Org. and Biomol. Chem.

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RSC - Org. Biomol. Chem. latest articles
Updated: 2 hours 11 min ago

A one-pot multicomponent coupling/cyclization for natural product herbicide (+/-)-thaxtomin A

2 hours 11 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01148A, CommunicationJean Paul Bourgault, Amarendar Reddy Maddirala, Peter R. Andreana
The herbicide (+/-)-thaxtomin A has been synthesized in a one-pot two step process through an Ugi reaction followed by base-mediated cyclization.
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Total Syntheses and Structural Validation of Lincitol A, Lincitol B, Uvacalol I, Uvacalol J, and Uvacalol K

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01329H, PaperKana M Sureshan, Soumik Mondal
Natural carbasugars are important class of biologically active compounds. Due to their conformational freedom and due to the subtle difference in spectral characteristics between isomers, often their NMR-based structural assignments...
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Effect of LNA nucleobases as an enhancer for the binding of amiloride to an abasic site in DNA/DNA and DNA/RNA duplexes

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00977K, PaperYusuke Sato, Tetsushi Sato, Takaya Sato, Seiichi Nishizawa, Norio Teramae
We report on a significant effect of locked nucleic acid (LNA) nucleobases on the binding of amiloride for abasic site (AP)-containing DNA duplexes. Fluorescence titration experiments showed that the binding...
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Direct Intermolecular C-H Arylation of Unactivated Arenes with Aryl Bromides Catalysed by 2-Pyridyl Carbinol

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01211A, CommunicationYinuo Wu, Pui Ying Choy, Fuk Yee (Michael) Kwong
Direct intermolecular C-H arylation employing aryl bromide as the arene source has been developed. This process proceeds via a simple transition-metal free pathway. With the aid of inexpensive and commercially...
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L-Rhamnose-containing supramolecular nanofibrils as a potential immunosuppressive material

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01362J, CommunicationFan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll, Bing Xu
An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, contrasting to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the...
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Microwave assisted synthesis and QSAR study of novel NSAID acetaminophen conjugates with amino acid linkers

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01281J, PaperAnand D Tiwari, Siva S Panda, AS Girgis, Sandhyamayee Sahu, Riham F George, Aladdin M Srour, Brian La Starza, Abdullah M. Asiri, Charles Dennis Hall, Alan R Katritzky
Novel, 6a-l non-steroidal anti-inflammatory drug (NSAID), acetaminophen conjugates with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates (6b,...
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Removal of amino in anilines through diazonium salt-based reactions

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01286K, Review ArticleLinman He, Guanyinsheng Qiu, Yueqiu Gao, Jie Wu
This minireview draws a conclusion on the applications of in situ generated diazonium salts from anilines in organic synthesis. In situ generation of diazonium salts from anilines represents an efficient...
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New reagents for detecting free radicals and oxidative stress

2 hours 11 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01172D, Review ArticleMina Barzegar Amiri Olia, Carl H. Schiesser, Michelle K. Taylor
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
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An Easy Access to [small alpha]-Aryl Substituted [gamma]-Ketophosphonates: Lewis Acid Mediated Reactions of 1,3-diketones with [small alpha]-hydroxyphosphonates and Tandem Regioselective C-C Bond Cleavage

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01091D, PaperGangaram Pallikonda, manab chakravarty, Manoj Kumar Sahoo
A range of [small alpha]-aryl substituted [gamma]-ketophosphonates is synthesised by Lewis acid mediated reactions of 1,3-diketones and easily accessible, inexpensive benzylic [small alpha]-hydroxyphosphonates in an operationally-simple method under solvent-free conditions without exclusion...
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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

2 hours 11 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
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Design and Synthesis of a Macrosphelide A-Biotin Chimera

