Royal Society of Chemistry

First Water-Soluble Bowl Complex: Molecular Recognition of Acetate by the Biomimetic Tris(imidazole) Zn(II) System at pH 7.4

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02514H, Communicationstephanie rat, jerome gout, Olivia Bistri, Olivia Reinaud
A supramolecular approach for modeling active sites of metallo-enzymes relies on the association of a metal ion bound to a tris(imidazole) core under the control of a cavity. One step...
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Biotin-Conjugated Pyridine-Based Isatoic Anhydride, a Selective Room Temperature RNA-Acylating Agent for the Nucleic Acid Separation.

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02636E, PaperSylvain Ursuegui, Rodrigue Yougnia, Severine Moutin, Arnaud Burr, Christine Fossey, Thomas Cailly, Ali Laayoun, Alain Laurent, Frederic Fabis
Isatoic anhydride derivatives, including a biotin and a disulfide linker were specifically designed for nucleic acid separation. 2'-OH selective RNA acylation, capture of biotinylated RNA adducts by streptavidin-coated magnetic beads...
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Correction: A novel enantioselective synthesis of 6H-dibenzopyran derivatives by combined palladium/norbornene and cinchona alkaloid catalysis

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90021B, CorrectionDi Xu, Li Dai, Marta Catellani, Elena Motti, Nicola Della Ca', Zhiming Zhou
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Correction: Using Hansen solubility parameters to study the encapsulation of caffeine in MOFs

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB90016F, CorrectionLorena Paseta, Gregory Potier, Steven Abbott, Joaquin Coronas
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Exploration of the active site of [small beta]4GalT7: Modifications of the aglycon of aromatic xylosides

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02632B, PaperAnna Siegbahn, Karin Thorsheim, Jonas Stahle, Sophie Manner, Christoffer Hamark, Andrea Persson, Emil Tykesson, Katrin Mani, Gunilla Westergren-Thorsson, Goran Widmalm, Ulf Ellervik
Proteoglycans (PGs) are macromolecules that consist of long linear polysaccharides, glycosaminoglycan (GAG) chains, covalently attached to a core protein by the carbohydrate xylose. The biosynthesis of GAG chains is initiated...
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Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as Tubulin Targeting Anticancer Agents and Apoptotic Inducers

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02449D, PaperAhmed Kamal, Santhosh Reddy Vangala, Anver Basha Shaik, Bharath Kumar G, Sowjanya Polepalli, Vishnuvardhan MVPS, Nishant Jainb
A library of new pyrazole and isoxazole conjugates were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds have shown significant cytotoxicity with lower...
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Fluorination of 2-substituted benzo[b]furans with SelectfluorTM

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02691H, CommunicationXun Sun, Mingliang Wang, Xixi Liu, Lu Zhou, Jidong Zhu
An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with SelectfluorTM as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydration agent, the compounds above were...
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Rhodium-catalyzed hydroarylation of alkynes via tetrazole-directed C-H activation

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00064E, CommunicationJin-Tao Yu, Yan Jiang, Jiang Cheng, Bin Chen
A rhodium-catalyzed hydroarylation of alkynes with aryl tetrazoles through tetrazole-directed C-H activation was developed. This procedure has broad substrate scopes, a variety of mono- and dialkenylated products were regioselectively obtained...
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Synthesis of Indolo[1,2-f]phenanthridines by Pd-catalyzed Domino C-N Coupling/Hydroamination/C-H Arylation Reactions

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00013K, PaperNgoc Thang, Peter Ehlers, Tuan T Dang, Alexander Villinger, Peter Langer
A new and convenient method for the synthesis of indolo[1,2-f]phenanthridines via palladium-catalyzed domino C-N coupling/hydroamination/C-H arylation reactions was developed. The reactions allow for the synthesis of various phenanthridines in good...
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GGCT fluorogenic probe: Design, synthesis and application to cancer-related cells

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00086F, CommunicationTaku Yoshiya, Hiromi Ii, Shugo Tsuda, Susumu Kageyama, Tatsuhiro Yoshiki, Yuji Nishiuchi
Cancer-related [gamma]-glutamyl cyclotransferase (GGCT) specifically converts [gamma]-glutamyl amino acids ([gamma]-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa). Here we report a novel GGCT fluorogenic probe "LISA-101". Upon cleavage of...
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Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes.

