Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Hydrolytic inhibition of [small alpha]-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01936A, PaperGloria Uccello-Barretta, Federica Balzano, Federica Aiello, Letizia Vanni, Mattia Mori, Sergio Menta, Andrea Calcaterra, Bruno Botta
A rationale for the inhibition of hydrolytic efficiency of [small alpha]-chymotrypsin by a resorcin[4]arene derivative was obtained by NMR spectroscopy and molecular modeling.
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Selective detection of Al3+ and citric acid with a fluorescent amphiphile

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02095B, PaperZiya Kostereli, Kay Severin
The assembly and disassembly of a fluorescent amphiphile by Al3+ and citrate, respectively, can be used to sense these analytes by fluorescence spectroscopy.
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Self-organizing behaviour of glycosteroidal bolaphiles: insights into lipidic microsegregation

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02191F, PaperR. Xu, F. Ali-Rachedi, N. M. Xavier, S. Chambert, F. Ferkous, Y. Queneau, S. J. Cowling, E. J. Davis, J. W. Goodby
The synthesis of glycosteroidal bolaphile biomimics are described along with the liquid-crystalline behaviours as a function of increasing aliphatic composition.
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Palladium(0)-catalyzed synthesis of cyclic glucosides

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB01975J, PaperXin Huang, Chunling Fu, Shengming Ma
A highly regio- and stereo-selective synthesis of cyclic [small beta]-D-glucosides 3via Pd(0)-catalyzed coupling cyclization of allenyl [small beta]-D-glucoside 1 and organic iodides in 20-38% yields is reported.
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Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02120G, PaperThomas C. Pijper, Jort Robertus, Wesley R. Browne, Ben L. Feringa
Rapid conversion of thio-ethers to thio-acetates using TiCl4 that tolerates a wide variety of functionalities, in good to excellent yields.
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Cucurbituril-based supramolecular engineered nanostructured materials

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02065K, Review ArticleSinem Gurbuz, Muazzam Idris, Donus Tuncel
Nanostructured materials, including nanoparticles, nanocomposites, vesicles, and rods, have been prepared by taking advantage of the interesting features of cucurbituril homologues.
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New synthesis and biological evaluation of uniflorine A derivatives: towards specific insect trehalase inhibitors

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02016B, PaperGiampiero D'Adamio, Antonella Sgambato, Matilde Forcella, Silvia Caccia, Camilla Parmeggiani, Morena Casartelli, Paolo Parenti, Davide Bini, Laura Cipolla, Paola Fusi, Francesca Cardona
(-)-Uniflorine A and 7-deoxy-uniflorine A are selective inhibitors of insect trehalases from C. riparius and S. littoralis.
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Transfer of antioxidants at the interfaces of model food emulsions: distributions and thermodynamic parameters

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02058H, PaperSonia Losada-Barreiro, Veronica Sanchez-Paz, Carlos Bravo-Diaz
Caffeic acid and [small alpha]-tocopherol (vitamin E) incorporate spontaneously into the interfacial regions of emulsions and their transfer processes are entropy driven.
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Kinetic evaluation of glucose 1-phosphate analogues with a thymidylyltransferase using a continuous coupled enzyme assay

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02057J, PaperS. M. Forget, A. Jee, D. A. Smithen, R. Jagdhane, S. Anjum, S. A. Beaton, D. R. J. Palmer, R. T. Syvitski, D. L. Jakeman
We have developed a continuous spectrophotometric kinetic assay for the detection of PPi and have applied the assay to evaluate Cps2L, a nucleotidylyltransferase, kinetics with five synthetic substrate analogues (2-6).
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The direct electrophilic cyanation of [small beta]-keto esters and amides with cyano benziodoxole

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02032D, CommunicationYao-Feng Wang, Jiashen Qiu, Dejie Kong, Yongtao Gao, Feipeng Lu, Pran Gopal Karmaker, Fu-Xue Chen
Electrophilic cyanating agent C1 accomplishes the direct cyanation of [small beta]-keto esters and amides without any catalyst and base.
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A unified lead-oriented synthesis of over fifty molecular scaffolds