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01028K, PaperYoung-Ger Suh, Hwayoung Yun, Jaehoon Sim, Hongchan An, Jeeyeon Lee, Hun Seok Lee, Young Kee Shin, Seung-Mann Paek
The rational design and synthesis of a biochemical probe of natural (+)-macrosphelide A, a potent cell-cell adhesion inhibitor, was completed to aid in the identification of its biological target. The...
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Large dipole moment to promote gelation for 4-nitrophenylacrylonitrile derivatives with gelation-induced emission enhancement property

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00768A, Paperpeng chong Xue, Boqi Yao, Yuan Zhang, Peng Chen, kechang li, Baijun Liu, Ran Lu, Qiux xu
A series of 4-nitrophenylacrylonitrile and phenylacrylonitrile derivatives consisting of carbazole moiety was synthesized. Some of these derivatives with longer alkyl chains and nitro group could gelatinize some organic solvents, such...
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Effect of Conformational Rigidity on the Stereoselectivity of Nucleophilic Additions to Five-membered Ring Bicyclic Oxocarbenium Ion Intermediates

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01251H, PaperOlga Lavinda, Vi Tran, Keith Woerpel
Nucleophilic substitution reactions of five-membered ring acetals bearing fused rings reveal that subtle changes in structure of the fused ring can exert dramatic influences on selectivity. If the fused ring...
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Expedient Synthesis of [small alpha]-S-(1[rightward arrow]6)-Linked Pentaglucosyl Thiol

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01094A, PaperHuali Wang, Xiangming Zhu
An [small alpha]-S-(1[rightward arrow]6)-linked pentaglucosyl thiol has been synthesized in a convenient and stereoselective way. Key steps of the synthesis involved thioglycosylation of 6-iodinated sugars with [small alpha]-glycosyl thiols under phase transfer conditions....
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Recent Advances in Catalytic C-N bond Formation: A Comparison of Cascade Hydroaminomethylation and Reductive Amination Reactions with the Corresponding Hydroamidomethylation and Reductive Amidation Reactions

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00620H, Review Articlesaeed raoufmoghaddam
The design and catalytic implementation of tandem reactions to selectively create nitrogen-containing products under mild conditions has encountered numerous challenges in synthetic chemistry. Several known classes of the homogeneously catalyzed...
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Total synthesis of putative montamine and a proposed structural reassignment

2 hours 11 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01304B, PaperLachlan M. Blair, Elizabeth A. Colby Davie, Jonathan Sperry
The spectroscopic data for synthetic montamine does not match the proposed N,N[prime or minute]-linked structure and closely resembles a known 4,4[prime or minute]-bismoschamine natural product.
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

2 hours 11 min ago

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E. Nielsen
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
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Ratiometric fluorescent chemosensor based on Tyrosine derivatives for monitoring mercury ions in aqueous solutions

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01044B, PaperPoonaboina Thirupathi, Ponnaboina Saritha, Keun-Hyeung Lee
Ratiometric fluorescent chemosensors, 1 and 2 were synthesized based on Tyrosine amino acid derivatives with a pyrene fluorophore. 1 and 2 displayed high selectivity for Hg(II) ions among 13 metal...
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A General catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB00846D, PaperHui Peng, Ya-Qin Chen, Shu-Lan Mao, Yunxiao Pi, You Chen, Zeyu Lian, Tong Meng, Shenghua Liu, Guang-Ao Yu
We report the synthesis of 2-(3-sulfonatomesityl)-5-sulfonatoindenyl) dicyclohexylphosphine hydrate sodium salt and its use in palladium-catalyzed Suzuki-Miyaura and Sonogashira coupling reactions in water (and biphasic water-organic solvent mixtures) to prepare a...
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Highly Efficient Synthesis of A Tristable Molecular Shuttle and Its Controlled Motion Under Chemical Stimuli

2 hours 11 min ago
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01283F, PaperZheng Meng, Chuan-Feng Chen
According to the threading-followed-by-stoppering approach, a tristable molecular shuttle could be efficiently synthesized in 76% yield by using K+ ions template and bulky isocyanate stopper. This high yield was reasoned...
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