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02670E, PaperPavel K. Mykhailiuk
Three-component reaction between RCF2CH2NH2*HCl, NaNO2 and alkynes drastically depends on substituents "R" and "R1". The reaction gives the fluorinated pyrazoles in high yields when "R" is fluorine atom or fluoroalkyl...
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3-Nitro-2-pyridinesulfenyl-mediated Solid-phase Disulfide Ligation in the Synthesis of Disulfide Bond-containing Cyclic Peptides

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00030K, CommunicationAkihiro Taguchi, Kentarou Fukumoto, Yuya Asahina, Akihiro Kajiyama, Shunsuke Shimura, Keisuke Hamada, Kentaro Takayama, Fumika Yakushiji , Hironobu Hojo , Yoshio Hayashi
A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular...
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A New Method for the Synthesis of Difluoromethyl Enol Ethers by O-Difluoromethylation of 1,3-Diones with ClCF2CO2Et

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00020C, PaperZhiqiang Weng, Xiaoxi Lin
A facile, efficient, single-step protocol for the synthesis of difluoromethyl enol ethers derivatives by O-difluoromethylation of 1,3-diones via in situ generation of difluorocarbene from ClCF2CO2Et has been developed. The functional...
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Polyphosphate-Containing Bisubstrate Analogues as Inhibitors of a Bacterial Cell Wall Thymidylyltransferase

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02583K, PaperDeborah A Smithen, Stephanie M. Forget, Nicole E McCormick, Raymond T Syvitski, David L Jakeman
A series of polyphosphate containing sugar nucleotide analogues were synthesized and evaluated as bisubstrate inhibitors of [small alpha]-D-glucose 1-phosphate thymidylyltransferase Cps2L, the first enzyme in Streptococcus pneumoniae L-rhamnose biosynthesis, and a...
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Synthesis of the tricyclic core of manzamine A

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C4OB02582B, PaperRavindra Pathak, Benjamin Dobson, Nandita Ghosh, Khalid Ageel, Madeha Alshawish, Rungroj Saruengkhanphasit, I Coldham
An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in...
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Combining an Hsp70 inhibitor with either an N- or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes

Org. and Biomol. Chem. - 29 January, 2015 - 08:54
Org. Biomol. Chem., 2015, Accepted Manuscript
DOI: 10.1039/C5OB00147A, PaperYao Wang, Shelli Renee McAlpine
Blocking the function of both heat shock protein 90 and 70 (Hsp90 and Hsp70) simultaneously limits these chaperones' cytoprotective effects on cancer cells. The unique phenotype associated with modulating Hsp90's...
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A modular synthesis of functionalised phenols enabled by controlled boron speciation

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C5OB00078E, PaperJohn J. Molloy, Robert P. Law, James W. B. Fyfe, Ciaran P. Seath, David J. Hirst, Allan J. B. Watson
Functionalised biaryl phenols can be rapidly accessed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation, and oxidation.
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Physicochemical studies on the copper(II) binding by glycated collagen telopeptides

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02536A, PaperMeder Kamalov, Paul W. R. Harris, Christian G. Hartinger, Gordon M. Miskelly, Garth J. S. Cooper, Margaret A. Brimble
The strong interaction between advanced glycation end-products and Cu(II) ions has been revealed using site-specifically glycated collagenous peptides.
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Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02574A, PaperZheng-Le Zhao, Qing-Long Xu, Qing Gu, Xin-Yan Wu, Shu-Li You
Pd-catalyzed asymmetric intramolecular allylic alkylation reaction of phenols was developed, affording C4 substituted tetrahydroisoquinolines in moderate to excellent yields, enantioselectivity and regioselectivity.
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Acid-promoted direct electrophilic trifluoromethylthiolation of phenols

Org. and Biomol. Chem. - 29 January, 2015 - 08:54

Org. Biomol. Chem., 2015, Advance Article
DOI: 10.1039/C4OB02633K, PaperMarjan Jereb, Kaja Gosak
A highly selective and effective, acid-promoted, electrophilic trifluoromethylthiolation of phenols is described.
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