Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
Updated: 12 hours 49 min ago

Synthesis and assessment of 4-aminotetrahydroquinazoline derivatives as tick-borne encephalitis virus reproduction inhibitors

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02649G, PaperKseniya N Sedenkova, Evgenia V Dueva, Elena B. Averina, Y K. Grishin, Dmitry I. Osolodkin, Liubov I Kozlovskaya, Vladimir A Palyulin, Evgenii N Savelyev, Boris S Orlinson, Ivan A Novakov, Gennady M Butov, Tamara S Kuznetsova, Galina G Karganova, Nikolay S. Zefirov
Tick-borne encephalitis virus (TBEV) belonging to Flavivirus genus causes severe infection in humans. The search for therapeutically relevant compounds targeting TBEV requires the exploration of novel chemotypes. A versatile synthesis...
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Kinetics of reactions at interface: Functionalisation of silicate glass with porphyrins via covalent bonds

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02053G, PaperTakahiro Fujimoto, Nao Furuta, Tadashi Mizutani
Porphyrins carrying either a primary alcohol, tertiary alcohol or primary bromide linker group were allowed to react with the surface silanol groups on silicate glass thermally at 80-240 oC to...
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Total syntheses of five uvacalols: Structural validation of uvacalol A, uvacalol B and uvacalol C and disproval of the structures of uvacalol E and uvacalol G

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02663B, PaperKana M Sureshan, Adiyala Vidyasagar
Uvacalols are novel carbasugars belonging to the family of C7-cyclitols, and are isolated from the roots of the medicinal plant, Uvaria calamistrata. In this study, we report the first syntheses...
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Iodine-catalyzed regioselective thiolation of imidazo[1,2-a]pyridines using sulfonyl hydrazides as a thiol surrogate

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00033E, PaperAlakananda Hajra, Avik Kumar Bagdi, Shubhanjan Mitra, Monoranjan Ghosh
Iodine-catalyzed regioselective sulfenylation of imidazo[1,2-a]pyridines via C(sp2)-H bond functionalization has been achieved using sulfonyl hydrazides as a thiol surrogate. A library of 3-sulfanylimidazopyridines with broad functionalities was synthesized under metal...
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Tuning of colour and chemical stability of model boranils: a strong effect of structural modifications

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02545H, PaperGrzegorz Jan Wesela-Bauman, Mateusz Urban, Sergiusz Lulinski, Janusz Serwatowski, Krzysztof Wozniak
A series of diarylborinic complexes with salicydeneaniline ligands bearing various functional groups at the 6-position, have been synthesized with high yields by applying a straightforward one-pot multicomponent protocol. UV-Vis measurements...
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Convergent synthesis of isomeric heterosaccharides related to the fragments of galactomannan from Aspergillus fumigatus

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02634A, PaperDmitry A. Argunov, Vadim B. Krylov, Nikolay E. Nifantiev
Aspergillus fumigatus is a very common fungus with severe pathogenic potential for immunosuppressed hospital patients. A. fumigatus galactomannan, being the part of its cell-wall, is considered as a promising candidate...
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Metal-Free TBAI-Catalyzed Arylsulfonylation of Activated Alkenes with Sulfonylhydrazides

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB01651C, PaperWu bin Yu, Peizhu Hu, Yuanyuan Fan, Congyao yu, Xinhan Yan, Xiaoqing Li, Xiangsheng xu
Efficient metal-free oxidative arylsulfonylation of [small alpha],[small beta]-unsaturated imides with sulfonylhydrazides leading to isoquinoline-1,3(2H,4H)-dione derivatives has been developed. The procedure involves the generation of sulfonyl radicals via cleavage of S-N bond of...
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Synthesis and DNA binding profile of N-mono- and N,N'-disubstituted indolo[3,2-b]carbazoles

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02566K, CommunicationThomas Minehan, Harmanpreet Panesar, Jennifer Solano
A series of N-monosubstituted and N,N'-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It...
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Correction: Studies towards asymmetric synthesis of 4(S)-11-dihydroxydocosahexaenoic acid (diHDHA) featuring cross-coupling of chiral stannane under mild conditions

12 hours 49 min ago
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90015H, CorrectionRui Wang, Anyu He, Errabelli Ramu, John R. Falck
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Synthesis of indoles, benzofurans, and related heterocycles via an acetylene-activated SNAr/intramolecular cyclization cascade sequence in water or DMSO

