved via chemoselective glycosylation and a [1 + 1 + 2] synthetic strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry

Remote conformational control of a molecular switch via methylation and deprotonation

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9384-9388
DOI: 10.1039/C4OB01991A, PaperPeter C. Knipe, Ian M. Jones, Sam Thompson, Andrew D. Hamilton
Methylation and deprotonation at remote sites of a diphenylacetylene-based molecular switch exert global conformational changes through subtle tuning of a hydrogen-bonding network.
The content of this RSS Feed (c) The Royal Society of Chemistry

Magnetic resonance and optical imaging probes for NMDA receptors on the cell surface of neurons: synthesis and evaluation in cellulo

11 November, 2014 - 13:54

Org. Biomol. Chem., 2014, 12,9389-9404
DOI: 10.1039/C4OB01848F, PaperNeil Sim, Robert Pal, David Parker, Joern Engelmann, Anurag Mishra, Sven Gottschalk
A second generation of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been synthesised, based on bicyclic NMDA receptor antagonists and show selective and reversible cell-surface binding.
The content of this RSS Feed (c) The Royal Society of Chemistry

WebElements: the periodic table on the WWW [http://www.webelements.com/]

Copyright 1993-2011 Mark Winter [The University of Sheffield and WebElements Ltd, UK]. All rights reserved.