Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
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Recent advances in heterobimetallic Pd(II)/Cu(II) catalyzed domino difunctionalization of carbon-carbon multiple bonds

23 July, 2014 - 09:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00610K, Review ArticleGianluigi Broggini, Egle Maria Beccalli, silvia gazzola, Alberto Mazza
The double functionalization of carbon-carbon multiple bonds in one-pot processes has emerged in recent years as a fruitful tool for the rapid synthesis of complex molecular scaffolds. This review covers...
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Dithienylethene-Based Rotaxanes: Synthesis, Characterization and Properties

23 July, 2014 - 09:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01213E, PaperJun Yin, Fang Hu, Juanyun Huang, Meijiao Cao, zhao chen, Ying-Wei Yang, Shenghua Liu
Three ammonium templates with dithienylethene backbone were synthesized. And they were utilized to construct photo-responsive rotaxanes and pseudorotaxane by template-directed clipping reaction and threading approach. The behavior of photoisomerization was...
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Diaporine, a novel endophyte-derived regulator of macrophage differentiation

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01123F, CommunicationHao Chen Wu, Hui Ming Ge, Le Yun Zang, Yun Cheng Bei, Zhi Yuan Niu, Wei Wei, Xiu Jing Feng, Sen Ding, Seik Weng Ng, Ping Ping Shen, Ren Xiang Tan
Diaporine (1), an unprecedented symmetric polyketide, was characterized from the endophytic fungus Diaporthe sp. Diaporine was demonstrated to inhibit significantly the differentiation of macrophages.
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Combinatorial Synthesis of Nicotine Analogs Using an Ugi 4-CR/Cyclization-Reduction Strategy

23 July, 2014 - 09:54
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00767K, PaperLuis Angel Polindara-Garcia, Alfredo Vazquez
A practical one-pot synthesis of nicotine analogs from Ugi 4-CR/propargyl adducts is reported. This methodology allows the rapid construction of the pyrrolidine moiety present in nicotine through an intramolecular base-promoted...
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A study on the chiral inversion of mandelic acid in humans

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C3OB42515K, PaperMaksims Yevglevskis, Catherine R. Bowskill, Chloe C. Y. Chan, Justin H.-J. Heng, Michael D. Threadgill, Timothy J. Woodman, Matthew D. Lloyd
Mandelic acid 1 undergoes uni-directional chiral inversion in mammalian cells by a separate pathway to that of Ibuprofen 3.
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Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01208A, PaperRenata Kowalczyk, Margaret A. Brimble, Yusuke Tomabechi, Antony J. Fairbanks, Madeleine Fletcher, Debbie L. Hay
The synthesis of a library of N-glycosylated pramlintide analogues to establish the SAR of amylin receptor agonism has been undertaken.
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TBAI-catalyzed oxidative synthesis of benzamides from acetophenones and carbinols

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01203H, CommunicationMuhammad Sharif, Jianbin Chen, Peter Langer, Matthias Beller, Xiao-Feng Wu
An interesting and convenient procedure for the oxidative transformation of acetophenones and carbinols to primary benzamides has been developed.
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Catalytic control over the formation of supramolecular materials

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01108B, PerspectiveRienk Eelkema, Jan H. van Esch
Catalytic formation of self-assembling building blocks provides control over the morphology, mechanical properties and spatial distribution of soft supramolecular materials.
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Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01025F, CommunicationLiang Gong, Li-Juan Xing, Tong Xu, Xue-Ping Zhu, Wen Zhou, Ning Kang, Bin Wang
An oxidative olefination reaction between aliphatic primary amines and benzylic sp3 C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant.
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Access to novel functionalized trifluoromethyl [small beta]-lactams by ring expansion of aziridines

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01262C, CommunicationS. Decamps, L. Sevaille, S. Ongeri, B. Crousse
A wide variety of CF3-[small beta]-lactams functionalized at position C-3 were obtained stereoselectively by ring expansion of aziridines.
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Highly selective fluorescence off-on probes for biothiols and imaging in live cells

