Royal Society of Chemistry

Palladium-catalyzed carbonylation of halo arene-cis-dihydrodiols to the corresponding carboxylates. Access to compounds unavailable by toluene dioxygenase-mediated dihydroxylation of the corresponding benzoate esters.

Org. and Biomol. Chem. - 20 August, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01417K, PaperJordan Froese, Jason Reed Hudlicky, T Hudlicky
A series of arene-cis-dihydrodiol carboxylates was prepared by palladium-catalyzed carbonylation of (1S, 2S-cis)-3-iodo-3,5-cyclohexadiene-1,2-diol, which is obtained in high titers by enzymatic dihydroxylation of iodobenzene. Both the free diol and the...
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Catalytic amide allylation of [small alpha]-ketoesters: extremely high enantioselective synthesis of ester functionalised [small alpha]-methylene-[gamma]-butyrolactones

Org. and Biomol. Chem. - 20 August, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01508H, CommunicationMasaki Takahashi, Yusuke Murata, Masahiro Ishida, Yagishita Fumitoshi, Masami Sakamoto, Tetsuya Sengoku, Hidemi Yoda
This communication reports a significant breakthrough on the novel catalytic amide allylation to the acyclic [small alpha]-ketoester systems, achieving satisfactorily high yields and extremely high levels of the asymmetric induction to...
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Rhodium-catalyzed olefination of aryl tetrazoles via direct C-H bond activation

Org. and Biomol. Chem. - 20 August, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01440E, CommunicationLiang Wang, Wen Wu, Qun Chen, Ming-Yang He
Rh(III)-catalyzed direct olefination reaction via aromatic C-H bond activation is described using tetrazole as the directing group. This reaction provides a straightforward way for the synthesis of ortho-alkenyl aryl tetrazoles....
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Oxidative cleavage of benzylic C-N bond under metal-free conditions

Org. and Biomol. Chem. - 20 August, 2014 - 18:17
Org. Biomol. Chem., 2014, Accepted Manuscript
DOI: 10.1039/C4OB01633E, CommunicationXiao-Feng Wu, xinxin qi, Jin-Long Gong, duo wei, jian-bo feng
An interesting procedure for the oxidative cleavage of benzylic C-N bond has been developed. By using TBAI as the catalyst and H2O2 as the oxidant, various benzyl amines were transformed...
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Iridium-catalyzed C-H borylation of pyridines

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01565G, PaperScott A. Sadler, Hazmi Tajuddin, Ibraheem A. I. Mkhalid, Andrei S. Batsanov, David Albesa-Jove, Man Sing Cheung, Aoife C. Maxwell, Lena Shukla, Bryan Roberts, David C. Blakemore, Zhenyang Lin, Todd B. Marder, Patrick G. Steel
Iridium-catalysed C-H borylation is an efficient method for the preparation of pyridyl and related azinyl boronate esters.
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Cooperative hybridization of [gamma]PNA miniprobes to a repeating sequence motif and application to telomere analysis

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00953C, PaperHa H. Pham, Connor T. Murphy, Gopalsamy Sureshkumar, Danith H. Ly, Patricia L. Opresko, Bruce A. Armitage
High affinity [gamma]PNA oligomers hybridize cooperatively on telomeric DNA and provide bright fluorescent signals.
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First total synthesis of antihypertensive natural products S-(+)-XJP and R-(-)-XJP

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01470G, PaperChaolei Wang, Guoxiang Wei, Xue Yang, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu, Jinyi Xu
The first total synthesis of S-(+)-XJP and R-(-)-XJP has been achieved via intramolecular Heck reaction. A latent functionality strategy was implemented to circumvent the racemization in this endeavor.
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Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6812-6815
DOI: 10.1039/C4OB01164C, CommunicationHiroki Iwasaki, Kenji Suzuki, Mitsunari Yamane, Shohei Yoshida, Naoto Kojima, Minoru Ozeki, Masayuki Yamashita
A novel method for indole skeleton synthesis under mild conditions mediated by samarium(II) diiodide has been developed.
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68 Ga based probe for Alzheimer's disease: synthesis and preclinical evaluation of homodimeric chalcone in [small beta]-amyloid imaging