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02549K, PaperR. Hudson, N. P. Bizier, K. N. Esdale, J. L. Katz
The synthesis of 2-substituted indoles and benzofurans was achieved by nucleophilic aromatic substitution, followed by subsequent 5-endo-dig cyclization between the nucleophile and an ortho acetylene.
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Synthesis of novel azole-fused quinazolines via one-pot, sequential Ullmann-type coupling and intramolecular dehydrogenative C-N bonding

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02375G, PaperNitesh Kumar Nandwana, Kasiviswanadharaju Pericherla, Pinku Kaswan, Anil Kumar
An efficient one-pot sequential procedure is described for the synthesis of novel azole-fused quinazolines through Ullmann-type coupling followed by cross dehydrogenative coupling of various azoles with 2-(2-bromophenyl)-1H-imidazole/benzimidazoles.
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Cooperative effect of Lewis pair in Friedel-Crafts hydroxyalkylation reaction: A simple and effective route for the synthesis of (+/-)-carbinoxamine

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02597K, PaperRAMANATHAN C R, Hari Krishnan A, Sanjeevi J
An efficient C-C bond formation strategy between aromatic/heteroaromatic [small pi]-nucleophiles and Lewis acid activated aldehydes is described. This aromatic electrophilic substitution reaction of arenes or heteroarenes is facilitated by Lewis acid...
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Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02424A, PaperXin-Shan Ye, Chang-Xin Huo, Xiu-Jing Zheng, An Xiao, Chang-Cheng Liu, Shuang Sun, Zhuo Lv
It is well known that tumor cells express some aberrant glycans, termed tumor-associated carbohydrate antigens (TACAs). TACAs are good targets for the development of carbohydrate-based anticancer vaccines. However, one of...
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The first study about the relationship between the extractability of thiacalix[4]arene derivatives and the position of the coordination binding sites

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02393E, PaperJiang-Lin Zhao, Hirotsugu Tomiyasu, Xin-Long Ni, xi zeng, Mark Robert James Elsegood, Carl Redshaw, Shofiur Rahman, Paris Elias Georghiou, Takehiko Yamato
Three organic ionophores (2 - 4) based on the p-tert-butylthiacalix[4]arene backbone, blocked in the 1,3-alternate conformation, bearing two pyridyl coordinating moieties (ortho for 2, meta for 3 and para for...
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Alkynylation of heterocyclic compounds using hypervalent iodine reagent

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02625J, CommunicationMartin Kamlar, Ivana Cisarova, Jan Vesely
Organocatalytic alkynylation of various nitrogen- and/or sulphur-containing heterocyclic comounds using hypervalent iodine TMS-EBX by catalysis of tertiary amines under mild conditions is described. Developed metal-free methodology enables to obtain corresponding...
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A modular synthesis of functionalised phenols enabled by controlled boron speciation

12 hours 49 min ago
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00078E, PaperAllan John Bell Watson, John J Molloy, Robert P Law, James WB Fyfe, Ciaran P Seath, David J Hirst
A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic...
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A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02543A, CommunicationGary Noonan, Andrew G. Leach
Boronic acids that undergo protodeboronation as solids are stable in solution: the solid state organizes them for reaction.
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Chiral nanostructuring of multivalent macrocycles in solution and on surfaces

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02643H, PaperOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marco Caricato, Arnaud Delforge, Davide Bonifazi, Daniele Dondi, Andrea Mazzanti, Dario Pasini
A chiral, multivalent macrocycle assembles upon metal-pyridine coordination into ordered nanostructures in solution and on surfaces.
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B(C6F5)3-catalyzed metal-free hydrogenation of naphthylamines

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00009B, CommunicationGen Li, Yongbing Liu, Haifeng Du
A catalytic metal-free hydrogenation of naphthylamines using B(C6F5)3 was achieved under mild conditions for the first time to furnish tetrahydronaphthylamines in high yields.
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Tuning temperature responsive poly(2-alkyl-2-oxazoline)s by supramolecular host-guest interactions

12 hours 49 min ago

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02654C, PaperVictor R. de la Rosa, Werner M. Nau, Richard Hoogenboom
A poly[(2-ethyl-2-oxazoline)-ran-(2-nonyl-2-oxazoline)] random copolymer was synthesized and its thermoresponsive behavior in aqueous solution modulated by the addition of different supramolecular host molecules.
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