Royal Society of Chemistry

Hybridization of an A[small beta]-specific antibody fragment with aminopyrazole-based [small beta]-sheet ligands displays striking enhancement of target affinity

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02411G, PaperMarco Hellmert, Andreas Muller-Schiffmann, Max Sena Peters, Carsten Korth, Thomas Schrader
A His-tagged antibody is combined with an NTA-[small beta]-sheet breaker and displays a striking increase in A[small beta] affinity.
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Cyclopenta[b]naphthalene cyanoacrylate dyes: synthesis and evaluation as fluorescent molecular rotors

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02563F, PaperLaura S. Kocsis, Kristyna M. Elbel, Billie A. Hardigree, Kay M. Brummond, Mark A. Haidekker, Emmanuel A. Theodorakis
The application of an intramolecular dehydrogenative dehydro-Diels-Alder (IDDDA) reaction to the construction of fluorescent molecular rotors (D-[small pi]-A motif) containing a cyclopenta[b]naphthalene ring system is described.
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Fractional transfer of a free unpaired electron to overcome energy barriers in the formation of Fe4+ from Fe3+ during the core contraction of macrocycles: implication for heme distortion

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02429J, PaperQiuhua Liu, Xiaochun Zhou, Haomin Liu, Xi Zhang, Zaichun Zhou
The free unpaired electron in Fe3+ ions cannot be directly removed, and needs a transfer pathway with at least four steps to overcome the high energy barriers to form Fe4+ ions.
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Synthesis of directly fused porphyrin dimers through Fe(OTf)3-mediated oxidative coupling

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02644F, CommunicationChuan-Mi Feng, Yi-Zhou Zhu, Shao-Chun Zhang, Yun Zang, Jian-Yu Zheng
A practical and general Fe(OTf)3-mediated oxidative coupling method was developed for the synthesis of doubly or triply linked porphyrin dimers.
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A [gamma]-cyclodextrin duplex connected with two disulfide bonds: synthesis, structure and inclusion complexes

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02464H, PaperSergey Volkov, Lukas Kumprecht, Milos Budesinsky, Martin Lepsik, Michal Dusek, Tomas Kraus
Oxidative dimerization of 6I,6V-disulfanyl-[gamma]-cyclodextrin yields a duplex tubular structure with internal volume of [similar]740 A3 allowing formation of very stable inclusion complexes with medium to large organic molecules in water (Ka [similar] 108 M-1).
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Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02508C, PaperGanesan Bharathiraja, Mani Sengoden, Masanam Kannan, Tharmalingam Punniyamurthy
Various tetrasubstituted pyrroles/pyrazoles have been prepared from nitro-substituted 1,3-enynes with aromatic amines/hydrazines via a copper-catalyzed cascade aza-Michael addition, cyclization and aromatization.
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Alkylidene malonates and [small alpha],[small beta]-unsaturated [small alpha][prime or minute]-hydroxyketones as practical substrates for vinylogous Friedel-Crafts alkylations in water catalysed by scandium(III) triflate/SDS

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02487G, PaperJens Oelerich, Gerard Roelfes
Alkylidene malonates and [small alpha],[small beta]-unsaturated [small alpha][prime or minute]-hydroxyketones are excellent substrates for the Sc(OTf)3/SDS catalysed Friedel-Crafts alkylation in water.
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Gas phase chemistry of N-benzylbenzamides with silver(I) cations: characterization of benzylsilver cation

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02355B, CommunicationHezhi Sun, Zhe Jin, Hong Quan, Cuirong Sun, Yuanjiang Pan
Benzylsilver cations are synthesized in the gas phase from the collisional dissociation of argentinated N-benzylbenzamides, when the carbonyl oxygen nucleophilically attacks an [small alpha]-hydrogen.
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Validating the alkene and alkyne hydrophosphonylation as an entry to organophosphonates

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02501F, PerspectiveAlessandro Dondoni, Alberto Marra
The hydrophosphonylation of terminal alkenes and alkynes by H-phosphonates affords Markovnikov and/or anti-Markovnikov adducts depending on the catalyst (a metal or a radical initiator) and the reaction conditions.
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Solid-state circularly polarised luminescence of atropisomeric fluorophores embedded in achiral myo-inositol-containing polyurethanes