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB00941J, PaperKanchan Chauhan, Anupama Datta, Anupriya Adhikari, Krishna Chuttani, Ajai Kumar Singh, Anil K. Mishra
68 Ga complex of chalcone-based bivalent ligand as a potential candidate for cost-effective PET imaging of Alzheimer's disease: a new perspective.
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Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01220H, PaperLina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang, Wei Zhao
A concise synthesis of (2S,5R) and (2S,5S)-5-hydroxy-lysine was achieved by utilizing D-galactose as a chiral-precursor with stereo retention. Using the diazido intermediate, the derived [small beta]-D-galactopyranosyl and [small alpha]-D-glucopyranosyl-(1[rightward arrow]2)-[small beta]-D-galactosyl moieties were synthesized.
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Directed arene/alkyne annulation reactions via aerobic copper catalysis

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, Advance Article
DOI: 10.1039/C4OB01312C, PaperYi Zhang, Qian Wang, Huidong Yu, Yong Huang
We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen.
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CoPc-catalyzed selective radical arylation of anilines with arylhydrazines for synthesis of 2-aminobiaryls

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6922-6926
DOI: 10.1039/C4OB00798K, PaperTao Jiang, Sheng-Yan Chen, Guo-Yu Zhang, Run-Sheng Zeng, Jian-Ping Zou
CoPc-catalyzed selective radical arylation of anilines with arylhydrazines to afford 2-aminobiaryls in moderate to good yields is described.
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Orthogonal functionalisation of [small alpha]-helix mimetics

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6794-6799
DOI: 10.1039/C4OB00915K, CommunicationOpen Access Open Access Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Barnard, Kerya Long, David J. Yeo, Jennifer A. Miles, Valeria Azzarito, George M. Burslem, Panchami Prabhakaran, Thomas A. Edwards, Andrew J. Wilson
We present methodology to modify N-alkylated aromatic oligoamide [small alpha]-helix mimetics using 'click' chemistry.
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Direct intermolecular C-H arylation of unactivated arenes with aryl bromides catalysed by 2-pyridyl carbinol

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6820-6823
DOI: 10.1039/C4OB01211A, CommunicationYinuo Wu, Pui Ying Choy, Fuk Yee Kwong
A general C-H arylation of unactivated arenes by aryl/heteroaryl bromides in the presence of 2-pyridyl carbinol and potassium tert-butoxide is described.
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L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6816-6819
DOI: 10.1039/C4OB01362J, CommunicationFan Zhao, Balthasar A. Heesters, Isaac Chiu, Yuan Gao, Junfeng Shi, Ning Zhou, Michael C. Carroll, Bing Xu
The nanofibrils of an L-rhamnose-based hydrogelator illustrate the first example of the supramolecular assemblies of a saccharide to suppress immunity.
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New reagents for detecting free radicals and oxidative stress

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6757-6766
DOI: 10.1039/C4OB01172D, Review ArticleMina Barzegar Amiri Olia, Carl H. Schiesser, Michelle K. Taylor
This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species, a key step on the road to their understanding and ultimate control.
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Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6842-6854
DOI: 10.1039/C4OB00738G, PaperArun K. Ghosh, Gary E. Schiltz, Linah N. Rusere, Heather L. Osswald, D. Eric Walters, Masayuki Amano, Hiroaki Mitsuya
A series of potent macrocyclic HIV-1 protease inhibitors have been designed and synthesized.
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Total synthesis of putative montamine and a proposed structural reassignment

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6878-6884
DOI: 10.1039/C4OB01304B, PaperLachlan M. Blair, Elizabeth A. Colby Davie, Jonathan Sperry
The spectroscopic data for synthetic montamine does not match the proposed N,N[prime or minute]-linked structure and closely resembles a known 4,4[prime or minute]-bismoschamine natural product.
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Cross-catalytic peptide nucleic acid (PNA) replication based on templated ligation

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6901-6907
DOI: 10.1039/C4OB01158A, PaperAbhishek Singhal, Peter E. Nielsen
PNA replication via decameric template directed cross-catalytic ligation follows product inhibited kinetics yielding approximately two replication rounds.
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A general catalyst for Suzuki-Miyaura and Sonogashira reactions of aryl and heteroaryl chlorides in water

Org. and Biomol. Chem. - 20 August, 2014 - 18:17

Org. Biomol. Chem., 2014, 12,6944-6952
DOI: 10.1039/C4OB00846D, PaperHui Peng, Ya-Qin Chen, Shu-Lan Mao, Yun-Xiao Pi, You Chen, Ze-Yu Lian, Tong Meng, Sheng-Hua Liu, Guang-Ao Yu
An air-stable sulfonated indenyl phosphine/Pd-catalyst system was used in Suzuki-Miyaura and Sonogashira coupling reactions in water.
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