21 November, 2014 - 16:17

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02287D, PaperRichard G. Doveston, Paolo Tosatti, Mark Dow, Daniel J. Foley, Ho Yin Li, Amanda J. Campbell, David House, Ian Churcher, Stephen P. Marsden, Adam Nelson
Sourcing large numbers of lead-like compounds is a major challenge; a unified synthetic approach enabled the efficient synthesis of 52 diverse lead-like molecular scaffolds from just 13 precursors.
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The Synthesis of Head-to-Tail Cyclic Sulfono-[gamma]-AApeptides

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02232G, CommunicationHaifan Wu, Fengyu She, Wen-Yang Gao, Austin Prince, Yaqiong Li, Lulu Wei, Allison Mercer, Lukasz Wojtas, Shengqian Ma, Jianfeng cai
We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-[gamma]-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In...
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Water-Soluble Aryl-Extended Calix[4]pyrroles with Unperturbed Aromatic Cavities: Synthesis and Binding Studies

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02108H, PaperPablo Ballester, Stanislaw Zankowski, Daniel Hernandez-Alonso, Louis Adriaenssens
We report the synthesis of a novel, water-soluble aryl-extended calix[4]pyrrole receptor. The water-solubilising groups are placed at the lower rim of the receptor, leaving the binding pocket unperturbed and open...
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UV-visible and 1H-15N NMR Spectroscopic Studies of Colorimetric Thiosemicarbazide Anion Sensors

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02091J, PaperKristina N Farrugia, Damjan Makuc, Agnieszka Podborska, Konrad Szacilowski, Janez Plavec, David C Magri
Four model thiosemicarbazide anion chemosensors containing three N-H bonds, substituted with phenyl and/or 4-nitrophenyl units, were synthesised and studied for their anion binding abilities with hydroxide, fluoride, acetate, hypophosphate and...
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A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluation

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01605J, PaperGaofei Wei, Shuai Wang, Weijing Luan, Shanshan Cui, Fengran Li, Yongliang Liu, Yang Liu, Mao-sheng Cheng
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds...
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Gd(OTf)3-Catalyzed the Synthesis of Geranyl Esters for the Intramolecular Radical Cyclization of their Epoxides Mediated by Titanocene(III)

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02312A, PaperWilliam Hernan Garcia, Carlos Eduardo Puerto Galvis, Vladimir V. Kouznetsov
A selective and mild method for the esterification of a variety of carboxylic acids with geraniol was developed. We demonstrated that the use of triphenylphosphine, I2, 2-methyl imidazole or imidazole...
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Accelerated Fmoc Solid-phase Synthesis of Peptides with Aggregation-disrupting Backbones

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02260B, PaperYi-Chao Huang, chaojian guan, Xiang-Long Tan, chenchen chen, Qingxiang Guo, Yiming Li
In this work, we describe an accelerated solid-phase synthetic protocol of ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl...
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Metal-Catalyzed Formation of 1,3-Cyclohexadienes: A Catalyst-Dependent Reaction

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01922A, PaperShifa Zhu, Xiaobing Huang, Tian-Qi Zhao, Tongmei Ma, Huanfeng Jiang
A metal-dependent and complementary catalytic method to synthesize the cyclohexadienes has been developed. When gold or indium salts were used as catalysts, 1,3-cyclohexadiene (1,3-CHD) could be obtained; when Cu(OTf)2 was...
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Probing coiled-coil assembly by paramagnetic NMR spectroscopy

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB02125H, PaperTingting zheng, Aimee Boyle, Hana Robson Marsden, Dayenne Valdink, Giuliana Martelli, jan raap, alexander kros
Here a new method to determine the oligomeric state and orientation of coiled-coil peptide motifs is described. Peptides K and E, which are designed to form a parallel heterodimeric complex...
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Multi-substituted 8-Aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme Reaction and Their Hsp90 Inhibitory Activity

21 November, 2014 - 16:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01865F, PaperRen Jing, Yang Min, Liu Hongchun, Cao Danyan, Chen Danqi, Li Jian, Tang Le, He Jianhua, Yue-Lei Chen, Meiyu Geng, Bing Xiong, Jingkang Shen
Using 2,3-diamino pyrazine substrate and yttrium triflate catalyst, various 2-alkyl and aryl substituted 3,8-diaminoimidazo[1,2-a]pyrazines could be efficiently prepared through Groebke-Blackburn-Bienayme MCR. In particular, a novel 2-piperonyl 3,8-diaminoimidazo[1,2-a]pyrazine structure could be...
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