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02553A, PaperTomoyuki Amako, Kazuki Nakabayashi, Atsushi Sudo, Michiya Fujiki, Yoshitane Imai
Two chiral binaphthyl fluorophores in two myo-inositol based polyurethane matrices with high grass transition temperatures emitted circularly polarised luminescence with a high circular anisotropy factor.
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Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02587C, PaperClare S. Mahon, Martin A. Fascione, Chadamas Sakonsinsiri, Tom E. McAllister, W. Bruce Turnbull, David A. Fulton
The templation of carbohydrate-functionalised Polymer-Scaffolded Dynamic Combinatorial Libraries affords polymers possessing significantly enhanced affinities for the template, with enhancements in free energy of binding in the range of 5.2-8.8 kJ mol-1 observed.
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Supramolecular control of transition metal complexes in water by a hydrophobic cavity: a bio-inspired strategy

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02511C, Review ArticleOlivia Bistri, Olivia Reinaud
Different strategies for obtaining water-soluble cavity-appended metal complexes are described, and their resulting interlocked assets are discussed in relationship with the very specific properties of water as a solvent.
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Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02284J, PaperYuanxiang Wang, Brendan Frett, Nick McConnell, Hong-yu Li
The first example of metal-free regioselective hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate is accomplished.
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Synthesis of a [small beta]-CCT-lanthanide conjugate for binding the dopamine transporter

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02165G, CommunicationGregory R. Naumiec, Grace Lincourt, Jeremy P. Clever, Michael A. McGregor, Abraham Kovoor, Brenton DeBoef
The development of a [small beta]-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (Kd = 303 nM) is described. This molecular probe could be used for in vivo or in vitro studies of the DAT via MRI, PET or SPECT.
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Cyclopropanation using flow-generated diazo compounds

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00019J, CommunicationNuria M. Roda, Duc N. Tran, Claudio Battilocchio, Ricardo Labes, Richard J. Ingham, Joel M. Hawkins, Steven V. Ley
A practical and mild protocol for the cyclopropanation of unstabilised diazo compounds is reported.
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TEMPO-mediated homocoupling of aryl Grignard reagents: mechanistic studies

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02689F, PaperSandip Murarka, Juri Mobus, Gerhard Erker, Christian Muck-Lichtenfeld, Armido Studer
The mechanism of TEMPO mediated oxidative homo-coupling of aryl Grignard reagents to biphenyls is investigated in detail by experimental and computational studies.
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Oxidative asymmetric umpolung alkylation of Evans' [small beta]-ketoimides using dialkylzinc nucleophiles

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02601B, CommunicationTom A. Targel, Jayprakash N. Kumar, O. Svetlana Shneider, Sukanta Bar, Natalia Fridman, Shimon Maximenko, Alex M. Szpilman
Umpolung alkylation of Evans' auxiliary substituted [small beta]-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%.
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Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02334J, Review ArticlePatricia M. R. Pereira, Barbara Korsak, Bruno Sarmento, Rudolf J. Schneider, Rosa Fernandes, Joao P. C. Tome
Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT).
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Total synthesis of a thromboxane receptor antagonist, terutroban

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02302A, PaperWasim Ahmed, Prathama S. Mainkar, Srihari Pabbaraja, Srivari Chandrasekhar
Synthesis of terutroban (2) is achieved following a non-Diels-Alder approach using cost-effective chemicals.
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Synthesis of 7-alkylidene-7,12-dihydroindolo[3,2-d]benzazepine-6-(5H)-ones (7-alkylidene-paullones) by N-cyclization-oxidative Heck cascade and characterization as sirtuin modulators

Org. and Biomol. Chem. - 25 January, 2015 - 07:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02493A, PaperJ. G. Denis, G. Franci, L. Altucci, J. M. Aurrecoechea, A. R. de Lera, R. Alvarez
A palladium-induced cascade of N-cyclization and oxidative Heck reaction of o-alkynylanilines produced 7-alkylidene-indolobenzazepinones (paullones) that have sirtuin modulation activities.
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