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01031K, PaperDi Zhang, Wei Chen, Jianming Kang, Yong Ye, Yufen Zhao, Ming Xian
Three sulfonyl benzothiazole-based fluorescence off-on probes for biothiols are developed and applied for visualizing endogenous thiols in living cells.
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Photo-responsive [2]catenanes: synthesis and properties

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01120A, PaperZiyong Li, Fang Hu, Guoxing Liu, Wen Xue, Xiaoqiang Chen, Sheng Hua Liu, Jun Yin
A series of novel dithienylethene-based macrocycles containing ammonium moieties has been synthesized.
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Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of [small alpha]-glucosidase inhibitors

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00486H, PaperInderpreet Arora, Vivek Kr. Kashyap, Alok Kumar Singh, Arunava Dasgupta, Brijesh Kumar, Arun K. Shaw
Selective inhibition by conformational restriction of pyrrolidine iminosugars. Click conceived pyrrolidotriazoles incorporate essential features to access the mimicry of the transition state of carbohydrate processing enzymes.
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Copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with arylsulfonohydrazides: synthesis of sulfonated oxindoles

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01231C, CommunicationQingshan Tian, Ping He, Chunxiang Kuang
A copper-catalyzed arylsulfonylation of N-arylsulfonyl-acrylamides with sulfonylhydrazides through a tandem radical process was developed.
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Asymmetric borylation of [small alpha],[small beta]-unsaturated esters catalyzed by novel ring expanded N-heterocyclic carbenes based on chiral 3,4-dihydro-quinazolinium compounds

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01101E, CommunicationLiliang Huang, Yong Cao, Manping Zhao, Zhongfeng Tang, Zhihua Sun
A series of novel ring expanded N-heterocyclic carbene (NHC) precursors were synthesized, which showed excellent enantioselectivities for borylation of [small alpha],[small beta]-unsaturated esters.
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Comparison of the substrate selectivity and biochemical properties of human and bacterial [gamma]-butyrobetaine hydroxylase

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01167H, CommunicationAnna M. Rydzik, Ivanhoe K. H. Leung, Grazyna T. Kochan, Nikita D. Loik, Luc Henry, Michael A. McDonough, Timothy D. W. Claridge, Christopher J. Schofield
BBOX is a 2-oxoglutarate dependent oxygenase that can catalyse formation of vicinal diols and amino alcohols.
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Total synthesis of the cyclic monoterpenoid pyrano[3,2-a]carbazole alkaloids derived from 2-hydroxy-6-methylcarbazole

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01151A, PaperCemena Gassner, Ronny Hesse, Arndt W. Schmidt, Hans-Joachim Knolker
The synthesis of seven pyrano[3,2-a]carbazole alkaloids has been achieved using their putative biogenetic precursor 2-hydroxy-6-methylcarbazole as key intermediate.
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Demonstration of a common indole-based aromatic core in natural and synthetic eumelanins by solid-state NMR

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01066C, PaperSubhasish Chatterjee, Rafael Prados-Rosales, Sindy Tan, Boris Itin, Arturo Casadevall, Ruth E. Stark
Comparing natural and synthetic eumelanin pigment structures: high-field 2D solid-state NMR reveals a common indole-based aromatic core for ubiquitous protective pigments that inspire engineered materials.
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Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric [small alpha]-hydrophosphonylation

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5843-5846
DOI: 10.1039/C4OB01144A, CommunicationTao Deng, Hongjun Wang, Chun Cai
A copper-catalyzed asymmetric [small alpha]-hydrophosphonylation of isatins with a novel fluorous bis(oxazoline) as a ligand is presented.
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A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp3)-H/C(sp2)-H functionalizations

23 July, 2014 - 09:54

Org. Biomol. Chem., 2014, 12,5839-5842
DOI: 10.1039/C4OB01256A, CommunicationZhi-Qiang Zhu, Tian-Tian Wang, Peng Bai, Zhi-Zhen Huang
A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines has been developed through dual C(sp3)-H/C(sp2)-H functionalizations.
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